PPIP5K2 (diphosphoinositol pentakisphosphate kinase 2)

Gene

• Entrez ID: 23262
• Gene name: Diphosphoinositol pentakisphosphate kinase 2
• Gene symbol: PPIP5K2
• Synonyms (NCBI Gene): CFAP160, DFNB100, HISPPD1, IP7K2, VIP2
• Chromosome: 5
• Chromosome location: 5q21.1
• Summary: This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack phosphatase activity. This k

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs548137246	G>A	Pathogenic	Coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT720154	hsa-miR-15b-5p	HITS-CLIP	19536157
MIRT720153	hsa-miR-15a-5p	HITS-CLIP	19536157
MIRT720152	hsa-miR-16-5p	HITS-CLIP	19536157
MIRT720151	hsa-miR-6838-5p	HITS-CLIP	19536157
MIRT720150	hsa-miR-497-5p	HITS-CLIP	19536157
MIRT720149	hsa-miR-424-5p	HITS-CLIP	19536157
MIRT720148	hsa-miR-195-5p	HITS-CLIP	19536157
MIRT720147	hsa-miR-548ae-3p	HITS-CLIP	19536157
MIRT720146	hsa-miR-548ah-3p	HITS-CLIP	19536157
MIRT720145	hsa-miR-548aj-3p	HITS-CLIP	19536157
MIRT720144	hsa-miR-548am-3p	HITS-CLIP	19536157
MIRT720143	hsa-miR-548aq-3p	HITS-CLIP	19536157
MIRT720142	hsa-miR-548j-3p	HITS-CLIP	19536157
MIRT720141	hsa-miR-548x-3p	HITS-CLIP	19536157
MIRT720140	hsa-miR-5582-3p	HITS-CLIP	19536157
MIRT720139	hsa-miR-548e-5p	HITS-CLIP	19536157
MIRT720138	hsa-miR-548p	HITS-CLIP	19536157
MIRT720137	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT720136	hsa-miR-545-3p	HITS-CLIP	19536157
MIRT720135	hsa-miR-4762-3p	HITS-CLIP	19536157
MIRT712284	hsa-miR-136-3p	HITS-CLIP	19536157
MIRT712283	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT712282	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT712281	hsa-miR-4310	HITS-CLIP	19536157
MIRT712280	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT712279	hsa-miR-6731-3p	HITS-CLIP	19536157
MIRT712278	hsa-miR-26a-1-3p	HITS-CLIP	19536157
MIRT712277	hsa-miR-26a-2-3p	HITS-CLIP	19536157
MIRT712276	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT712275	hsa-miR-4291	HITS-CLIP	19536157
MIRT712274	hsa-miR-374a-3p	HITS-CLIP	19536157
MIRT712273	hsa-miR-7159-3p	HITS-CLIP	19536157
MIRT712272	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT517696	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT517697	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT517695	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT560812	hsa-miR-4302	PAR-CLIP	20371350
MIRT560811	hsa-miR-4289	PAR-CLIP	20371350
MIRT560810	hsa-miR-145-3p	PAR-CLIP	20371350
MIRT560809	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT560808	hsa-miR-6077	PAR-CLIP	20371350
MIRT560807	hsa-miR-6717-5p	PAR-CLIP	20371350
MIRT560806	hsa-miR-8053	PAR-CLIP	20371350
MIRT560805	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT560804	hsa-miR-644a	PAR-CLIP	20371350
MIRT560802	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT560803	hsa-miR-4752	PAR-CLIP	20371350
MIRT560801	hsa-miR-670-3p	PAR-CLIP	20371350
MIRT517706	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT517705	hsa-miR-541-5p	PAR-CLIP	23446348
MIRT517704	hsa-miR-3159	PAR-CLIP	23446348
MIRT517703	hsa-miR-885-5p	PAR-CLIP	23446348
MIRT517702	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT517701	hsa-miR-6861-5p	PAR-CLIP	23446348
MIRT517700	hsa-miR-4252	PAR-CLIP	23446348
MIRT517699	hsa-miR-503-3p	PAR-CLIP	23446348
MIRT517698	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT517696	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT517697	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT517695	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT498368	hsa-miR-4714-3p	PAR-CLIP	22291592
MIRT498367	hsa-miR-5189-3p	PAR-CLIP	22291592
MIRT446780	hsa-miR-1225-3p	PAR-CLIP	22100165
MIRT446779	hsa-miR-1233-3p	PAR-CLIP	22100165
MIRT446778	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446777	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT446776	hsa-miR-578	PAR-CLIP	22100165
MIRT720154	hsa-miR-15b-5p	HITS-CLIP	19536157
MIRT720153	hsa-miR-15a-5p	HITS-CLIP	19536157
MIRT720152	hsa-miR-16-5p	HITS-CLIP	19536157
MIRT720151	hsa-miR-6838-5p	HITS-CLIP	19536157
MIRT720150	hsa-miR-497-5p	HITS-CLIP	19536157
MIRT720149	hsa-miR-424-5p	HITS-CLIP	19536157
MIRT720148	hsa-miR-195-5p	HITS-CLIP	19536157
MIRT720147	hsa-miR-548ae-3p	HITS-CLIP	19536157
MIRT720146	hsa-miR-548ah-3p	HITS-CLIP	19536157
MIRT720145	hsa-miR-548aj-3p	HITS-CLIP	19536157
MIRT720144	hsa-miR-548am-3p	HITS-CLIP	19536157
MIRT720143	hsa-miR-548aq-3p	HITS-CLIP	19536157
MIRT720142	hsa-miR-548j-3p	HITS-CLIP	19536157
MIRT720141	hsa-miR-548x-3p	HITS-CLIP	19536157
MIRT720140	hsa-miR-5582-3p	HITS-CLIP	19536157
MIRT720139	hsa-miR-548e-5p	HITS-CLIP	19536157
MIRT720138	hsa-miR-548p	HITS-CLIP	19536157
MIRT720137	hsa-miR-3613-3p	HITS-CLIP	19536157
MIRT720136	hsa-miR-545-3p	HITS-CLIP	19536157
MIRT720135	hsa-miR-4762-3p	HITS-CLIP	19536157
MIRT712284	hsa-miR-136-3p	HITS-CLIP	19536157
MIRT712283	hsa-miR-892c-5p	HITS-CLIP	19536157
MIRT712282	hsa-miR-506-5p	HITS-CLIP	19536157
MIRT712281	hsa-miR-4310	HITS-CLIP	19536157
MIRT712280	hsa-miR-7157-5p	HITS-CLIP	19536157
MIRT712279	hsa-miR-6731-3p	HITS-CLIP	19536157
MIRT712278	hsa-miR-26a-1-3p	HITS-CLIP	19536157
MIRT712277	hsa-miR-26a-2-3p	HITS-CLIP	19536157
MIRT712276	hsa-miR-3160-5p	HITS-CLIP	19536157
MIRT712275	hsa-miR-4291	HITS-CLIP	19536157
MIRT712274	hsa-miR-374a-3p	HITS-CLIP	19536157
MIRT712273	hsa-miR-7159-3p	HITS-CLIP	19536157
MIRT712272	hsa-miR-4482-3p	HITS-CLIP	19536157
MIRT517696	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT517697	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT517695	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT560812	hsa-miR-4302	PAR-CLIP	20371350
MIRT560811	hsa-miR-4289	PAR-CLIP	20371350
MIRT560810	hsa-miR-145-3p	PAR-CLIP	20371350
MIRT560809	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT560808	hsa-miR-6077	PAR-CLIP	20371350
MIRT560807	hsa-miR-6717-5p	PAR-CLIP	20371350
MIRT560806	hsa-miR-8053	PAR-CLIP	20371350
MIRT560805	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT560804	hsa-miR-644a	PAR-CLIP	20371350
MIRT560802	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT560803	hsa-miR-4752	PAR-CLIP	20371350
MIRT560801	hsa-miR-670-3p	PAR-CLIP	20371350
MIRT517706	hsa-miR-551b-5p	PAR-CLIP	23446348
MIRT517705	hsa-miR-541-5p	PAR-CLIP	23446348
MIRT517704	hsa-miR-3159	PAR-CLIP	23446348
MIRT517703	hsa-miR-885-5p	PAR-CLIP	23446348
MIRT517702	hsa-miR-186-3p	PAR-CLIP	23446348
MIRT517701	hsa-miR-6861-5p	PAR-CLIP	23446348
MIRT517700	hsa-miR-4252	PAR-CLIP	23446348
MIRT517699	hsa-miR-503-3p	PAR-CLIP	23446348
MIRT517698	hsa-miR-340-5p	PAR-CLIP	23446348
MIRT517696	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT517697	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT517695	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT498368	hsa-miR-4714-3p	PAR-CLIP	22291592
MIRT498367	hsa-miR-5189-3p	PAR-CLIP	22291592
MIRT446780	hsa-miR-1225-3p	PAR-CLIP	22100165
MIRT446779	hsa-miR-1233-3p	PAR-CLIP	22100165
MIRT446778	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446777	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT446776	hsa-miR-578	PAR-CLIP	22100165
MIRT1253466	hsa-miR-103a	CLIP-seq
MIRT1253467	hsa-miR-107	CLIP-seq
MIRT1253468	hsa-miR-1178	CLIP-seq
MIRT1253469	hsa-miR-1179	CLIP-seq
MIRT1253470	hsa-miR-1184	CLIP-seq
MIRT1253471	hsa-miR-1205	CLIP-seq
MIRT1253472	hsa-miR-1208	CLIP-seq
MIRT1253473	hsa-miR-1253	CLIP-seq
MIRT1253474	hsa-miR-1284	CLIP-seq
MIRT1253475	hsa-miR-1301	CLIP-seq
MIRT1253476	hsa-miR-145	CLIP-seq
MIRT1253477	hsa-miR-18a	CLIP-seq
MIRT1253478	hsa-miR-18b	CLIP-seq
MIRT1253479	hsa-miR-194	CLIP-seq
MIRT1253480	hsa-miR-200b	CLIP-seq
MIRT1253481	hsa-miR-200c	CLIP-seq
MIRT1253482	hsa-miR-2053	CLIP-seq
MIRT1253483	hsa-miR-25	CLIP-seq
MIRT1253484	hsa-miR-3145-5p	CLIP-seq
MIRT1253485	hsa-miR-3153	CLIP-seq
MIRT1253486	hsa-miR-3158-5p	CLIP-seq
MIRT1253487	hsa-miR-3185	CLIP-seq
MIRT1253488	hsa-miR-32	CLIP-seq
MIRT1253489	hsa-miR-338-5p	CLIP-seq
MIRT1253490	hsa-miR-363	CLIP-seq
MIRT1253491	hsa-miR-367	CLIP-seq
MIRT1253492	hsa-miR-369-3p	CLIP-seq
MIRT1253493	hsa-miR-376c	CLIP-seq
MIRT1253494	hsa-miR-3925-3p	CLIP-seq
MIRT1253495	hsa-miR-429	CLIP-seq
MIRT1253496	hsa-miR-4477b	CLIP-seq
MIRT1253497	hsa-miR-4494	CLIP-seq
MIRT1253498	hsa-miR-4522	CLIP-seq
MIRT1253499	hsa-miR-4637	CLIP-seq
MIRT1253500	hsa-miR-4668-5p	CLIP-seq
MIRT1253501	hsa-miR-4709-3p	CLIP-seq
MIRT1253502	hsa-miR-4735-3p	CLIP-seq
MIRT1253503	hsa-miR-485-3p	CLIP-seq
MIRT1253504	hsa-miR-495	CLIP-seq
MIRT1253505	hsa-miR-499a-5p	CLIP-seq
MIRT1253506	hsa-miR-5047	CLIP-seq
MIRT1253507	hsa-miR-508-5p	CLIP-seq
MIRT1253508	hsa-miR-579	CLIP-seq
MIRT1253509	hsa-miR-664	CLIP-seq
MIRT1253510	hsa-miR-668	CLIP-seq
MIRT1253511	hsa-miR-767-3p	CLIP-seq
MIRT1253512	hsa-miR-92a	CLIP-seq
MIRT1253513	hsa-miR-92b	CLIP-seq
MIRT2074676	hsa-miR-1245b-3p	CLIP-seq
MIRT2074677	hsa-miR-23a	CLIP-seq
MIRT2074678	hsa-miR-23b	CLIP-seq
MIRT2074679	hsa-miR-23c	CLIP-seq
MIRT2074680	hsa-miR-29a	CLIP-seq
MIRT2074681	hsa-miR-29b	CLIP-seq
MIRT2074682	hsa-miR-29c	CLIP-seq
MIRT1253485	hsa-miR-3153	CLIP-seq
MIRT2074683	hsa-miR-3545-3p	CLIP-seq
MIRT2074684	hsa-miR-3617	CLIP-seq
MIRT2074685	hsa-miR-410	CLIP-seq
MIRT2074686	hsa-miR-4272	CLIP-seq
MIRT2074687	hsa-miR-4447	CLIP-seq
MIRT2074688	hsa-miR-4472	CLIP-seq
MIRT2074689	hsa-miR-452	CLIP-seq
MIRT1253498	hsa-miR-4522	CLIP-seq
MIRT2074690	hsa-miR-4676-3p	CLIP-seq
MIRT2074691	hsa-miR-4729	CLIP-seq
MIRT2074692	hsa-miR-4789-5p	CLIP-seq
MIRT2074693	hsa-miR-499-3p	CLIP-seq
MIRT2074694	hsa-miR-499a-3p	CLIP-seq
MIRT2074695	hsa-miR-505	CLIP-seq
MIRT2074696	hsa-miR-5096	CLIP-seq
MIRT2074697	hsa-miR-541	CLIP-seq
MIRT2074698	hsa-miR-582-5p	CLIP-seq
MIRT2074699	hsa-miR-587	CLIP-seq
MIRT2074700	hsa-miR-625	CLIP-seq
MIRT2074701	hsa-miR-641	CLIP-seq
MIRT2074702	hsa-miR-654-5p	CLIP-seq
MIRT2074703	hsa-miR-9	CLIP-seq
MIRT2074704	hsa-miR-944	CLIP-seq
MIRT1253466	hsa-miR-103a	CLIP-seq
MIRT1253467	hsa-miR-107	CLIP-seq
MIRT1253468	hsa-miR-1178	CLIP-seq
MIRT1253472	hsa-miR-1208	CLIP-seq
MIRT2074676	hsa-miR-1245b-3p	CLIP-seq
MIRT2301572	hsa-miR-1279	CLIP-seq
MIRT1253475	hsa-miR-1301	CLIP-seq
MIRT1253479	hsa-miR-194	CLIP-seq
MIRT1253480	hsa-miR-200b	CLIP-seq
MIRT1253481	hsa-miR-200c	CLIP-seq
MIRT2301573	hsa-miR-219-5p	CLIP-seq
MIRT2301574	hsa-miR-224	CLIP-seq
MIRT1253483	hsa-miR-25	CLIP-seq
MIRT2301575	hsa-miR-30a	CLIP-seq
MIRT2301576	hsa-miR-30b	CLIP-seq
MIRT2301577	hsa-miR-30c	CLIP-seq
MIRT2301578	hsa-miR-30d	CLIP-seq
MIRT2301579	hsa-miR-30e	CLIP-seq
MIRT1253485	hsa-miR-3153	CLIP-seq
MIRT1253488	hsa-miR-32	CLIP-seq
MIRT2301580	hsa-miR-33a	CLIP-seq
MIRT2301581	hsa-miR-33b	CLIP-seq
MIRT2301582	hsa-miR-34c-3p	CLIP-seq
MIRT2301583	hsa-miR-361-5p	CLIP-seq
MIRT2074684	hsa-miR-3617	CLIP-seq
MIRT1253490	hsa-miR-363	CLIP-seq
MIRT1253491	hsa-miR-367	CLIP-seq
MIRT2301584	hsa-miR-4267	CLIP-seq
MIRT2074686	hsa-miR-4272	CLIP-seq
MIRT1253495	hsa-miR-429	CLIP-seq
MIRT2074687	hsa-miR-4447	CLIP-seq
MIRT2074688	hsa-miR-4472	CLIP-seq
MIRT2074689	hsa-miR-452	CLIP-seq
MIRT2301585	hsa-miR-4639-5p	CLIP-seq
MIRT2301586	hsa-miR-4646-3p	CLIP-seq
MIRT1253500	hsa-miR-4668-5p	CLIP-seq
MIRT2074690	hsa-miR-4676-3p	CLIP-seq
MIRT2301587	hsa-miR-4717-3p	CLIP-seq
MIRT2301588	hsa-miR-4782-3p	CLIP-seq
MIRT2301589	hsa-miR-498	CLIP-seq
MIRT2074693	hsa-miR-499-3p	CLIP-seq
MIRT2074694	hsa-miR-499a-3p	CLIP-seq
MIRT1253506	hsa-miR-5047	CLIP-seq
MIRT2301590	hsa-miR-513b	CLIP-seq
MIRT2074697	hsa-miR-541	CLIP-seq
MIRT2301591	hsa-miR-553	CLIP-seq
MIRT2301592	hsa-miR-569	CLIP-seq
MIRT2301593	hsa-miR-576-5p	CLIP-seq
MIRT2074698	hsa-miR-582-5p	CLIP-seq
MIRT2074700	hsa-miR-625	CLIP-seq
MIRT2074701	hsa-miR-641	CLIP-seq
MIRT2074702	hsa-miR-654-5p	CLIP-seq
MIRT1253510	hsa-miR-668	CLIP-seq
MIRT1253511	hsa-miR-767-3p	CLIP-seq
MIRT1253512	hsa-miR-92a	CLIP-seq
MIRT1253513	hsa-miR-92b	CLIP-seq
MIRT2074704	hsa-miR-944	CLIP-seq
MIRT1253466	hsa-miR-103a	CLIP-seq
MIRT1253467	hsa-miR-107	CLIP-seq
MIRT1253472	hsa-miR-1208	CLIP-seq
MIRT1253475	hsa-miR-1301	CLIP-seq
MIRT1253479	hsa-miR-194	CLIP-seq
MIRT1253483	hsa-miR-25	CLIP-seq
MIRT1253488	hsa-miR-32	CLIP-seq
MIRT1253490	hsa-miR-363	CLIP-seq
MIRT1253491	hsa-miR-367	CLIP-seq
MIRT1253506	hsa-miR-5047	CLIP-seq
MIRT1253510	hsa-miR-668	CLIP-seq
MIRT1253512	hsa-miR-92a	CLIP-seq
MIRT1253513	hsa-miR-92b	CLIP-seq
MIRT2074684	hsa-miR-3617	CLIP-seq
MIRT2074686	hsa-miR-4272	CLIP-seq
MIRT2074689	hsa-miR-452	CLIP-seq
MIRT2074690	hsa-miR-4676-3p	CLIP-seq
MIRT2074701	hsa-miR-641	CLIP-seq
MIRT2598260	hsa-miR-1263	CLIP-seq
MIRT1253474	hsa-miR-1284	CLIP-seq
MIRT1253480	hsa-miR-200b	CLIP-seq
MIRT1253481	hsa-miR-200c	CLIP-seq
MIRT2598261	hsa-miR-3143	CLIP-seq
MIRT2598262	hsa-miR-337-3p	CLIP-seq
MIRT2074683	hsa-miR-3545-3p	CLIP-seq
MIRT2598263	hsa-miR-3685	CLIP-seq
MIRT2598264	hsa-miR-3688-3p	CLIP-seq
MIRT1253492	hsa-miR-369-3p	CLIP-seq
MIRT2598265	hsa-miR-384	CLIP-seq
MIRT2598266	hsa-miR-3942-3p	CLIP-seq
MIRT2598267	hsa-miR-4279	CLIP-seq
MIRT1253495	hsa-miR-429	CLIP-seq
MIRT2598268	hsa-miR-4490	CLIP-seq
MIRT1253498	hsa-miR-4522	CLIP-seq
MIRT1253499	hsa-miR-4637	CLIP-seq
MIRT2598269	hsa-miR-4704-5p	CLIP-seq
MIRT2598270	hsa-miR-4760-5p	CLIP-seq
MIRT2598271	hsa-miR-4774-5p	CLIP-seq
MIRT2598272	hsa-miR-4803	CLIP-seq
MIRT2598273	hsa-miR-522	CLIP-seq
MIRT2598274	hsa-miR-543	CLIP-seq
MIRT2598275	hsa-miR-548ac	CLIP-seq
MIRT2598276	hsa-miR-548ae	CLIP-seq
MIRT2598277	hsa-miR-548aj	CLIP-seq
MIRT2598278	hsa-miR-548am	CLIP-seq
MIRT2598279	hsa-miR-548d-3p	CLIP-seq
MIRT2598280	hsa-miR-548x	CLIP-seq
MIRT2598281	hsa-miR-548z	CLIP-seq
MIRT2074699	hsa-miR-587	CLIP-seq
MIRT2598282	hsa-miR-600	CLIP-seq
MIRT2598283	hsa-miR-617	CLIP-seq
MIRT2598284	hsa-miR-653	CLIP-seq
MIRT2598285	hsa-miR-889	CLIP-seq
MIRT2598260	hsa-miR-1263	CLIP-seq
MIRT1253474	hsa-miR-1284	CLIP-seq
MIRT1253480	hsa-miR-200b	CLIP-seq
MIRT1253481	hsa-miR-200c	CLIP-seq
MIRT2598261	hsa-miR-3143	CLIP-seq
MIRT2074683	hsa-miR-3545-3p	CLIP-seq
MIRT2598263	hsa-miR-3685	CLIP-seq
MIRT2598264	hsa-miR-3688-3p	CLIP-seq
MIRT1253492	hsa-miR-369-3p	CLIP-seq
MIRT2598265	hsa-miR-384	CLIP-seq
MIRT2598266	hsa-miR-3942-3p	CLIP-seq
MIRT2598267	hsa-miR-4279	CLIP-seq
MIRT1253495	hsa-miR-429	CLIP-seq
MIRT2598268	hsa-miR-4490	CLIP-seq
MIRT1253498	hsa-miR-4522	CLIP-seq
MIRT1253499	hsa-miR-4637	CLIP-seq
MIRT2598269	hsa-miR-4704-5p	CLIP-seq
MIRT2598271	hsa-miR-4774-5p	CLIP-seq
MIRT2598272	hsa-miR-4803	CLIP-seq
MIRT2598273	hsa-miR-522	CLIP-seq
MIRT2598274	hsa-miR-543	CLIP-seq
MIRT2598275	hsa-miR-548ac	CLIP-seq
MIRT2598276	hsa-miR-548ae	CLIP-seq
MIRT2598277	hsa-miR-548aj	CLIP-seq
MIRT2598278	hsa-miR-548am	CLIP-seq
MIRT2598279	hsa-miR-548d-3p	CLIP-seq
MIRT2598280	hsa-miR-548x	CLIP-seq
MIRT2598281	hsa-miR-548z	CLIP-seq
MIRT2074699	hsa-miR-587	CLIP-seq
MIRT2598282	hsa-miR-600	CLIP-seq
MIRT2598283	hsa-miR-617	CLIP-seq
MIRT2598284	hsa-miR-653	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000827	Function	Inositol-1,3,4,5,6-pentakisphosphate kinase activity	ISS
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IBA
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IDA	17690096
GO:0000828	Function	Inositol hexakisphosphate kinase activity	IEA
GO:0000828	Function	Inositol hexakisphosphate kinase activity	TAS
GO:0000829	Function	Diphosphoinositol pentakisphosphate kinase activity	IEA
GO:0000829	Function	Diphosphoinositol pentakisphosphate kinase activity	TAS
GO:0000832	Function	Inositol hexakisphosphate 5-kinase activity	ISS
GO:0005515	Function	Protein binding	IPI	32296183, 36931259
GO:0005524	Function	ATP binding	IDA	22119861
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	17690096
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006020	Process	Inositol metabolic process	ISS
GO:0007605	Process	Sensory perception of sound	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032958	Process	Inositol phosphate biosynthetic process	IBA
GO:0033857	Function	5-diphosphoinositol pentakisphosphate 1-kinase activity	IBA
GO:0033857	Function	5-diphosphoinositol pentakisphosphate 1-kinase activity	IDA	17690096
GO:0033857	Function	5-diphosphoinositol pentakisphosphate 1-kinase activity	IEA
GO:0033857	Function	5-diphosphoinositol pentakisphosphate 1-kinase activity	ISS
GO:0043647	Process	Inositol phosphate metabolic process	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0052723	Function	Inositol hexakisphosphate 1-kinase activity	IEA

Other IDs

• MIM: 611648
• HGNC: 29035
• e!Ensembl: ENSG00000145725

Protein

• UniProt ID: O43314
• Protein name: Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (EC 2.7.4.24) (Diphosphoinositol pentakisphosphate kinase 2) (Histidine acid phosphatase domain-containing protein 1) (InsP6 and PP-IP5 kinase 2) (VIP1 homolog 2) (hsVIP2)
• Protein function: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrak
• PDB: 3T54, 3T7A, 3T99, 3T9A, 3T9B, 3T9C, 3T9D, 3T9E, 3T9F, 4HN2, 4NZM, 4NZN, 4NZO, 4Q4C, 4Q4D, 5BYA, 5BYB, 5DGH, 5DGI, 6N5C, 8G9E
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF18086	PPIP5K2_N	44 → 133	Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain	Domain
  PF00328	His_Phos_2	379 → 894	Histidine phosphatase superfamily (branch 2)	Family

• Sequence:

  MSEAPRFFVGPEDTEINPGNYRHFFHHADEDDEEEDDSPPERQIVVGICSMAKKSKSKPM
  KEILERISLFKYITVVVFEEEVILNEPVENWPLCDCLISFHSKGFPLDKAVAYAKLRNPF
  VINDLNMQYLIQDRREVYSILQAEGILLPRYAILNRDPNNPKECNLIEGEDHVEVNGEVF
  QKPFVEKPVSAEDHNVYIYYPTSAGGGSQRLFRKIGSRSSVYSPESNVRKTGSYIYEEFM
  PTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVILNAREKLIAWKVCLA
  FKQTVCGFDLLRANGQSYVCDVNGFSFVKNSMKYYDDCAKILGNIVMRELAPQFHIPWSI
  PLEAEDIPIVPTTSGTMMELRCVIAVIRHGDRTPKQKMKMEVRHQKFFDLFEKCDGYKSG
  KLKLKKPKQLQEVLDIARQLLMELGQNNDSEIEENKPKLEQLKTVLEMYGHFSGINRKVQ
  LTYLPHGCPKTSSEEEDSRREEPSLLLVLKWGGELTPAGRVQAEELGRAFRCMYPGGQGD
  YAGFPGCGLLRLHSTYRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSAN
  MNGLLDSDSDSLSSCQQRVKARLHEILQKDRDFTAEDYEKLTPSGSISLIKSMHLIKNPV
  KTCDKVYSLIQSLTSQIRHRMEDPKSSDIQLYHSETLELMLRRWSKLEKDFKTKNGRYDI
  SKIPDIYDCIKYDVQHNGSLKLENTMELYRLSKALADIVIPQEYGITKAEKLEIAKGYCT
  PLVRKIRSDLQRTQDDDTVNKLHPVYSRGVLSPERHVRTRLYFTSESHVHSLLSILRYGA
  LCNESKDEQWKRAMDYLNVVNELNYMTQIVIMLYEDPNKDLSSEERFHVELHFSPGAKGC
  EEDKNLPSGYGYRPASRENEGRRPFKIDNDDEPHTSKRDEVDRAVILFKPMVSEPIHIHR
  KSPLPRSRKTATNDEESPLSVSSPEGTGTWLHYTSGVGTGRRRRRSGEQITSSPVSPKSL
  AFTSSIFGSWQQVVSENANYLRTPRTLVEQKQNPTVGSHCAGLFSTSVLGGSSSAPNLQD
  YARTHRKKLTSSGCIDDATRGSAVKRFSISFARHPTNGFELYSMVPSICPLETLHNALSL
  KQVDEFLASIASPSSDVPRKTAEISSTALRSSPIMRKKVSLNTYTPAKILPTPPATLKST
  KASSKPATSGPSSAVVPNTSSRKKNITSKTETHEHKKNTGKKK

• Sequence length: 1243

Pathways

KEGG:

Phosphatidylinositol signaling system

Reactome:

Synthesis of pyrophosphates in the cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AUTOSOMAL RECESSIVE ISOLATED SENSORINEURAL DEAFNESS TYPE DFNB	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEAFNESS, AUTOSOMAL RECESSIVE 100	—	Disgenet, HPO Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC EYE DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS, AUTOSOMAL RECESSIVE	—	ClinGen, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hearing loss, autosomal recessive 100	Uncertain significance	ClinVar ClinVar, GenCC	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PPIP5K2-related disorder	Benign; Likely benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Autistic Disorder	Autism	Pubtator	26204995	Associate	★☆☆☆☆ Found in Text Mining only
Autosomal recessive non-syndromic sensorineural deafness type DFNB	Non-Syndromic Sensorineural Deafness	Orphanet			★☆☆☆☆ Found in Text Mining only
Sensorineural Hearing Loss (disorder)	Hearing Loss	HPO_DG			★☆☆☆☆ Found in Text Mining only