Gene Gene information from NCBI Gene database.
Entrez ID 23276
Gene name Kelch like family member 18
Gene symbol KLHL18
Synonyms (NCBI Gene)
-
Chromosome 3
Chromosome location 3p21.31
miRNA miRNA information provided by mirtarbase database.
381
miRTarBase ID miRNA Experiments Reference
MIRT027008 hsa-miR-103a-3p Sequencing 20371350
MIRT474444 hsa-miR-4496 PAR-CLIP 21572407
MIRT474445 hsa-miR-6808-5p PAR-CLIP 21572407
MIRT474443 hsa-miR-6893-5p PAR-CLIP 21572407
MIRT474442 hsa-miR-940 PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
9
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 23213400, 25416956, 31696965, 32814053, 35156780
GO:0005737 Component Cytoplasm IBA
GO:0016567 Process Protein ubiquitination IDA 23213400
GO:0016567 Process Protein ubiquitination IEA
GO:0031463 Component Cul3-RING ubiquitin ligase complex IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619926 29120 ENSG00000114648
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O94889
Protein name Kelch-like protein 18
Protein function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis (PubMed:23213400). The BCR(KLHL18) E3 ubiquitin ligase complex mediates the ubiquitination of AURKA leading
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00651 BTB 28 135 BTB/POZ domain Domain
PF07707 BACK 140 242 BTB And C-terminal Kelch Domain
PF01344 Kelch_1 277 323 Kelch motif Repeat
PF01344 Kelch_1 325 370 Kelch motif Repeat
PF01344 Kelch_1 372 417 Kelch motif Repeat
PF01344 Kelch_1 419 464 Kelch motif Repeat
PF01344 Kelch_1 466 511 Kelch motif Repeat
PF01344 Kelch_1 513 558 Kelch motif Repeat
Sequence
Sequence length 574
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Colorectal Neoplasms Colorectal neoplasm Pubtator 27120998 Associate
★☆☆☆☆
Found in Text Mining only