Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23200
Gene name	ATPase phospholipid transporting 11B (putative)
Gene symbol	ATP11B
Synonyms (NCBI Gene)	ATPIFATPIR
Chromosome	3
Chromosome location	3q26.33
Summary	P-type ATPases, such as ATP11B, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily transports heavy metal ions, such as Cu(2+) or Cd

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miRTarBase ID	miRNA	Experiments	Reference
MIRT030997	hsa-miR-21-5p	Microarray	18591254
MIRT046578	hsa-miR-222-3p	CLASH	23622248
MIRT039507	hsa-miR-652-3p	CLASH	23622248
MIRT806515	hsa-miR-1238	CLIP-seq
MIRT806516	hsa-miR-1284	CLIP-seq
MIRT806517	hsa-miR-136	CLIP-seq
MIRT806518	hsa-miR-181a	CLIP-seq
MIRT806519	hsa-miR-181b	CLIP-seq
MIRT806520	hsa-miR-181c	CLIP-seq
MIRT806521	hsa-miR-181d	CLIP-seq
MIRT806522	hsa-miR-300	CLIP-seq
MIRT806523	hsa-miR-3148	CLIP-seq
MIRT806524	hsa-miR-3168	CLIP-seq
MIRT806525	hsa-miR-3180-5p	CLIP-seq
MIRT806526	hsa-miR-3182	CLIP-seq
MIRT806527	hsa-miR-323-3p	CLIP-seq
MIRT806528	hsa-miR-3591-3p	CLIP-seq
MIRT806529	hsa-miR-381	CLIP-seq
MIRT806530	hsa-miR-3924	CLIP-seq
MIRT806531	hsa-miR-4262	CLIP-seq
MIRT806532	hsa-miR-4291	CLIP-seq
MIRT806533	hsa-miR-4310	CLIP-seq
MIRT806534	hsa-miR-4487	CLIP-seq
MIRT806535	hsa-miR-4517	CLIP-seq
MIRT806536	hsa-miR-4528	CLIP-seq
MIRT806537	hsa-miR-4666-3p	CLIP-seq
MIRT806538	hsa-miR-4672	CLIP-seq
MIRT806539	hsa-miR-4700-3p	CLIP-seq
MIRT806540	hsa-miR-4766-3p	CLIP-seq
MIRT806541	hsa-miR-4789-5p	CLIP-seq
MIRT806542	hsa-miR-4802-3p	CLIP-seq
MIRT806543	hsa-miR-5095	CLIP-seq
MIRT806544	hsa-miR-513c	CLIP-seq
MIRT806545	hsa-miR-514b-5p	CLIP-seq
MIRT806546	hsa-miR-520a-5p	CLIP-seq
MIRT806547	hsa-miR-525-5p	CLIP-seq
MIRT806548	hsa-miR-548c-3p	CLIP-seq
MIRT806549	hsa-miR-555	CLIP-seq
MIRT806550	hsa-miR-633	CLIP-seq
MIRT806551	hsa-miR-889	CLIP-seq
MIRT1545603	hsa-miR-298	CLIP-seq
MIRT1545604	hsa-miR-3158-5p	CLIP-seq
MIRT1938198	hsa-miR-1208	CLIP-seq
MIRT1938199	hsa-miR-1289	CLIP-seq
MIRT1938200	hsa-miR-1302	CLIP-seq
MIRT1938201	hsa-miR-3121-3p	CLIP-seq
MIRT1938202	hsa-miR-3124-3p	CLIP-seq
MIRT1938203	hsa-miR-3143	CLIP-seq
MIRT1938204	hsa-miR-3680	CLIP-seq
MIRT1938205	hsa-miR-3685	CLIP-seq
MIRT1938206	hsa-miR-371-5p	CLIP-seq
MIRT1938207	hsa-miR-371b-5p	CLIP-seq
MIRT1938208	hsa-miR-384	CLIP-seq
MIRT1938209	hsa-miR-3922-5p	CLIP-seq
MIRT1938210	hsa-miR-3942-3p	CLIP-seq
MIRT1938211	hsa-miR-3978	CLIP-seq
MIRT1938212	hsa-miR-4266	CLIP-seq
MIRT806532	hsa-miR-4291	CLIP-seq
MIRT1938213	hsa-miR-4298	CLIP-seq
MIRT806533	hsa-miR-4310	CLIP-seq
MIRT1938214	hsa-miR-4312	CLIP-seq
MIRT1938215	hsa-miR-4424	CLIP-seq
MIRT1938216	hsa-miR-4446-5p	CLIP-seq
MIRT1938217	hsa-miR-4455	CLIP-seq
MIRT1938218	hsa-miR-4470	CLIP-seq
MIRT1938219	hsa-miR-4474-5p	CLIP-seq
MIRT1938220	hsa-miR-4633-5p	CLIP-seq
MIRT1938221	hsa-miR-4742-3p	CLIP-seq
MIRT1938222	hsa-miR-4753-3p	CLIP-seq
MIRT1938223	hsa-miR-4775	CLIP-seq
MIRT806544	hsa-miR-513c	CLIP-seq
MIRT806545	hsa-miR-514b-5p	CLIP-seq
MIRT1938224	hsa-miR-532-5p	CLIP-seq
MIRT1938225	hsa-miR-590-3p	CLIP-seq
MIRT1938226	hsa-miR-593	CLIP-seq
MIRT1938227	hsa-miR-609	CLIP-seq
MIRT1938228	hsa-miR-618	CLIP-seq
MIRT1938229	hsa-miR-644	CLIP-seq
MIRT1938230	hsa-miR-648	CLIP-seq
MIRT1938198	hsa-miR-1208	CLIP-seq
MIRT2177592	hsa-miR-1228	CLIP-seq
MIRT2177593	hsa-miR-1278	CLIP-seq
MIRT2177594	hsa-miR-1296	CLIP-seq
MIRT1938200	hsa-miR-1302	CLIP-seq
MIRT806518	hsa-miR-181a	CLIP-seq
MIRT806519	hsa-miR-181b	CLIP-seq
MIRT806520	hsa-miR-181c	CLIP-seq
MIRT806521	hsa-miR-181d	CLIP-seq
MIRT2177595	hsa-miR-1915	CLIP-seq
MIRT2177596	hsa-miR-200b	CLIP-seq
MIRT2177597	hsa-miR-200c	CLIP-seq
MIRT2177598	hsa-miR-203	CLIP-seq
MIRT2177599	hsa-miR-3126-5p	CLIP-seq
MIRT806527	hsa-miR-323-3p	CLIP-seq
MIRT2177600	hsa-miR-3622a-3p	CLIP-seq
MIRT2177601	hsa-miR-3622b-3p	CLIP-seq
MIRT2177602	hsa-miR-3647-3p	CLIP-seq
MIRT2177603	hsa-miR-3664-5p	CLIP-seq
MIRT1938204	hsa-miR-3680	CLIP-seq
MIRT2177604	hsa-miR-3692	CLIP-seq
MIRT806531	hsa-miR-4262	CLIP-seq
MIRT2177605	hsa-miR-4267	CLIP-seq
MIRT2177606	hsa-miR-4287	CLIP-seq
MIRT2177607	hsa-miR-429	CLIP-seq
MIRT806532	hsa-miR-4291	CLIP-seq
MIRT1938213	hsa-miR-4298	CLIP-seq
MIRT806533	hsa-miR-4310	CLIP-seq
MIRT2177608	hsa-miR-4311	CLIP-seq
MIRT1938214	hsa-miR-4312	CLIP-seq
MIRT2177609	hsa-miR-4419a	CLIP-seq
MIRT2177610	hsa-miR-4420	CLIP-seq
MIRT2177611	hsa-miR-4457	CLIP-seq
MIRT2177612	hsa-miR-4469	CLIP-seq
MIRT2177613	hsa-miR-4510	CLIP-seq
MIRT1938220	hsa-miR-4633-5p	CLIP-seq
MIRT2177614	hsa-miR-4685-3p	CLIP-seq
MIRT2177615	hsa-miR-4691-3p	CLIP-seq
MIRT2177616	hsa-miR-4714-5p	CLIP-seq
MIRT2177617	hsa-miR-4719	CLIP-seq
MIRT2177618	hsa-miR-4722-3p	CLIP-seq
MIRT1938221	hsa-miR-4742-3p	CLIP-seq
MIRT806544	hsa-miR-513c	CLIP-seq
MIRT806545	hsa-miR-514b-5p	CLIP-seq
MIRT1938224	hsa-miR-532-5p	CLIP-seq
MIRT2177619	hsa-miR-548g	CLIP-seq
MIRT2177620	hsa-miR-568	CLIP-seq
MIRT2177621	hsa-miR-605	CLIP-seq
MIRT1938229	hsa-miR-644	CLIP-seq
MIRT2435567	hsa-miR-1266	CLIP-seq
MIRT2435568	hsa-miR-128	CLIP-seq
MIRT2435569	hsa-miR-3664-3p	CLIP-seq
MIRT2435570	hsa-miR-4282	CLIP-seq
MIRT2435571	hsa-miR-4518	CLIP-seq
MIRT1938225	hsa-miR-590-3p	CLIP-seq
MIRT2481034	hsa-miR-1200	CLIP-seq
MIRT2435567	hsa-miR-1266	CLIP-seq
MIRT2435568	hsa-miR-128	CLIP-seq
MIRT2481035	hsa-miR-137	CLIP-seq
MIRT2481036	hsa-miR-221	CLIP-seq
MIRT2481037	hsa-miR-222	CLIP-seq
MIRT2481038	hsa-miR-2467-3p	CLIP-seq
MIRT2481039	hsa-miR-30a	CLIP-seq
MIRT2481040	hsa-miR-30b	CLIP-seq
MIRT2481041	hsa-miR-30c	CLIP-seq
MIRT2481042	hsa-miR-30d	CLIP-seq
MIRT2481043	hsa-miR-30e	CLIP-seq
MIRT2481044	hsa-miR-3123	CLIP-seq
MIRT2481045	hsa-miR-3149	CLIP-seq
MIRT2481046	hsa-miR-3159	CLIP-seq
MIRT806525	hsa-miR-3180-5p	CLIP-seq
MIRT806527	hsa-miR-323-3p	CLIP-seq
MIRT2481047	hsa-miR-338-5p	CLIP-seq
MIRT2481048	hsa-miR-3616-5p	CLIP-seq
MIRT2481049	hsa-miR-3647-5p	CLIP-seq
MIRT2435569	hsa-miR-3664-3p	CLIP-seq
MIRT2481050	hsa-miR-3678-3p	CLIP-seq
MIRT2481051	hsa-miR-3919	CLIP-seq
MIRT2435570	hsa-miR-4282	CLIP-seq
MIRT2435571	hsa-miR-4518	CLIP-seq
MIRT2481052	hsa-miR-4670-3p	CLIP-seq
MIRT2177615	hsa-miR-4691-3p	CLIP-seq
MIRT2177617	hsa-miR-4719	CLIP-seq
MIRT2481053	hsa-miR-492	CLIP-seq
MIRT806546	hsa-miR-520a-5p	CLIP-seq
MIRT806547	hsa-miR-525-5p	CLIP-seq
MIRT806548	hsa-miR-548c-3p	CLIP-seq
MIRT2481054	hsa-miR-548v	CLIP-seq
MIRT2177620	hsa-miR-568	CLIP-seq
MIRT2481055	hsa-miR-573	CLIP-seq
MIRT1938225	hsa-miR-590-3p	CLIP-seq
MIRT2481056	hsa-miR-887	CLIP-seq
MIRT2435567	hsa-miR-1266	CLIP-seq
MIRT2435568	hsa-miR-128	CLIP-seq
MIRT2481035	hsa-miR-137	CLIP-seq
MIRT2481036	hsa-miR-221	CLIP-seq
MIRT2481037	hsa-miR-222	CLIP-seq
MIRT2481038	hsa-miR-2467-3p	CLIP-seq
MIRT2481039	hsa-miR-30a	CLIP-seq
MIRT2481040	hsa-miR-30b	CLIP-seq
MIRT2481041	hsa-miR-30c	CLIP-seq
MIRT2481042	hsa-miR-30d	CLIP-seq
MIRT2481043	hsa-miR-30e	CLIP-seq
MIRT2481044	hsa-miR-3123	CLIP-seq
MIRT2481046	hsa-miR-3159	CLIP-seq
MIRT806525	hsa-miR-3180-5p	CLIP-seq
MIRT806527	hsa-miR-323-3p	CLIP-seq
MIRT2481047	hsa-miR-338-5p	CLIP-seq
MIRT2435569	hsa-miR-3664-3p	CLIP-seq
MIRT2481050	hsa-miR-3678-3p	CLIP-seq
MIRT2481051	hsa-miR-3919	CLIP-seq
MIRT2435570	hsa-miR-4282	CLIP-seq
MIRT2435571	hsa-miR-4518	CLIP-seq
MIRT2177615	hsa-miR-4691-3p	CLIP-seq
MIRT2177617	hsa-miR-4719	CLIP-seq
MIRT806546	hsa-miR-520a-5p	CLIP-seq
MIRT806547	hsa-miR-525-5p	CLIP-seq
MIRT806548	hsa-miR-548c-3p	CLIP-seq
MIRT2481054	hsa-miR-548v	CLIP-seq
MIRT1938225	hsa-miR-590-3p	CLIP-seq

Show/Hide all (37)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	21914794, 28514442, 31571211, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005637	Component	Nuclear inner membrane	NAS	11790799
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	21914794
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	NAS	11790799
GO:0006869	Process	Lipid transport	IEA
GO:0012505	Component	Endomembrane system	IEA
GO:0015075	Function	Monoatomic ion transmembrane transporter activity	NAS	11790799
GO:0015914	Process	Phospholipid transport	IEA
GO:0015917	Process	Aminophospholipid transport	TAS	11015572
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	IPI	31571211
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0031901	Component	Early endosome membrane	IDA	31571211
GO:0034220	Process	Monoatomic ion transmembrane transport	TAS
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0045332	Process	Phospholipid translocation	IBA
GO:0045332	Process	Phospholipid translocation	NAS	21914794
GO:0046872	Function	Metal ion binding	IEA
GO:0055037	Component	Recycling endosome	IBA
GO:0055037	Component	Recycling endosome	IDA	21914794
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0090556	Function	Phosphatidylserine floppase activity	IEA
GO:0140326	Function	ATPase-coupled intramembrane lipid transporter activity	IBA
GO:0140326	Function	ATPase-coupled intramembrane lipid transporter activity	IEA
GO:0140326	Function	ATPase-coupled intramembrane lipid transporter activity	TAS	11015572
GO:1990531	Component	Phospholipid-translocating ATPase complex	IPI	31571211

MIM	HGNC	e!Ensembl
605869	13553	ENSG00000058063

Q9Y2G3

Protein name

Phospholipid-transporting ATPase IF (EC 7.6.2.1) (ATPase IR) (ATPase class VI type 11B) (P4-ATPase flippase complex alpha subunit ATP11B)

Protein function

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intrace

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16209	PhoLip_ATPase_N	22 → 91	Phospholipid-translocating ATPase N-terminal	Family
PF00122	E1-E2_ATPase	118 → 369		Family
PF13246	Cation_ATPase	469 → 607		Family
PF16212	PhoLip_ATPase_C	847 → 1100	Phospholipid-translocating P-type ATPase C-terminal	Family

Sequence

MWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLF
EQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVN
GAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGE
TNLKTHVAVPETALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPE
SLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISE
AVISTILKYTWQAEEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPISLYVT
VEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFR
ECSINGMKYQEINGRLVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPENETE
LIKEHDLFFKAVSLCHTVQISNVQTDCTGDGPWQSNLAPSQLEYYASSPDEKALVEAAAR
IGIVFIGNSEETMEVKTLGKLERYKLLHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESS
ILPKCIGGEIEKTRIHVDEFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEK
LAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSC
GHFHRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLF
MEVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMG
KEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYC
LFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKT
FLYWTILGFSHAFIFFFGSYLLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALE
THFWTWINHLVTWGSIIFYFVFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMV
VTCLFLDIIKKVFDRHLHPTSTEKAQLTETNAGIKCLDSMCCFPEGEAACASVGRMLERV
IGRCSPTHISRSWSASDPFYTNDRSILTLSTMDSSTC

Sequence length

1177

Interactions

View interactions

	KEGG		Reactome
	Efferocytosis		Neutrophil degranulation Ion transport by P-type ATPases

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma of the head and neck	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	23585472		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Small Vessel Diseases	Cerebral microangiopathy	Pubtator	36510145	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	23585472		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	23585472		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	23585472		★★★★★ ★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	23585472		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary Graft Dysfunction	Primary graft dysfunction	Pubtator	18727701	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ATP11B (ATPase phospholipid transporting 11B (putative))