Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23223
Gene name	Ribosomal RNA processing 12 homolog
Gene symbol	RRP12
Synonyms (NCBI Gene)	KIAA0690
Chromosome	10
Chromosome location	10q24.1

Show/Hide all (79)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030475	hsa-miR-24-3p	Microarray	19748357
MIRT031543	hsa-miR-16-5p	Proteomics	18668040
MIRT043788	hsa-miR-328-3p	CLASH	23622248
MIRT038758	hsa-miR-93-3p	CLASH	23622248
MIRT1320170	hsa-miR-128	CLIP-seq
MIRT1320171	hsa-miR-216a	CLIP-seq
MIRT1320172	hsa-miR-27a	CLIP-seq
MIRT1320173	hsa-miR-27b	CLIP-seq
MIRT1320174	hsa-miR-3663-5p	CLIP-seq
MIRT1320175	hsa-miR-1270	CLIP-seq
MIRT1320176	hsa-miR-1285	CLIP-seq
MIRT1320177	hsa-miR-18a	CLIP-seq
MIRT1320178	hsa-miR-18b	CLIP-seq
MIRT1320179	hsa-miR-3179	CLIP-seq
MIRT1320180	hsa-miR-3187-5p	CLIP-seq
MIRT1320181	hsa-miR-326	CLIP-seq
MIRT1320182	hsa-miR-330-5p	CLIP-seq
MIRT1320183	hsa-miR-378g	CLIP-seq
MIRT1320184	hsa-miR-3907	CLIP-seq
MIRT1320185	hsa-miR-3921	CLIP-seq
MIRT1320186	hsa-miR-4269	CLIP-seq
MIRT1320187	hsa-miR-4299	CLIP-seq
MIRT1320188	hsa-miR-4456	CLIP-seq
MIRT1320189	hsa-miR-4486	CLIP-seq
MIRT1320190	hsa-miR-4653-5p	CLIP-seq
MIRT1320191	hsa-miR-4683	CLIP-seq
MIRT1320192	hsa-miR-4694-3p	CLIP-seq
MIRT1320193	hsa-miR-4701-5p	CLIP-seq
MIRT1320194	hsa-miR-4730	CLIP-seq
MIRT1320195	hsa-miR-4733-3p	CLIP-seq
MIRT1320196	hsa-miR-4735-3p	CLIP-seq
MIRT1320197	hsa-miR-548q	CLIP-seq
MIRT1320198	hsa-miR-588	CLIP-seq
MIRT1320199	hsa-miR-593	CLIP-seq
MIRT1320200	hsa-miR-612	CLIP-seq
MIRT1320201	hsa-miR-620	CLIP-seq
MIRT2095061	hsa-miR-1207-3p	CLIP-seq
MIRT2095062	hsa-miR-4438	CLIP-seq
MIRT2095063	hsa-miR-4463	CLIP-seq
MIRT2095064	hsa-miR-4494	CLIP-seq
MIRT2095065	hsa-miR-4514	CLIP-seq
MIRT2095066	hsa-miR-4692	CLIP-seq
MIRT2095067	hsa-miR-499a-5p	CLIP-seq
MIRT2095068	hsa-miR-5095	CLIP-seq
MIRT2095069	hsa-miR-548v	CLIP-seq
MIRT1320179	hsa-miR-3179	CLIP-seq
MIRT2615196	hsa-miR-3198	CLIP-seq
MIRT1320185	hsa-miR-3921	CLIP-seq
MIRT2615197	hsa-miR-3925-3p	CLIP-seq
MIRT2615198	hsa-miR-4251	CLIP-seq
MIRT1320186	hsa-miR-4269	CLIP-seq
MIRT2615199	hsa-miR-4303	CLIP-seq
MIRT2615200	hsa-miR-4309	CLIP-seq
MIRT2615201	hsa-miR-4329	CLIP-seq
MIRT2615202	hsa-miR-4645-5p	CLIP-seq
MIRT2615203	hsa-miR-4653-3p	CLIP-seq
MIRT1320190	hsa-miR-4653-5p	CLIP-seq
MIRT2615204	hsa-miR-4668-3p	CLIP-seq
MIRT2615205	hsa-miR-4673	CLIP-seq
MIRT2615206	hsa-miR-4717-5p	CLIP-seq
MIRT1320195	hsa-miR-4733-3p	CLIP-seq
MIRT1320199	hsa-miR-593	CLIP-seq
MIRT2615207	hsa-miR-665	CLIP-seq
MIRT2615208	hsa-miR-766	CLIP-seq
MIRT1320179	hsa-miR-3179	CLIP-seq
MIRT2615196	hsa-miR-3198	CLIP-seq
MIRT1320185	hsa-miR-3921	CLIP-seq
MIRT2615197	hsa-miR-3925-3p	CLIP-seq
MIRT1320186	hsa-miR-4269	CLIP-seq
MIRT2615200	hsa-miR-4309	CLIP-seq
MIRT2615202	hsa-miR-4645-5p	CLIP-seq
MIRT2615203	hsa-miR-4653-3p	CLIP-seq
MIRT1320190	hsa-miR-4653-5p	CLIP-seq
MIRT2615204	hsa-miR-4668-3p	CLIP-seq
MIRT2615205	hsa-miR-4673	CLIP-seq
MIRT2615206	hsa-miR-4717-5p	CLIP-seq
MIRT1320195	hsa-miR-4733-3p	CLIP-seq
MIRT1320199	hsa-miR-593	CLIP-seq
MIRT2615208	hsa-miR-766	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA
GO:0016020	Component	Membrane	IEA
GO:0031965	Component	Nuclear membrane	IEA

MIM	HGNC	e!Ensembl
617723	29100	ENSG00000052749

Q5JTH9

Protein name

RRP12-like protein

PDB

7WTS , 7WTT , 7WTU , 7WTV , 7WTW , 7WTX , 7WTZ , 7WU0

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08161	NUC173	470 → 672	NUC173 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Weakly expressed. Expressed at intermediate level in testis and ovary. {ECO:0000269|PubMed:9734811}.

Sequence

MGRSGKLPSGVSAKLKRWKKGHSSDSNPAICRHRQAARSRFFSRPSGRSDLTVDAVKLHN
ELQSGSLRLGKSEAPETPMEEEAELVLTEKSSGTFLSGLSDCTNVTFSKVQRFWESNSAA
HKEICAVLAAVTEVIRSQGGKETETEYFAALMTTMEAVESPESLAAVAYLLNLVLKRVPS
PVLIKKFSDTSKAFMDIMSAQASSGSTSVLRWVLSCLATLLRKQDLEAWGYPVTLQVYHG
LLSFTVHPKPKIRKAAQHGVCSVLKGSEFMFEKAPAHHPAAISTAKFCIQEIEKSGGSKE
ATTTLHMLTLLKDLLPCFPEGLVKSCSETLLRVMTLSHVLVTACAMQAFHSLFHARPGLS
TLSAELNAQIITALYDYVPSENDLQPLLAWLKVMEKAHINLVRLQWDLGLGHLPRFFGTA
VTCLLSPHSQVLTAATQSLKEILKECVAPHMADIGSVTSSASGPAQSVAKMFRAVEEGLT
YKFHAAWSSVLQLLCVFFEACGRQAHPVMRKCLQSLCDLRLSPHFPHTAALDQAVGAAVT
SMGPEVVLQAVPLEIDGSEETLDFPRSWLLPVIRDHVQETRLGFFTTYFLPLANTLKSKA
MDLAQAGSTVESKIYDTLQWQMWTLLPGFCTRPTDVAISFKGLARTLGMAISERPDLRVT
VCQALRTLITKGCQAEADRAEVSRFAKNFLPILFNLYGQPVAAGDTPAPRRAVLETIRTY
LTITDTQLVNSLLEKASEKVLDPASSDFTRLSVLDLVVALAPCADEAAISKLYSTIRPYL
ESKAHGVQKKAYRVLEEVCASPQGPGALFVQSHLEDLKKTLLDSLRSTSSPAKRPRLKCL
LHIVRKLSAEHKEFITALIPEVILCTKEVSVGARKNAFALLVEMGHAFLRFGSNQEEALQ
CYLVLIYPGLVGAVTMVSCSILALTHLLFEFKGLMGTSTVEQLLENVCLLLASRTRDVVK
SALGFIKVAVTVMDVAHLAKHVQLVMEAIGKLSDDMRRHFRMKLRNLFTKFIRKFGFELV
KRLLPEEYHRVLVNIRKAEARAKRHRALSQAAVEEEEEEEEEEEPAQGKGDSIEEILADS
EDEEDNEEEERSRGKEQRKLARQRSRAWLKEGGGDEPLNFLDPKVAQRVLATQPGPGRGR
KKDHGFKVSADGRLIIREEADGNKMEEEEGAKGEDEEMADPMEDVIIRNKKHQKLKHQKE
AEEEELEIPPQYQAGGSGIHRPVAKKAMPGAEYKAKKAKGDVKKKGRPDPYAYIPLNRSK
LNRRKKMKLQGQFKGLVKAARRGSQVGHKNRRKDRRP

Sequence length

1297

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHOLELITHIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GALLSTONES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEPHROTIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	28351365	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	26499779		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	26499779	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	25149474	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

RRP12 (ribosomal RNA processing 12 homolog)