Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23302
Gene name	WSC domain containing 1
Gene symbol	WSCD1
Synonyms (NCBI Gene)	-
Chromosome	17
Chromosome location	17p13.2

118

Show/Hide all (118)

miRTarBase ID	miRNA	Experiments	Reference
MIRT486051	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT486050	hsa-miR-3960	PAR-CLIP	20371350
MIRT486049	hsa-miR-8072	PAR-CLIP	20371350
MIRT486048	hsa-miR-4467	PAR-CLIP	20371350
MIRT486047	hsa-miR-3180	PAR-CLIP	20371350
MIRT486046	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT486044	hsa-miR-3196	PAR-CLIP	20371350
MIRT486045	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT486043	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486042	hsa-miR-4488	PAR-CLIP	20371350
MIRT486041	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486051	hsa-miR-4781-5p	PAR-CLIP	23592263
MIRT486050	hsa-miR-3960	PAR-CLIP	23592263
MIRT486049	hsa-miR-8072	PAR-CLIP	23592263
MIRT486048	hsa-miR-4467	PAR-CLIP	23592263
MIRT486047	hsa-miR-3180	PAR-CLIP	23592263
MIRT486046	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT486044	hsa-miR-3196	PAR-CLIP	23592263
MIRT486045	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT486043	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT486042	hsa-miR-4488	PAR-CLIP	23592263
MIRT486041	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT486051	hsa-miR-4781-5p	PAR-CLIP	20371350
MIRT486050	hsa-miR-3960	PAR-CLIP	20371350
MIRT486049	hsa-miR-8072	PAR-CLIP	20371350
MIRT486048	hsa-miR-4467	PAR-CLIP	20371350
MIRT486047	hsa-miR-3180	PAR-CLIP	20371350
MIRT486046	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT486044	hsa-miR-3196	PAR-CLIP	20371350
MIRT486045	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT486043	hsa-miR-1237-5p	PAR-CLIP	20371350
MIRT486042	hsa-miR-4488	PAR-CLIP	20371350
MIRT486041	hsa-miR-4697-5p	PAR-CLIP	20371350
MIRT486051	hsa-miR-4781-5p	PAR-CLIP	23592263
MIRT486050	hsa-miR-3960	PAR-CLIP	23592263
MIRT486049	hsa-miR-8072	PAR-CLIP	23592263
MIRT486048	hsa-miR-4467	PAR-CLIP	23592263
MIRT486047	hsa-miR-3180	PAR-CLIP	23592263
MIRT486046	hsa-miR-3180-3p	PAR-CLIP	23592263
MIRT486044	hsa-miR-3196	PAR-CLIP	23592263
MIRT486045	hsa-miR-6816-5p	PAR-CLIP	23592263
MIRT486043	hsa-miR-1237-5p	PAR-CLIP	23592263
MIRT486042	hsa-miR-4488	PAR-CLIP	23592263
MIRT486041	hsa-miR-4697-5p	PAR-CLIP	23592263
MIRT1494381	hsa-miR-1224-3p	CLIP-seq
MIRT1494382	hsa-miR-125a-5p	CLIP-seq
MIRT1494383	hsa-miR-125b	CLIP-seq
MIRT1494384	hsa-miR-1260	CLIP-seq
MIRT1494385	hsa-miR-1260b	CLIP-seq
MIRT1494386	hsa-miR-1280	CLIP-seq
MIRT1494387	hsa-miR-15a	CLIP-seq
MIRT1494388	hsa-miR-15b	CLIP-seq
MIRT1494389	hsa-miR-16	CLIP-seq
MIRT1494390	hsa-miR-188-3p	CLIP-seq
MIRT1494391	hsa-miR-1915	CLIP-seq
MIRT1494392	hsa-miR-195	CLIP-seq
MIRT1494393	hsa-miR-3153	CLIP-seq
MIRT1494394	hsa-miR-3156-3p	CLIP-seq
MIRT1494395	hsa-miR-3620	CLIP-seq
MIRT1494396	hsa-miR-3918	CLIP-seq
MIRT1494397	hsa-miR-412	CLIP-seq
MIRT1494398	hsa-miR-424	CLIP-seq
MIRT1494399	hsa-miR-4274	CLIP-seq
MIRT1494400	hsa-miR-4308	CLIP-seq
MIRT1494401	hsa-miR-4319	CLIP-seq
MIRT1494402	hsa-miR-4512	CLIP-seq
MIRT1494403	hsa-miR-4639-3p	CLIP-seq
MIRT1494404	hsa-miR-4646-5p	CLIP-seq
MIRT1494405	hsa-miR-4668-5p	CLIP-seq
MIRT1494406	hsa-miR-4685-5p	CLIP-seq
MIRT1494407	hsa-miR-4714-3p	CLIP-seq
MIRT1494408	hsa-miR-4731-5p	CLIP-seq
MIRT1494409	hsa-miR-4732-3p	CLIP-seq
MIRT1494410	hsa-miR-4763-5p	CLIP-seq
MIRT1494411	hsa-miR-4793-3p	CLIP-seq
MIRT1494412	hsa-miR-497	CLIP-seq
MIRT1494413	hsa-miR-670	CLIP-seq
MIRT1494414	hsa-miR-671-5p	CLIP-seq
MIRT2148938	hsa-miR-150	CLIP-seq
MIRT2148939	hsa-miR-1912	CLIP-seq
MIRT2148940	hsa-miR-3115	CLIP-seq
MIRT1494393	hsa-miR-3153	CLIP-seq
MIRT2148941	hsa-miR-3202	CLIP-seq
MIRT2148942	hsa-miR-338-3p	CLIP-seq
MIRT2148943	hsa-miR-3661	CLIP-seq
MIRT2148944	hsa-miR-4438	CLIP-seq
MIRT1494405	hsa-miR-4668-5p	CLIP-seq
MIRT2148945	hsa-miR-4713-5p	CLIP-seq
MIRT2148946	hsa-miR-4729	CLIP-seq
MIRT2148947	hsa-miR-4764-3p	CLIP-seq
MIRT2148948	hsa-miR-532-3p	CLIP-seq
MIRT2148949	hsa-miR-631	CLIP-seq
MIRT2369315	hsa-miR-1293	CLIP-seq
MIRT2369316	hsa-miR-199a-5p	CLIP-seq
MIRT2369317	hsa-miR-199b-5p	CLIP-seq
MIRT2369318	hsa-miR-19a	CLIP-seq
MIRT2369319	hsa-miR-19b	CLIP-seq
MIRT2369320	hsa-miR-29a	CLIP-seq
MIRT2369321	hsa-miR-29b	CLIP-seq
MIRT2369322	hsa-miR-29c	CLIP-seq
MIRT2369323	hsa-miR-3065-3p	CLIP-seq
MIRT2148940	hsa-miR-3115	CLIP-seq
MIRT2369324	hsa-miR-3922-5p	CLIP-seq
MIRT2369325	hsa-miR-4302	CLIP-seq
MIRT2369326	hsa-miR-4483	CLIP-seq
MIRT2369327	hsa-miR-4682	CLIP-seq
MIRT2369328	hsa-miR-4717-5p	CLIP-seq
MIRT2369329	hsa-miR-4733-3p	CLIP-seq
MIRT2369330	hsa-miR-648	CLIP-seq
MIRT2397043	hsa-miR-1225-3p	CLIP-seq
MIRT2397044	hsa-miR-1233	CLIP-seq
MIRT2369327	hsa-miR-4682	CLIP-seq
MIRT2397045	hsa-miR-576-3p	CLIP-seq
MIRT2434852	hsa-miR-1972	CLIP-seq
MIRT2434853	hsa-miR-3179	CLIP-seq
MIRT2434854	hsa-miR-4446-3p	CLIP-seq
MIRT2434855	hsa-miR-4650-5p	CLIP-seq
MIRT2369327	hsa-miR-4682	CLIP-seq

Show/Hide all (6)

GO ID	Ontology	Definition	Evidence
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	ISS
GO:0005794	Component	Golgi apparatus	IEA
GO:0008146	Function	Sulfotransferase activity	IEA
GO:0008146	Function	Sulfotransferase activity	ISS
GO:0016020	Component	Membrane	IEA

MIM	HGNC	e!Ensembl
619584	29060	ENSG00000179314

Q658N2

Protein name

Sialate:O-sulfotransferase 1 (WSC domain-containing protein 1)

Protein function

Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS) as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans. Displays selectivity toward glycolipids such as GM1 ganglio

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01822	WSC	145 → 224	WSC domain	Domain
PF01822	WSC	248 → 330	WSC domain	Domain
PF00685	Sulfotransfer_1	416 → 525	Sulfotransferase domain	Domain

Sequence

MAKPFFRLQKFLRRTQFLLFFLTAAYLMTGSLLLLQRVRVALPQGPRAPGPLQTLPVAAV
ALGVGLLDSRALHDPRVSPELLLGVDMLQSPLTRPRPGPRWLRSRNSELRQLRRRWFHHF
MSDSQGPPALGPEAARPAIHSRGTYIGCFSDDGHERTLKGAVFYDLRKMTVSHCQDACAE
RSYVYAGLEAGAECYCGNRLPAVSVGLEECNHECKGEKGSVCGAVDRLSVYRVDELQPGS
RKRRTATYRGCFRLPENITHAFPSSLIQANVTVGTCSGFCSQKEFPLAILRGWECYCAYP
TPRFNLRDAMDSSVCGQDPEAQRLAEYCEVYQTPVQDTRCTDRRFLPNKSKVFVALSSFP
GAGNTWARHLIEHATGFYTGSYYFDGTLYNKGFKGEKDHWRSRRTICVKTHESGRREIEM
FDSAILLIRNPYRSLVAEFNRKCAGHLGYAADRNWKSKEWPDFVNSYASWWSSHVLDWLK
YGKRLLVVHYEELRRSLVPTLREMVAFLNVSVSEERLLCVENNKEGSFRRRGRRSHDPEP
FTPEMKDLINGYIRTVDQALRDHNWTGLPREYVPR

Sequence length

575

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORNEAL NEOVASCULARIZATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL TREMOR	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IRRITABLE BOWEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SMALL CELL LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Liver neoplasms	Liver neoplasms	CTD_human_DG	19233941	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of liver	Liver Cancer	CTD_human_DG	19233941	★★★★★ ★☆☆☆☆ Found in Text Mining only

WSCD1 (WSC domain containing 1)