Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23304
Gene name	Ubiquitin protein ligase E3 component n-recognin 2
Gene symbol	UBR2
Synonyms (NCBI Gene)	C6orf133bA49A4.1dJ242G1.1dJ392M17.3
Chromosome	6
Chromosome location	6p21.1
Summary	This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript var

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Show/Hide all (259)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017640	hsa-miR-335-5p	Microarray	18185580
MIRT443294	hsa-miR-5580-3p	PAR-CLIP	22100165
MIRT443294	hsa-miR-5580-3p	PAR-CLIP	22100165
MIRT1471320	hsa-miR-1185	CLIP-seq
MIRT1471321	hsa-miR-122	CLIP-seq
MIRT1471322	hsa-miR-1265	CLIP-seq
MIRT1471323	hsa-miR-130a	CLIP-seq
MIRT1471324	hsa-miR-130b	CLIP-seq
MIRT1471325	hsa-miR-135a	CLIP-seq
MIRT1471326	hsa-miR-135b	CLIP-seq
MIRT1471327	hsa-miR-301a	CLIP-seq
MIRT1471328	hsa-miR-301b	CLIP-seq
MIRT1471329	hsa-miR-3135b	CLIP-seq
MIRT1471330	hsa-miR-3605-5p	CLIP-seq
MIRT1471331	hsa-miR-3622b-5p	CLIP-seq
MIRT1471332	hsa-miR-3652	CLIP-seq
MIRT1471333	hsa-miR-3666	CLIP-seq
MIRT1471334	hsa-miR-3679-5p	CLIP-seq
MIRT1471335	hsa-miR-4295	CLIP-seq
MIRT1471336	hsa-miR-4430	CLIP-seq
MIRT1471337	hsa-miR-4455	CLIP-seq
MIRT1471338	hsa-miR-4491	CLIP-seq
MIRT1471339	hsa-miR-454	CLIP-seq
MIRT1471340	hsa-miR-4657	CLIP-seq
MIRT1471341	hsa-miR-4661-5p	CLIP-seq
MIRT1471342	hsa-miR-4695-3p	CLIP-seq
MIRT1471343	hsa-miR-4710	CLIP-seq
MIRT1471344	hsa-miR-4764-5p	CLIP-seq
MIRT1471345	hsa-miR-4792	CLIP-seq
MIRT1471346	hsa-miR-548aa	CLIP-seq
MIRT1471347	hsa-miR-609	CLIP-seq
MIRT1471348	hsa-miR-1208	CLIP-seq
MIRT1471349	hsa-miR-124	CLIP-seq
MIRT1471350	hsa-miR-129-5p	CLIP-seq
MIRT1471351	hsa-miR-1304	CLIP-seq
MIRT1471352	hsa-miR-181a	CLIP-seq
MIRT1471353	hsa-miR-181b	CLIP-seq
MIRT1471354	hsa-miR-181c	CLIP-seq
MIRT1471355	hsa-miR-181d	CLIP-seq
MIRT1471356	hsa-miR-3120-3p	CLIP-seq
MIRT1471357	hsa-miR-3120-5p	CLIP-seq
MIRT1471358	hsa-miR-3174	CLIP-seq
MIRT1471359	hsa-miR-3184	CLIP-seq
MIRT1471360	hsa-miR-323-5p	CLIP-seq
MIRT1471361	hsa-miR-330-3p	CLIP-seq
MIRT1471362	hsa-miR-34c-3p	CLIP-seq
MIRT1471363	hsa-miR-3617	CLIP-seq
MIRT1471332	hsa-miR-3652	CLIP-seq
MIRT1471364	hsa-miR-3691-3p	CLIP-seq
MIRT1471365	hsa-miR-371-5p	CLIP-seq
MIRT1471366	hsa-miR-371b-5p	CLIP-seq
MIRT1471367	hsa-miR-382	CLIP-seq
MIRT1471368	hsa-miR-423-5p	CLIP-seq
MIRT1471369	hsa-miR-4262	CLIP-seq
MIRT1471370	hsa-miR-4273	CLIP-seq
MIRT1471336	hsa-miR-4430	CLIP-seq
MIRT1471371	hsa-miR-4476	CLIP-seq
MIRT1471372	hsa-miR-4505	CLIP-seq
MIRT1471373	hsa-miR-4511	CLIP-seq
MIRT1471374	hsa-miR-4528	CLIP-seq
MIRT1471375	hsa-miR-4677-5p	CLIP-seq
MIRT1471376	hsa-miR-4687-5p	CLIP-seq
MIRT1471377	hsa-miR-4688	CLIP-seq
MIRT1471378	hsa-miR-4766-5p	CLIP-seq
MIRT1471379	hsa-miR-4797-3p	CLIP-seq
MIRT1471380	hsa-miR-494	CLIP-seq
MIRT1471381	hsa-miR-506	CLIP-seq
MIRT1471382	hsa-miR-513c	CLIP-seq
MIRT1471383	hsa-miR-514b-5p	CLIP-seq
MIRT1471384	hsa-miR-545	CLIP-seq
MIRT1471385	hsa-miR-548b-3p	CLIP-seq
MIRT1471386	hsa-miR-590-3p	CLIP-seq
MIRT1471387	hsa-miR-599	CLIP-seq
MIRT1471388	hsa-miR-630	CLIP-seq
MIRT1471389	hsa-miR-641	CLIP-seq
MIRT1471390	hsa-miR-876-3p	CLIP-seq
MIRT1471321	hsa-miR-122	CLIP-seq
MIRT1471323	hsa-miR-130a	CLIP-seq
MIRT1471324	hsa-miR-130b	CLIP-seq
MIRT1471325	hsa-miR-135a	CLIP-seq
MIRT1471326	hsa-miR-135b	CLIP-seq
MIRT1471327	hsa-miR-301a	CLIP-seq
MIRT1471328	hsa-miR-301b	CLIP-seq
MIRT1471329	hsa-miR-3135b	CLIP-seq
MIRT1471332	hsa-miR-3652	CLIP-seq
MIRT1471333	hsa-miR-3666	CLIP-seq
MIRT1471335	hsa-miR-4295	CLIP-seq
MIRT1471336	hsa-miR-4430	CLIP-seq
MIRT1471339	hsa-miR-454	CLIP-seq
MIRT1471342	hsa-miR-4695-3p	CLIP-seq
MIRT2141875	hsa-miR-670	CLIP-seq
MIRT2362498	hsa-miR-1	CLIP-seq
MIRT2362499	hsa-miR-125a-5p	CLIP-seq
MIRT2362500	hsa-miR-125b	CLIP-seq
MIRT2362501	hsa-miR-1270	CLIP-seq
MIRT2362502	hsa-miR-185	CLIP-seq
MIRT2362503	hsa-miR-190	CLIP-seq
MIRT2362504	hsa-miR-190b	CLIP-seq
MIRT2362505	hsa-miR-206	CLIP-seq
MIRT2362506	hsa-miR-214	CLIP-seq
MIRT1471356	hsa-miR-3120-3p	CLIP-seq
MIRT2362507	hsa-miR-3125	CLIP-seq
MIRT2362508	hsa-miR-3199	CLIP-seq
MIRT2362509	hsa-miR-3200-3p	CLIP-seq
MIRT2362510	hsa-miR-3619-5p	CLIP-seq
MIRT1471332	hsa-miR-3652	CLIP-seq
MIRT2362511	hsa-miR-3916	CLIP-seq
MIRT2362512	hsa-miR-4268	CLIP-seq
MIRT2362513	hsa-miR-4274	CLIP-seq
MIRT2362514	hsa-miR-4291	CLIP-seq
MIRT2362515	hsa-miR-4306	CLIP-seq
MIRT2362516	hsa-miR-4319	CLIP-seq
MIRT2362517	hsa-miR-432	CLIP-seq
MIRT2362518	hsa-miR-4421	CLIP-seq
MIRT1471336	hsa-miR-4430	CLIP-seq
MIRT2362519	hsa-miR-4446-5p	CLIP-seq
MIRT2362520	hsa-miR-4448	CLIP-seq
MIRT2362521	hsa-miR-4474-3p	CLIP-seq
MIRT1471371	hsa-miR-4476	CLIP-seq
MIRT1471372	hsa-miR-4505	CLIP-seq
MIRT2362522	hsa-miR-4531	CLIP-seq
MIRT2362523	hsa-miR-4639-3p	CLIP-seq
MIRT2362524	hsa-miR-4644	CLIP-seq
MIRT1471377	hsa-miR-4688	CLIP-seq
MIRT2362525	hsa-miR-4704-3p	CLIP-seq
MIRT2362526	hsa-miR-4732-3p	CLIP-seq
MIRT2362527	hsa-miR-4755-5p	CLIP-seq
MIRT2362528	hsa-miR-485-3p	CLIP-seq
MIRT2362529	hsa-miR-499-3p	CLIP-seq
MIRT2362530	hsa-miR-499a-3p	CLIP-seq
MIRT1471384	hsa-miR-545	CLIP-seq
MIRT1471386	hsa-miR-590-3p	CLIP-seq
MIRT2362531	hsa-miR-603	CLIP-seq
MIRT2362532	hsa-miR-613	CLIP-seq
MIRT2362533	hsa-miR-620	CLIP-seq
MIRT2362534	hsa-miR-668	CLIP-seq
MIRT2141875	hsa-miR-670	CLIP-seq
MIRT2362535	hsa-miR-761	CLIP-seq
MIRT2362536	hsa-miR-922	CLIP-seq
MIRT2396610	hsa-miR-4679	CLIP-seq
MIRT2362498	hsa-miR-1	CLIP-seq
MIRT2656433	hsa-miR-105	CLIP-seq
MIRT2656434	hsa-miR-1207-3p	CLIP-seq
MIRT2656435	hsa-miR-1248	CLIP-seq
MIRT2656436	hsa-miR-1252	CLIP-seq
MIRT2656437	hsa-miR-1257	CLIP-seq
MIRT2362499	hsa-miR-125a-5p	CLIP-seq
MIRT2362500	hsa-miR-125b	CLIP-seq
MIRT2362501	hsa-miR-1270	CLIP-seq
MIRT2656438	hsa-miR-133a	CLIP-seq
MIRT2656439	hsa-miR-133b	CLIP-seq
MIRT2656440	hsa-miR-140-3p	CLIP-seq
MIRT1471352	hsa-miR-181a	CLIP-seq
MIRT1471353	hsa-miR-181b	CLIP-seq
MIRT1471354	hsa-miR-181c	CLIP-seq
MIRT1471355	hsa-miR-181d	CLIP-seq
MIRT2362502	hsa-miR-185	CLIP-seq
MIRT2656441	hsa-miR-186	CLIP-seq
MIRT2362503	hsa-miR-190	CLIP-seq
MIRT2362504	hsa-miR-190b	CLIP-seq
MIRT2362505	hsa-miR-206	CLIP-seq
MIRT2362507	hsa-miR-3125	CLIP-seq
MIRT2656442	hsa-miR-3175	CLIP-seq
MIRT2656443	hsa-miR-3180-5p	CLIP-seq
MIRT2656444	hsa-miR-3183	CLIP-seq
MIRT2362509	hsa-miR-3200-3p	CLIP-seq
MIRT1471362	hsa-miR-34c-3p	CLIP-seq
MIRT2656445	hsa-miR-3647-3p	CLIP-seq
MIRT2656446	hsa-miR-3651	CLIP-seq
MIRT2656447	hsa-miR-3688-3p	CLIP-seq
MIRT1471367	hsa-miR-382	CLIP-seq
MIRT2362511	hsa-miR-3916	CLIP-seq
MIRT2656448	hsa-miR-3926	CLIP-seq
MIRT2656449	hsa-miR-3978	CLIP-seq
MIRT2656450	hsa-miR-4256	CLIP-seq
MIRT1471369	hsa-miR-4262	CLIP-seq
MIRT2656451	hsa-miR-4277	CLIP-seq
MIRT2362515	hsa-miR-4306	CLIP-seq
MIRT2656452	hsa-miR-4318	CLIP-seq
MIRT2362516	hsa-miR-4319	CLIP-seq
MIRT2362517	hsa-miR-432	CLIP-seq
MIRT2362519	hsa-miR-4446-5p	CLIP-seq
MIRT2656453	hsa-miR-4453	CLIP-seq
MIRT2362521	hsa-miR-4474-3p	CLIP-seq
MIRT1471371	hsa-miR-4476	CLIP-seq
MIRT2656454	hsa-miR-4477a	CLIP-seq
MIRT2656455	hsa-miR-4493	CLIP-seq
MIRT2362522	hsa-miR-4531	CLIP-seq
MIRT2656456	hsa-miR-4538	CLIP-seq
MIRT2656457	hsa-miR-4633-5p	CLIP-seq
MIRT2362524	hsa-miR-4644	CLIP-seq
MIRT2656458	hsa-miR-4662a-5p	CLIP-seq
MIRT2656459	hsa-miR-4690-3p	CLIP-seq
MIRT2656460	hsa-miR-4693-5p	CLIP-seq
MIRT2656461	hsa-miR-4715-3p	CLIP-seq
MIRT2656462	hsa-miR-4716-3p	CLIP-seq
MIRT2656463	hsa-miR-4723-3p	CLIP-seq
MIRT2656464	hsa-miR-4723-5p	CLIP-seq
MIRT2362526	hsa-miR-4732-3p	CLIP-seq
MIRT2656465	hsa-miR-4753-5p	CLIP-seq
MIRT2362527	hsa-miR-4755-5p	CLIP-seq
MIRT2656466	hsa-miR-4757-5p	CLIP-seq
MIRT2656467	hsa-miR-4762-3p	CLIP-seq
MIRT1471378	hsa-miR-4766-5p	CLIP-seq
MIRT2656468	hsa-miR-4777-5p	CLIP-seq
MIRT2656469	hsa-miR-4778-3p	CLIP-seq
MIRT2656470	hsa-miR-4795-3p	CLIP-seq
MIRT2656471	hsa-miR-4799-5p	CLIP-seq
MIRT1471380	hsa-miR-494	CLIP-seq
MIRT2656472	hsa-miR-513a-3p	CLIP-seq
MIRT2656473	hsa-miR-520a-5p	CLIP-seq
MIRT2656474	hsa-miR-525-5p	CLIP-seq
MIRT2656475	hsa-miR-561	CLIP-seq
MIRT1471386	hsa-miR-590-3p	CLIP-seq
MIRT2362531	hsa-miR-603	CLIP-seq
MIRT2362532	hsa-miR-613	CLIP-seq
MIRT2362533	hsa-miR-620	CLIP-seq
MIRT1471388	hsa-miR-630	CLIP-seq
MIRT2656476	hsa-miR-651	CLIP-seq
MIRT2141875	hsa-miR-670	CLIP-seq
MIRT2656477	hsa-miR-888	CLIP-seq
MIRT2656478	hsa-miR-892a	CLIP-seq
MIRT2656433	hsa-miR-105	CLIP-seq
MIRT2656436	hsa-miR-1252	CLIP-seq
MIRT2656440	hsa-miR-140-3p	CLIP-seq
MIRT1471352	hsa-miR-181a	CLIP-seq
MIRT1471353	hsa-miR-181b	CLIP-seq
MIRT1471354	hsa-miR-181c	CLIP-seq
MIRT1471355	hsa-miR-181d	CLIP-seq
MIRT2362502	hsa-miR-185	CLIP-seq
MIRT2656441	hsa-miR-186	CLIP-seq
MIRT2656442	hsa-miR-3175	CLIP-seq
MIRT1471362	hsa-miR-34c-3p	CLIP-seq
MIRT2656445	hsa-miR-3647-3p	CLIP-seq
MIRT2656446	hsa-miR-3651	CLIP-seq
MIRT1471367	hsa-miR-382	CLIP-seq
MIRT2656448	hsa-miR-3926	CLIP-seq
MIRT2656449	hsa-miR-3978	CLIP-seq
MIRT1471369	hsa-miR-4262	CLIP-seq
MIRT2362515	hsa-miR-4306	CLIP-seq
MIRT1471371	hsa-miR-4476	CLIP-seq
MIRT2656455	hsa-miR-4493	CLIP-seq
MIRT2656457	hsa-miR-4633-5p	CLIP-seq
MIRT2362524	hsa-miR-4644	CLIP-seq
MIRT2656458	hsa-miR-4662a-5p	CLIP-seq
MIRT2656459	hsa-miR-4690-3p	CLIP-seq
MIRT2656461	hsa-miR-4715-3p	CLIP-seq
MIRT2656462	hsa-miR-4716-3p	CLIP-seq
MIRT2656464	hsa-miR-4723-5p	CLIP-seq
MIRT2656465	hsa-miR-4753-5p	CLIP-seq
MIRT2656466	hsa-miR-4757-5p	CLIP-seq
MIRT2656468	hsa-miR-4777-5p	CLIP-seq
MIRT2656471	hsa-miR-4799-5p	CLIP-seq
MIRT1471380	hsa-miR-494	CLIP-seq
MIRT2656475	hsa-miR-561	CLIP-seq
MIRT1471386	hsa-miR-590-3p	CLIP-seq
MIRT1471388	hsa-miR-630	CLIP-seq
MIRT2656476	hsa-miR-651	CLIP-seq
MIRT2656477	hsa-miR-888	CLIP-seq

Show/Hide all (45)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IBA
GO:0000151	Component	Ubiquitin ligase complex	IEA
GO:0000785	Component	Chromatin	IEA
GO:0005515	Function	Protein binding	IPI	22190034, 30455355, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IC	38225265
GO:0005829	Component	Cytosol	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0007131	Process	Reciprocal meiotic recombination	IEA
GO:0007131	Process	Reciprocal meiotic recombination	ISS
GO:0007140	Process	Male meiotic nuclear division	IEA
GO:0007140	Process	Male meiotic nuclear division	ISS
GO:0007141	Process	Male meiosis I	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0008270	Function	Zinc ion binding	IEA
GO:0010526	Process	Transposable element silencing	IEA
GO:0010526	Process	Transposable element silencing	ISS
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030163	Process	Protein catabolic process	IEA
GO:0031507	Process	Heterochromatin formation	IEA
GO:0031507	Process	Heterochromatin formation	ISS
GO:0032007	Process	Negative regulation of TOR signaling	IEA
GO:0032007	Process	Negative regulation of TOR signaling	IMP	20298436
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	15548684
GO:0046872	Function	Metal ion binding	IEA
GO:0050852	Process	T cell receptor signaling pathway	IDA	8943371
GO:0050862	Process	Positive regulation of T cell receptor signaling pathway	IDA	38225265
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	15548684, 38225265
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	38225265
GO:0070728	Function	L-leucine binding	IDA	20298436
GO:0070728	Function	L-leucine binding	IEA
GO:0071233	Process	Cellular response to L-leucine	IDA	20298436
GO:0071233	Process	Cellular response to L-leucine	IEA
GO:0071596	Process	Ubiquitin-dependent protein catabolic process via the N-end rule pathway	IBA
GO:0071596	Process	Ubiquitin-dependent protein catabolic process via the N-end rule pathway	IDA	20835242, 28392261
GO:0071596	Process	Ubiquitin-dependent protein catabolic process via the N-end rule pathway	IEA
GO:0141053	Function	Histone H2A ubiquitin ligase activity	IEA
GO:0141053	Function	Histone H2A ubiquitin ligase activity	ISS

MIM	HGNC	e!Ensembl
609134	21289	ENSG00000024048

Q8IWV8

Protein name

E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II)

Protein function

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway (PubMed:15548684, PubMed:20835242, PubMed:28392261). Recognizes and binds to proteins bearing specific N-terminal residues (N-degrons) that are destabilizing according to

PDB

3NY2 , 3NY3 , 5TDA , 5TDB , 5TDD , 5UM3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02207	zf-UBR	98 → 166	Putative zinc finger in N-recognin (UBR box)	Family
PF02617	ClpS	222 → 301	ATP-dependent Clp protease adaptor protein ClpS	Family
PF18995	PRT6_C	1308 → 1730	Proteolysis_6 C-terminal	Domain

Tissue specificity

TISSUE SPECIFICITY: Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level). {ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:16311597}.

Sequence

MASELEPEVQAIDRSLLECSAEEIAGKWLQATDLTREVYQHLAHYVPKIYCRGPNPFPQK
EDMLAQHVLLGPMEWYLCGEDPAFGFPKLEQANKPSHLCGRVFKVGEPTYSCRDCAVDPT
CVLCMECFLGSIHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHELNTSEIEEEEDPL
VHLSEDVIARTYNIFAITFRYAVEILTWEKESELPADLEMVEKSDTYYCMLFNDEVHTYE
QVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRNTSRQTKPLKV
QVMHSSIVAHQNFGLKLLSWLGSIIGYSDGLRRILCQVGLQEGPDGENSSLVDRLMLSDS
KLWKGARSVYHQLFMSSLLMDLKYKKLFAVRFAKNYQQLQRDFMEDDHERAVSVTALSVQ
FFTAPTLARMLITEENLMSIIIKTFMDHLRHRDAQGRFQFERYTALQAFKFRRVQSLILD
LKYVLISKPTEWSDELRQKFLEGFDAFLELLKCMQGMDPITRQVGQHIEMEPEWEAAFTL
QMKLTHVISMMQDWCASDEKVLIEAYKKCLAVLMQCHGGYTDGEQPITLSICGHSVETIR
YCVSQEKVSIHLPVSRLLAGLHVLLSKSEVAYKFPELLPLSELSPPMLIEHPLRCLVLCA
QVHAGMWRRNGFSLVNQIYYYHNVKCRREMFDKDVVMLQTGVSMMDPNHFLMIMLSRFEL
YQIFSTPDYGKRFSSEITHKDVVQQNNTLIEEMLYLIIMLVGERFSPGVGQVNATDEIKR
EIIHQLSIKPMAHSELVKSLPEDENKETGMESVIEAVAHFKKPGLTGRGMYELKPECAKE
FNLYFYHFSRAEQSKAEEAQRKLKRQNREDTALPPPVLPPFCPLFASLVNILQSDVMLCI
MGTILQWAVEHNGYAWSESMLQRVLHLIGMALQEEKQHLENVTEEHVVTFTFTQKISKPG
EAPKNSPSILAMLETLQNAPYLEVHKDMIRWILKTFNAVKKMRESSPTSPVAETEGTIME
ESSRDKDKAERKRKAEIARLRREKIMAQMSEMQRHFIDENKELFQQTLELDASTSAVLDH
SPVASDMTLTALGPAQTQVPEQRQFVTCILCQEEQEVKVESRAMVLAAFVQRSTVLSKNR
SKFIQDPEKYDPLFMHPDLSCGTHTSSCGHIMHAHCWQRYFDSVQAKEQRRQQRLRLHTS
YDVENGEFLCPLCECLSNTVIPLLLPPRNIFNNRLNFSDQPNLTQWIRTISQQIKALQFL
RKEESTPNNASTKNSENVDELQLPEGFRPDFRPKIPYSESIKEMLTTFGTATYKVGLKVH
PNEEDPRVPIMCWGSCAYTIQSIERILSDEDKPLFGPLPCRLDDCLRSLTRFAAAHWTVA
SVSVVQGHFCKLFASLVPNDSHEELPCILDIDMFHLLVGLVLAFPALQCQDFSGISLGTG
DLHIFHLVTMAHIIQILLTSCTEENGMDQENPPCEEESAVLALYKTLHQYTGSALKEIPS
GWHLWRSVRAGIMPFLKCSALFFHYLNGVPSPPDIQVPGTSHFEHLCSYLSLPNNLICLF
QENSEIMNSLIESWCRNSEVKRYLEGERDAIRYPRESNKLINLPEDYSSLINQASNFSCP
KSGGDKSRAPTLCLVCGSLLCSQSYCCQTELEGEDVGACTAHTYSCGSGVGIFLRVRECQ
VLFLAGKTKGCFYSPPYLDDYGETDQGLRRGNPLHLCKERFKKIQKLWHQHSVTEEIGHA
QEANQTLVGIDWQHL

Sequence length

1755

Interactions

View interactions

	Reactome
			Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autoimmune Lymphoproliferative Syndrome	Autoimmune lymphoproliferative disorder	Pubtator	33288741	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	BEFREE	21573678		★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia	Azoospermia	Pubtator	21573678, 25739334	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	33288741	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	34385509	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Neoplasms	Liver neoplasm	Pubtator	22027401	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	28895255		★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	31170158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Oligospermia	Oligospermia	BEFREE	26940145		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	28895255		★★★★★ ★☆☆☆☆ Found in Text Mining only

UBR2 (ubiquitin protein ligase E3 component n-recognin 2)