FMO4 (flavin containing dimethylaniline monoxygenase 4)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 2329
Gene name Flavin containing dimethylaniline monoxygenase 4
Gene symbol FMO4
Synonyms (NCBI Gene)
FMO2
Chromosome 1
Chromosome location 1q24.3
Summary Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes
miRNA miRNA information provided by mirtarbase database.
122
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (122)
miRTarBase ID miRNA Experiments Reference
MIRT617864 hsa-miR-888-3p HITS-CLIP 23824327
MIRT617862 hsa-miR-4695-5p HITS-CLIP 23824327
MIRT617861 hsa-miR-4779 HITS-CLIP 23824327
MIRT617860 hsa-miR-196a-5p HITS-CLIP 23824327
MIRT617859 hsa-miR-196b-5p HITS-CLIP 23824327
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
FOS Activation 20188076
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0004497 Function Monooxygenase activity IEA
GO:0004499 Function N,N-dimethylaniline monooxygenase activity IBA
GO:0004499 Function N,N-dimethylaniline monooxygenase activity IEA
GO:0004499 Function N,N-dimethylaniline monooxygenase activity NAS 1417778
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
136131 3772 ENSG00000076258
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P31512
Protein name Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4)
Protein function This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00743 FMO-like 2 → 532 Flavin-binding monooxygenase-like Family
Tissue specificity TISSUE SPECIFICITY: Liver.
Sequence
Sequence length 558
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG 
  Taurine and hypotaurine metabolism
Drug metabolism - cytochrome P450
Metabolic pathways 		 
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (5)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTISM SPECTRUM DISORDER — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BRAIN ANEURYSM — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Trimethylaminuria Uncertain significance ClinVar
Disgenet
★★★★★
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
Show/Hide Text Mining Associations (8)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Breast Neoplasms Breast neoplasm Pubtator 37963835 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Carcinogenesis Pubtator 37963835 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Endometrioma Endometrioma CTD_human_DG 20864642
★★★★★
★☆☆☆☆
Found in Text Mining only
Endometriosis Endometriosis CTD_human_DG 20864642
★★★★★
★☆☆☆☆
Found in Text Mining only
Intracranial Aneurysm Intracranial Aneurysm GWASCAT_DG 30823506
★★★★★
★☆☆☆☆
Found in Text Mining only
Invasive Ductal Breast Carcinoma Invasive Duct and Lobular Carcinoma BEFREE 16428471
★★★★★
★☆☆☆☆
Found in Text Mining only
Prader-Willi Syndrome Prader-Willi Syndrome BEFREE 8434620
★★★★★
★☆☆☆☆
Found in Text Mining only
Trimethylaminuria Trimethylaminuria BEFREE 8434620
★★★★★
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)