Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23199
Gene name	Gse1 coiled-coil protein
Gene symbol	GSE1
Synonyms (NCBI Gene)	CRHSP24KIAA0182
Chromosome	16
Chromosome location	16q24.1
Summary	This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast cancer and enhanced expression of the encoded protein has been obse

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018548	hsa-miR-335-5p	Microarray	18185580
MIRT043553	hsa-miR-331-3p	CLASH	23622248
MIRT039190	hsa-miR-769-5p	CLASH	23622248
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	24398324
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	24398324
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	24398324
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	24398324
MIRT476034	hsa-miR-4773	PAR-CLIP	24398324
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	24398324
MIRT386572	hsa-miR-759	PAR-CLIP	24398324
MIRT386570	hsa-miR-361-3p	PAR-CLIP	24398324
MIRT386573	hsa-miR-1913	PAR-CLIP	24398324
MIRT386571	hsa-miR-324-3p	PAR-CLIP	24398324
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	24398324
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	24398324
MIRT476031	hsa-miR-4313	PAR-CLIP	24398324
MIRT476030	hsa-miR-4775	PAR-CLIP	24398324
MIRT476029	hsa-miR-5687	PAR-CLIP	24398324
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	24398324
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	23592263
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	23592263
MIRT476034	hsa-miR-4773	PAR-CLIP	23592263
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT386572	hsa-miR-759	PAR-CLIP	23592263
MIRT386570	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT386573	hsa-miR-1913	PAR-CLIP	23592263
MIRT386571	hsa-miR-324-3p	PAR-CLIP	23592263
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	23592263
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	23592263
MIRT476031	hsa-miR-4313	PAR-CLIP	23592263
MIRT476030	hsa-miR-4775	PAR-CLIP	23592263
MIRT476029	hsa-miR-5687	PAR-CLIP	23592263
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT731266	hsa-miR-489-3p	Luciferase reporter assay	26828271
MIRT731266	hsa-miR-489-3p	Luciferase reporter assay	26828271
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	26701625
MIRT386573	hsa-miR-1913	PAR-CLIP	26701625
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	26701625
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	26701625
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	26701625
MIRT386571	hsa-miR-324-3p	PAR-CLIP	26701625
MIRT386570	hsa-miR-361-3p	PAR-CLIP	26701625
MIRT476031	hsa-miR-4313	PAR-CLIP	26701625
MIRT476034	hsa-miR-4773	PAR-CLIP	26701625
MIRT476030	hsa-miR-4775	PAR-CLIP	26701625
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	26701625
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	26701625
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	26701625
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	26701625
MIRT476029	hsa-miR-5687	PAR-CLIP	26701625
MIRT386572	hsa-miR-759	PAR-CLIP	26701625
MIRT735939	hsa-miR-4665-3p	Western blottingMicroarrayqRT-PCR	31692505
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	24398324
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	24398324
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	24398324
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	24398324
MIRT476034	hsa-miR-4773	PAR-CLIP	24398324
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	24398324
MIRT386572	hsa-miR-759	PAR-CLIP	24398324
MIRT386570	hsa-miR-361-3p	PAR-CLIP	24398324
MIRT386573	hsa-miR-1913	PAR-CLIP	24398324
MIRT386571	hsa-miR-324-3p	PAR-CLIP	24398324
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	24398324
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	24398324
MIRT476031	hsa-miR-4313	PAR-CLIP	24398324
MIRT476030	hsa-miR-4775	PAR-CLIP	24398324
MIRT476029	hsa-miR-5687	PAR-CLIP	24398324
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	24398324
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	23592263
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	23592263
MIRT476034	hsa-miR-4773	PAR-CLIP	23592263
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT386572	hsa-miR-759	PAR-CLIP	23592263
MIRT386570	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT386573	hsa-miR-1913	PAR-CLIP	23592263
MIRT386571	hsa-miR-324-3p	PAR-CLIP	23592263
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	23592263
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	23592263
MIRT476031	hsa-miR-4313	PAR-CLIP	23592263
MIRT476030	hsa-miR-4775	PAR-CLIP	23592263
MIRT476029	hsa-miR-5687	PAR-CLIP	23592263
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	23592263

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0001890	Process	Placenta development	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 25416956, 29568061, 29892012, 32296183, 32814053
GO:0010467	Process	Gene expression	IEA

MIM	HGNC	e!Ensembl
616886	28979	ENSG00000131149

Q14687

Protein name

Genetic suppressor element 1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12540	DUF3736	71 → 239	Protein of unknown function (DUF3736)	Family
PF12540	DUF3736	732 → 873	Protein of unknown function (DUF3736)	Family

Sequence

MKGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSF
AAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPST
PPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTP
YPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLG
LDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLH
LSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRREREREREREREREADREREKE
REREREKEREQEKEREREKERERELERQREQRAREKELLAAKALEPSFLPVAELHGLRGH
ATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHTVPSLISNHGIFSLPSS
SAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEH
RPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTALWNPVSLMDNTLETRRA
ESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGG
SLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAP
DPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAE
QPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPS
PRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSA
AVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQEL
SRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVA
EEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHN
GQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQ
NLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCL
ALPAMHWPRGYLKGYPR

Sequence length

1217

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EARLY-ONSET ALZHEIMERS DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESOPHAGEAL SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPORADIC AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alopecia	Alopecia	GWASCAT_DG	28196072		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	26828271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	22282400	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	22282400		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	22282400	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	22282400	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	30888986	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	33623790	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	26828271		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	29367342		★★★★★ ★☆☆☆☆ Found in Text Mining only
Meningioma	Meningioma	Pubtator	31470906	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29367342		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	29367342		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	33623790	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

GSE1 (Gse1 coiled-coil protein)