Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23195
Gene name	Midasin AAA ATPase 1
Gene symbol	MDN1
Synonyms (NCBI Gene)	Rea1
Chromosome	6
Chromosome location	6q15

188

Show/Hide all (188)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031497	hsa-miR-16-5p	Proteomics	18668040
MIRT049165	hsa-miR-92a-3p	CLASH	23622248
MIRT046580	hsa-miR-222-3p	CLASH	23622248
MIRT045292	hsa-miR-186-5p	CLASH	23622248
MIRT041859	hsa-miR-484	CLASH	23622248
MIRT039573	hsa-miR-642a-5p	CLASH	23622248
MIRT052773	hsa-miR-1260b	CLASH	23622248
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT623280	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT623279	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT623278	hsa-miR-589-5p	HITS-CLIP	23824327
MIRT623277	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT623276	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT623275	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT610551	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT623280	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT623279	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT623280	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT623279	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT623278	hsa-miR-589-5p	HITS-CLIP	23824327
MIRT623277	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT623276	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT623275	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT610551	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT623280	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT623279	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT623278	hsa-miR-589-5p	HITS-CLIP	23824327
MIRT623277	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT623276	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT623275	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT610551	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT623280	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT623279	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT623278	hsa-miR-589-5p	HITS-CLIP	23824327
MIRT623277	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT623276	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT623275	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT610551	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT623280	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT623279	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT623280	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT623279	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT623278	hsa-miR-589-5p	HITS-CLIP	23824327
MIRT623277	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT623276	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT623275	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT610551	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT623280	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT623279	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT623278	hsa-miR-589-5p	HITS-CLIP	23824327
MIRT623277	hsa-miR-146a-5p	HITS-CLIP	23824327
MIRT623276	hsa-miR-146b-5p	HITS-CLIP	23824327
MIRT623275	hsa-miR-7153-5p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT613991	hsa-miR-8485	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT610551	hsa-miR-7848-3p	HITS-CLIP	23824327
MIRT610550	hsa-miR-155-3p	HITS-CLIP	23824327
MIRT610549	hsa-miR-3685	HITS-CLIP	23824327
MIRT610548	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT1139542	hsa-miR-103a	CLIP-seq
MIRT1139543	hsa-miR-107	CLIP-seq
MIRT1139544	hsa-miR-1207-3p	CLIP-seq
MIRT1139545	hsa-miR-1237	CLIP-seq
MIRT1139546	hsa-miR-140-3p	CLIP-seq
MIRT1139547	hsa-miR-331-3p	CLIP-seq
MIRT1139548	hsa-miR-378g	CLIP-seq
MIRT1139549	hsa-miR-4256	CLIP-seq
MIRT1139550	hsa-miR-4268	CLIP-seq
MIRT1139551	hsa-miR-4279	CLIP-seq
MIRT1139552	hsa-miR-4437	CLIP-seq
MIRT1139553	hsa-miR-4448	CLIP-seq
MIRT1139554	hsa-miR-4501	CLIP-seq
MIRT1139555	hsa-miR-4514	CLIP-seq
MIRT1139556	hsa-miR-4674	CLIP-seq
MIRT1139557	hsa-miR-4692	CLIP-seq
MIRT1139558	hsa-miR-570	CLIP-seq
MIRT1139559	hsa-miR-759	CLIP-seq
MIRT1139560	hsa-miR-764	CLIP-seq
MIRT1139561	hsa-miR-885-3p	CLIP-seq
MIRT2039479	hsa-miR-1207-5p	CLIP-seq
MIRT1139545	hsa-miR-1237	CLIP-seq
MIRT1139546	hsa-miR-140-3p	CLIP-seq
MIRT2039480	hsa-miR-2115	CLIP-seq
MIRT2039481	hsa-miR-3158-3p	CLIP-seq
MIRT2039482	hsa-miR-3185	CLIP-seq
MIRT2039483	hsa-miR-3714	CLIP-seq
MIRT1139549	hsa-miR-4256	CLIP-seq
MIRT1139554	hsa-miR-4501	CLIP-seq
MIRT2039484	hsa-miR-4685-5p	CLIP-seq
MIRT2039485	hsa-miR-4763-3p	CLIP-seq
MIRT2039486	hsa-miR-4773	CLIP-seq
MIRT2039487	hsa-miR-940	CLIP-seq
MIRT2039479	hsa-miR-1207-5p	CLIP-seq
MIRT2269441	hsa-miR-129-5p	CLIP-seq
MIRT2269442	hsa-miR-182	CLIP-seq
MIRT2039480	hsa-miR-2115	CLIP-seq
MIRT2269443	hsa-miR-31	CLIP-seq
MIRT2039481	hsa-miR-3158-3p	CLIP-seq
MIRT2269444	hsa-miR-3163	CLIP-seq
MIRT2039482	hsa-miR-3185	CLIP-seq
MIRT1139547	hsa-miR-331-3p	CLIP-seq
MIRT2269445	hsa-miR-3663-3p	CLIP-seq
MIRT2269446	hsa-miR-3674	CLIP-seq
MIRT2039483	hsa-miR-3714	CLIP-seq
MIRT2269447	hsa-miR-3908	CLIP-seq
MIRT2269448	hsa-miR-4282	CLIP-seq
MIRT2269449	hsa-miR-4703-3p	CLIP-seq
MIRT2269450	hsa-miR-4708-3p	CLIP-seq
MIRT2039485	hsa-miR-4763-3p	CLIP-seq
MIRT2039486	hsa-miR-4773	CLIP-seq
MIRT2269451	hsa-miR-555	CLIP-seq
MIRT2269452	hsa-miR-603	CLIP-seq
MIRT1139561	hsa-miR-885-3p	CLIP-seq
MIRT2039487	hsa-miR-940	CLIP-seq
MIRT1139542	hsa-miR-103a	CLIP-seq
MIRT1139543	hsa-miR-107	CLIP-seq
MIRT1139544	hsa-miR-1207-3p	CLIP-seq
MIRT2568743	hsa-miR-124	CLIP-seq
MIRT1139547	hsa-miR-331-3p	CLIP-seq
MIRT1139548	hsa-miR-378g	CLIP-seq
MIRT2568744	hsa-miR-3922-5p	CLIP-seq
MIRT1139550	hsa-miR-4268	CLIP-seq
MIRT1139551	hsa-miR-4279	CLIP-seq
MIRT1139552	hsa-miR-4437	CLIP-seq
MIRT1139553	hsa-miR-4448	CLIP-seq
MIRT1139555	hsa-miR-4514	CLIP-seq
MIRT1139556	hsa-miR-4674	CLIP-seq
MIRT1139557	hsa-miR-4692	CLIP-seq
MIRT2568745	hsa-miR-506	CLIP-seq
MIRT2568746	hsa-miR-552	CLIP-seq
MIRT1139558	hsa-miR-570	CLIP-seq
MIRT1139559	hsa-miR-759	CLIP-seq
MIRT1139560	hsa-miR-764	CLIP-seq
MIRT1139561	hsa-miR-885-3p	CLIP-seq
MIRT1139542	hsa-miR-103a	CLIP-seq
MIRT1139543	hsa-miR-107	CLIP-seq
MIRT2568743	hsa-miR-124	CLIP-seq
MIRT1139547	hsa-miR-331-3p	CLIP-seq
MIRT2568744	hsa-miR-3922-5p	CLIP-seq
MIRT1139550	hsa-miR-4268	CLIP-seq
MIRT1139551	hsa-miR-4279	CLIP-seq
MIRT1139553	hsa-miR-4448	CLIP-seq
MIRT2568745	hsa-miR-506	CLIP-seq
MIRT2568746	hsa-miR-552	CLIP-seq
MIRT1139558	hsa-miR-570	CLIP-seq
MIRT1139559	hsa-miR-759	CLIP-seq
MIRT1139560	hsa-miR-764	CLIP-seq
MIRT1139561	hsa-miR-885-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000027	Process	Ribosomal large subunit assembly	IBA
GO:0000027	Process	Ribosomal large subunit assembly	IDA	27814492
GO:0000027	Process	Ribosomal large subunit assembly	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0005515	Function	Protein binding	IPI	21326211
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	27814492
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0045111	Component	Intermediate filament cytoskeleton	IDA

MIM	HGNC	e!Ensembl
618200	18302	ENSG00000112159

Q9NU22

Protein name

Midasin (Dynein-related AAA-ATPase MDN1) (MIDAS-containing protein)

Protein function

Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07728	AAA_5	324 → 460	AAA domain (dynein-related subfamily)	Domain
PF17867	AAA_lid_7	480 → 604	Midasin AAA lid domain	Domain
PF07728	AAA_5	672 → 785	AAA domain (dynein-related subfamily)	Domain
PF07728	AAA_5	788 → 902	AAA domain (dynein-related subfamily)	Domain
PF17865	AAA_lid_5	915 → 1017	Midasin AAA lid domain	Domain
PF07728	AAA_5	1079 → 1215	AAA domain (dynein-related subfamily)	Domain
PF17867	AAA_lid_7	1227 → 1330	Midasin AAA lid domain	Domain
PF07728	AAA_5	1385 → 1540	AAA domain (dynein-related subfamily)	Domain
PF07728	AAA_5	1748 → 1888	AAA domain (dynein-related subfamily)	Domain
PF17867	AAA_lid_7	1900 → 2001	Midasin AAA lid domain	Domain
PF07728	AAA_5	2061 → 2125	AAA domain (dynein-related subfamily)	Domain
PF07728	AAA_5	2208 → 2306	AAA domain (dynein-related subfamily)	Domain

Sequence

MEHFLLEVAAAPLRLIAAKNEKSRSELGRFLAKQVWTPQDRQCVLSTLAQLLLDKDCTVL
VGRQLRPLLLDLLERNAEAIKAGGQINHDLHERLCVSMSKLIGNHPDVLPFALRYFKDTS
PVFQRLFLESSDANPVRYGRRRMKLRDLMEAAFKFLQQEQSVFRELWDWSVCVPLLRSHD
TLVRWYTANCLALVTCMNEEHKLSFLKKIFNSDELIHFRLRLLEEAQLQDLEKALVLANP
EVSLWRKQKELQYLQGHLVSSDLSPRVTAVCGVVLPGQLPAPGELGGNRSSSREQELALR
SYVLVESVCKSLQTLAMAVASQNAVLLEGPIGCGKTSLVEYLAAVTGRTKPPQLLKVQLG
DQTDSKMLLGMYRCTDVPGEFVWQPGTLTQAATMGHWILLEDIDYAPLDVVSVLIPLLEN
GELLIPGRGDCLKVAPGFQFFATRRLLSCGGNWYRPLNSHATLLDKYWTKIHLDNLDKRE
LNEVLQSRYPSLLAVVDHLLDIYIQLTGEKHHSWSDSSVGCEQAPEEVSEARRENKRPTL
EGRELSLRDLLNWCNRIAHSFDSSSLSASLNIFQEALDCFTAMLSEHTSKLKMAEVIGSK
LNISRKKAEFFCQLYKPEIVINELDLQVGRVRLLRKQSEAVHLQREKFTFAATRPSSVLI
EQLAVCVSKGEPVLLVGETGTGKTSTIQYLAHITGHRLRVVNMNQQSDTADLLGGYKPVD
HKLIWLPLREAFEELFAQTFSKKQNFTFLGHIQTCYRQKRWHDLLRLMQHVHKSAVNKDG
KDSETGLLIKEKWEAFGLRLNHAQQQMKMTENTLLFAFVEGTLAQAVKKGEWILLDEINL
AAPEILECLSGLLEGSSGSLVLLDRGDTEPLVRHPDFRLFACMNPATDVGKRNLPPGIRN
RFTELYVEELESKEDLQVLIVDYLKGLSVNKNTVQGIINFYTALRKESGTKLVDGTGHRP
HYSLRTLCRALRFAASNPCGNIQRSLYEGFCLGFLTQLDRASHPIVQKLICQHIVPGNVK
SLLKQPIPEPKGGRLIQVEGYWIAVGDKEPTIDETYILTSSVKLNLRDIVRVVSAGTYPV
LIQGETSVGKTSLIQWLAAATGNHCVRINNHEHTDIQEYIGCYTSDSSGKLVFKEGVLID
AMRKGYWIILDELNLAPTDVLEALNRLLDDNRELLVTETQEVVKAHPRFMLFATQNPPGL
YGGRKVLSRAFRNRFVELHFDELPSSELETILHKRCSLPPSYCSKLVKVMLDLQSYRRSS
SVFAGKQGFITLRDLFRWAERYRLAEPTEKEYDWLQHLANDGYMLLAGRVRKQEEIDVIQ
EVLEKHFKKKLCPQSLFSKENVLKLLGKLSTQISTLECNFGHIVWTEGMRRLAMLVGRAL
EFGEPVLLVGDTGCGKTTICQVFAALANQKLYSVSCHLHMETSDFLGGLRPVRQKPNDKE
EIDTSRLFEWHDGPLVQAMKEDGFFLLDEISLADDSVLERLNSVLEVEKSLVLAEKGSPE
DKDSEIELLTAGKKFRILATMNPGGDFGKKELSPALRNRFTEIWCPQSTSREDLIQIISH
NLRPGLCLGRIDPKGSDIPEVMLDFIDWLTHQEFGRKCVVSIRDILSWVNFMNKMGEEAA
LKRPEIISTVTSFVHAACLVYIDGIGSGVTSSGFGTALLARKECLKFLIKRLAKIVRLTE
YQKNELKIYDRMKAKEFTGIDNLWGIHPFFIPRGPVLHRNNIADYALSAGTTAMNAQRLL
RATKLKKPILLEGSPGVGKTSLVGALAKASGNTLVRINLSEQTDITDLFGADLPVEGGKG
GEFAWRDGPLLAALKAGHWVVLDELNLASQSVLEGLNACFDHRGEIYVPELGMSFQVQHE
KTKIFGCQNPFRQGGGRKGLPRSFLNRFTQVFVDPLTVIDMEFIASTLFPAIEKNIVKKM
VAFNNQIDHEVTVEKKWGQKGGPWEFNLRDLFRWCQLMLVDQSPGCYDPGQHVFLVYGER
MRTEEDKKKVIAVFKDVFGSNSNPYMGTRLFRITPYDVQLGYSVLSRGSCVPHPSRHPLL
LLHQSFQPLESIMKCVQMSWMVILVGPASVGKTSLVQLLAHLTGHTLKIMAMNSAMDTTE
LLGGFEQVDLIRPWRRLLEKVEGTVRALLRDSLLISADDAEVVLRAWSHFLLTYKPKCLG
EGGKAITMEIVNKLEAVLLLMQRLNNKINSYCKAEFAKLVEEFRSFGVKLTQLASGHSHG
TFEWVDSMLVQALKSGDWLLMDNVNFCNPSVLDRLNALLEPGGVLTISERGMIDGSTPTI
TPNPNFRLFLSMDPVHGDISRAMRNRGLEIYISGEGDASTPDNLDLKVLLHSLGLVGNSV
CDILLALHTETRSTVVGSPTSSVSTLIQTAILIVQYLQRGLSLDRAFSEACWEVYVCSQH
SPANRKLVQALLEKHVSSLRAHETWGDSILGMGLWPDSVPSALFATEDSHLSTVRRDGQI
LVYCLNRMSMKTSSWTRSQPFTLQDLEKIMQSPSPENLKFNAVEVNTYWIDEPDVLVMAV
KLLIERATNQDWMLRVKWLYHLAKNIPQGLESIQIHLEASAASLRNFYSHSLSGAVSNVF
KILQPNTTDEFVIPLDPRWNMQALDMIRNLMDFDPQTDQPDQLFALLESAANKTIIYLDR
EKRVFTEANLVSVGSKKLRESVLRMSFEFHQDPESYHTLPHEIVVNLAAFFELCDALVLL
WVQSSQGMVSDASANEILGSLRWRDRFWTVADTVKVDAPGLALLALHWHWVLKHLVHQIP
RLLMNYEDKYYKEVQTVSEHIQNCLGSQTGGFAGIKKLQKFLGRPFPFKDKLVVECFSQL
KVLNKVLAIREQMSALGESGWQEDINRLQVVASQWTLKKSLLQAWGLILRANILEDVSLD
ELKNFVHAQCLELKAKGLSLGFLEKKHDEASSLSHPDLTSVIHLTRSVQLWPAMEYLAML
WRYKVTADFMAQACLRRCSKNQQPQINEEISHLISFCLYHTPVTPQELRDLWSLLHHQKV
SPEEITSLWSELFNSMFMSFWSSTVTTNPEYWLMWNPLPGMQQREAPKSVLDSTLKGPGN
LNRPIFSKCCFEVLTSSWRASPWDVSGLPILSSSHVTLGEWVERTQQLQDISSMLWTNMA
ISSVAEFRRTDSQLQGQVLFRHLAGLAELLPESRRQEYMQNCEQLLLGSSQAFQHVGQTL
GDMAGQEVLPKELLCQLLTSLHHFVGEGESKRSLPEPAQRGSLWVSLGLLQIQTWLPQAR
FDPAVKREYKLNYVKEELHQLQCEWKTRNLSSQLQTGRDLEDEVVVSYSHPHVRLLRQRM
DRLDNLTCHLLKKQAFRPQLPAYESLVQEIHHYVTSIAKAPAVQDLLTRLLQALHIDGPR
SAQVAQSLLKEEASWQQSHHQFRKRLSEEYTFYPDAVSPLQASILQLQHGMRLVASELHT
SLHSSMVGADRLGTLATALLAFPSVGPTFPTYYAHADTLCSVKSEEVLRGLGKLILKRSG
GKELEGKGQKACPTREQLLMNALLYLRSHVLCKGELDQRALQLFRHVCQEIISEWDEQER
IAQEKAEQESGLYRYRSRNSRTALSEEEEEEREFRKQFPLHEKDFADILVQPTLEENKGT
SDGQEEEAGTNPALLSQNSMQAVMLIHQQLCLNFARSLWYQQTLPPHEAKHYLSLFLSCY
QTGASLVTHFYPLMGVELNDRLLGSQLLACTLSHNTLFGEAPSDLMVKPDGPYDFYQHPN
VPEARQCQPVLQGFSEAVSHLLQDWPEHPALEQLLVVMDRIRSFPLSSPISKFLNGLEIL
LAKAQDWEENASRALSLRKHLDLISQMIIRWRKLELNCWSMSLDNTMKRHTEKSTKHWFS
IYQMLEKHMQEQTEEQEDDKQMTLMLLVSTLQAFIEGSSLGEFHVRLQMLLVFHCHVLLM
PQVEGKDSLCSVLWNLYHYYKQFFDRVQAKIVELRSPLEKELKEFVKISKWNDVSFWSIK
QSVEKTHRTLFKFMKKFEAVLSEPCRSSLVESDKEEQPDFLPRPTDGAASELSSIQNLNR
ALRETLLAQPAAGQATIPEWCQGAAPSGLEGELLRRLPKLRKRMRKMCLTFMKESPLPRL
VEGLDQFTGEVISSVSELQSLKVEPSAEKEKQRSEAKHILMQKQRALSDLFKHLAKIGLS
YRKGLAWARSKNPQEMLHLHPLDLQSALSIVSSTQEADSRLLTEISSSWDGCQKYFYRSL
ARHARLNAALATPAKEMGMGNVERCRGFSAHLMKMLVRQRRSLTTLSEQWIILRNLLSCV
QEIHSRLMGPQAYPVAFPPQDGVQQWTERLQHLAMQCQILLEQLSWLLQCCPSVGPAPGH
GNVQVLGQPPGPCLEGPELSKGQLCGVVLDLIPSNLSYPSPIPGSQLPSGCRMRKQDHLW
QQSTTRLTEMLKTIKTVKADVDKIRQQSCETLFHSWKDFEVCSSALSCLSQVSVHLQGLE
SLFILPGMEVEQRDSQMALVESLEYVRGEISKAMADFTTWKTHLLTSDSQGGNQMLDEGF
VEDFSEQMEIAIRAILCAIQNLEERKNEKAEENTDQASPQEDYAGFERLQSGHLTKLLED
DFWADVSTLHVQKIISAISELLERLKSYGEDGTAAKHLFFSQSCSLLVRLVPVLSSYSDL
VLFFLTMSLATHRSTAKLLSVLAQVFTELAQKGFCLPKEFMEDSAGEGATEFHDYEGGGI
GEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGKMHDG
ELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETGP
GMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDERDYDE
NEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGH
EAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQ
QSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVEN
MQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRK
PGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDA
QTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAPL
GFDEMEVEIQTVKTEEDQDPRTDKAHKETENEKPERSRESTIHTAHQFLMDTIFQPFLKD
VNELRQELERQLEMWQPRESGNPEEEKVAAEMWQSYLILTAPLSQRLCEELRLILEPTQA
AKLKGDYRTGKRLNIRKVIPYIASQFRKDKIWLRRTKPSKRQYQICLAIDDSSSMVDNHT
KQLAFESLAVIGNALTLLEVGQIAVCSFGESVKLLHPFHEQFSDYSGSQILRLCKFQQKK
TKIAQFLESVANMFAAAQQLSQNISSETAQLLLVVSDGRGLFLEGKERVLAAVQAARNAN
IFVIFVVLDNPSSRDSILDIKVPIFKGPGEMPEIRSYMEEFPFPYYIILRDVNALPETLS
DALRQWFELVTASDHP

Sequence length

5596

Interactions

View interactions

	KEGG
	Ribosome biogenesis in eukaryotes

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (18)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Adrenocortical carcinoma, hereditary	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IGA GLOMERULONEPHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MDN1-related disorder	Benign; Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATIC DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	24416132	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cleft Palate	Cleft palate	Pubtator	36468602	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	12742158		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma, Follicular	Lymphoma	BEFREE	12742158		★★★★★ ★☆☆☆☆ Found in Text Mining only

MDN1 (midasin AAA ATPase 1)