Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23210
Gene name	Jumonji domain containing 6, arginine demethylase and lysine hydroxylase
Gene symbol	JMJD6
Synonyms (NCBI Gene)	PSRPTDSRPTDSR1
Chromosome	17
Chromosome location	17q25.1
Summary	This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins are predicted to function as protein hydroxylases or histone demethylases. This protein was first identified as a putative phosphatidylserine receptor involved in phag

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miRTarBase ID	miRNA	Experiments	Reference
MIRT049750	hsa-miR-92a-3p	CLASH	23622248
MIRT041794	hsa-miR-484	CLASH	23622248
MIRT052729	hsa-miR-1260b	CLASH	23622248
MIRT1076993	hsa-let-7a	CLIP-seq
MIRT1076994	hsa-let-7b	CLIP-seq
MIRT1076995	hsa-let-7c	CLIP-seq
MIRT1076996	hsa-let-7d	CLIP-seq
MIRT1076997	hsa-let-7e	CLIP-seq
MIRT1076998	hsa-let-7f	CLIP-seq
MIRT1076999	hsa-let-7g	CLIP-seq
MIRT1077000	hsa-let-7i	CLIP-seq
MIRT1077001	hsa-miR-1227	CLIP-seq
MIRT1077002	hsa-miR-1228	CLIP-seq
MIRT1077003	hsa-miR-1245	CLIP-seq
MIRT1077004	hsa-miR-1272	CLIP-seq
MIRT1077005	hsa-miR-1294	CLIP-seq
MIRT1077006	hsa-miR-1303	CLIP-seq
MIRT1077007	hsa-miR-194	CLIP-seq
MIRT1077008	hsa-miR-202	CLIP-seq
MIRT1077009	hsa-miR-3130-3p	CLIP-seq
MIRT1077010	hsa-miR-3145-5p	CLIP-seq
MIRT1077011	hsa-miR-3148	CLIP-seq
MIRT1077012	hsa-miR-3149	CLIP-seq
MIRT1077013	hsa-miR-3176	CLIP-seq
MIRT1077014	hsa-miR-3187-3p	CLIP-seq
MIRT1077015	hsa-miR-3545-3p	CLIP-seq
MIRT1077016	hsa-miR-3612	CLIP-seq
MIRT1077017	hsa-miR-3622a-5p	CLIP-seq
MIRT1077018	hsa-miR-3662	CLIP-seq
MIRT1077019	hsa-miR-3663-5p	CLIP-seq
MIRT1077020	hsa-miR-3690	CLIP-seq
MIRT1077021	hsa-miR-378	CLIP-seq
MIRT1077022	hsa-miR-378b	CLIP-seq
MIRT1077023	hsa-miR-378c	CLIP-seq
MIRT1077024	hsa-miR-378d	CLIP-seq
MIRT1077025	hsa-miR-378e	CLIP-seq
MIRT1077026	hsa-miR-378f	CLIP-seq
MIRT1077027	hsa-miR-378h	CLIP-seq
MIRT1077028	hsa-miR-378i	CLIP-seq
MIRT1077029	hsa-miR-3922-3p	CLIP-seq
MIRT1077030	hsa-miR-3934	CLIP-seq
MIRT1077031	hsa-miR-411	CLIP-seq
MIRT1077032	hsa-miR-422a	CLIP-seq
MIRT1077033	hsa-miR-4252	CLIP-seq
MIRT1077034	hsa-miR-4254	CLIP-seq
MIRT1077035	hsa-miR-4435	CLIP-seq
MIRT1077036	hsa-miR-4458	CLIP-seq
MIRT1077037	hsa-miR-4459	CLIP-seq
MIRT1077038	hsa-miR-4463	CLIP-seq
MIRT1077039	hsa-miR-4476	CLIP-seq
MIRT1077040	hsa-miR-4500	CLIP-seq
MIRT1077041	hsa-miR-455-5p	CLIP-seq
MIRT1077042	hsa-miR-4635	CLIP-seq
MIRT1077043	hsa-miR-4670-3p	CLIP-seq
MIRT1077044	hsa-miR-4680-5p	CLIP-seq
MIRT1077045	hsa-miR-4695-5p	CLIP-seq
MIRT1077046	hsa-miR-4701-5p	CLIP-seq
MIRT1077047	hsa-miR-4715-3p	CLIP-seq
MIRT1077048	hsa-miR-4731-3p	CLIP-seq
MIRT1077049	hsa-miR-4735-5p	CLIP-seq
MIRT1077050	hsa-miR-4755-3p	CLIP-seq
MIRT1077051	hsa-miR-4766-5p	CLIP-seq
MIRT1077052	hsa-miR-4775	CLIP-seq
MIRT1077053	hsa-miR-4794	CLIP-seq
MIRT1077054	hsa-miR-4801	CLIP-seq
MIRT1077055	hsa-miR-483-5p	CLIP-seq
MIRT1077056	hsa-miR-488	CLIP-seq
MIRT1077057	hsa-miR-508-5p	CLIP-seq
MIRT1077058	hsa-miR-5095	CLIP-seq
MIRT1077059	hsa-miR-5096	CLIP-seq
MIRT1077060	hsa-miR-548a-3p	CLIP-seq
MIRT1077061	hsa-miR-548ag	CLIP-seq
MIRT1077062	hsa-miR-548ai	CLIP-seq
MIRT1077063	hsa-miR-548e	CLIP-seq
MIRT1077064	hsa-miR-548f	CLIP-seq
MIRT1077065	hsa-miR-548g	CLIP-seq
MIRT1077066	hsa-miR-548s	CLIP-seq
MIRT1077067	hsa-miR-549	CLIP-seq
MIRT1077068	hsa-miR-552	CLIP-seq
MIRT1077069	hsa-miR-561	CLIP-seq
MIRT1077070	hsa-miR-574-5p	CLIP-seq
MIRT1077071	hsa-miR-588	CLIP-seq
MIRT1077072	hsa-miR-590-3p	CLIP-seq
MIRT1077073	hsa-miR-640	CLIP-seq
MIRT1077074	hsa-miR-648	CLIP-seq
MIRT1077075	hsa-miR-650	CLIP-seq
MIRT1077076	hsa-miR-653	CLIP-seq
MIRT1077077	hsa-miR-665	CLIP-seq
MIRT1077078	hsa-miR-767-3p	CLIP-seq
MIRT1077079	hsa-miR-877	CLIP-seq
MIRT1077080	hsa-miR-98	CLIP-seq
MIRT2019140	hsa-miR-23a	CLIP-seq
MIRT2019141	hsa-miR-23b	CLIP-seq
MIRT2019142	hsa-miR-23c	CLIP-seq
MIRT2019143	hsa-miR-4686	CLIP-seq
MIRT2019144	hsa-miR-4753-3p	CLIP-seq
MIRT2251060	hsa-miR-1972	CLIP-seq
MIRT2251061	hsa-miR-3654	CLIP-seq
MIRT2389550	hsa-miR-33a	CLIP-seq
MIRT2389551	hsa-miR-33b	CLIP-seq
MIRT2019143	hsa-miR-4686	CLIP-seq
MIRT1077001	hsa-miR-1227	CLIP-seq
MIRT1077002	hsa-miR-1228	CLIP-seq
MIRT2452080	hsa-miR-217	CLIP-seq
MIRT1077012	hsa-miR-3149	CLIP-seq
MIRT2452081	hsa-miR-3199	CLIP-seq
MIRT1077031	hsa-miR-411	CLIP-seq
MIRT2452082	hsa-miR-4310	CLIP-seq
MIRT2452083	hsa-miR-4418	CLIP-seq
MIRT2452084	hsa-miR-4438	CLIP-seq
MIRT1077041	hsa-miR-455-5p	CLIP-seq
MIRT2452085	hsa-miR-4699-3p	CLIP-seq
MIRT1077047	hsa-miR-4715-3p	CLIP-seq
MIRT1077049	hsa-miR-4735-5p	CLIP-seq
MIRT1077052	hsa-miR-4775	CLIP-seq
MIRT1077053	hsa-miR-4794	CLIP-seq
MIRT1077055	hsa-miR-483-5p	CLIP-seq
MIRT2452086	hsa-miR-509-3-5p	CLIP-seq
MIRT1077058	hsa-miR-5095	CLIP-seq
MIRT2452087	hsa-miR-509-5p	CLIP-seq
MIRT1077072	hsa-miR-590-3p	CLIP-seq
MIRT1077002	hsa-miR-1228	CLIP-seq
MIRT1077012	hsa-miR-3149	CLIP-seq
MIRT1077014	hsa-miR-3187-3p	CLIP-seq
MIRT1077031	hsa-miR-411	CLIP-seq
MIRT1077035	hsa-miR-4435	CLIP-seq
MIRT1077046	hsa-miR-4701-5p	CLIP-seq
MIRT1077047	hsa-miR-4715-3p	CLIP-seq
MIRT1077049	hsa-miR-4735-5p	CLIP-seq
MIRT1077052	hsa-miR-4775	CLIP-seq
MIRT1077053	hsa-miR-4794	CLIP-seq
MIRT1077055	hsa-miR-483-5p	CLIP-seq
MIRT1077059	hsa-miR-5096	CLIP-seq
MIRT1077066	hsa-miR-548s	CLIP-seq
MIRT1077071	hsa-miR-588	CLIP-seq
MIRT1077072	hsa-miR-590-3p	CLIP-seq
MIRT2554472	hsa-miR-1202	CLIP-seq
MIRT2554473	hsa-miR-1207-3p	CLIP-seq
MIRT2554474	hsa-miR-122	CLIP-seq
MIRT1077001	hsa-miR-1227	CLIP-seq
MIRT1077002	hsa-miR-1228	CLIP-seq
MIRT2554475	hsa-miR-1248	CLIP-seq
MIRT2554476	hsa-miR-1257	CLIP-seq
MIRT2554477	hsa-miR-1260	CLIP-seq
MIRT2554478	hsa-miR-1270	CLIP-seq
MIRT1077004	hsa-miR-1272	CLIP-seq
MIRT2554479	hsa-miR-1273g	CLIP-seq
MIRT2554480	hsa-miR-1291	CLIP-seq
MIRT2554481	hsa-miR-1305	CLIP-seq
MIRT2554482	hsa-miR-149	CLIP-seq
MIRT2554483	hsa-miR-1587	CLIP-seq
MIRT2554484	hsa-miR-188-3p	CLIP-seq
MIRT2554485	hsa-miR-1915	CLIP-seq
MIRT2554486	hsa-miR-208a	CLIP-seq
MIRT2554487	hsa-miR-208b	CLIP-seq
MIRT2554488	hsa-miR-2276	CLIP-seq
MIRT2554489	hsa-miR-298	CLIP-seq
MIRT2554490	hsa-miR-3120-3p	CLIP-seq
MIRT2554491	hsa-miR-3136-5p	CLIP-seq
MIRT2554492	hsa-miR-3137	CLIP-seq
MIRT1077010	hsa-miR-3145-5p	CLIP-seq
MIRT1077012	hsa-miR-3149	CLIP-seq
MIRT2554493	hsa-miR-3156-3p	CLIP-seq
MIRT2554494	hsa-miR-3160-3p	CLIP-seq
MIRT2554495	hsa-miR-3182	CLIP-seq
MIRT2554496	hsa-miR-3185	CLIP-seq
MIRT1077014	hsa-miR-3187-3p	CLIP-seq
MIRT2554497	hsa-miR-3190	CLIP-seq
MIRT2554498	hsa-miR-3194-5p	CLIP-seq
MIRT2452081	hsa-miR-3199	CLIP-seq
MIRT2554499	hsa-miR-328	CLIP-seq
MIRT1077016	hsa-miR-3612	CLIP-seq
MIRT2554500	hsa-miR-3617	CLIP-seq
MIRT2554501	hsa-miR-3620	CLIP-seq
MIRT1077017	hsa-miR-3622a-5p	CLIP-seq
MIRT2554502	hsa-miR-3671	CLIP-seq
MIRT2554503	hsa-miR-3682-3p	CLIP-seq
MIRT2554504	hsa-miR-3686	CLIP-seq
MIRT2554505	hsa-miR-3689a-3p	CLIP-seq
MIRT2554506	hsa-miR-3689c	CLIP-seq
MIRT2554507	hsa-miR-371-5p	CLIP-seq
MIRT2554508	hsa-miR-3911	CLIP-seq
MIRT2554509	hsa-miR-3942-5p	CLIP-seq
MIRT2554510	hsa-miR-3944-5p	CLIP-seq
MIRT2554511	hsa-miR-3972	CLIP-seq
MIRT1077031	hsa-miR-411	CLIP-seq
MIRT2554512	hsa-miR-423-3p	CLIP-seq
MIRT1077033	hsa-miR-4252	CLIP-seq
MIRT2554513	hsa-miR-4265	CLIP-seq
MIRT2554514	hsa-miR-4276	CLIP-seq
MIRT2554515	hsa-miR-4277	CLIP-seq
MIRT2554516	hsa-miR-4279	CLIP-seq
MIRT2554517	hsa-miR-4283	CLIP-seq
MIRT2554518	hsa-miR-4296	CLIP-seq
MIRT2554519	hsa-miR-4301	CLIP-seq
MIRT2554520	hsa-miR-4302	CLIP-seq
MIRT2554521	hsa-miR-4312	CLIP-seq
MIRT2554522	hsa-miR-4322	CLIP-seq
MIRT2554523	hsa-miR-4417	CLIP-seq
MIRT2554524	hsa-miR-4420	CLIP-seq
MIRT1077035	hsa-miR-4435	CLIP-seq
MIRT2554525	hsa-miR-4436b-5p	CLIP-seq
MIRT2452084	hsa-miR-4438	CLIP-seq
MIRT2554526	hsa-miR-4439	CLIP-seq
MIRT2554527	hsa-miR-4452	CLIP-seq
MIRT1077037	hsa-miR-4459	CLIP-seq
MIRT2554528	hsa-miR-4462	CLIP-seq
MIRT2554529	hsa-miR-4477a	CLIP-seq
MIRT2554530	hsa-miR-4487	CLIP-seq
MIRT2554531	hsa-miR-4489	CLIP-seq
MIRT2554532	hsa-miR-4492	CLIP-seq
MIRT2554533	hsa-miR-4498	CLIP-seq
MIRT2554534	hsa-miR-4502	CLIP-seq
MIRT2554535	hsa-miR-4531	CLIP-seq
MIRT1077041	hsa-miR-455-5p	CLIP-seq
MIRT2554536	hsa-miR-4656	CLIP-seq
MIRT2554537	hsa-miR-4659a-3p	CLIP-seq
MIRT2554538	hsa-miR-4659b-3p	CLIP-seq
MIRT2554539	hsa-miR-4675	CLIP-seq
MIRT2554540	hsa-miR-4685-5p	CLIP-seq
MIRT2554541	hsa-miR-4695-3p	CLIP-seq
MIRT1077045	hsa-miR-4695-5p	CLIP-seq
MIRT2554542	hsa-miR-4696	CLIP-seq
MIRT2554543	hsa-miR-4698	CLIP-seq
MIRT1077046	hsa-miR-4701-5p	CLIP-seq
MIRT2554544	hsa-miR-4703-5p	CLIP-seq
MIRT2554545	hsa-miR-4704-3p	CLIP-seq
MIRT1077047	hsa-miR-4715-3p	CLIP-seq
MIRT2554546	hsa-miR-4722-3p	CLIP-seq
MIRT2554547	hsa-miR-4726-3p	CLIP-seq
MIRT2554548	hsa-miR-4727-3p	CLIP-seq
MIRT2554549	hsa-miR-4728-5p	CLIP-seq
MIRT1077048	hsa-miR-4731-3p	CLIP-seq
MIRT2554550	hsa-miR-4731-5p	CLIP-seq
MIRT1077049	hsa-miR-4735-5p	CLIP-seq
MIRT2554551	hsa-miR-4741	CLIP-seq
MIRT2554552	hsa-miR-4762-5p	CLIP-seq
MIRT2554553	hsa-miR-4772-3p	CLIP-seq
MIRT1077052	hsa-miR-4775	CLIP-seq
MIRT1077053	hsa-miR-4794	CLIP-seq
MIRT1077054	hsa-miR-4801	CLIP-seq
MIRT1077055	hsa-miR-483-5p	CLIP-seq
MIRT2554554	hsa-miR-499-5p	CLIP-seq
MIRT1077057	hsa-miR-508-5p	CLIP-seq
MIRT1077058	hsa-miR-5095	CLIP-seq
MIRT1077059	hsa-miR-5096	CLIP-seq
MIRT2554555	hsa-miR-545	CLIP-seq
MIRT2554556	hsa-miR-548p	CLIP-seq
MIRT1077066	hsa-miR-548s	CLIP-seq
MIRT1077067	hsa-miR-549	CLIP-seq
MIRT2554557	hsa-miR-558	CLIP-seq
MIRT2554558	hsa-miR-563	CLIP-seq
MIRT1077070	hsa-miR-574-5p	CLIP-seq
MIRT2554559	hsa-miR-586	CLIP-seq
MIRT1077071	hsa-miR-588	CLIP-seq
MIRT1077072	hsa-miR-590-3p	CLIP-seq
MIRT2554560	hsa-miR-607	CLIP-seq
MIRT2554561	hsa-miR-620	CLIP-seq
MIRT2554562	hsa-miR-624	CLIP-seq
MIRT2554563	hsa-miR-634	CLIP-seq
MIRT2554564	hsa-miR-641	CLIP-seq
MIRT2554565	hsa-miR-642a	CLIP-seq
MIRT2554566	hsa-miR-642b	CLIP-seq
MIRT1077074	hsa-miR-648	CLIP-seq
MIRT1077075	hsa-miR-650	CLIP-seq
MIRT1077077	hsa-miR-665	CLIP-seq
MIRT2554567	hsa-miR-7	CLIP-seq
MIRT2554568	hsa-miR-762	CLIP-seq
MIRT2554569	hsa-miR-887	CLIP-seq
MIRT2554570	hsa-miR-892b	CLIP-seq
MIRT2554571	hsa-miR-943	CLIP-seq
MIRT2554572	hsa-miR-944	CLIP-seq
MIRT2554473	hsa-miR-1207-3p	CLIP-seq
MIRT2554474	hsa-miR-122	CLIP-seq
MIRT1077001	hsa-miR-1227	CLIP-seq
MIRT1077002	hsa-miR-1228	CLIP-seq
MIRT2554475	hsa-miR-1248	CLIP-seq
MIRT2554477	hsa-miR-1260	CLIP-seq
MIRT2554478	hsa-miR-1270	CLIP-seq
MIRT1077004	hsa-miR-1272	CLIP-seq
MIRT2554483	hsa-miR-1587	CLIP-seq
MIRT2554484	hsa-miR-188-3p	CLIP-seq
MIRT2554489	hsa-miR-298	CLIP-seq
MIRT2683111	hsa-miR-3135b	CLIP-seq
MIRT2554492	hsa-miR-3137	CLIP-seq
MIRT1077010	hsa-miR-3145-5p	CLIP-seq
MIRT1077012	hsa-miR-3149	CLIP-seq
MIRT2683112	hsa-miR-3154	CLIP-seq
MIRT2554493	hsa-miR-3156-3p	CLIP-seq
MIRT2554495	hsa-miR-3182	CLIP-seq
MIRT2554496	hsa-miR-3185	CLIP-seq
MIRT2452081	hsa-miR-3199	CLIP-seq
MIRT1077016	hsa-miR-3612	CLIP-seq
MIRT1077017	hsa-miR-3622a-5p	CLIP-seq
MIRT2683113	hsa-miR-3652	CLIP-seq
MIRT2683114	hsa-miR-3667-3p	CLIP-seq
MIRT2554503	hsa-miR-3682-3p	CLIP-seq
MIRT2554504	hsa-miR-3686	CLIP-seq
MIRT2683115	hsa-miR-3691-3p	CLIP-seq
MIRT2554510	hsa-miR-3944-5p	CLIP-seq
MIRT1077031	hsa-miR-411	CLIP-seq
MIRT1077033	hsa-miR-4252	CLIP-seq
MIRT2554513	hsa-miR-4265	CLIP-seq
MIRT2554514	hsa-miR-4276	CLIP-seq
MIRT2554515	hsa-miR-4277	CLIP-seq
MIRT2554518	hsa-miR-4296	CLIP-seq
MIRT2554519	hsa-miR-4301	CLIP-seq
MIRT2554520	hsa-miR-4302	CLIP-seq
MIRT2554522	hsa-miR-4322	CLIP-seq
MIRT2554523	hsa-miR-4417	CLIP-seq
MIRT2683116	hsa-miR-4430	CLIP-seq
MIRT1077035	hsa-miR-4435	CLIP-seq
MIRT2452084	hsa-miR-4438	CLIP-seq
MIRT1077037	hsa-miR-4459	CLIP-seq
MIRT2554532	hsa-miR-4492	CLIP-seq
MIRT2554533	hsa-miR-4498	CLIP-seq
MIRT2554534	hsa-miR-4502	CLIP-seq
MIRT2554535	hsa-miR-4531	CLIP-seq
MIRT1077041	hsa-miR-455-5p	CLIP-seq
MIRT2554536	hsa-miR-4656	CLIP-seq
MIRT2554537	hsa-miR-4659a-3p	CLIP-seq
MIRT2554538	hsa-miR-4659b-3p	CLIP-seq
MIRT2554539	hsa-miR-4675	CLIP-seq
MIRT1077045	hsa-miR-4695-5p	CLIP-seq
MIRT2683117	hsa-miR-4700-3p	CLIP-seq
MIRT2554545	hsa-miR-4704-3p	CLIP-seq
MIRT1077047	hsa-miR-4715-3p	CLIP-seq
MIRT1077048	hsa-miR-4731-3p	CLIP-seq
MIRT1077049	hsa-miR-4735-5p	CLIP-seq
MIRT2554551	hsa-miR-4741	CLIP-seq
MIRT1077052	hsa-miR-4775	CLIP-seq
MIRT2683118	hsa-miR-4789-3p	CLIP-seq
MIRT1077053	hsa-miR-4794	CLIP-seq
MIRT1077054	hsa-miR-4801	CLIP-seq
MIRT1077055	hsa-miR-483-5p	CLIP-seq
MIRT1077057	hsa-miR-508-5p	CLIP-seq
MIRT1077058	hsa-miR-5095	CLIP-seq
MIRT1077059	hsa-miR-5096	CLIP-seq
MIRT1077067	hsa-miR-549	CLIP-seq
MIRT1077070	hsa-miR-574-5p	CLIP-seq
MIRT2554559	hsa-miR-586	CLIP-seq
MIRT1077072	hsa-miR-590-3p	CLIP-seq
MIRT2554561	hsa-miR-620	CLIP-seq
MIRT2554562	hsa-miR-624	CLIP-seq
MIRT2554566	hsa-miR-642b	CLIP-seq
MIRT1077074	hsa-miR-648	CLIP-seq
MIRT1077075	hsa-miR-650	CLIP-seq
MIRT1077077	hsa-miR-665	CLIP-seq
MIRT2554568	hsa-miR-762	CLIP-seq

Show/Hide all (71)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001568	Process	Blood vessel development	IEA
GO:0001822	Process	Kidney development	IEA
GO:0002040	Process	Sprouting angiogenesis	IEA
GO:0002040	Process	Sprouting angiogenesis	ISS
GO:0003723	Function	RNA binding	IEA
GO:0003723	Function	RNA binding	TAS	21060799
GO:0003727	Function	Single-stranded RNA binding	IDA	20679243, 29176719
GO:0005506	Function	Iron ion binding	IDA	20679243
GO:0005515	Function	Protein binding	IPI	19574390, 21555454, 23455924, 24360279, 24498420, 24667498, 25416956, 29176719, 30698747, 32296183, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	14729065, 17534701
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IMP	21555454
GO:0005634	Component	Nucleus	ISS	33443146
GO:0005654	Component	Nucleoplasm	IDA	21060799
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA	21060799
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	24498420
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	IDA	17947579
GO:0006397	Process	MRNA processing	IEA
GO:0006909	Process	Phagocytosis	IBA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007507	Process	Heart development	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0018395	Process	Peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine	IDA	19574390
GO:0030154	Process	Cell differentiation	IEA
GO:0030324	Process	Lung development	IEA
GO:0032452	Function	Histone demethylase activity	IDA	24498420
GO:0032452	Function	Histone demethylase activity	TAS
GO:0032463	Process	Negative regulation of protein homooligomerization	IEA
GO:0032463	Process	Negative regulation of protein homooligomerization	ISS	33443146
GO:0033077	Process	T cell differentiation in thymus	IEA
GO:0033746	Function	Histone H3R2 demethylase activity	IDA	17947579
GO:0033749	Function	Histone H4R3 demethylase activity	IBA
GO:0033749	Function	Histone H4R3 demethylase activity	IDA	17947579, 24360279
GO:0035513	Process	Oxidative RNA demethylation	IDA	24360279
GO:0035515	Function	Oxidative RNA demethylase activity	IMP	24360279
GO:0038023	Function	Signaling receptor activity	IEA
GO:0042116	Process	Macrophage activation	IEA
GO:0042802	Function	Identical protein binding	IDA	17534701
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	24360279
GO:0043277	Process	Apoptotic cell clearance	IEA
GO:0043654	Process	Recognition of apoptotic cell	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IMP	21555454
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	24360279
GO:0046872	Function	Metal ion binding	IEA
GO:0048024	Process	Regulation of mRNA splicing, via spliceosome	IEA
GO:0048024	Process	Regulation of mRNA splicing, via spliceosome	IMP	19574390
GO:0048821	Process	Erythrocyte development	IEA
GO:0051213	Function	Dioxygenase activity	IEA
GO:0051260	Process	Protein homooligomerization	IDA	22189873, 24360279
GO:0060041	Process	Retina development in camera-type eye	IEA
GO:0070815	Function	Peptidyl-lysine 5-dioxygenase activity	EXP	23303181
GO:0070815	Function	Peptidyl-lysine 5-dioxygenase activity	IDA	19574390, 22189873
GO:0070815	Function	Peptidyl-lysine 5-dioxygenase activity	IEA
GO:0106140	Function	P-TEFb complex binding	IBA
GO:0106140	Function	P-TEFb complex binding	IDA	24360279
GO:0140457	Function	Protein demethylase activity	IDA	24498420
GO:0140537	Function	Transcription regulator activator activity	IMP	21555454
GO:0140694	Process	Membraneless organelle assembly	IEA
GO:0140694	Process	Membraneless organelle assembly	ISS	33443146
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
604914	19355	ENSG00000070495

Q6NYC1

Protein name

Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phos

Protein function

Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase (PubMed:17947579, PubMed:20684070, PubMed:21060799, PubMed:22189873, PubMed:24498420). Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine

PDB

3K2O , 3LD8 , 3LDB , 6BNH , 6GDY , 6MEV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02373	JmjC	174 → 288	JmjC domain, hydroxylase	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatiti

Sequence

MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFV
ERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEY
MESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPP
RSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIY
PRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHK
TVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIASDSSSDSSSSSSSSSSDSDSE
CESGSEGDGTVHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR

Sequence length

403

Interactions

View interactions

	Reactome
			HDMs demethylate histones

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA, CUTANEOUS MALIGNANT	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MESOTHELIOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UVEAL MELANOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (73)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	24667498		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	23595221, 27613418		★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	37188718	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Dissection	Aortic dissection	Pubtator	40239861	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autistic Disorder	Autism	Pubtator	18378158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	28546003		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Diseases	Brain disease	Pubtator	18378158	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22621393, 25951181, 29229759, 29628309, 30185813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	CTD_human_DG	30619488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22621393, 33215431, 33246425, 36419768, 36867680	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Bronchiectasis	Bronchiectasis	LHGDN	11877474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	26645717, 35764091, 35969736	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37880710	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35764091	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	31637004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Choriocarcinoma	Choriocarcinoma	BEFREE	26037477		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	24667498, 31445935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Complete atrioventricular block	Complete Atrioventricular Block	BEFREE	25219359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cutaneous Melanoma	Melanoma	CTD_human_DG	30619488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	LHGDN	11877474		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes, Autoimmune	Autoimmune Diabetes	BEFREE	28546003		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endocrine System Diseases	Endocrine system disease	Pubtator	33822745	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	37488513	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gingivitis	Gingivitis	BEFREE	21405936		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	16254489	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	28678782		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	28678782		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28592121		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure, Acute	Kidney Failure	BEFREE	29693725		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	32068780	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30125344		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	30125344		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22621393, 25951181, 29229759, 29628309, 30185813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	CTD_human_DG	30619488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	28587176		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	CTD_human_DG	30619488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	31637004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	30619488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	24667498, 28360925, 28592121, 31147442, 31172440, 31445935, 31637004, 31788057		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	24667498, 29176719, 31445935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Carcinoma, Human	Marfan Syndrome	CTD_human_DG	30619488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	25951181, 29229759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	CTD_human_DG	30619488		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms, Human	Mammary Neoplasms	CTD_human_DG	30619488		★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	29187213, 30619488		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
melanoma	Melanoma	CTD_human_DG	30619488		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mesothelioma	Mesothelioma	CTD_human_DG	30619488		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mouth Neoplasms	Mouth neoplasm	Pubtator	26645717	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	38166895	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	22621393, 23595221, 25951181, 27081402, 28882645, 29229759, 30619488, 31346162, 31445935		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	31346162		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nevus comedonicus	Nevus comedonicus	BEFREE	29620141		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28882645		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oestrogen receptor positive breast cancer	Oestrogen Receptor Positive Breast Cancer	BEFREE	27081402		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	35442509	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	CTD_human_DG	30619488		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	31637004		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatitis Chronic	Pancreatitis	Pubtator	15622002	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontal Diseases	Periodontal Diseases	BEFREE	23066400		★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	BEFREE	21405936		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	30619488		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	33822745	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	26645717	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	31788057		★★★★★ ★☆☆☆☆ Found in Text Mining only
Transient Cerebral Ischemia	Cerebral Ischemia	BEFREE	28783808		★★★★★ ★☆☆☆☆ Found in Text Mining only
Transient Ischemic Attack	Transient Ischemic Attack	BEFREE	28783808		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	30185813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	33246425	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveal melanoma	Uveal Melanoma	CTD_human_DG	30619488		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Uveal Melanoma	BEFREE	31736361		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Uveal melanoma	Pubtator	31736361	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Vascular Diseases	Vascular disease	Pubtator	40239861	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Von Hippel-Lindau Syndrome	Von Hippel-Lindau Syndrome	BEFREE	26037477		★★★★★ ★☆☆☆☆ Found in Text Mining only

JMJD6 (jumonji domain containing 6, arginine demethylase and lysine hydroxylase)