SLC9A8 (solute carrier family 9 member A8)

Gene

• Entrez ID: 23315
• Gene name: Solute carrier family 9 member A8
• Gene symbol: SLC9A8
• Synonyms (NCBI Gene): NHE-8, NHE8
• Chromosome: 20
• Chromosome location: 20q13.13
• Summary: Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral N

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT713755	hsa-miR-4293	HITS-CLIP	19536157
MIRT713754	hsa-miR-596	HITS-CLIP	19536157
MIRT713753	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT713752	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT713751	hsa-miR-4534	HITS-CLIP	19536157
MIRT713750	hsa-miR-8082	HITS-CLIP	19536157
MIRT713749	hsa-miR-3134	HITS-CLIP	19536157
MIRT441898	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT713755	hsa-miR-4293	HITS-CLIP	19536157
MIRT713754	hsa-miR-596	HITS-CLIP	19536157
MIRT713753	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT713752	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT713751	hsa-miR-4534	HITS-CLIP	19536157
MIRT713750	hsa-miR-8082	HITS-CLIP	19536157
MIRT713749	hsa-miR-3134	HITS-CLIP	19536157
MIRT441898	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT630590	hsa-miR-3662	HITS-CLIP	23824327
MIRT630589	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT630588	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT630587	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT630586	hsa-miR-1537-5p	HITS-CLIP	23824327
MIRT630585	hsa-miR-4718	HITS-CLIP	23824327
MIRT630584	hsa-miR-4999-5p	HITS-CLIP	23824327
MIRT441901	hsa-miR-6830-5p	PAR-CLIP	22291592
MIRT441900	hsa-miR-4480	PAR-CLIP	22291592
MIRT441899	hsa-miR-4792	PAR-CLIP	22291592
MIRT441898	hsa-miR-6807-5p	PAR-CLIP	22291592
MIRT441897	hsa-miR-192-3p	PAR-CLIP	22291592
MIRT441901	hsa-miR-6830-5p	PAR-CLIP	23708386
MIRT441900	hsa-miR-4480	PAR-CLIP	23708386
MIRT441899	hsa-miR-4792	PAR-CLIP	23708386
MIRT441898	hsa-miR-6807-5p	PAR-CLIP	23708386
MIRT441897	hsa-miR-192-3p	PAR-CLIP	23708386
MIRT441901	hsa-miR-6830-5p	PAR-CLIP	22100165
MIRT441900	hsa-miR-4480	PAR-CLIP	22100165
MIRT441899	hsa-miR-4792	PAR-CLIP	22100165
MIRT441898	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT441897	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT713755	hsa-miR-4293	HITS-CLIP	19536157
MIRT713754	hsa-miR-596	HITS-CLIP	19536157
MIRT713753	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT713752	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT713751	hsa-miR-4534	HITS-CLIP	19536157
MIRT713750	hsa-miR-8082	HITS-CLIP	19536157
MIRT713749	hsa-miR-3134	HITS-CLIP	19536157
MIRT441898	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT713755	hsa-miR-4293	HITS-CLIP	19536157
MIRT713754	hsa-miR-596	HITS-CLIP	19536157
MIRT713753	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT713752	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT713751	hsa-miR-4534	HITS-CLIP	19536157
MIRT713750	hsa-miR-8082	HITS-CLIP	19536157
MIRT713749	hsa-miR-3134	HITS-CLIP	19536157
MIRT441898	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT630590	hsa-miR-3662	HITS-CLIP	23824327
MIRT630589	hsa-miR-3065-3p	HITS-CLIP	23824327
MIRT630588	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT630587	hsa-miR-3607-3p	HITS-CLIP	23824327
MIRT630586	hsa-miR-1537-5p	HITS-CLIP	23824327
MIRT630585	hsa-miR-4718	HITS-CLIP	23824327
MIRT630584	hsa-miR-4999-5p	HITS-CLIP	23824327
MIRT441901	hsa-miR-6830-5p	PAR-CLIP	22291592
MIRT441900	hsa-miR-4480	PAR-CLIP	22291592
MIRT441899	hsa-miR-4792	PAR-CLIP	22291592
MIRT441898	hsa-miR-6807-5p	PAR-CLIP	22291592
MIRT441897	hsa-miR-192-3p	PAR-CLIP	22291592
MIRT441901	hsa-miR-6830-5p	PAR-CLIP	23708386
MIRT441900	hsa-miR-4480	PAR-CLIP	23708386
MIRT441899	hsa-miR-4792	PAR-CLIP	23708386
MIRT441898	hsa-miR-6807-5p	PAR-CLIP	23708386
MIRT441897	hsa-miR-192-3p	PAR-CLIP	23708386
MIRT441901	hsa-miR-6830-5p	PAR-CLIP	22100165
MIRT441900	hsa-miR-4480	PAR-CLIP	22100165
MIRT441899	hsa-miR-4792	PAR-CLIP	22100165
MIRT441898	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT441897	hsa-miR-192-3p	PAR-CLIP	22100165
MIRT1369084	hsa-miR-1178	CLIP-seq
MIRT1369085	hsa-miR-1206	CLIP-seq
MIRT1369086	hsa-miR-1224-5p	CLIP-seq
MIRT1369087	hsa-miR-1226	CLIP-seq
MIRT1369088	hsa-miR-1266	CLIP-seq
MIRT1369089	hsa-miR-1270	CLIP-seq
MIRT1369090	hsa-miR-1273f	CLIP-seq
MIRT1369091	hsa-miR-1304	CLIP-seq
MIRT1369092	hsa-miR-1468	CLIP-seq
MIRT1369093	hsa-miR-151-3p	CLIP-seq
MIRT1369094	hsa-miR-15a	CLIP-seq
MIRT1369095	hsa-miR-15b	CLIP-seq
MIRT1369096	hsa-miR-16	CLIP-seq
MIRT1369097	hsa-miR-181a	CLIP-seq
MIRT1369098	hsa-miR-181b	CLIP-seq
MIRT1369099	hsa-miR-181c	CLIP-seq
MIRT1369100	hsa-miR-181d	CLIP-seq
MIRT1369101	hsa-miR-1825	CLIP-seq
MIRT1369102	hsa-miR-1911	CLIP-seq
MIRT1369103	hsa-miR-1912	CLIP-seq
MIRT1369104	hsa-miR-195	CLIP-seq
MIRT1369105	hsa-miR-199a-5p	CLIP-seq
MIRT1369106	hsa-miR-199b-5p	CLIP-seq
MIRT1369107	hsa-miR-218	CLIP-seq
MIRT1369108	hsa-miR-30a	CLIP-seq
MIRT1369109	hsa-miR-30b	CLIP-seq
MIRT1369110	hsa-miR-30c	CLIP-seq
MIRT1369111	hsa-miR-30d	CLIP-seq
MIRT1369112	hsa-miR-30e	CLIP-seq
MIRT1369113	hsa-miR-3120-3p	CLIP-seq
MIRT1369114	hsa-miR-3121-3p	CLIP-seq
MIRT1369115	hsa-miR-3126-5p	CLIP-seq
MIRT1369116	hsa-miR-3130-5p	CLIP-seq
MIRT1369117	hsa-miR-3150a-3p	CLIP-seq
MIRT1369118	hsa-miR-3154	CLIP-seq
MIRT1369119	hsa-miR-3175	CLIP-seq
MIRT1369120	hsa-miR-3190	CLIP-seq
MIRT1369121	hsa-miR-3529	CLIP-seq
MIRT1369122	hsa-miR-3611	CLIP-seq
MIRT1369123	hsa-miR-3649	CLIP-seq
MIRT1369124	hsa-miR-3652	CLIP-seq
MIRT1369125	hsa-miR-3664-3p	CLIP-seq
MIRT1369126	hsa-miR-379	CLIP-seq
MIRT1369127	hsa-miR-3915	CLIP-seq
MIRT1369128	hsa-miR-3919	CLIP-seq
MIRT1369129	hsa-miR-3921	CLIP-seq
MIRT1369130	hsa-miR-3927	CLIP-seq
MIRT1369131	hsa-miR-3974	CLIP-seq
MIRT1369132	hsa-miR-424	CLIP-seq
MIRT1369133	hsa-miR-4262	CLIP-seq
MIRT1369134	hsa-miR-4263	CLIP-seq
MIRT1369135	hsa-miR-4267	CLIP-seq
MIRT1369136	hsa-miR-4269	CLIP-seq
MIRT1369137	hsa-miR-4286	CLIP-seq
MIRT1369138	hsa-miR-4292	CLIP-seq
MIRT1369139	hsa-miR-4308	CLIP-seq
MIRT1369140	hsa-miR-4327	CLIP-seq
MIRT1369141	hsa-miR-4419a	CLIP-seq
MIRT1369142	hsa-miR-4430	CLIP-seq
MIRT1369143	hsa-miR-4436b-3p	CLIP-seq
MIRT1369144	hsa-miR-4446-3p	CLIP-seq
MIRT1369145	hsa-miR-4462	CLIP-seq
MIRT1369146	hsa-miR-4463	CLIP-seq
MIRT1369147	hsa-miR-4482	CLIP-seq
MIRT1369148	hsa-miR-4492	CLIP-seq
MIRT1369149	hsa-miR-4498	CLIP-seq
MIRT1369150	hsa-miR-4499	CLIP-seq
MIRT1369151	hsa-miR-4505	CLIP-seq
MIRT1369152	hsa-miR-4509	CLIP-seq
MIRT1369153	hsa-miR-4510	CLIP-seq
MIRT1369154	hsa-miR-4514	CLIP-seq
MIRT1369155	hsa-miR-4518	CLIP-seq
MIRT1369156	hsa-miR-451b	CLIP-seq
MIRT1369157	hsa-miR-4649-3p	CLIP-seq
MIRT1369158	hsa-miR-4651	CLIP-seq
MIRT1369159	hsa-miR-4653-5p	CLIP-seq
MIRT1369160	hsa-miR-4671-5p	CLIP-seq
MIRT1369161	hsa-miR-4676-5p	CLIP-seq
MIRT1369162	hsa-miR-4681	CLIP-seq
MIRT1369163	hsa-miR-4683	CLIP-seq
MIRT1369164	hsa-miR-4689	CLIP-seq
MIRT1369165	hsa-miR-4692	CLIP-seq
MIRT1369166	hsa-miR-4705	CLIP-seq
MIRT1369167	hsa-miR-4709-3p	CLIP-seq
MIRT1369168	hsa-miR-4717-5p	CLIP-seq
MIRT1369169	hsa-miR-4733-3p	CLIP-seq
MIRT1369170	hsa-miR-4742-5p	CLIP-seq
MIRT1369171	hsa-miR-4751	CLIP-seq
MIRT1369172	hsa-miR-4768-5p	CLIP-seq
MIRT1369173	hsa-miR-4786-3p	CLIP-seq
MIRT1369174	hsa-miR-4790-3p	CLIP-seq
MIRT1369175	hsa-miR-4799-5p	CLIP-seq
MIRT1369176	hsa-miR-483-3p	CLIP-seq
MIRT1369177	hsa-miR-485-3p	CLIP-seq
MIRT1369178	hsa-miR-491-5p	CLIP-seq
MIRT1369179	hsa-miR-497	CLIP-seq
MIRT1369180	hsa-miR-498	CLIP-seq
MIRT1369181	hsa-miR-513a-5p	CLIP-seq
MIRT1369182	hsa-miR-516b	CLIP-seq
MIRT1369183	hsa-miR-526b	CLIP-seq
MIRT1369184	hsa-miR-541	CLIP-seq
MIRT1369185	hsa-miR-543	CLIP-seq
MIRT1369186	hsa-miR-544b	CLIP-seq
MIRT1369187	hsa-miR-548m	CLIP-seq
MIRT1369188	hsa-miR-575	CLIP-seq
MIRT1369189	hsa-miR-576-3p	CLIP-seq
MIRT1369190	hsa-miR-576-5p	CLIP-seq
MIRT1369191	hsa-miR-586	CLIP-seq
MIRT1369192	hsa-miR-608	CLIP-seq
MIRT1369193	hsa-miR-620	CLIP-seq
MIRT1369194	hsa-miR-634	CLIP-seq
MIRT1369195	hsa-miR-636	CLIP-seq
MIRT1369196	hsa-miR-654-5p	CLIP-seq
MIRT1369197	hsa-miR-668	CLIP-seq
MIRT1369198	hsa-miR-7	CLIP-seq
MIRT1369199	hsa-miR-711	CLIP-seq
MIRT1369200	hsa-miR-762	CLIP-seq
MIRT1369201	hsa-miR-767-3p	CLIP-seq
MIRT1369202	hsa-miR-885-3p	CLIP-seq
MIRT1369203	hsa-miR-939	CLIP-seq
MIRT2109639	hsa-miR-1205	CLIP-seq
MIRT2109640	hsa-miR-1343	CLIP-seq
MIRT2109641	hsa-miR-149	CLIP-seq
MIRT1369094	hsa-miR-15a	CLIP-seq
MIRT1369095	hsa-miR-15b	CLIP-seq
MIRT1369096	hsa-miR-16	CLIP-seq
MIRT2109642	hsa-miR-1909	CLIP-seq
MIRT1369104	hsa-miR-195	CLIP-seq
MIRT2109643	hsa-miR-3150b-3p	CLIP-seq
MIRT2109644	hsa-miR-3166	CLIP-seq
MIRT2109645	hsa-miR-3176	CLIP-seq
MIRT2109646	hsa-miR-3922-3p	CLIP-seq
MIRT1369132	hsa-miR-424	CLIP-seq
MIRT2109647	hsa-miR-4265	CLIP-seq
MIRT2109648	hsa-miR-4296	CLIP-seq
MIRT2109649	hsa-miR-4322	CLIP-seq
MIRT2109650	hsa-miR-4417	CLIP-seq
MIRT2109651	hsa-miR-4418	CLIP-seq
MIRT2109652	hsa-miR-4468	CLIP-seq
MIRT2109653	hsa-miR-4519	CLIP-seq
MIRT1369164	hsa-miR-4689	CLIP-seq
MIRT2109654	hsa-miR-4757-5p	CLIP-seq
MIRT2109655	hsa-miR-4784	CLIP-seq
MIRT1369179	hsa-miR-497	CLIP-seq
MIRT2109656	hsa-miR-499a-5p	CLIP-seq
MIRT2109657	hsa-miR-509-3-5p	CLIP-seq
MIRT2109658	hsa-miR-509-5p	CLIP-seq
MIRT2109659	hsa-miR-658	CLIP-seq
MIRT2332841	hsa-miR-103a	CLIP-seq
MIRT2332842	hsa-miR-107	CLIP-seq
MIRT2332843	hsa-miR-1183	CLIP-seq
MIRT2332844	hsa-miR-1245b-3p	CLIP-seq
MIRT2332845	hsa-miR-125a-5p	CLIP-seq
MIRT2332846	hsa-miR-125b	CLIP-seq
MIRT1369088	hsa-miR-1266	CLIP-seq
MIRT1369090	hsa-miR-1273f	CLIP-seq
MIRT2332847	hsa-miR-128	CLIP-seq
MIRT2332848	hsa-miR-143	CLIP-seq
MIRT1369092	hsa-miR-1468	CLIP-seq
MIRT2332849	hsa-miR-1470	CLIP-seq
MIRT2109641	hsa-miR-149	CLIP-seq
MIRT2332850	hsa-miR-1587	CLIP-seq
MIRT2332851	hsa-miR-182	CLIP-seq
MIRT2332852	hsa-miR-183	CLIP-seq
MIRT2332853	hsa-miR-1908	CLIP-seq
MIRT2109642	hsa-miR-1909	CLIP-seq
MIRT2332854	hsa-miR-1976	CLIP-seq
MIRT2332855	hsa-miR-210	CLIP-seq
MIRT2332856	hsa-miR-23a	CLIP-seq
MIRT2332857	hsa-miR-23b	CLIP-seq
MIRT2332858	hsa-miR-23c	CLIP-seq
MIRT2332859	hsa-miR-27a	CLIP-seq
MIRT2332860	hsa-miR-27b	CLIP-seq
MIRT2332861	hsa-miR-3121-5p	CLIP-seq
MIRT1369115	hsa-miR-3126-5p	CLIP-seq
MIRT2332862	hsa-miR-3127-5p	CLIP-seq
MIRT2332863	hsa-miR-3133	CLIP-seq
MIRT2109643	hsa-miR-3150b-3p	CLIP-seq
MIRT1369118	hsa-miR-3154	CLIP-seq
MIRT2332864	hsa-miR-3184	CLIP-seq
MIRT2332865	hsa-miR-3189-5p	CLIP-seq
MIRT2332866	hsa-miR-342-5p	CLIP-seq
MIRT2332867	hsa-miR-345	CLIP-seq
MIRT2332868	hsa-miR-3620	CLIP-seq
MIRT2332869	hsa-miR-3650	CLIP-seq
MIRT1369124	hsa-miR-3652	CLIP-seq
MIRT2332870	hsa-miR-3657	CLIP-seq
MIRT2332871	hsa-miR-3677-5p	CLIP-seq
MIRT2332872	hsa-miR-3714	CLIP-seq
MIRT2332873	hsa-miR-3907	CLIP-seq
MIRT1369128	hsa-miR-3919	CLIP-seq
MIRT1369129	hsa-miR-3921	CLIP-seq
MIRT2332874	hsa-miR-3935	CLIP-seq
MIRT1369131	hsa-miR-3974	CLIP-seq
MIRT2332875	hsa-miR-423-5p	CLIP-seq
MIRT2332876	hsa-miR-4256	CLIP-seq
MIRT2109647	hsa-miR-4265	CLIP-seq
MIRT2332877	hsa-miR-4268	CLIP-seq
MIRT2332878	hsa-miR-4270	CLIP-seq
MIRT2332879	hsa-miR-4283	CLIP-seq
MIRT2109648	hsa-miR-4296	CLIP-seq
MIRT2332880	hsa-miR-4319	CLIP-seq
MIRT2109649	hsa-miR-4322	CLIP-seq
MIRT2109650	hsa-miR-4417	CLIP-seq
MIRT1369141	hsa-miR-4419a	CLIP-seq
MIRT1369142	hsa-miR-4430	CLIP-seq
MIRT1369143	hsa-miR-4436b-3p	CLIP-seq
MIRT2332881	hsa-miR-4441	CLIP-seq
MIRT1369144	hsa-miR-4446-3p	CLIP-seq
MIRT2332882	hsa-miR-4447	CLIP-seq
MIRT2332883	hsa-miR-4448	CLIP-seq
MIRT2332884	hsa-miR-4455	CLIP-seq
MIRT2332885	hsa-miR-4469	CLIP-seq
MIRT2332886	hsa-miR-4472	CLIP-seq
MIRT1369148	hsa-miR-4492	CLIP-seq
MIRT2332887	hsa-miR-4493	CLIP-seq
MIRT1369149	hsa-miR-4498	CLIP-seq
MIRT1369151	hsa-miR-4505	CLIP-seq
MIRT1369153	hsa-miR-4510	CLIP-seq
MIRT1369155	hsa-miR-4518	CLIP-seq
MIRT1369157	hsa-miR-4649-3p	CLIP-seq
MIRT1369158	hsa-miR-4651	CLIP-seq
MIRT1369159	hsa-miR-4653-5p	CLIP-seq
MIRT2332888	hsa-miR-4656	CLIP-seq
MIRT2332889	hsa-miR-4660	CLIP-seq
MIRT2332890	hsa-miR-4664-5p	CLIP-seq
MIRT2332891	hsa-miR-4667-3p	CLIP-seq
MIRT2332892	hsa-miR-4669	CLIP-seq
MIRT2332893	hsa-miR-4675	CLIP-seq
MIRT1369164	hsa-miR-4689	CLIP-seq
MIRT2332894	hsa-miR-4715-5p	CLIP-seq
MIRT2332895	hsa-miR-4719	CLIP-seq
MIRT2332896	hsa-miR-4731-5p	CLIP-seq
MIRT2332897	hsa-miR-4741	CLIP-seq
MIRT1369171	hsa-miR-4751	CLIP-seq
MIRT2109654	hsa-miR-4757-5p	CLIP-seq
MIRT1369172	hsa-miR-4768-5p	CLIP-seq
MIRT2332898	hsa-miR-4770	CLIP-seq
MIRT2109655	hsa-miR-4784	CLIP-seq
MIRT1369173	hsa-miR-4786-3p	CLIP-seq
MIRT1369176	hsa-miR-483-3p	CLIP-seq
MIRT2332899	hsa-miR-485-5p	CLIP-seq
MIRT2332900	hsa-miR-486-3p	CLIP-seq
MIRT1369181	hsa-miR-513a-5p	CLIP-seq
MIRT2332901	hsa-miR-548an	CLIP-seq
MIRT1369192	hsa-miR-608	CLIP-seq
MIRT2332902	hsa-miR-615-5p	CLIP-seq
MIRT2332903	hsa-miR-617	CLIP-seq
MIRT2332904	hsa-miR-645	CLIP-seq
MIRT2332905	hsa-miR-663	CLIP-seq
MIRT2332906	hsa-miR-665	CLIP-seq
MIRT1369197	hsa-miR-668	CLIP-seq
MIRT2332907	hsa-miR-760	CLIP-seq
MIRT1369200	hsa-miR-762	CLIP-seq
MIRT1369202	hsa-miR-885-3p	CLIP-seq
MIRT2332844	hsa-miR-1245b-3p	CLIP-seq
MIRT1369124	hsa-miR-3652	CLIP-seq
MIRT1369142	hsa-miR-4430	CLIP-seq
MIRT1369151	hsa-miR-4505	CLIP-seq
MIRT1369158	hsa-miR-4651	CLIP-seq
MIRT1369163	hsa-miR-4683	CLIP-seq
MIRT2394824	hsa-miR-4688	CLIP-seq
MIRT2394825	hsa-miR-4736	CLIP-seq
MIRT1369192	hsa-miR-608	CLIP-seq
MIRT2459940	hsa-miR-2467-5p	CLIP-seq
MIRT1369114	hsa-miR-3121-3p	CLIP-seq
MIRT2459941	hsa-miR-3188	CLIP-seq
MIRT2459942	hsa-miR-3975	CLIP-seq
MIRT1369134	hsa-miR-4263	CLIP-seq
MIRT1369157	hsa-miR-4649-3p	CLIP-seq
MIRT1369175	hsa-miR-4799-5p	CLIP-seq
MIRT2332899	hsa-miR-485-5p	CLIP-seq
MIRT1369186	hsa-miR-544b	CLIP-seq
MIRT1369190	hsa-miR-576-5p	CLIP-seq
MIRT2332907	hsa-miR-760	CLIP-seq
MIRT2627242	hsa-miR-1257	CLIP-seq
MIRT2627243	hsa-miR-3658	CLIP-seq
MIRT2627244	hsa-miR-4317	CLIP-seq
MIRT2627245	hsa-miR-4323	CLIP-seq
MIRT2627246	hsa-miR-4522	CLIP-seq
MIRT2627247	hsa-miR-4677-3p	CLIP-seq
MIRT2627248	hsa-miR-4679	CLIP-seq
MIRT2627249	hsa-miR-4690-3p	CLIP-seq
MIRT2627250	hsa-miR-4758-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IDA	15522866
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0001669	Component	Acrosomal vesicle	ISS
GO:0001675	Process	Acrosome assembly	IEA
GO:0001675	Process	Acrosome assembly	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005768	Component	Endosome	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006811	Process	Monoatomic ion transport	TAS
GO:0006812	Process	Monoatomic cation transport	IEA
GO:0006814	Process	Sodium ion transport	IEA
GO:0006885	Process	Regulation of pH	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0015297	Function	Antiporter activity	IEA
GO:0015385	Function	Sodium:proton antiporter activity	IBA
GO:0015385	Function	Sodium:proton antiporter activity	IDA	15522866
GO:0015385	Function	Sodium:proton antiporter activity	IEA
GO:0015385	Function	Sodium:proton antiporter activity	TAS
GO:0015386	Function	Potassium:proton antiporter activity	IBA
GO:0015386	Function	Potassium:proton antiporter activity	IDA	15522866
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IDA	34288721
GO:0016324	Component	Apical plasma membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032585	Component	Multivesicular body membrane	IDA	20719963
GO:0032585	Component	Multivesicular body membrane	IEA
GO:0032588	Component	Trans-Golgi network membrane	IDA	15522866, 20719963
GO:0035725	Process	Sodium ion transmembrane transport	IDA	15522866
GO:0051453	Process	Regulation of intracellular pH	IBA
GO:0051453	Process	Regulation of intracellular pH	IEA
GO:0051453	Process	Regulation of intracellular pH	IMP	34288721
GO:0055085	Process	Transmembrane transport	IEA
GO:0071805	Process	Potassium ion transmembrane transport	IBA
GO:1902600	Process	Proton transmembrane transport	IDA	15522866
GO:1902600	Process	Proton transmembrane transport	IEA
GO:1905526	Process	Regulation of Golgi lumen acidification	IDA	15522866

Other IDs

• MIM: 612730
• HGNC: 20728
• e!Ensembl: ENSG00000197818

Protein

• UniProt ID: Q9Y2E8
• Protein name: Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8)
• Protein function: Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (PubMed:15522866). Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulat
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00999	Na_H_Exchanger	62 → 473	Sodium/hydrogen exchanger family	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous. Strongly expressed in skeletal muscle and kidney (PubMed:15522866). Detected throughout the entire gastrointestinal tract, with high expression detected in stomach, duodenum and ascending colon (PubMed:18209477). {ECO:00002
• Sequence:

  MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGM
  TIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEM
  FRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQAD
  VISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTA
  EGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFG
  MMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCET
  CVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIM
  WFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAK
  AHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFT
  RRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL

• Sequence length: 581

Pathways

Reactome:

Sodium/Proton exchangers

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANKYLOSING SPONDYLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS VULGARIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	33541344	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ankylosing spondylitis	Ankylosing Spondylitis	GWASCAT_DG	26974007		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangitis, Sclerosing	Cholangitis	GWASCAT_DG	26974007		★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	Pubtator	40434024	Associate	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	40434024	Inhibit	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34965262	Associate	★☆☆☆☆ Found in Text Mining only
Congenital secretory diarrhea, sodium type (disorder)	Congenital secretory diarrhea	BEFREE	21666503		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	GWASCAT_DG	26974007		★☆☆☆☆ Found in Text Mining only
Deep Vein Thrombosis	Thrombosis	BEFREE	29864786		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	CTD_human_DG	19234771		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	21360476		★☆☆☆☆ Found in Text Mining only
Familial Dementia	Dementia	CTD_human_DG	19234771		★☆☆☆☆ Found in Text Mining only
Frontotemporal Dementia	Frontotemporal dementia	Pubtator	37979250	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	GWASCAT_DG	24076602		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obstructive azoospermia	Obstructive azoospermia	BEFREE	30956978		★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	GWASCAT_DG	26974007		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Senile Paranoid Dementia	Senile Paranoid Dementia	CTD_human_DG	19234771		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	GWASCAT_DG	26974007		★★☆☆☆ Found in Text Mining + Unknown/Other Associations