Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23201
Gene name	Family with sequence similarity 168 member A
Gene symbol	FAM168A
Synonyms (NCBI Gene)	KIAA0280TCRP1
Chromosome	11
Chromosome location	11q13.4

184

Show/Hide all (184)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032061	hsa-miR-16-5p	Sequencing	20371350
MIRT047685	hsa-miR-10a-5p	CLASH	23622248
MIRT507347	hsa-miR-548e-5p	PAR-CLIP	23446348
MIRT507346	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT507345	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT507344	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT507343	hsa-miR-940	PAR-CLIP	23446348
MIRT507342	hsa-miR-4259	PAR-CLIP	23446348
MIRT507341	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT507340	hsa-miR-1827	PAR-CLIP	23446348
MIRT507338	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT507339	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT507337	hsa-miR-8085	PAR-CLIP	23446348
MIRT507336	hsa-miR-3175	PAR-CLIP	23446348
MIRT507335	hsa-miR-1343-5p	PAR-CLIP	23446348
MIRT507334	hsa-miR-939-5p	PAR-CLIP	23446348
MIRT507333	hsa-miR-6825-5p	PAR-CLIP	23446348
MIRT507332	hsa-miR-2110	PAR-CLIP	23446348
MIRT507331	hsa-miR-6810-5p	PAR-CLIP	23446348
MIRT507330	hsa-miR-3150a-3p	PAR-CLIP	23446348
MIRT507329	hsa-miR-6763-5p	PAR-CLIP	23446348
MIRT507328	hsa-miR-6857-5p	PAR-CLIP	23446348
MIRT507327	hsa-miR-450a-2-3p	PAR-CLIP	23446348
MIRT477094	hsa-miR-4476	PAR-CLIP	23592263
MIRT477093	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT477092	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT477091	hsa-miR-4779	PAR-CLIP	23592263
MIRT477090	hsa-miR-3179	PAR-CLIP	23592263
MIRT477089	hsa-miR-3202	PAR-CLIP	23592263
MIRT477088	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT477086	hsa-miR-6801-5p	PAR-CLIP	23592263
MIRT477087	hsa-miR-4266	PAR-CLIP	23592263
MIRT448196	hsa-miR-4428	PAR-CLIP	22100165
MIRT448195	hsa-miR-3173-3p	PAR-CLIP	22100165
MIRT448194	hsa-miR-6891-5p	PAR-CLIP	22100165
MIRT448193	hsa-miR-28-5p	PAR-CLIP	22100165
MIRT448191	hsa-miR-3139	PAR-CLIP	22100165
MIRT448192	hsa-miR-708-5p	PAR-CLIP	22100165
MIRT448190	hsa-miR-331-3p	PAR-CLIP	22100165
MIRT448189	hsa-miR-4292	PAR-CLIP	22100165
MIRT448188	hsa-miR-6791-5p	PAR-CLIP	22100165
MIRT448187	hsa-miR-6742-3p	PAR-CLIP	22100165
MIRT448186	hsa-miR-6861-5p	PAR-CLIP	22100165
MIRT448185	hsa-miR-5702	PAR-CLIP	22100165
MIRT448184	hsa-miR-765	PAR-CLIP	22100165
MIRT448183	hsa-miR-555	PAR-CLIP	22100165
MIRT448182	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448181	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448180	hsa-miR-8081	PAR-CLIP	22100165
MIRT507347	hsa-miR-548e-5p	PAR-CLIP	23446348
MIRT507346	hsa-miR-6888-5p	PAR-CLIP	23446348
MIRT507345	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT507344	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT507343	hsa-miR-940	PAR-CLIP	23446348
MIRT507342	hsa-miR-4259	PAR-CLIP	23446348
MIRT507341	hsa-miR-4768-3p	PAR-CLIP	23446348
MIRT507340	hsa-miR-1827	PAR-CLIP	23446348
MIRT507338	hsa-miR-4722-5p	PAR-CLIP	23446348
MIRT507339	hsa-miR-6731-5p	PAR-CLIP	23446348
MIRT507337	hsa-miR-8085	PAR-CLIP	23446348
MIRT507336	hsa-miR-3175	PAR-CLIP	23446348
MIRT507335	hsa-miR-1343-5p	PAR-CLIP	23446348
MIRT507334	hsa-miR-939-5p	PAR-CLIP	23446348
MIRT507333	hsa-miR-6825-5p	PAR-CLIP	23446348
MIRT507332	hsa-miR-2110	PAR-CLIP	23446348
MIRT507331	hsa-miR-6810-5p	PAR-CLIP	23446348
MIRT507330	hsa-miR-3150a-3p	PAR-CLIP	23446348
MIRT507329	hsa-miR-6763-5p	PAR-CLIP	23446348
MIRT507328	hsa-miR-6857-5p	PAR-CLIP	23446348
MIRT507327	hsa-miR-450a-2-3p	PAR-CLIP	23446348
MIRT477094	hsa-miR-4476	PAR-CLIP	23592263
MIRT477093	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT477092	hsa-miR-4695-5p	PAR-CLIP	23592263
MIRT477091	hsa-miR-4779	PAR-CLIP	23592263
MIRT477090	hsa-miR-3179	PAR-CLIP	23592263
MIRT477089	hsa-miR-3202	PAR-CLIP	23592263
MIRT477088	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT477086	hsa-miR-6801-5p	PAR-CLIP	23592263
MIRT477087	hsa-miR-4266	PAR-CLIP	23592263
MIRT448196	hsa-miR-4428	PAR-CLIP	22100165
MIRT448195	hsa-miR-3173-3p	PAR-CLIP	22100165
MIRT448194	hsa-miR-6891-5p	PAR-CLIP	22100165
MIRT448193	hsa-miR-28-5p	PAR-CLIP	22100165
MIRT448191	hsa-miR-3139	PAR-CLIP	22100165
MIRT448192	hsa-miR-708-5p	PAR-CLIP	22100165
MIRT448190	hsa-miR-331-3p	PAR-CLIP	22100165
MIRT448189	hsa-miR-4292	PAR-CLIP	22100165
MIRT448188	hsa-miR-6791-5p	PAR-CLIP	22100165
MIRT448187	hsa-miR-6742-3p	PAR-CLIP	22100165
MIRT448186	hsa-miR-6861-5p	PAR-CLIP	22100165
MIRT448185	hsa-miR-5702	PAR-CLIP	22100165
MIRT448184	hsa-miR-765	PAR-CLIP	22100165
MIRT448183	hsa-miR-555	PAR-CLIP	22100165
MIRT448182	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT448181	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT448180	hsa-miR-8081	PAR-CLIP	22100165
MIRT981654	hsa-miR-1193	CLIP-seq
MIRT981655	hsa-miR-1197	CLIP-seq
MIRT981656	hsa-miR-1205	CLIP-seq
MIRT981657	hsa-miR-1587	CLIP-seq
MIRT981658	hsa-miR-1915	CLIP-seq
MIRT981659	hsa-miR-2355-5p	CLIP-seq
MIRT981660	hsa-miR-3162-5p	CLIP-seq
MIRT981661	hsa-miR-4436a	CLIP-seq
MIRT981662	hsa-miR-4492	CLIP-seq
MIRT981663	hsa-miR-4498	CLIP-seq
MIRT981664	hsa-miR-4656	CLIP-seq
MIRT981665	hsa-miR-4675	CLIP-seq
MIRT981666	hsa-miR-4700-3p	CLIP-seq
MIRT981667	hsa-miR-4741	CLIP-seq
MIRT981668	hsa-miR-762	CLIP-seq
MIRT981655	hsa-miR-1197	CLIP-seq
MIRT1990829	hsa-miR-1236	CLIP-seq
MIRT1990830	hsa-miR-1244	CLIP-seq
MIRT1990831	hsa-miR-1468	CLIP-seq
MIRT981658	hsa-miR-1915	CLIP-seq
MIRT1990832	hsa-miR-2278	CLIP-seq
MIRT981659	hsa-miR-2355-5p	CLIP-seq
MIRT1990833	hsa-miR-3065-3p	CLIP-seq
MIRT1990834	hsa-miR-3121-3p	CLIP-seq
MIRT981660	hsa-miR-3162-5p	CLIP-seq
MIRT1990835	hsa-miR-338-3p	CLIP-seq
MIRT1990836	hsa-miR-3907	CLIP-seq
MIRT1990837	hsa-miR-3918	CLIP-seq
MIRT1990838	hsa-miR-4325	CLIP-seq
MIRT1990839	hsa-miR-4432	CLIP-seq
MIRT981661	hsa-miR-4436a	CLIP-seq
MIRT1990840	hsa-miR-4468	CLIP-seq
MIRT1990841	hsa-miR-4471	CLIP-seq
MIRT1990842	hsa-miR-4530	CLIP-seq
MIRT1990843	hsa-miR-4640-5p	CLIP-seq
MIRT1990844	hsa-miR-4685-5p	CLIP-seq
MIRT981666	hsa-miR-4700-3p	CLIP-seq
MIRT1990845	hsa-miR-4725-5p	CLIP-seq
MIRT1990846	hsa-miR-4726-5p	CLIP-seq
MIRT1990847	hsa-miR-4778-3p	CLIP-seq
MIRT1990848	hsa-miR-493	CLIP-seq
MIRT1990849	hsa-miR-499-5p	CLIP-seq
MIRT1990850	hsa-miR-504	CLIP-seq
MIRT1990851	hsa-miR-518a-5p	CLIP-seq
MIRT1990852	hsa-miR-520d-5p	CLIP-seq
MIRT1990853	hsa-miR-524-5p	CLIP-seq
MIRT1990854	hsa-miR-527	CLIP-seq
MIRT1990855	hsa-miR-593	CLIP-seq
MIRT1990856	hsa-miR-646	CLIP-seq
MIRT1990857	hsa-miR-766	CLIP-seq
MIRT981655	hsa-miR-1197	CLIP-seq
MIRT2225042	hsa-miR-1207-5p	CLIP-seq
MIRT1990829	hsa-miR-1236	CLIP-seq
MIRT1990831	hsa-miR-1468	CLIP-seq
MIRT2225043	hsa-miR-1909	CLIP-seq
MIRT981658	hsa-miR-1915	CLIP-seq
MIRT981659	hsa-miR-2355-5p	CLIP-seq
MIRT1990834	hsa-miR-3121-3p	CLIP-seq
MIRT981660	hsa-miR-3162-5p	CLIP-seq
MIRT2225044	hsa-miR-3187-3p	CLIP-seq
MIRT1990836	hsa-miR-3907	CLIP-seq
MIRT1990837	hsa-miR-3918	CLIP-seq
MIRT1990838	hsa-miR-4325	CLIP-seq
MIRT2225045	hsa-miR-4435	CLIP-seq
MIRT981661	hsa-miR-4436a	CLIP-seq
MIRT2225046	hsa-miR-4436b-3p	CLIP-seq
MIRT1990841	hsa-miR-4471	CLIP-seq
MIRT2225047	hsa-miR-4487	CLIP-seq
MIRT2225048	hsa-miR-4489	CLIP-seq
MIRT2225049	hsa-miR-4533	CLIP-seq
MIRT1990843	hsa-miR-4640-5p	CLIP-seq
MIRT1990844	hsa-miR-4685-5p	CLIP-seq
MIRT981666	hsa-miR-4700-3p	CLIP-seq
MIRT2225050	hsa-miR-4701-5p	CLIP-seq
MIRT2225051	hsa-miR-4716-3p	CLIP-seq
MIRT1990845	hsa-miR-4725-5p	CLIP-seq
MIRT1990846	hsa-miR-4726-5p	CLIP-seq
MIRT2225052	hsa-miR-4763-3p	CLIP-seq
MIRT1990847	hsa-miR-4778-3p	CLIP-seq
MIRT1990848	hsa-miR-493	CLIP-seq
MIRT1990850	hsa-miR-504	CLIP-seq
MIRT1990851	hsa-miR-518a-5p	CLIP-seq
MIRT1990854	hsa-miR-527	CLIP-seq
MIRT2225053	hsa-miR-548s	CLIP-seq
MIRT2225054	hsa-miR-588	CLIP-seq
MIRT1990855	hsa-miR-593	CLIP-seq
MIRT2225055	hsa-miR-607	CLIP-seq
MIRT2225056	hsa-miR-769-5p	CLIP-seq

Show/Hide all (3)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	21516116, 23251525, 24722188, 25260657, 25416956, 26871637, 31515488, 32296183
GO:1905053	Process	Positive regulation of base-excision repair	IBA
GO:1905053	Process	Positive regulation of base-excision repair	IDA	25260657

MIM	HGNC	e!Ensembl
616316	28999	ENSG00000054965

Q92567

Protein name

Protein FAM168A (Tongue cancer chemotherapy resistance-associated protein 1)

Protein function

In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels. {ECO:0000

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF14944	TCRP1	1 → 244	Tongue Cancer Chemotherapy Resistant Protein 1	Family

Sequence

MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYA
TLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAP
PPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAI
YPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYV
PPHW

Sequence length

244

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
STOMACH NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (17)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma of lung	Lung carcinoma	BEFREE	25260657, 28436990, 28454268, 28623290, 28859669		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	28454268		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Diffuse Gastric Cancer	Gastric Cancer	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	31291942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28974556		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28859669	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	25260657, 28436990, 28454268, 28623290, 28859669		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	28454268		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of tongue	Malignant Neoplasm Of Tongue	BEFREE	21334329, 21603883, 25260657, 28436990, 28454268, 28859669, 31291942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28436990, 28623290		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	31291942		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31291942		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	28454268		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	21334329, 23251525		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	21334329, 23251525	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	CTD_human_DG	21364753		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

FAM168A (family with sequence similarity 168 member A)