TMEM131L (transmembrane 131 like)

Gene

• Entrez ID: 23240
• Gene name: Transmembrane 131 like
• Gene symbol: TMEM131L
• Synonyms (NCBI Gene): KIAA0922
• Chromosome: 4
• Chromosome location: 4q31.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT721253	hsa-miR-3150a-5p	HITS-CLIP	19536157
MIRT721252	hsa-miR-3150b-5p	HITS-CLIP	19536157
MIRT721251	hsa-miR-216b-5p	HITS-CLIP	19536157
MIRT721250	hsa-miR-4724-5p	HITS-CLIP	19536157
MIRT721249	hsa-miR-3675-3p	HITS-CLIP	19536157
MIRT721248	hsa-miR-4684-5p	HITS-CLIP	19536157
MIRT721247	hsa-miR-606	HITS-CLIP	19536157
MIRT536503	hsa-miR-20a-5p	PAR-CLIP	22012620
MIRT536502	hsa-miR-17-5p	PAR-CLIP	22012620
MIRT536501	hsa-miR-106b-5p	PAR-CLIP	22012620
MIRT536500	hsa-miR-106a-5p	PAR-CLIP	22012620
MIRT536499	hsa-miR-20b-5p	PAR-CLIP	22012620
MIRT536498	hsa-miR-93-5p	PAR-CLIP	22012620
MIRT536497	hsa-miR-519d-3p	PAR-CLIP	22012620
MIRT536496	hsa-miR-526b-3p	PAR-CLIP	22012620
MIRT536495	hsa-miR-548n	PAR-CLIP	22012620
MIRT400828	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT400826	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT536494	hsa-miR-513b-3p	PAR-CLIP	22012620
MIRT536493	hsa-miR-3163	PAR-CLIP	22012620
MIRT536492	hsa-miR-5092	PAR-CLIP	22012620
MIRT536491	hsa-miR-5007-3p	PAR-CLIP	22012620
MIRT400824	hsa-miR-335-3p	PAR-CLIP	22012620

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IDA	23690469
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	23690469
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0033088	Process	Negative regulation of immature T cell proliferation in thymus	IMP	23690469
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IDA	23690469

Other IDs

• MIM: 616243
• HGNC: 29146
• e!Ensembl: ENSG00000121210

Protein

• UniProt ID: A2VDJ0
• Protein name: Transmembrane protein 131-like
• Protein function: [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12371	TMEM131_like	91 → 174	Transmembrane protein 131-like	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in thymocytes. {ECO:0000269|PubMed:23690469}.
• Sequence:

  MAGLRRPQPGCYCRTAAAVNLLLGVFQVLLPCCRPGGAQGQAIEPLPNVVELWQAEEGEL
  LLPTQGDSEEGLEEPSQEQSFSDKLFSGKGLHFQPSVLDFGIQFLGHPVAKILHAYNPSR
  DSEVVVNSVFAAAGHFHVPPVPCRVIPAMGKTSFRIIFLPTEEGSIESSLFINTSSYGVL
  SYHVSGIGTRRISTEGSAKQLPNAYFLLPKVQSIQLSQMQAETTNTSLLQVQLECSLHNK
  VCQQLKGCYLESDDVLRLQMSIMVTMENFSKEFEENTQHLLDHLSIVYVATDESETSDDS
  AVNMYILHSGNSLIWIQDIRHFSQRDALSLQFEPVLLPTSTTNFTKIASFTCKATSCDSG
  IIEDVKKTTHTPTLKACLFSSVAQGYFRMDSSATQFHIETHENTSGLWSIWYRNHFDRSV
  VLNDVFLSKETKHMLKILNFTGPLFLPPGCWNIFSLKLAVKDIAINLFTNVFLTTNIGAI
  FAIPLQIYSAPTKEGSLGFEVIAHCGMHYFMGKSKAGNPNWNGSLSLDQSTWNVDSELAN
  KLYERWKKYKNGDVCKRNVLGTTRFAHLKKSKESESFVFFLPRLIAEPGLMLNFSATALR
  SRMIKYFVVQNPSSWPVSLQLLPLSLYPKPEALVHLLHRWFGTDMQMINFTTGEFQLTEA
  CPYLGTHSEESRFGILHLHLQPLEMKRVGVVFTPADYGKVTSLILIRNNLTVIDMIGVEG
  FGARELLKVGGRLPGAGGSLRFKVPESTLMDCRRQLKDSKQILSITKNFKVENIGPLPIT
  VSSLKINGYNCQGYGFEVLDCHQFSLDPNTSRDISIVFTPDFTSSWVIRDLSLVTAADLE
  FRFTLNVTLPHHLLPLCADVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEF
  MKTRQRQNASSSSQQNNGPMDVISPHSYKSNCKNFLDTYGPSDKGRGKNCLPVNTPQSRI
  QNAAKRSPATYGHSQKKHKCSVYYSKHKTSTAAASSTSTTTEEKQTSPLGSSLPAAKEDI
  CTDAMRENWISLRYASGINVNLQKNLTLPKNLLNKEENTLKNTIVFSNPSSECSMKEGIQ
  TCMFPKETDIKTSENTAEFKERELCPLKTSKKLPENHLPRNSPQYHQPDLPEISRKNNGN
  NQQVPVKNEVDHCENLKKVDTKPSSEKKIHKTSREDMFSEKQDIPFVEQEDPYRKKKLQE
  KREGNLQNLNWSKSRTCRKNKKRGVAPVSRPPEQSDLKLVCSDFERSELSSDINVRSWCI
  QESTREVCKADAEIASSLPAAQREAEGYYQKPEKKCVDKFCSDSSSDCGSSSGSVRASRG
  SWGSWSSTSSSDGDKKPMVDAQHFLPAGDSVSQNDFPSEAPISLNLSHNICNPMTVNSLP
  QYAEPSCPSLPAGPTGVEEDKGLYSPGDLWPTPPVCVTSSLNCTLENGVPCVIQESAPVH
  NSFIDWSATCEGQFSSAYCPLELNDYNAFPEENMNYANGFPCPADVQTDFIDHNSQSTWN
  TPPNMPAAWGHASFISSPPYLTSTRSLSPMSGLFGSIWAPQSDVYENCCPINPTTEHSTH
  MENQAVVCKEYYPGFNPFRAYMNLDIWTTTANRNANFPLSRDSSYCGNV

• Sequence length: 1609

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
APPENDICITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DISORDER OF APPENDIX	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Carcinoma	Breast Carcinoma	BEFREE	28187708		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25803781, 28187708	Associate	★☆☆☆☆ Found in Text Mining only
Carotid Artery Thrombosis	Carotid artery thrombosis	Pubtator	24578102	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	37696853	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28187708		★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★☆☆☆☆ Found in Text Mining only
Wilms Tumor	Wilms tumor	Pubtator	32149111	Associate	★☆☆☆☆ Found in Text Mining only