TRIM2 (tripartite motif containing 2)

Gene

• Entrez ID: 23321
• Gene name: Tripartite motif containing 2
• Gene symbol: TRIM2
• Synonyms (NCBI Gene): CMT2R, RNF86
• Chromosome: 4
• Chromosome location: 4q31.3
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs116558260	C>A,T	Conflicting-interpretations-of-pathogenicity	Coding sequence variant, genic downstream transcript variant, synonymous variant
rs587777063	A>T	Pathogenic	Intron variant, missense variant, coding sequence variant, genic downstream transcript variant
rs587777838	A>-	Pathogenic	Frameshift variant, coding sequence variant, genic downstream transcript variant
rs746386202	C>A,T	Pathogenic	Missense variant, stop gained, coding sequence variant, genic downstream transcript variant
rs879253863	A>C	Likely-pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant
rs1159989977	->TGCA	Likely-pathogenic	Initiator codon variant, genic upstream transcript variant, intron variant, frameshift variant, 5 prime UTR variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT002748	hsa-miR-1-3p	Microarray	15685193
MIRT006877	hsa-miR-181c-5p	In situ hybridization, Luciferase reporter assay	21720722
MIRT017162	hsa-miR-335-5p	Microarray	18185580
MIRT020230	hsa-miR-130b-3p	Sequencing	20371350
MIRT002748	hsa-miR-1-3p	Microarray;Other	15685193
MIRT025122	hsa-miR-181a-5p	Sequencing	20371350
MIRT025626	hsa-miR-10a-5p	Sequencing	20371350
MIRT030775	hsa-miR-21-5p	Microarray	18591254
MIRT031116	hsa-miR-19b-3p	Sequencing	20371350
MIRT045106	hsa-miR-186-5p	CLASH	23622248
MIRT509470	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509469	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT509468	hsa-miR-5690	HITS-CLIP	21572407
MIRT509467	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT509466	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT509465	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509464	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509463	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT309534	hsa-miR-10b-5p	PAR-CLIP	20371350
MIRT025626	hsa-miR-10a-5p	PAR-CLIP	20371350
MIRT553402	hsa-miR-504-5p	PAR-CLIP	20371350
MIRT553401	hsa-miR-1197	PAR-CLIP	20371350
MIRT553400	hsa-miR-1244	PAR-CLIP	20371350
MIRT553398	hsa-miR-3681-5p	PAR-CLIP	20371350
MIRT553399	hsa-miR-6849-5p	PAR-CLIP	20371350
MIRT553397	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT553396	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT309537	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT553394	hsa-miR-3117-3p	PAR-CLIP	20371350
MIRT553393	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT553392	hsa-miR-6079	PAR-CLIP	20371350
MIRT520477	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT520476	hsa-miR-5692b	PAR-CLIP	21572407
MIRT520475	hsa-miR-5692c	PAR-CLIP	21572407
MIRT520474	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509469	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509468	hsa-miR-5690	PAR-CLIP	21572407
MIRT509467	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT520473	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT520472	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509463	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT309534	hsa-miR-10b-5p	PAR-CLIP	21572407
MIRT025626	hsa-miR-10a-5p	PAR-CLIP	21572407
MIRT553402	hsa-miR-504-5p	PAR-CLIP	21572407
MIRT553401	hsa-miR-1197	PAR-CLIP	21572407
MIRT553400	hsa-miR-1244	PAR-CLIP	21572407
MIRT553398	hsa-miR-3681-5p	PAR-CLIP	21572407
MIRT553399	hsa-miR-6849-5p	PAR-CLIP	21572407
MIRT553397	hsa-miR-6828-5p	PAR-CLIP	21572407
MIRT553396	hsa-miR-671-5p	PAR-CLIP	21572407
MIRT309537	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT553395	hsa-miR-1258	PAR-CLIP	21572407
MIRT553394	hsa-miR-3117-3p	PAR-CLIP	21572407
MIRT553393	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT553392	hsa-miR-6079	PAR-CLIP	21572407
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509469	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509467	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509463	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT520477	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT520476	hsa-miR-5692b	PAR-CLIP	21572407
MIRT520475	hsa-miR-5692c	PAR-CLIP	21572407
MIRT520474	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509469	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509468	hsa-miR-5690	PAR-CLIP	21572407
MIRT509467	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT520473	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT520472	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT520471	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT520470	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509463	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT520477	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT520476	hsa-miR-5692b	PAR-CLIP	23446348
MIRT520475	hsa-miR-5692c	PAR-CLIP	23446348
MIRT520474	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509469	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509468	hsa-miR-5690	PAR-CLIP	23446348
MIRT509467	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT520473	hsa-miR-374c-5p	PAR-CLIP	23446348
MIRT520472	hsa-miR-655-3p	PAR-CLIP	23446348
MIRT520471	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT520470	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509463	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509469	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509468	hsa-miR-5690	PAR-CLIP	23446348
MIRT509467	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509463	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT439392	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT439392	hsa-miR-493-5p	HITS-CLIP	24374217
MIRT006877	hsa-miR-181c-5p	Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	27933582
MIRT006877	hsa-miR-181c-5p	Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	27933582
MIRT006877	hsa-miR-181c-5p	Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	27933582
MIRT006877	hsa-miR-181c-5p	Immunofluorescence, Immunoprecipitaion, Luciferase reporter assay, qRT-PCR, Western blot	27933582
MIRT509470	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509469	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT509468	hsa-miR-5690	HITS-CLIP	21572407
MIRT509467	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT509466	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT509465	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509464	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT509463	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT309534	hsa-miR-10b-5p	PAR-CLIP	20371350
MIRT025626	hsa-miR-10a-5p	PAR-CLIP	20371350
MIRT553402	hsa-miR-504-5p	PAR-CLIP	20371350
MIRT553401	hsa-miR-1197	PAR-CLIP	20371350
MIRT553400	hsa-miR-1244	PAR-CLIP	20371350
MIRT553398	hsa-miR-3681-5p	PAR-CLIP	20371350
MIRT553399	hsa-miR-6849-5p	PAR-CLIP	20371350
MIRT553397	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT553396	hsa-miR-671-5p	PAR-CLIP	20371350
MIRT309537	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT553394	hsa-miR-3117-3p	PAR-CLIP	20371350
MIRT553393	hsa-miR-411-5p	PAR-CLIP	20371350
MIRT553392	hsa-miR-6079	PAR-CLIP	20371350
MIRT520477	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT520476	hsa-miR-5692b	PAR-CLIP	21572407
MIRT520475	hsa-miR-5692c	PAR-CLIP	21572407
MIRT520474	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509469	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509468	hsa-miR-5690	PAR-CLIP	21572407
MIRT509467	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT520473	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT520472	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509463	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT309534	hsa-miR-10b-5p	PAR-CLIP	21572407
MIRT025626	hsa-miR-10a-5p	PAR-CLIP	21572407
MIRT553402	hsa-miR-504-5p	PAR-CLIP	21572407
MIRT553401	hsa-miR-1197	PAR-CLIP	21572407
MIRT553400	hsa-miR-1244	PAR-CLIP	21572407
MIRT553398	hsa-miR-3681-5p	PAR-CLIP	21572407
MIRT553399	hsa-miR-6849-5p	PAR-CLIP	21572407
MIRT553397	hsa-miR-6828-5p	PAR-CLIP	21572407
MIRT553396	hsa-miR-671-5p	PAR-CLIP	21572407
MIRT309537	hsa-miR-3190-3p	PAR-CLIP	21572407
MIRT553395	hsa-miR-1258	PAR-CLIP	21572407
MIRT553394	hsa-miR-3117-3p	PAR-CLIP	21572407
MIRT553393	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT553392	hsa-miR-6079	PAR-CLIP	21572407
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509469	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509467	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509463	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT520477	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT520476	hsa-miR-5692b	PAR-CLIP	21572407
MIRT520475	hsa-miR-5692c	PAR-CLIP	21572407
MIRT520474	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509469	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509468	hsa-miR-5690	PAR-CLIP	21572407
MIRT509467	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	21572407
MIRT520473	hsa-miR-374c-5p	PAR-CLIP	21572407
MIRT520472	hsa-miR-655-3p	PAR-CLIP	21572407
MIRT520471	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT520470	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT509463	hsa-miR-574-5p	PAR-CLIP	21572407
MIRT520477	hsa-miR-369-3p	PAR-CLIP	23446348
MIRT520476	hsa-miR-5692b	PAR-CLIP	23446348
MIRT520475	hsa-miR-5692c	PAR-CLIP	23446348
MIRT520474	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509469	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509468	hsa-miR-5690	PAR-CLIP	23446348
MIRT509467	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT520473	hsa-miR-374c-5p	PAR-CLIP	23446348
MIRT520472	hsa-miR-655-3p	PAR-CLIP	23446348
MIRT520471	hsa-miR-374a-5p	PAR-CLIP	23446348
MIRT520470	hsa-miR-374b-5p	PAR-CLIP	23446348
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509463	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT509470	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509469	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509468	hsa-miR-5690	PAR-CLIP	23446348
MIRT509467	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509466	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT509465	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509464	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509463	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT1453271	hsa-miR-129-5p	CLIP-seq
MIRT1453272	hsa-miR-142-5p	CLIP-seq
MIRT1453273	hsa-miR-145	CLIP-seq
MIRT1453274	hsa-miR-1915	CLIP-seq
MIRT1453275	hsa-miR-200b	CLIP-seq
MIRT1453276	hsa-miR-200c	CLIP-seq
MIRT1453277	hsa-miR-22	CLIP-seq
MIRT1453278	hsa-miR-300	CLIP-seq
MIRT1453279	hsa-miR-3120-5p	CLIP-seq
MIRT1453280	hsa-miR-3148	CLIP-seq
MIRT1453281	hsa-miR-3182	CLIP-seq
MIRT1453282	hsa-miR-3190	CLIP-seq
MIRT1453283	hsa-miR-3192	CLIP-seq
MIRT1453284	hsa-miR-340	CLIP-seq
MIRT1453285	hsa-miR-3652	CLIP-seq
MIRT1453286	hsa-miR-3668	CLIP-seq
MIRT1453287	hsa-miR-3671	CLIP-seq
MIRT1453288	hsa-miR-3689a-3p	CLIP-seq
MIRT1453289	hsa-miR-3689c	CLIP-seq
MIRT1453290	hsa-miR-381	CLIP-seq
MIRT1453291	hsa-miR-3942-3p	CLIP-seq
MIRT1453292	hsa-miR-3977	CLIP-seq
MIRT1453293	hsa-miR-3978	CLIP-seq
MIRT1453294	hsa-miR-429	CLIP-seq
MIRT1453295	hsa-miR-4318	CLIP-seq
MIRT1453296	hsa-miR-432	CLIP-seq
MIRT1453297	hsa-miR-4328	CLIP-seq
MIRT1453298	hsa-miR-4418	CLIP-seq
MIRT1453299	hsa-miR-4422	CLIP-seq
MIRT1453300	hsa-miR-4430	CLIP-seq
MIRT1453301	hsa-miR-4457	CLIP-seq
MIRT1453302	hsa-miR-4470	CLIP-seq
MIRT1453303	hsa-miR-4493	CLIP-seq
MIRT1453304	hsa-miR-4495	CLIP-seq
MIRT1453305	hsa-miR-4505	CLIP-seq
MIRT1453306	hsa-miR-4536	CLIP-seq
MIRT1453307	hsa-miR-4693-5p	CLIP-seq
MIRT1453308	hsa-miR-4716-5p	CLIP-seq
MIRT1453309	hsa-miR-4728-5p	CLIP-seq
MIRT1453310	hsa-miR-4731-5p	CLIP-seq
MIRT1453311	hsa-miR-4753-5p	CLIP-seq
MIRT1453312	hsa-miR-4761-5p	CLIP-seq
MIRT1453313	hsa-miR-4762-5p	CLIP-seq
MIRT1453314	hsa-miR-4764-3p	CLIP-seq
MIRT1453315	hsa-miR-4772-3p	CLIP-seq
MIRT1453316	hsa-miR-488	CLIP-seq
MIRT1453317	hsa-miR-490-5p	CLIP-seq
MIRT1453318	hsa-miR-496	CLIP-seq
MIRT1453319	hsa-miR-509-3-5p	CLIP-seq
MIRT1453320	hsa-miR-509-5p	CLIP-seq
MIRT1453321	hsa-miR-511	CLIP-seq
MIRT1453322	hsa-miR-512-3p	CLIP-seq
MIRT1453323	hsa-miR-513b	CLIP-seq
MIRT1453324	hsa-miR-516b	CLIP-seq
MIRT1453325	hsa-miR-548a-3p	CLIP-seq
MIRT1453326	hsa-miR-548a-5p	CLIP-seq
MIRT1453327	hsa-miR-548aa	CLIP-seq
MIRT1453328	hsa-miR-548ab	CLIP-seq
MIRT1453329	hsa-miR-548ak	CLIP-seq
MIRT1453330	hsa-miR-548b-5p	CLIP-seq
MIRT1453331	hsa-miR-548c-5p	CLIP-seq
MIRT1453332	hsa-miR-548d-5p	CLIP-seq
MIRT1453333	hsa-miR-548e	CLIP-seq
MIRT1453334	hsa-miR-548f	CLIP-seq
MIRT1453335	hsa-miR-548h	CLIP-seq
MIRT1453336	hsa-miR-548i	CLIP-seq
MIRT1453337	hsa-miR-548j	CLIP-seq
MIRT1453338	hsa-miR-548k	CLIP-seq
MIRT1453339	hsa-miR-548l	CLIP-seq
MIRT1453340	hsa-miR-548w	CLIP-seq
MIRT1453341	hsa-miR-548y	CLIP-seq
MIRT1453342	hsa-miR-554	CLIP-seq
MIRT1453343	hsa-miR-559	CLIP-seq
MIRT1453344	hsa-miR-561	CLIP-seq
MIRT1453345	hsa-miR-595	CLIP-seq
MIRT1453346	hsa-miR-607	CLIP-seq
MIRT1453347	hsa-miR-624	CLIP-seq
MIRT1453348	hsa-miR-628-5p	CLIP-seq
MIRT1453349	hsa-miR-637	CLIP-seq
MIRT1453350	hsa-miR-759	CLIP-seq
MIRT1453351	hsa-miR-892a	CLIP-seq
MIRT1453352	hsa-miR-944	CLIP-seq
MIRT1453353	hsa-miR-203	CLIP-seq
MIRT1453354	hsa-miR-3074-3p	CLIP-seq
MIRT1453355	hsa-miR-3133	CLIP-seq
MIRT1453285	hsa-miR-3652	CLIP-seq
MIRT1453356	hsa-miR-3691-3p	CLIP-seq
MIRT1453300	hsa-miR-4430	CLIP-seq
MIRT1453305	hsa-miR-4505	CLIP-seq
MIRT1453357	hsa-miR-4709-3p	CLIP-seq
MIRT1453358	hsa-miR-4709-5p	CLIP-seq
MIRT1453315	hsa-miR-4772-3p	CLIP-seq
MIRT1453345	hsa-miR-595	CLIP-seq
MIRT1555190	hsa-miR-2682	CLIP-seq
MIRT1555191	hsa-miR-449c	CLIP-seq
MIRT1453354	hsa-miR-3074-3p	CLIP-seq
MIRT1453299	hsa-miR-4422	CLIP-seq
MIRT2135799	hsa-miR-1193	CLIP-seq
MIRT2135800	hsa-miR-1227	CLIP-seq
MIRT2135801	hsa-miR-1263	CLIP-seq
MIRT2135802	hsa-miR-1298	CLIP-seq
MIRT2135803	hsa-miR-1299	CLIP-seq
MIRT2135804	hsa-miR-130a	CLIP-seq
MIRT2135805	hsa-miR-130b	CLIP-seq
MIRT1453273	hsa-miR-145	CLIP-seq
MIRT2135806	hsa-miR-148a	CLIP-seq
MIRT2135807	hsa-miR-148b	CLIP-seq
MIRT2135808	hsa-miR-152	CLIP-seq
MIRT2135809	hsa-miR-155	CLIP-seq
MIRT2135810	hsa-miR-181a	CLIP-seq
MIRT2135811	hsa-miR-181b	CLIP-seq
MIRT2135812	hsa-miR-181c	CLIP-seq
MIRT2135813	hsa-miR-181d	CLIP-seq
MIRT2135814	hsa-miR-1825	CLIP-seq
MIRT2135815	hsa-miR-198	CLIP-seq
MIRT2135816	hsa-miR-199a-5p	CLIP-seq
MIRT2135817	hsa-miR-199b-5p	CLIP-seq
MIRT2135818	hsa-miR-2113	CLIP-seq
MIRT2135819	hsa-miR-2681	CLIP-seq
MIRT2135820	hsa-miR-27a	CLIP-seq
MIRT2135821	hsa-miR-27b	CLIP-seq
MIRT2135822	hsa-miR-301a	CLIP-seq
MIRT2135823	hsa-miR-301b	CLIP-seq
MIRT1453354	hsa-miR-3074-3p	CLIP-seq
MIRT1453355	hsa-miR-3133	CLIP-seq
MIRT2135824	hsa-miR-3143	CLIP-seq
MIRT2135825	hsa-miR-3160-5p	CLIP-seq
MIRT2135826	hsa-miR-3180-5p	CLIP-seq
MIRT2135827	hsa-miR-338-3p	CLIP-seq
MIRT2135828	hsa-miR-345	CLIP-seq
MIRT2135829	hsa-miR-34b	CLIP-seq
MIRT2135830	hsa-miR-3613-3p	CLIP-seq
MIRT2135831	hsa-miR-3666	CLIP-seq
MIRT2135832	hsa-miR-3681	CLIP-seq
MIRT2135833	hsa-miR-4256	CLIP-seq
MIRT2135834	hsa-miR-4262	CLIP-seq
MIRT2135835	hsa-miR-4276	CLIP-seq
MIRT2135836	hsa-miR-4295	CLIP-seq
MIRT1453297	hsa-miR-4328	CLIP-seq
MIRT2135837	hsa-miR-4427	CLIP-seq
MIRT1453303	hsa-miR-4493	CLIP-seq
MIRT1453304	hsa-miR-4495	CLIP-seq
MIRT2135838	hsa-miR-4509	CLIP-seq
MIRT2135839	hsa-miR-4522	CLIP-seq
MIRT2135840	hsa-miR-4530	CLIP-seq
MIRT2135841	hsa-miR-454	CLIP-seq
MIRT2135842	hsa-miR-4680-3p	CLIP-seq
MIRT2135843	hsa-miR-4742-3p	CLIP-seq
MIRT1453311	hsa-miR-4753-5p	CLIP-seq
MIRT2135844	hsa-miR-4762-3p	CLIP-seq
MIRT2135845	hsa-miR-4782-5p	CLIP-seq
MIRT2135846	hsa-miR-485-3p	CLIP-seq
MIRT2135847	hsa-miR-498	CLIP-seq
MIRT2135848	hsa-miR-513a-5p	CLIP-seq
MIRT2135849	hsa-miR-515-3p	CLIP-seq
MIRT2135850	hsa-miR-515-5p	CLIP-seq
MIRT1453324	hsa-miR-516b	CLIP-seq
MIRT2135851	hsa-miR-519e	CLIP-seq
MIRT1453325	hsa-miR-548a-3p	CLIP-seq
MIRT1453333	hsa-miR-548e	CLIP-seq
MIRT1453334	hsa-miR-548f	CLIP-seq
MIRT2135852	hsa-miR-548m	CLIP-seq
MIRT1453346	hsa-miR-607	CLIP-seq
MIRT2135853	hsa-miR-664	CLIP-seq
MIRT2135854	hsa-miR-890	CLIP-seq
MIRT2135855	hsa-miR-9	CLIP-seq
MIRT2135856	hsa-miR-938	CLIP-seq
MIRT1453354	hsa-miR-3074-3p	CLIP-seq
MIRT2356939	hsa-miR-3121-3p	CLIP-seq
MIRT2356940	hsa-miR-325	CLIP-seq
MIRT2356941	hsa-miR-4797-3p	CLIP-seq
MIRT2356942	hsa-miR-510	CLIP-seq
MIRT2356943	hsa-miR-512-5p	CLIP-seq
MIRT2135853	hsa-miR-664	CLIP-seq
MIRT2356944	hsa-miR-4420	CLIP-seq
MIRT2462343	hsa-miR-3185	CLIP-seq
MIRT2462344	hsa-miR-3667-5p	CLIP-seq
MIRT2135835	hsa-miR-4276	CLIP-seq
MIRT2650403	hsa-miR-101	CLIP-seq
MIRT2650404	hsa-miR-10a	CLIP-seq
MIRT2650405	hsa-miR-10b	CLIP-seq
MIRT2650406	hsa-miR-1183	CLIP-seq
MIRT2650407	hsa-miR-1253	CLIP-seq
MIRT2650408	hsa-miR-1273d	CLIP-seq
MIRT2650409	hsa-miR-1286	CLIP-seq
MIRT2650410	hsa-miR-1293	CLIP-seq
MIRT2650411	hsa-miR-1294	CLIP-seq
MIRT2650412	hsa-miR-135a	CLIP-seq
MIRT2650413	hsa-miR-135b	CLIP-seq
MIRT2650414	hsa-miR-141	CLIP-seq
MIRT2650415	hsa-miR-144	CLIP-seq
MIRT1453273	hsa-miR-145	CLIP-seq
MIRT2650416	hsa-miR-154	CLIP-seq
MIRT2135809	hsa-miR-155	CLIP-seq
MIRT2650417	hsa-miR-15a	CLIP-seq
MIRT2650418	hsa-miR-15b	CLIP-seq
MIRT2650419	hsa-miR-16	CLIP-seq
MIRT2650420	hsa-miR-1910	CLIP-seq
MIRT2650421	hsa-miR-1912	CLIP-seq
MIRT2650422	hsa-miR-192	CLIP-seq
MIRT2650423	hsa-miR-193a-5p	CLIP-seq
MIRT2650424	hsa-miR-195	CLIP-seq
MIRT2650425	hsa-miR-200a	CLIP-seq
MIRT2650426	hsa-miR-2052	CLIP-seq
MIRT2650427	hsa-miR-21	CLIP-seq
MIRT2650428	hsa-miR-214	CLIP-seq
MIRT2650429	hsa-miR-215	CLIP-seq
MIRT1453278	hsa-miR-300	CLIP-seq
MIRT2650430	hsa-miR-3064-3p	CLIP-seq
MIRT1453354	hsa-miR-3074-3p	CLIP-seq
MIRT1453355	hsa-miR-3133	CLIP-seq
MIRT2650431	hsa-miR-3144-3p	CLIP-seq
MIRT2135825	hsa-miR-3160-5p	CLIP-seq
MIRT2650432	hsa-miR-320a	CLIP-seq
MIRT2650433	hsa-miR-320b	CLIP-seq
MIRT2650434	hsa-miR-320c	CLIP-seq
MIRT2650435	hsa-miR-320d	CLIP-seq
MIRT2650436	hsa-miR-338-5p	CLIP-seq
MIRT2650437	hsa-miR-3607-3p	CLIP-seq
MIRT2650438	hsa-miR-3609	CLIP-seq
MIRT2135830	hsa-miR-3613-3p	CLIP-seq
MIRT2650439	hsa-miR-361-3p	CLIP-seq
MIRT2650440	hsa-miR-3618	CLIP-seq
MIRT2650441	hsa-miR-3619-5p	CLIP-seq
MIRT2650442	hsa-miR-3646	CLIP-seq
MIRT2650443	hsa-miR-3674	CLIP-seq
MIRT2650444	hsa-miR-3679-3p	CLIP-seq
MIRT1453290	hsa-miR-381	CLIP-seq
MIRT2650445	hsa-miR-3936	CLIP-seq
MIRT2650446	hsa-miR-3938	CLIP-seq
MIRT2650447	hsa-miR-409-3p	CLIP-seq
MIRT2650448	hsa-miR-410	CLIP-seq
MIRT2650449	hsa-miR-424	CLIP-seq
MIRT2650450	hsa-miR-4263	CLIP-seq
MIRT2650451	hsa-miR-4280	CLIP-seq
MIRT2650452	hsa-miR-4282	CLIP-seq
MIRT2650453	hsa-miR-4291	CLIP-seq
MIRT2650454	hsa-miR-4292	CLIP-seq
MIRT2650455	hsa-miR-4308	CLIP-seq
MIRT2650456	hsa-miR-4315	CLIP-seq
MIRT2650457	hsa-miR-433	CLIP-seq
MIRT1453299	hsa-miR-4422	CLIP-seq
MIRT2650458	hsa-miR-4429	CLIP-seq
MIRT2650459	hsa-miR-4446-3p	CLIP-seq
MIRT1453301	hsa-miR-4457	CLIP-seq
MIRT2650460	hsa-miR-4459	CLIP-seq
MIRT2650461	hsa-miR-4483	CLIP-seq
MIRT2650462	hsa-miR-4487	CLIP-seq
MIRT2650463	hsa-miR-4503	CLIP-seq
MIRT2650464	hsa-miR-450b-3p	CLIP-seq
MIRT2650465	hsa-miR-450b-5p	CLIP-seq
MIRT2650466	hsa-miR-4521	CLIP-seq
MIRT2650467	hsa-miR-4539	CLIP-seq
MIRT2650468	hsa-miR-455-3p	CLIP-seq
MIRT2650469	hsa-miR-4651	CLIP-seq
MIRT2650470	hsa-miR-4666-5p	CLIP-seq
MIRT2650471	hsa-miR-4680-5p	CLIP-seq
MIRT2650472	hsa-miR-4691-5p	CLIP-seq
MIRT1453307	hsa-miR-4693-5p	CLIP-seq
MIRT2650473	hsa-miR-4696	CLIP-seq
MIRT2650474	hsa-miR-4699-5p	CLIP-seq
MIRT2650475	hsa-miR-4713-3p	CLIP-seq
MIRT2650476	hsa-miR-4716-3p	CLIP-seq
MIRT1453308	hsa-miR-4716-5p	CLIP-seq
MIRT2650477	hsa-miR-4721	CLIP-seq
MIRT2650478	hsa-miR-4722-5p	CLIP-seq
MIRT2650479	hsa-miR-4729	CLIP-seq
MIRT2650480	hsa-miR-4760-3p	CLIP-seq
MIRT1453312	hsa-miR-4761-5p	CLIP-seq
MIRT1453313	hsa-miR-4762-5p	CLIP-seq
MIRT1453314	hsa-miR-4764-3p	CLIP-seq
MIRT2650481	hsa-miR-4790-5p	CLIP-seq
MIRT2650482	hsa-miR-4792	CLIP-seq
MIRT2650483	hsa-miR-487a	CLIP-seq
MIRT2650484	hsa-miR-497	CLIP-seq
MIRT2135847	hsa-miR-498	CLIP-seq
MIRT2650485	hsa-miR-507	CLIP-seq
MIRT2650486	hsa-miR-508-5p	CLIP-seq
MIRT2650487	hsa-miR-513a-3p	CLIP-seq
MIRT1453323	hsa-miR-513b	CLIP-seq
MIRT2650488	hsa-miR-520a-5p	CLIP-seq
MIRT2650489	hsa-miR-525-5p	CLIP-seq
MIRT2650490	hsa-miR-543	CLIP-seq
MIRT2650491	hsa-miR-548ah	CLIP-seq
MIRT2650492	hsa-miR-548n	CLIP-seq
MIRT2650493	hsa-miR-548p	CLIP-seq
MIRT2650494	hsa-miR-548t	CLIP-seq
MIRT2650495	hsa-miR-557	CLIP-seq
MIRT1453344	hsa-miR-561	CLIP-seq
MIRT2650496	hsa-miR-570	CLIP-seq
MIRT2650497	hsa-miR-576-5p	CLIP-seq
MIRT2650498	hsa-miR-577	CLIP-seq
MIRT2650499	hsa-miR-579	CLIP-seq
MIRT2650500	hsa-miR-581	CLIP-seq
MIRT2650501	hsa-miR-590-5p	CLIP-seq
MIRT2650502	hsa-miR-606	CLIP-seq
MIRT2650503	hsa-miR-608	CLIP-seq
MIRT2650504	hsa-miR-616	CLIP-seq
MIRT1453347	hsa-miR-624	CLIP-seq
MIRT1453348	hsa-miR-628-5p	CLIP-seq
MIRT2650505	hsa-miR-638	CLIP-seq
MIRT2650506	hsa-miR-643	CLIP-seq
MIRT2135853	hsa-miR-664	CLIP-seq
MIRT2650507	hsa-miR-670	CLIP-seq
MIRT2650508	hsa-miR-676	CLIP-seq
MIRT2650509	hsa-miR-758	CLIP-seq
MIRT2650510	hsa-miR-760	CLIP-seq
MIRT2650511	hsa-miR-761	CLIP-seq
MIRT2650512	hsa-miR-769-3p	CLIP-seq
MIRT2650513	hsa-miR-873	CLIP-seq
MIRT2135855	hsa-miR-9	CLIP-seq
MIRT2650514	hsa-miR-922	CLIP-seq
MIRT2650515	hsa-miR-934	CLIP-seq
MIRT2135856	hsa-miR-938	CLIP-seq
MIRT2135825	hsa-miR-3160-5p	CLIP-seq
MIRT1453299	hsa-miR-4422	CLIP-seq
MIRT2650490	hsa-miR-543	CLIP-seq
MIRT2650406	hsa-miR-1183	CLIP-seq
MIRT2650407	hsa-miR-1253	CLIP-seq
MIRT2694122	hsa-miR-1270	CLIP-seq
MIRT2650408	hsa-miR-1273d	CLIP-seq
MIRT2694123	hsa-miR-1284	CLIP-seq
MIRT2650409	hsa-miR-1286	CLIP-seq
MIRT2650410	hsa-miR-1293	CLIP-seq
MIRT2650411	hsa-miR-1294	CLIP-seq
MIRT2135804	hsa-miR-130a	CLIP-seq
MIRT2135805	hsa-miR-130b	CLIP-seq
MIRT2650412	hsa-miR-135a	CLIP-seq
MIRT2650413	hsa-miR-135b	CLIP-seq
MIRT2650414	hsa-miR-141	CLIP-seq
MIRT2650416	hsa-miR-154	CLIP-seq
MIRT2135809	hsa-miR-155	CLIP-seq
MIRT2650417	hsa-miR-15a	CLIP-seq
MIRT2650418	hsa-miR-15b	CLIP-seq
MIRT2650419	hsa-miR-16	CLIP-seq
MIRT2650420	hsa-miR-1910	CLIP-seq
MIRT2650421	hsa-miR-1912	CLIP-seq
MIRT2650422	hsa-miR-192	CLIP-seq
MIRT2650423	hsa-miR-193a-5p	CLIP-seq
MIRT2650424	hsa-miR-195	CLIP-seq
MIRT2650425	hsa-miR-200a	CLIP-seq
MIRT2650426	hsa-miR-2052	CLIP-seq
MIRT2650427	hsa-miR-21	CLIP-seq
MIRT2650428	hsa-miR-214	CLIP-seq
MIRT2650429	hsa-miR-215	CLIP-seq
MIRT1453278	hsa-miR-300	CLIP-seq
MIRT2135822	hsa-miR-301a	CLIP-seq
MIRT2135823	hsa-miR-301b	CLIP-seq
MIRT2650430	hsa-miR-3064-3p	CLIP-seq
MIRT1453354	hsa-miR-3074-3p	CLIP-seq
MIRT1453355	hsa-miR-3133	CLIP-seq
MIRT2135825	hsa-miR-3160-5p	CLIP-seq
MIRT2650432	hsa-miR-320a	CLIP-seq
MIRT2650433	hsa-miR-320b	CLIP-seq
MIRT2650434	hsa-miR-320c	CLIP-seq
MIRT2650435	hsa-miR-320d	CLIP-seq
MIRT2650436	hsa-miR-338-5p	CLIP-seq
MIRT2694124	hsa-miR-3591-5p	CLIP-seq
MIRT2650437	hsa-miR-3607-3p	CLIP-seq
MIRT2650438	hsa-miR-3609	CLIP-seq
MIRT2135830	hsa-miR-3613-3p	CLIP-seq
MIRT2650439	hsa-miR-361-3p	CLIP-seq
MIRT2650440	hsa-miR-3618	CLIP-seq
MIRT2650441	hsa-miR-3619-5p	CLIP-seq
MIRT2650442	hsa-miR-3646	CLIP-seq
MIRT2135831	hsa-miR-3666	CLIP-seq
MIRT2650443	hsa-miR-3674	CLIP-seq
MIRT2650444	hsa-miR-3679-3p	CLIP-seq
MIRT2135832	hsa-miR-3681	CLIP-seq
MIRT2694125	hsa-miR-3685	CLIP-seq
MIRT1453290	hsa-miR-381	CLIP-seq
MIRT2694126	hsa-miR-384	CLIP-seq
MIRT2650445	hsa-miR-3936	CLIP-seq
MIRT2650446	hsa-miR-3938	CLIP-seq
MIRT2694127	hsa-miR-3973	CLIP-seq
MIRT2650447	hsa-miR-409-3p	CLIP-seq
MIRT2650448	hsa-miR-410	CLIP-seq
MIRT2650449	hsa-miR-424	CLIP-seq
MIRT2694128	hsa-miR-4254	CLIP-seq
MIRT2694129	hsa-miR-4255	CLIP-seq
MIRT2650450	hsa-miR-4263	CLIP-seq
MIRT2650452	hsa-miR-4282	CLIP-seq
MIRT2650453	hsa-miR-4291	CLIP-seq
MIRT2650454	hsa-miR-4292	CLIP-seq
MIRT2135836	hsa-miR-4295	CLIP-seq
MIRT2650455	hsa-miR-4308	CLIP-seq
MIRT2694130	hsa-miR-431	CLIP-seq
MIRT2650456	hsa-miR-4315	CLIP-seq
MIRT2650457	hsa-miR-433	CLIP-seq
MIRT1453299	hsa-miR-4422	CLIP-seq
MIRT2650458	hsa-miR-4429	CLIP-seq
MIRT2650459	hsa-miR-4446-3p	CLIP-seq
MIRT1453301	hsa-miR-4457	CLIP-seq
MIRT2650460	hsa-miR-4459	CLIP-seq
MIRT2694131	hsa-miR-4477b	CLIP-seq
MIRT2650461	hsa-miR-4483	CLIP-seq
MIRT2650462	hsa-miR-4487	CLIP-seq
MIRT2650463	hsa-miR-4503	CLIP-seq
MIRT2650464	hsa-miR-450b-3p	CLIP-seq
MIRT2650465	hsa-miR-450b-5p	CLIP-seq
MIRT2650466	hsa-miR-4521	CLIP-seq
MIRT2650467	hsa-miR-4539	CLIP-seq
MIRT2135841	hsa-miR-454	CLIP-seq
MIRT2650468	hsa-miR-455-3p	CLIP-seq
MIRT2650469	hsa-miR-4651	CLIP-seq
MIRT2650470	hsa-miR-4666-5p	CLIP-seq
MIRT2650471	hsa-miR-4680-5p	CLIP-seq
MIRT2694132	hsa-miR-4683	CLIP-seq
MIRT2650472	hsa-miR-4691-5p	CLIP-seq
MIRT2694133	hsa-miR-4693-3p	CLIP-seq
MIRT1453307	hsa-miR-4693-5p	CLIP-seq
MIRT2650473	hsa-miR-4696	CLIP-seq
MIRT2650474	hsa-miR-4699-5p	CLIP-seq
MIRT2694134	hsa-miR-4705	CLIP-seq
MIRT2650475	hsa-miR-4713-3p	CLIP-seq
MIRT2694135	hsa-miR-4717-3p	CLIP-seq
MIRT2650477	hsa-miR-4721	CLIP-seq
MIRT2650478	hsa-miR-4722-5p	CLIP-seq
MIRT2650479	hsa-miR-4729	CLIP-seq
MIRT2650480	hsa-miR-4760-3p	CLIP-seq
MIRT1453312	hsa-miR-4761-5p	CLIP-seq
MIRT2650481	hsa-miR-4790-5p	CLIP-seq
MIRT2650482	hsa-miR-4792	CLIP-seq
MIRT2650483	hsa-miR-487a	CLIP-seq
MIRT2650484	hsa-miR-497	CLIP-seq
MIRT2135847	hsa-miR-498	CLIP-seq
MIRT2650485	hsa-miR-507	CLIP-seq
MIRT2650486	hsa-miR-508-5p	CLIP-seq
MIRT2650487	hsa-miR-513a-3p	CLIP-seq
MIRT1453323	hsa-miR-513b	CLIP-seq
MIRT2650488	hsa-miR-520a-5p	CLIP-seq
MIRT2650489	hsa-miR-525-5p	CLIP-seq
MIRT2694136	hsa-miR-532-5p	CLIP-seq
MIRT2650490	hsa-miR-543	CLIP-seq
MIRT1453326	hsa-miR-548a-5p	CLIP-seq
MIRT1453328	hsa-miR-548ab	CLIP-seq
MIRT2650491	hsa-miR-548ah	CLIP-seq
MIRT1453329	hsa-miR-548ak	CLIP-seq
MIRT1453330	hsa-miR-548b-5p	CLIP-seq
MIRT1453331	hsa-miR-548c-5p	CLIP-seq
MIRT1453332	hsa-miR-548d-5p	CLIP-seq
MIRT1453335	hsa-miR-548h	CLIP-seq
MIRT1453336	hsa-miR-548i	CLIP-seq
MIRT1453337	hsa-miR-548j	CLIP-seq
MIRT2650492	hsa-miR-548n	CLIP-seq
MIRT2650493	hsa-miR-548p	CLIP-seq
MIRT2650494	hsa-miR-548t	CLIP-seq
MIRT1453340	hsa-miR-548w	CLIP-seq
MIRT1453341	hsa-miR-548y	CLIP-seq
MIRT2650495	hsa-miR-557	CLIP-seq
MIRT1453343	hsa-miR-559	CLIP-seq
MIRT1453344	hsa-miR-561	CLIP-seq
MIRT2650496	hsa-miR-570	CLIP-seq
MIRT2650497	hsa-miR-576-5p	CLIP-seq
MIRT2650498	hsa-miR-577	CLIP-seq
MIRT2650499	hsa-miR-579	CLIP-seq
MIRT2650500	hsa-miR-581	CLIP-seq
MIRT2650501	hsa-miR-590-5p	CLIP-seq
MIRT2650502	hsa-miR-606	CLIP-seq
MIRT2650503	hsa-miR-608	CLIP-seq
MIRT2650504	hsa-miR-616	CLIP-seq
MIRT2694137	hsa-miR-619	CLIP-seq
MIRT2694138	hsa-miR-620	CLIP-seq
MIRT1453347	hsa-miR-624	CLIP-seq
MIRT1453348	hsa-miR-628-5p	CLIP-seq
MIRT2650505	hsa-miR-638	CLIP-seq
MIRT2650506	hsa-miR-643	CLIP-seq
MIRT2694139	hsa-miR-659	CLIP-seq
MIRT2135853	hsa-miR-664	CLIP-seq
MIRT2650507	hsa-miR-670	CLIP-seq
MIRT2650508	hsa-miR-676	CLIP-seq
MIRT2650509	hsa-miR-758	CLIP-seq
MIRT2650510	hsa-miR-760	CLIP-seq
MIRT2650511	hsa-miR-761	CLIP-seq
MIRT2650512	hsa-miR-769-3p	CLIP-seq
MIRT2650513	hsa-miR-873	CLIP-seq
MIRT2135855	hsa-miR-9	CLIP-seq
MIRT2650514	hsa-miR-922	CLIP-seq
MIRT2650515	hsa-miR-934	CLIP-seq
MIRT2135856	hsa-miR-938	CLIP-seq
MIRT1453352	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IBA
GO:0004842	Function	Ubiquitin-protein transferase activity	IEA
GO:0004842	Function	Ubiquitin-protein transferase activity	ISS
GO:0005515	Function	Protein binding	IPI	21478148, 21516116, 25416956, 26871637, 28514442, 32296183, 32814053, 33961781, 36217029
GO:0005737	Component	Cytoplasm	IDA	11331580
GO:0005737	Component	Cytoplasm	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	NAS	11331580
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IBA
GO:0043523	Process	Regulation of neuron apoptotic process	IEA
GO:0043523	Process	Regulation of neuron apoptotic process	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA

Other IDs

• MIM: 614141
• HGNC: 15974
• e!Ensembl: ENSG00000109654

Protein

• UniProt ID: Q9C040
• Protein name: Tripartite motif-containing protein 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM2) (RING finger protein 86) (RING-type E3 ubiquitin transferase TRIM2)
• Protein function: UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and l
• PDB: 7B2R, 7B96, 7QRV, 7ZJ3, 8A38, 8AMS
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13445	zf-RING_UBOX	23 → 61	RING-type zinc-finger	Domain
  PF00643	zf-B_box	113 → 154	B-box zinc finger	Domain
  PF00630	Filamin	322 → 418	Filamin/ABP280 repeat	Domain
  PF01436	NHL	486 → 513	NHL repeat	Repeat
  PF01436	NHL	533 → 560	NHL repeat	Repeat
  PF01436	NHL	575 → 602	NHL repeat	Repeat
  PF01436	NHL	622 → 649	NHL repeat	Repeat
  PF01436	NHL	669 → 696	NHL repeat	Repeat
  PF01436	NHL	713 → 740	NHL repeat	Repeat

• Sequence:

  MASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSC
  PVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPN
  HDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEID
  SALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQ
  LDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLD
  FIVETEGLKKSIHNLGTILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKT
  GNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLK
  VIRSADVSPTTEGVKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKG
  RNKGEFTNLQGVAASTNGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVA
  VHPSGDIIIADYDNKWVSIFSSDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVF
  IFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFG
  SNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLA
  LTSDGHVVVADSGNHCFKVYRYLQ

• Sequence length: 744

Pathways

Reactome:

Interferon gamma signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Charcot-Marie-Tooth disease type 2R	Likely pathogenic; Pathogenic	rs879253863, rs587777063, rs587777838	RCV000235081 RCV000074302 RCV000074303	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CHARCOT-MARIE-TOOTH DISEASE	—	ClinVar, Disgenet ClinVar, Disgenet ClinVar, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEJERINE-SOTTAS DISEASE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEREDITARY MOTOR AND SENSORY NEUROPATHIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEREDITARY MOTOR AND SENSORY NEUROPATHY, TYPES I-IV	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC NEUROPATHY OF INFANCY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Peripheral axonal neuropathy	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERONEAL MUSCULAR ATROPHY	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ROUSSY-LEVY SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN NEOPLASM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THYROTOXIC PERIODIC PARALYSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TRIM2-related disorder	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bilateral vocal cord paralysis	Vocal Cord Paralysis	BEFREE	25893792		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	28216417	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	33223511	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	26472353		★☆☆☆☆ Found in Text Mining only
Charcot-Marie-Tooth Disease	Charcot-Marie-Tooth Disease	BEFREE	30726215		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Charcot-Marie-Tooth disease type 2R	Charcot-Marie-Tooth Disease	Orphanet			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R	Charcot-Marie-Tooth Disease	GENOMICS_ENGLAND_DG	18687884, 23562820		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R	Charcot-Marie-Tooth Disease	ORPHANET_DG	23562820		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R	Charcot-Marie-Tooth Disease	UNIPROT_DG	23562820		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R	Charcot-Marie-Tooth Disease	CLINVAR_DG	25893792, 26257172		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2R	Charcot-Marie-Tooth Disease	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30916596		★☆☆☆☆ Found in Text Mining only
Congenital clubfoot	Congenital Clubfoot	HPO_DG			★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30538545		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	17568789		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	CTD_human_DG	17568789		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	27933582		★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	26472353		★☆☆☆☆ Found in Text Mining only
Esophagitis	Esotropia	Pubtator	29628359	Associate	★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	27933582		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	33118318	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	26472353, 30916596		★☆☆☆☆ Found in Text Mining only
Nervous System Diseases	Nervous system disease	Pubtator	25893792	Associate	★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	33378023	Associate	★☆☆☆☆ Found in Text Mining only
Neuropathy	Neuropathy	BEFREE	25893792		★☆☆☆☆ Found in Text Mining only
Osteoarthrosis Deformans	Osteoarthrosis Deformans	CTD_human_DG	17568789		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	30066883		★☆☆☆☆ Found in Text Mining only
Peripheral axonal neuropathy	Peripheral axonal neuropathy	HPO_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Peripheral Nervous System Diseases	Nervous System Diseases	BEFREE	25893792		★☆☆☆☆ Found in Text Mining only
Peripheral Nervous System Diseases	Peripheral nervous system disease	Pubtator	25893792	Associate	★☆☆☆☆ Found in Text Mining only
Peripheral Neuropathy	Peripheral Neuropathy	BEFREE	25893792		★☆☆☆☆ Found in Text Mining only
Presenile dementia	Senile Dementia	BEFREE	27933582		★☆☆☆☆ Found in Text Mining only
Seizures	Seizures	Pubtator	32233732	Associate	★☆☆☆☆ Found in Text Mining only
Tracheomalacia	Tracheomalacia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Vocal Cord Paralysis	Vocal Cord Paralysis	HPO_DG			★☆☆☆☆ Found in Text Mining only