SIN3B (SIN3 transcription regulator family member B)

Gene

• Entrez ID: 23309
• Gene name: SIN3 transcription regulator family member B
• Gene symbol: SIN3B
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19p13.11

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019064	hsa-miR-335-5p	Microarray	18185580
MIRT049321	hsa-miR-92a-3p	CLASH	23622248
MIRT049321	hsa-miR-92a-3p	CLASH	23622248
MIRT045249	hsa-miR-186-5p	CLASH	23622248
MIRT291999	hsa-miR-96-5p	PAR-CLIP	23592263
MIRT292001	hsa-miR-1271-5p	PAR-CLIP	23592263
MIRT468021	hsa-miR-4501	PAR-CLIP	23592263
MIRT292003	hsa-miR-3607-5p	PAR-CLIP	23592263
MIRT347200	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT347196	hsa-miR-4722-3p	PAR-CLIP	23592263
MIRT347199	hsa-miR-6727-3p	PAR-CLIP	23592263
MIRT292006	hsa-miR-5589-3p	PAR-CLIP	23592263
MIRT468020	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT347197	hsa-miR-4763-5p	PAR-CLIP	23592263
MIRT468019	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT347198	hsa-miR-5006-5p	PAR-CLIP	23592263
MIRT468018	hsa-miR-183-5p	PAR-CLIP	23592263
MIRT468017	hsa-miR-182-5p	PAR-CLIP	23592263
MIRT292001	hsa-miR-1271-5p	PAR-CLIP	26701625
MIRT468017	hsa-miR-182-5p	PAR-CLIP	26701625
MIRT468018	hsa-miR-183-5p	PAR-CLIP	26701625
MIRT468019	hsa-miR-3191-3p	PAR-CLIP	26701625
MIRT292003	hsa-miR-3607-5p	PAR-CLIP	26701625
MIRT468021	hsa-miR-4501	PAR-CLIP	26701625
MIRT347196	hsa-miR-4722-3p	PAR-CLIP	26701625
MIRT468020	hsa-miR-4755-3p	PAR-CLIP	26701625
MIRT347197	hsa-miR-4763-5p	PAR-CLIP	26701625
MIRT347198	hsa-miR-5006-5p	PAR-CLIP	26701625
MIRT292006	hsa-miR-5589-3p	PAR-CLIP	26701625
MIRT347199	hsa-miR-6727-3p	PAR-CLIP	26701625
MIRT347200	hsa-miR-7113-5p	PAR-CLIP	26701625
MIRT291999	hsa-miR-96-5p	PAR-CLIP	26701625
MIRT291999	hsa-miR-96-5p	PAR-CLIP	23592263
MIRT292001	hsa-miR-1271-5p	PAR-CLIP	23592263
MIRT468021	hsa-miR-4501	PAR-CLIP	23592263
MIRT292003	hsa-miR-3607-5p	PAR-CLIP	23592263
MIRT347200	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT347196	hsa-miR-4722-3p	PAR-CLIP	23592263
MIRT347199	hsa-miR-6727-3p	PAR-CLIP	23592263
MIRT292006	hsa-miR-5589-3p	PAR-CLIP	23592263
MIRT468020	hsa-miR-4755-3p	PAR-CLIP	23592263
MIRT347197	hsa-miR-4763-5p	PAR-CLIP	23592263
MIRT468019	hsa-miR-3191-3p	PAR-CLIP	23592263
MIRT347198	hsa-miR-5006-5p	PAR-CLIP	23592263
MIRT468018	hsa-miR-183-5p	PAR-CLIP	23592263
MIRT468017	hsa-miR-182-5p	PAR-CLIP	23592263
MIRT1349563	hsa-miR-1226	CLIP-seq
MIRT1349564	hsa-miR-1229	CLIP-seq
MIRT1349565	hsa-miR-1238	CLIP-seq
MIRT1349566	hsa-miR-1254	CLIP-seq
MIRT1349567	hsa-miR-1271	CLIP-seq
MIRT1349568	hsa-miR-1273e	CLIP-seq
MIRT1349569	hsa-miR-1281	CLIP-seq
MIRT1349570	hsa-miR-1289	CLIP-seq
MIRT1349571	hsa-miR-1293	CLIP-seq
MIRT1349572	hsa-miR-1299	CLIP-seq
MIRT1349573	hsa-miR-1302	CLIP-seq
MIRT1349574	hsa-miR-1305	CLIP-seq
MIRT1349575	hsa-miR-182	CLIP-seq
MIRT1349576	hsa-miR-191	CLIP-seq
MIRT1349577	hsa-miR-1915	CLIP-seq
MIRT1349578	hsa-miR-210	CLIP-seq
MIRT1349579	hsa-miR-2110	CLIP-seq
MIRT1349580	hsa-miR-2861	CLIP-seq
MIRT1349581	hsa-miR-3116	CLIP-seq
MIRT1349582	hsa-miR-3117-5p	CLIP-seq
MIRT1349583	hsa-miR-3150a-3p	CLIP-seq
MIRT1349584	hsa-miR-3175	CLIP-seq
MIRT1349585	hsa-miR-3179	CLIP-seq
MIRT1349586	hsa-miR-3191	CLIP-seq
MIRT1349587	hsa-miR-3197	CLIP-seq
MIRT1349588	hsa-miR-3198	CLIP-seq
MIRT1349589	hsa-miR-3202	CLIP-seq
MIRT1349590	hsa-miR-3591-3p	CLIP-seq
MIRT1349591	hsa-miR-3614-5p	CLIP-seq
MIRT1349592	hsa-miR-3616-3p	CLIP-seq
MIRT1349593	hsa-miR-3675-5p	CLIP-seq
MIRT1349594	hsa-miR-3680	CLIP-seq
MIRT1349595	hsa-miR-3910	CLIP-seq
MIRT1349596	hsa-miR-3921	CLIP-seq
MIRT1349597	hsa-miR-4251	CLIP-seq
MIRT1349598	hsa-miR-4254	CLIP-seq
MIRT1349599	hsa-miR-4292	CLIP-seq
MIRT1349600	hsa-miR-4294	CLIP-seq
MIRT1349601	hsa-miR-4298	CLIP-seq
MIRT1349602	hsa-miR-4308	CLIP-seq
MIRT1349603	hsa-miR-4309	CLIP-seq
MIRT1349604	hsa-miR-4323	CLIP-seq
MIRT1349605	hsa-miR-4329	CLIP-seq
MIRT1349606	hsa-miR-4433	CLIP-seq
MIRT1349607	hsa-miR-4459	CLIP-seq
MIRT1349608	hsa-miR-4464	CLIP-seq
MIRT1349609	hsa-miR-4476	CLIP-seq
MIRT1349610	hsa-miR-4483	CLIP-seq
MIRT1349611	hsa-miR-450b-3p	CLIP-seq
MIRT1349612	hsa-miR-4512	CLIP-seq
MIRT1349613	hsa-miR-4514	CLIP-seq
MIRT1349614	hsa-miR-4533	CLIP-seq
MIRT1349615	hsa-miR-4643	CLIP-seq
MIRT1349616	hsa-miR-4645-5p	CLIP-seq
MIRT1349617	hsa-miR-4651	CLIP-seq
MIRT1349618	hsa-miR-4653-5p	CLIP-seq
MIRT1349619	hsa-miR-4659a-3p	CLIP-seq
MIRT1349620	hsa-miR-4659b-3p	CLIP-seq
MIRT1349621	hsa-miR-466	CLIP-seq
MIRT1349622	hsa-miR-4673	CLIP-seq
MIRT1349623	hsa-miR-4690-3p	CLIP-seq
MIRT1349624	hsa-miR-4692	CLIP-seq
MIRT1349625	hsa-miR-4711-5p	CLIP-seq
MIRT1349626	hsa-miR-4713-3p	CLIP-seq
MIRT1349627	hsa-miR-4719	CLIP-seq
MIRT1349628	hsa-miR-4721	CLIP-seq
MIRT1349629	hsa-miR-4722-5p	CLIP-seq
MIRT1349630	hsa-miR-4726-3p	CLIP-seq
MIRT1349631	hsa-miR-4733-5p	CLIP-seq
MIRT1349632	hsa-miR-4748	CLIP-seq
MIRT1349633	hsa-miR-4749-3p	CLIP-seq
MIRT1349634	hsa-miR-4768-3p	CLIP-seq
MIRT1349635	hsa-miR-4773	CLIP-seq
MIRT1349636	hsa-miR-4778-5p	CLIP-seq
MIRT1349637	hsa-miR-4781-5p	CLIP-seq
MIRT1349638	hsa-miR-4782-5p	CLIP-seq
MIRT1349639	hsa-miR-4787-5p	CLIP-seq
MIRT1349640	hsa-miR-4789-3p	CLIP-seq
MIRT1349641	hsa-miR-4789-5p	CLIP-seq
MIRT1349642	hsa-miR-486-3p	CLIP-seq
MIRT1349643	hsa-miR-491-5p	CLIP-seq
MIRT1349644	hsa-miR-498	CLIP-seq
MIRT1349645	hsa-miR-516b	CLIP-seq
MIRT1349646	hsa-miR-518a-5p	CLIP-seq
MIRT1349647	hsa-miR-527	CLIP-seq
MIRT1349648	hsa-miR-541	CLIP-seq
MIRT1349649	hsa-miR-548an	CLIP-seq
MIRT1349650	hsa-miR-580	CLIP-seq
MIRT1349651	hsa-miR-583	CLIP-seq
MIRT1349652	hsa-miR-608	CLIP-seq
MIRT1349653	hsa-miR-638	CLIP-seq
MIRT1349654	hsa-miR-647	CLIP-seq
MIRT1349655	hsa-miR-654-5p	CLIP-seq
MIRT1349656	hsa-miR-665	CLIP-seq
MIRT1349657	hsa-miR-769-3p	CLIP-seq
MIRT1349658	hsa-miR-875-3p	CLIP-seq
MIRT1349659	hsa-miR-939	CLIP-seq
MIRT1349660	hsa-miR-942	CLIP-seq
MIRT1349661	hsa-miR-96	CLIP-seq
MIRT2103562	hsa-miR-122	CLIP-seq
MIRT1349563	hsa-miR-1226	CLIP-seq
MIRT2103563	hsa-miR-1248	CLIP-seq
MIRT1349566	hsa-miR-1254	CLIP-seq
MIRT2103564	hsa-miR-1262	CLIP-seq
MIRT1349567	hsa-miR-1271	CLIP-seq
MIRT1349569	hsa-miR-1281	CLIP-seq
MIRT2103565	hsa-miR-1285	CLIP-seq
MIRT2103566	hsa-miR-1287	CLIP-seq
MIRT1349570	hsa-miR-1289	CLIP-seq
MIRT2103567	hsa-miR-1323	CLIP-seq
MIRT2103568	hsa-miR-181a	CLIP-seq
MIRT2103569	hsa-miR-181b	CLIP-seq
MIRT2103570	hsa-miR-181c	CLIP-seq
MIRT2103571	hsa-miR-181d	CLIP-seq
MIRT1349575	hsa-miR-182	CLIP-seq
MIRT2103572	hsa-miR-1909	CLIP-seq
MIRT1349576	hsa-miR-191	CLIP-seq
MIRT2103573	hsa-miR-193a-3p	CLIP-seq
MIRT2103574	hsa-miR-193b	CLIP-seq
MIRT2103575	hsa-miR-200b	CLIP-seq
MIRT2103576	hsa-miR-200c	CLIP-seq
MIRT2103577	hsa-miR-204	CLIP-seq
MIRT2103578	hsa-miR-211	CLIP-seq
MIRT1349579	hsa-miR-2110	CLIP-seq
MIRT2103579	hsa-miR-214	CLIP-seq
MIRT1349580	hsa-miR-2861	CLIP-seq
MIRT2103580	hsa-miR-296-5p	CLIP-seq
MIRT2103581	hsa-miR-31	CLIP-seq
MIRT1349581	hsa-miR-3116	CLIP-seq
MIRT2103582	hsa-miR-3126-5p	CLIP-seq
MIRT2103583	hsa-miR-3135b	CLIP-seq
MIRT1349583	hsa-miR-3150a-3p	CLIP-seq
MIRT2103584	hsa-miR-3170	CLIP-seq
MIRT1349584	hsa-miR-3175	CLIP-seq
MIRT2103585	hsa-miR-3187-5p	CLIP-seq
MIRT1349586	hsa-miR-3191	CLIP-seq
MIRT1349587	hsa-miR-3197	CLIP-seq
MIRT1349588	hsa-miR-3198	CLIP-seq
MIRT1349591	hsa-miR-3614-5p	CLIP-seq
MIRT1349592	hsa-miR-3616-3p	CLIP-seq
MIRT2103586	hsa-miR-3619-5p	CLIP-seq
MIRT2103587	hsa-miR-3650	CLIP-seq
MIRT2103588	hsa-miR-3665	CLIP-seq
MIRT2103589	hsa-miR-3669	CLIP-seq
MIRT2103590	hsa-miR-3692	CLIP-seq
MIRT2103591	hsa-miR-378g	CLIP-seq
MIRT1349595	hsa-miR-3910	CLIP-seq
MIRT2103592	hsa-miR-3918	CLIP-seq
MIRT1349596	hsa-miR-3921	CLIP-seq
MIRT2103593	hsa-miR-3944-5p	CLIP-seq
MIRT1349598	hsa-miR-4254	CLIP-seq
MIRT2103594	hsa-miR-4259	CLIP-seq
MIRT2103595	hsa-miR-4262	CLIP-seq
MIRT2103596	hsa-miR-4265	CLIP-seq
MIRT2103597	hsa-miR-4267	CLIP-seq
MIRT2103598	hsa-miR-4283	CLIP-seq
MIRT2103599	hsa-miR-429	CLIP-seq
MIRT1349600	hsa-miR-4294	CLIP-seq
MIRT2103600	hsa-miR-4296	CLIP-seq
MIRT1349602	hsa-miR-4308	CLIP-seq
MIRT1349603	hsa-miR-4309	CLIP-seq
MIRT2103601	hsa-miR-4310	CLIP-seq
MIRT2103602	hsa-miR-4314	CLIP-seq
MIRT2103603	hsa-miR-4322	CLIP-seq
MIRT1349604	hsa-miR-4323	CLIP-seq
MIRT2103604	hsa-miR-4417	CLIP-seq
MIRT2103605	hsa-miR-4419a	CLIP-seq
MIRT1349606	hsa-miR-4433	CLIP-seq
MIRT2103606	hsa-miR-4436b-5p	CLIP-seq
MIRT2103607	hsa-miR-4455	CLIP-seq
MIRT1349607	hsa-miR-4459	CLIP-seq
MIRT1349608	hsa-miR-4464	CLIP-seq
MIRT1349609	hsa-miR-4476	CLIP-seq
MIRT2103608	hsa-miR-4485	CLIP-seq
MIRT2103609	hsa-miR-4486	CLIP-seq
MIRT2103610	hsa-miR-4488	CLIP-seq
MIRT2103611	hsa-miR-4505	CLIP-seq
MIRT2103612	hsa-miR-4510	CLIP-seq
MIRT1349614	hsa-miR-4533	CLIP-seq
MIRT2103613	hsa-miR-4632	CLIP-seq
MIRT2103614	hsa-miR-4640-5p	CLIP-seq
MIRT2103615	hsa-miR-4649-3p	CLIP-seq
MIRT1349617	hsa-miR-4651	CLIP-seq
MIRT2103616	hsa-miR-4653-3p	CLIP-seq
MIRT1349618	hsa-miR-4653-5p	CLIP-seq
MIRT2103617	hsa-miR-4685-5p	CLIP-seq
MIRT1349623	hsa-miR-4690-3p	CLIP-seq
MIRT2103618	hsa-miR-4697-5p	CLIP-seq
MIRT2103619	hsa-miR-4701-3p	CLIP-seq
MIRT2103620	hsa-miR-4707-3p	CLIP-seq
MIRT2103621	hsa-miR-4711-3p	CLIP-seq
MIRT1349625	hsa-miR-4711-5p	CLIP-seq
MIRT1349627	hsa-miR-4719	CLIP-seq
MIRT2103622	hsa-miR-4726-5p	CLIP-seq
MIRT1349632	hsa-miR-4748	CLIP-seq
MIRT1349633	hsa-miR-4749-3p	CLIP-seq
MIRT2103623	hsa-miR-4755-5p	CLIP-seq
MIRT2103624	hsa-miR-4758-3p	CLIP-seq
MIRT1349634	hsa-miR-4768-3p	CLIP-seq
MIRT1349635	hsa-miR-4773	CLIP-seq
MIRT1349636	hsa-miR-4778-5p	CLIP-seq
MIRT1349637	hsa-miR-4781-5p	CLIP-seq
MIRT1349639	hsa-miR-4787-5p	CLIP-seq
MIRT1349643	hsa-miR-491-5p	CLIP-seq
MIRT1349646	hsa-miR-518a-5p	CLIP-seq
MIRT1349647	hsa-miR-527	CLIP-seq
MIRT1349649	hsa-miR-548an	CLIP-seq
MIRT2103625	hsa-miR-548o	CLIP-seq
MIRT2103626	hsa-miR-571	CLIP-seq
MIRT1349651	hsa-miR-583	CLIP-seq
MIRT1349652	hsa-miR-608	CLIP-seq
MIRT2103627	hsa-miR-609	CLIP-seq
MIRT2103628	hsa-miR-612	CLIP-seq
MIRT2103629	hsa-miR-623	CLIP-seq
MIRT2103630	hsa-miR-657	CLIP-seq
MIRT1349656	hsa-miR-665	CLIP-seq
MIRT2103631	hsa-miR-760	CLIP-seq
MIRT2103632	hsa-miR-761	CLIP-seq
MIRT2103633	hsa-miR-892b	CLIP-seq
MIRT1349659	hsa-miR-939	CLIP-seq
MIRT1349661	hsa-miR-96	CLIP-seq
MIRT2103562	hsa-miR-122	CLIP-seq
MIRT2103564	hsa-miR-1262	CLIP-seq
MIRT1349567	hsa-miR-1271	CLIP-seq
MIRT1349571	hsa-miR-1293	CLIP-seq
MIRT2103567	hsa-miR-1323	CLIP-seq
MIRT2103568	hsa-miR-181a	CLIP-seq
MIRT2103569	hsa-miR-181b	CLIP-seq
MIRT2103570	hsa-miR-181c	CLIP-seq
MIRT2103571	hsa-miR-181d	CLIP-seq
MIRT1349575	hsa-miR-182	CLIP-seq
MIRT1349577	hsa-miR-1915	CLIP-seq
MIRT2103575	hsa-miR-200b	CLIP-seq
MIRT2103576	hsa-miR-200c	CLIP-seq
MIRT2103581	hsa-miR-31	CLIP-seq
MIRT2327756	hsa-miR-3127-5p	CLIP-seq
MIRT2327757	hsa-miR-3141	CLIP-seq
MIRT1349584	hsa-miR-3175	CLIP-seq
MIRT2327758	hsa-miR-3180	CLIP-seq
MIRT2327759	hsa-miR-3180-3p	CLIP-seq
MIRT2327760	hsa-miR-3189-3p	CLIP-seq
MIRT1349586	hsa-miR-3191	CLIP-seq
MIRT2327761	hsa-miR-3196	CLIP-seq
MIRT1349587	hsa-miR-3197	CLIP-seq
MIRT2327762	hsa-miR-3199	CLIP-seq
MIRT1349593	hsa-miR-3675-5p	CLIP-seq
MIRT2103590	hsa-miR-3692	CLIP-seq
MIRT2103592	hsa-miR-3918	CLIP-seq
MIRT1349598	hsa-miR-4254	CLIP-seq
MIRT2103595	hsa-miR-4262	CLIP-seq
MIRT2103598	hsa-miR-4283	CLIP-seq
MIRT2103599	hsa-miR-429	CLIP-seq
MIRT2327763	hsa-miR-4448	CLIP-seq
MIRT1349607	hsa-miR-4459	CLIP-seq
MIRT2327764	hsa-miR-4467	CLIP-seq
MIRT1349609	hsa-miR-4476	CLIP-seq
MIRT1349610	hsa-miR-4483	CLIP-seq
MIRT2103610	hsa-miR-4488	CLIP-seq
MIRT2327765	hsa-miR-4489	CLIP-seq
MIRT2103611	hsa-miR-4505	CLIP-seq
MIRT1349614	hsa-miR-4533	CLIP-seq
MIRT2327766	hsa-miR-4683	CLIP-seq
MIRT2327767	hsa-miR-4695-3p	CLIP-seq
MIRT2103618	hsa-miR-4697-5p	CLIP-seq
MIRT2103619	hsa-miR-4701-3p	CLIP-seq
MIRT2327768	hsa-miR-4706	CLIP-seq
MIRT1349630	hsa-miR-4726-3p	CLIP-seq
MIRT2327769	hsa-miR-4749-5p	CLIP-seq
MIRT1349637	hsa-miR-4781-5p	CLIP-seq
MIRT1349646	hsa-miR-518a-5p	CLIP-seq
MIRT1349647	hsa-miR-527	CLIP-seq
MIRT2327770	hsa-miR-542-5p	CLIP-seq
MIRT2103625	hsa-miR-548o	CLIP-seq
MIRT1349651	hsa-miR-583	CLIP-seq
MIRT2327771	hsa-miR-744	CLIP-seq
MIRT1349661	hsa-miR-96	CLIP-seq
MIRT2394555	hsa-miR-1286	CLIP-seq
MIRT1349572	hsa-miR-1299	CLIP-seq
MIRT1349577	hsa-miR-1915	CLIP-seq
MIRT1349579	hsa-miR-2110	CLIP-seq
MIRT1349583	hsa-miR-3150a-3p	CLIP-seq
MIRT1349584	hsa-miR-3175	CLIP-seq
MIRT1349589	hsa-miR-3202	CLIP-seq
MIRT1349591	hsa-miR-3614-5p	CLIP-seq
MIRT1349594	hsa-miR-3680	CLIP-seq
MIRT1349598	hsa-miR-4254	CLIP-seq
MIRT2394556	hsa-miR-4270	CLIP-seq
MIRT1349604	hsa-miR-4323	CLIP-seq
MIRT2394557	hsa-miR-4441	CLIP-seq
MIRT1349614	hsa-miR-4533	CLIP-seq
MIRT1349617	hsa-miR-4651	CLIP-seq
MIRT1349623	hsa-miR-4690-3p	CLIP-seq
MIRT2327767	hsa-miR-4695-3p	CLIP-seq
MIRT1349636	hsa-miR-4778-5p	CLIP-seq
MIRT1349637	hsa-miR-4781-5p	CLIP-seq
MIRT1349638	hsa-miR-4782-5p	CLIP-seq
MIRT1349639	hsa-miR-4787-5p	CLIP-seq
MIRT1349643	hsa-miR-491-5p	CLIP-seq
MIRT1349645	hsa-miR-516b	CLIP-seq
MIRT1349652	hsa-miR-608	CLIP-seq
MIRT1349658	hsa-miR-875-3p	CLIP-seq
MIRT1349659	hsa-miR-939	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	NAS	9651585
GO:0000785	Component	Chromatin	IBA
GO:0000805	Component	X chromosome	IEA
GO:0000806	Component	Y chromosome	IEA
GO:0001741	Component	XY body	IEA
GO:0003682	Function	Chromatin binding	IEA
GO:0003714	Function	Transcription corepressor activity	IBA
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0005515	Function	Protein binding	IPI	12670868, 18451802, 23460338, 24951594
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005634	Component	Nucleus	NAS	28554894
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0030336	Process	Negative regulation of cell migration	NAS	22984288
GO:0030849	Component	Autosome	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0070822	Component	Sin3-type complex	IBA
GO:0070822	Component	Sin3-type complex	NAS	28554894

Other IDs

• MIM: 607777
• HGNC: 19354
• e!Ensembl: ENSG00000127511

Protein

• UniProt ID: O75182
• Protein name: Paired amphipathic helix protein Sin3b (Histone deacetylase complex subunit Sin3b) (Transcriptional corepressor Sin3b)
• Protein function: Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SI
• PDB: 8BPA, 8BPB, 8BPC, 8C60
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02671	PAH	60 → 104	Paired amphipathic helix repeat	Repeat
  PF02671	PAH	181 → 235	Paired amphipathic helix repeat	Repeat
  PF02671	PAH	322 → 366	Paired amphipathic helix repeat	Repeat
  PF08295	Sin3_corepress	395 → 446	Sin3 family co-repressor	Domain
  PF08295	Sin3_corepress	424 → 522	Sin3 family co-repressor	Domain
  PF16879	Sin3a_C	775 → 1075	C-terminal domain of Sin3a protein	Family

• Sequence:

  MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPA
  TYNGFLEIMKEFKSQSIDTPGVIRRVSQLFHEHPDLIVGFNAFLPLGYRIDIPKNGKLNI
  QSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
  EIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEAKR
  SLFTGNGPCEMHSVQKNEHDKTPEHSRKRSRPSLLRPVSAPAKKKMKLRGTKDLSIAAVG
  KYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFA
  QFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAIC
  KELDHWTLLQGSWTDDYCMSKFKNTCWIPGYSAGVLNDTWVSFPSWSEDSTFVSSKKTPY
  EEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSEVIQ
  RRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAY
  LKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQ
  ILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSP
  QGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFANNN
  WYFFLRLHQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLKQPS
  EVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHL
  VSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQR
  KGQVIMTIELLDTEEAQTEDPVEVQHLARYVEQYVGTEGASSSPTEGFLLKPVFLQRNLK
  KFRRRWQSEQARALRGEARSSWKRLVGVESACDVDCRFKLSTHKMVFIVNSEDYMYRRGT
  LCRAKQVQPLVLLRHHQHFEEWHSRWLEDNVTVEAASLVQDWLMGEEDEDMVPCKTLCET
  VHVHGLPVTRYRVQYSRRPASP

• Sequence length: 1162

Pathways

Reactome:

Regulation of lipid metabolism by PPARalpha
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Familial cancer of breast	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SIN3B-related disorder	Benign; Uncertain significance; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WITTEVEEN KOLK SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of prostate	Prostate adenocarcinoma	BEFREE	28807943		★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	24691445		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26841866, 27780928		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26841866	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	30215728	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	22895069	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	22895069		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30215728		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26841866, 27780928		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	24691445		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	28807943		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28807943, 28956957		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	24951594		★☆☆☆☆ Found in Text Mining only
Mucopolysaccharidoses	Mucopolysaccharidosis	Pubtator	32886284	Associate	★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	30935420	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28807943		★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	24691445		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	28807943		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	27780928		★☆☆☆☆ Found in Text Mining only