Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23281
Gene name	Microtubule associated scaffold protein 2
Gene symbol	MTUS2
Synonyms (NCBI Gene)	CAZIPICISKIAA0774TIP150
Chromosome	13
Chromosome location	13q12.3

114

Show/Hide all (114)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021240	hsa-miR-146a-5p	Microarray	18057241
MIRT022821	hsa-miR-124-3p	Microarray	18668037
MIRT535776	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT535776	hsa-miR-4761-3p	PAR-CLIP	22012620
MIRT535776	hsa-miR-4761-3p	PAR-CLIP	20371350
MIRT535776	hsa-miR-4761-3p	PAR-CLIP	22012620
MIRT1165742	hsa-miR-1253	CLIP-seq
MIRT1165743	hsa-miR-3136-5p	CLIP-seq
MIRT1165744	hsa-miR-342-3p	CLIP-seq
MIRT1165745	hsa-miR-4251	CLIP-seq
MIRT1165746	hsa-miR-4439	CLIP-seq
MIRT1165747	hsa-miR-4513	CLIP-seq
MIRT1165748	hsa-miR-943	CLIP-seq
MIRT1165742	hsa-miR-1253	CLIP-seq
MIRT1165749	hsa-miR-1296	CLIP-seq
MIRT1165750	hsa-miR-1827	CLIP-seq
MIRT1165751	hsa-miR-193a-5p	CLIP-seq
MIRT1165752	hsa-miR-2909	CLIP-seq
MIRT1165753	hsa-miR-302a	CLIP-seq
MIRT1165754	hsa-miR-302b	CLIP-seq
MIRT1165755	hsa-miR-302c	CLIP-seq
MIRT1165756	hsa-miR-302d	CLIP-seq
MIRT1165757	hsa-miR-302e	CLIP-seq
MIRT1165758	hsa-miR-3120-5p	CLIP-seq
MIRT1165759	hsa-miR-3126-3p	CLIP-seq
MIRT1165760	hsa-miR-3127-5p	CLIP-seq
MIRT1165743	hsa-miR-3136-5p	CLIP-seq
MIRT1165744	hsa-miR-342-3p	CLIP-seq
MIRT1165761	hsa-miR-371-3p	CLIP-seq
MIRT1165762	hsa-miR-372	CLIP-seq
MIRT1165763	hsa-miR-373	CLIP-seq
MIRT1165764	hsa-miR-3918	CLIP-seq
MIRT1165765	hsa-miR-3974	CLIP-seq
MIRT1165745	hsa-miR-4251	CLIP-seq
MIRT1165766	hsa-miR-4299	CLIP-seq
MIRT1165767	hsa-miR-4436b-3p	CLIP-seq
MIRT1165746	hsa-miR-4439	CLIP-seq
MIRT1165768	hsa-miR-4456	CLIP-seq
MIRT1165747	hsa-miR-4513	CLIP-seq
MIRT1165769	hsa-miR-4649-3p	CLIP-seq
MIRT1165770	hsa-miR-4685-5p	CLIP-seq
MIRT1165771	hsa-miR-4733-3p	CLIP-seq
MIRT1165772	hsa-miR-4736	CLIP-seq
MIRT1165773	hsa-miR-519a	CLIP-seq
MIRT1165774	hsa-miR-519b-3p	CLIP-seq
MIRT1165775	hsa-miR-519c-3p	CLIP-seq
MIRT1165776	hsa-miR-520a-3p	CLIP-seq
MIRT1165777	hsa-miR-520b	CLIP-seq
MIRT1165778	hsa-miR-520c-3p	CLIP-seq
MIRT1165779	hsa-miR-520d-3p	CLIP-seq
MIRT1165780	hsa-miR-520e	CLIP-seq
MIRT1165781	hsa-miR-541	CLIP-seq
MIRT1165782	hsa-miR-548q	CLIP-seq
MIRT1165783	hsa-miR-654-5p	CLIP-seq
MIRT1165784	hsa-miR-657	CLIP-seq
MIRT1165748	hsa-miR-943	CLIP-seq
MIRT2047966	hsa-miR-214	CLIP-seq
MIRT2047967	hsa-miR-3619-5p	CLIP-seq
MIRT2047968	hsa-miR-4778-3p	CLIP-seq
MIRT2047969	hsa-miR-761	CLIP-seq
MIRT2276735	hsa-miR-1254	CLIP-seq
MIRT2276736	hsa-miR-219-5p	CLIP-seq
MIRT2276737	hsa-miR-2682	CLIP-seq
MIRT1165753	hsa-miR-302a	CLIP-seq
MIRT1165754	hsa-miR-302b	CLIP-seq
MIRT1165755	hsa-miR-302c	CLIP-seq
MIRT1165756	hsa-miR-302d	CLIP-seq
MIRT1165757	hsa-miR-302e	CLIP-seq
MIRT2276738	hsa-miR-3116	CLIP-seq
MIRT2276739	hsa-miR-3179	CLIP-seq
MIRT2276740	hsa-miR-3202	CLIP-seq
MIRT1165761	hsa-miR-371-3p	CLIP-seq
MIRT2276741	hsa-miR-3714	CLIP-seq
MIRT1165762	hsa-miR-372	CLIP-seq
MIRT1165763	hsa-miR-373	CLIP-seq
MIRT2276742	hsa-miR-3941	CLIP-seq
MIRT2276743	hsa-miR-4445	CLIP-seq
MIRT2276744	hsa-miR-449c	CLIP-seq
MIRT2276745	hsa-miR-4533	CLIP-seq
MIRT2276746	hsa-miR-4643	CLIP-seq
MIRT2276747	hsa-miR-4659a-3p	CLIP-seq
MIRT2276748	hsa-miR-4659b-3p	CLIP-seq
MIRT2276749	hsa-miR-466	CLIP-seq
MIRT2276750	hsa-miR-4672	CLIP-seq
MIRT2276751	hsa-miR-4698	CLIP-seq
MIRT2276752	hsa-miR-4742-3p	CLIP-seq
MIRT2047968	hsa-miR-4778-3p	CLIP-seq
MIRT2276753	hsa-miR-4782-3p	CLIP-seq
MIRT2276754	hsa-miR-4789-3p	CLIP-seq
MIRT2276755	hsa-miR-508-3p	CLIP-seq
MIRT1165773	hsa-miR-519a	CLIP-seq
MIRT1165774	hsa-miR-519b-3p	CLIP-seq
MIRT1165775	hsa-miR-519c-3p	CLIP-seq
MIRT1165776	hsa-miR-520a-3p	CLIP-seq
MIRT1165777	hsa-miR-520b	CLIP-seq
MIRT1165778	hsa-miR-520c-3p	CLIP-seq
MIRT1165779	hsa-miR-520d-3p	CLIP-seq
MIRT1165780	hsa-miR-520e	CLIP-seq
MIRT2276756	hsa-miR-548an	CLIP-seq
MIRT2276757	hsa-miR-550a	CLIP-seq
MIRT2276758	hsa-miR-661	CLIP-seq
MIRT2276759	hsa-miR-766	CLIP-seq
MIRT2276760	hsa-miR-935	CLIP-seq
MIRT2276761	hsa-miR-942	CLIP-seq
MIRT2454601	hsa-miR-1180	CLIP-seq
MIRT2454602	hsa-miR-1203	CLIP-seq
MIRT2454603	hsa-miR-3194-3p	CLIP-seq
MIRT2454604	hsa-miR-4307	CLIP-seq
MIRT2454605	hsa-miR-4659a-5p	CLIP-seq
MIRT2454606	hsa-miR-4659b-5p	CLIP-seq
MIRT2454607	hsa-miR-4664-3p	CLIP-seq
MIRT2454608	hsa-miR-4716-5p	CLIP-seq
MIRT2454609	hsa-miR-4727-5p	CLIP-seq
MIRT2454610	hsa-miR-4769-3p	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 19543227, 21516116, 25416956, 25910212, 26871637, 27107012, 28514442, 29892012, 30886144, 31515488, 32296183, 36217029
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	19806667
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	19543227
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005881	Component	Cytoplasmic microtubule	IDA	19543227
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IDA	19543227
GO:0015630	Component	Microtubule cytoskeleton	IDA
GO:0042803	Function	Protein homodimerization activity	IPI	19543227
GO:0045171	Component	Intercellular bridge	IDA

MIM	HGNC	e!Ensembl
619358	20595	ENSG00000132938

Q5JR59

Protein name

Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa)

Protein function

Binds microtubules. Together with MAPRE1 may target the microtubule depolymerase KIF2C to the plus-end of microtubules. May regulate the dynamics of microtubules at their growing distal tip.

Family and domains

Tissue specificity

TISSUE SPECIFICITY: Detected in embryonic stem cells differentiating to cardiomyocytes. {ECO:0000269|PubMed:19806667}.

Sequence

MSVPVAPKKSCYTQLRDNRNAARNNNESILSLGDTNANQIMLEVSSSHDESKTCDLGDEI
GNTNSSEPENRTHFHKEFHQLQGFGKGSQAGSASLKDFRLSSTIQRELNEEHTVERGTDS
LQTTRSIQGPSLSSWRNVMSEASLDVLAKRDAEIPRHVPKDKLAKTLDNEELRRHSLERA
SSSVAAVGSLTPQHPQPLSLDSREARGQIPGGGEGPQKTLPDHAVPAAFPATDSTSEGKS
VRHPKPSTSESKQSTPSETQTVGAHVLQVCSEHTSHSAHPEPALNLTLASKEIPSKLEAQ
LGQGKGEAKLDLKYVPPRRVEQEGKAAQEGYLGCHKEENLSALEGRDPCGEAHPEATDAL
GHLLNSDLHHLGVGRGNCEEKRGVNPGEQDSLHTTPKQGSASLGGADNQPTGKISPCAGE
KLGERTSSSFSPGDSHVAFIPNNLTDSKPLDVIEEERRLGSGNKDSVMVLVFNPSVGENK
TEVPEPLDPQSGRSEARESKEVTTSVAENRNLLENADKIESTSARADSVLNIPAPLHPET
TVNMTYQPTTPSSSFQDVSVFGMDAGSPLVVPPPTDSARLLNTSPKVPDKNTCPSGIPKP
VFTHSKDTPSSQEGMENYQVEKTEERTETKPIIMPKPKHVRPKIITYIRRNPQALGQVDA
SLVPVGLPYAPPTCTMPLPHEEKAAGGDLKPSANLYEKFKPDLQKPRVFSSGLMVSGIKP
PGHPFSQMSEKFLQEVTDHPGKEEFCSPPYAHYEVPPTFYRSAMLLKPQLGLGAMSRLPS
AKSRILIASQRSSASAIHPPGPITTATSLYSSDPSADLKKASSSNAAKSNLPKSGLRPPG
YSRLPAAKLAAFGFVRSSSVSSVSSTQSGDSAQPEQGRPATRSTFGNEEQPVLKASLPSK
DTPKGAGRVAPPASSSVTAPRRSLLPAPKSTSTPAGTKKDAQKDQDTNKPAVSSPKRVAA
STTKLHSPGYPKQRTAAARNGFPPKPDPQAREAERQLVLRLKERCEQQTRQLGVAQGELK
RAICGFDALAVATQHFFRKNESALVKEKELSIELANIRDEVAFHTAKCEKLQKEKEELER
RFEDEVKRLGWQQQAELQELEERLQLQFEAEMARLQEEHGDQLLSIRCQHQEQVEDLTAS
HDAALLEMENNHTVAITILQDDHDHKVQELMSTHELEKKELEENFEKLRLSLQDQVDTLT
FQSQSLRDRARRFEEALRKNTEEQLEIALAPYQHLEEDMKSLKQVLEMKNQQIHEQEKKI
LELEKLAEKNIILEEKIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKK
RLSRTNEELLWKLQTGDPTSPIKLSPTSPVYRGSSSGPSSPARVSTTPR

Sequence length

1369

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUMINAL A BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	26474971	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	28854418	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thrombocythemia, Essential	Thrombocythemia	BEFREE	25132286		★★★★★ ★☆☆☆☆ Found in Text Mining only

MTUS2 (microtubule associated scaffold protein 2)