Gene Gene information from NCBI Gene database.
Entrez ID 23308
Gene name Inducible T cell costimulator ligand
Gene symbol ICOSLG
Synonyms (NCBI Gene)
B7-H2B7H2B7RP-1B7RP1B7hCD275GL50ICOS-LICOSLIMD119LICOS
Chromosome 21
Chromosome location 21q22.3
SNPs SNP information provided by dbSNP.
1
SNP ID Visualize variation Clinical significance Consequence
rs1165558487 C>A,T Likely-pathogenic Intron variant, splice donor variant
miRNA miRNA information provided by mirtarbase database.
674
miRTarBase ID miRNA Experiments Reference
MIRT039046 hsa-miR-766-3p CLASH 23622248
MIRT716789 hsa-miR-6769a-3p HITS-CLIP 19536157
MIRT716790 hsa-miR-4733-3p HITS-CLIP 19536157
MIRT716788 hsa-miR-4459 HITS-CLIP 19536157
MIRT716787 hsa-miR-665 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0001817 Process Regulation of cytokine production IBA
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0005102 Function Signaling receptor binding IBA
GO:0005102 Function Signaling receptor binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605717 17087 ENSG00000160223
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75144
Protein name ICOS ligand (B7 homolog 2) (B7-H2) (B7-like protein Gl50) (B7-related protein 1) (B7RP-1) (CD antigen CD275)
Protein function Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion (PubMed:11007762, PubMed:11023515, PubMed:30498080). Also induces B-cell proliferation and differentiation
PDB 6X4G , 6X4T
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07686 V-set 20 133 Immunoglobulin V-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed on peripheral blood B-cells and monocytes, as well as on monocyte-derived dendritic cells (at protein level). {ECO:0000269|PubMed:10779774, ECO:0000269|PubMed:11007762, ECO:0000269|PubMed:11023515}.; TISSUE SPECIFICITY: [Isof
Sequence
MRLGSPGLLFLLFSSLRADTQEKEVRAMVGSDVELSCACPEGSRFDLNDVYVYWQTSESK
TVVTYHIPQNSSLENVDSRYRNRALMSPAGMLRGDFSLRLFNVTPQDEQKFHCLVLSQSL
GFQEVLSVEVTLH
VAANFSVPVVSAPHSPSQDELTFTCTSINGYPRPNVYWINKTDNSLL
DQALQNDTVFLNMRGLYDVVSVLRIARTPSVNIGCCIENVLLQQNLTVGSQTGNDIGERD
KITENPVSTGEKNAATWSILAVLCLLVVVAVAIGWVCRDRCLQHSYAGAWAVSPETELTG
HV
Sequence length 302
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cell adhesion molecules
Intestinal immune network for IgA production
  Costimulation by the CD28 family
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
13
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession Evidence Score
Combined immunodeficiency Likely pathogenic rs2146342598 RCV001824255
★★★★☆
ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CELIAC DISEASE CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
CTD, Disgenet, GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC LEFT-SIDED ULCERATIVE COLITIS Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLITIS, ULCERATIVE CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COMBINED IMMUNODEFICIENCY DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alopecia Alopecia BEFREE 23196741
★☆☆☆☆
Found in Text Mining only
Alopecia Areata Alopecia Areata BEFREE 23196741
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 29513931
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 17323353 Associate
★☆☆☆☆
Found in Text Mining only
Asthma Asthma GWASDB_DG 21150878
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 24661627, 25769613, 28810548
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases GWASDB_DG 21383967
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune disease Pubtator 26560438 Associate
★☆☆☆☆
Found in Text Mining only
Autoimmune Diseases Autoimmune Diseases BEFREE 30789152
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 31143539
★☆☆☆☆
Found in Text Mining only