MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3)

Gene

• Entrez ID: 23162
• Gene name: Mitogen-activated protein kinase 8 interacting protein 3
• Gene symbol: MAPK8IP3
• Synonyms (NCBI Gene): JIP-3, JIP3, JSAP1, NEDBA, SYD2, syd
• Chromosome: 16
• Chromosome location: 16p13.3
• Summary: The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and reg

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs770703007	C>G,T	Likely-pathogenic	Genic upstream transcript variant, synonymous variant, stop gained, non coding transcript variant, coding sequence variant, 5 prime UTR variant
rs1479142047	G>C,T	Likely-pathogenic	Coding sequence variant, non coding transcript variant, missense variant, genic upstream transcript variant, 5 prime UTR variant, stop gained
rs1567128142	G>-	Pathogenic	Frameshift variant, coding sequence variant, non coding transcript variant, genic upstream transcript variant, 5 prime UTR variant
rs1567198751	T>C	Likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1567203083	C>T	Pathogenic-likely-pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs1567214097	C>T	Likely-pathogenic	Missense variant, genic downstream transcript variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT044821	hsa-miR-320a	CLASH	23622248
MIRT711827	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT711826	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT711825	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT711824	hsa-miR-1248	HITS-CLIP	19536157
MIRT711823	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711822	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT724681	hsa-miR-378a-5p	HITS-CLIP	19536157
MIRT724680	hsa-miR-1200	HITS-CLIP	19536157
MIRT711821	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT711827	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT711826	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT711825	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT711824	hsa-miR-1248	HITS-CLIP	19536157
MIRT711823	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711822	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT711821	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT375251	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT500211	hsa-miR-3064-5p	PAR-CLIP	20371350
MIRT500210	hsa-miR-6504-5p	PAR-CLIP	20371350
MIRT500209	hsa-miR-3184-5p	PAR-CLIP	20371350
MIRT500208	hsa-miR-423-5p	PAR-CLIP	20371350
MIRT500207	hsa-miR-6720-3p	PAR-CLIP	20371350
MIRT500206	hsa-miR-3960	PAR-CLIP	20371350
MIRT500205	hsa-miR-8072	PAR-CLIP	20371350
MIRT500203	hsa-miR-566	PAR-CLIP	20371350
MIRT500202	hsa-miR-4467	PAR-CLIP	20371350
MIRT500201	hsa-miR-3652	PAR-CLIP	20371350
MIRT500200	hsa-miR-4430	PAR-CLIP	20371350
MIRT500198	hsa-miR-4505	PAR-CLIP	20371350
MIRT500199	hsa-miR-5787	PAR-CLIP	20371350
MIRT500197	hsa-miR-3180	PAR-CLIP	20371350
MIRT500196	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT500195	hsa-miR-3196	PAR-CLIP	20371350
MIRT500194	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT500193	hsa-miR-6842-3p	PAR-CLIP	20371350
MIRT375251	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT500211	hsa-miR-3064-5p	PAR-CLIP	20371350
MIRT500210	hsa-miR-6504-5p	PAR-CLIP	20371350
MIRT500209	hsa-miR-3184-5p	PAR-CLIP	20371350
MIRT500208	hsa-miR-423-5p	PAR-CLIP	20371350
MIRT500207	hsa-miR-6720-3p	PAR-CLIP	20371350
MIRT500206	hsa-miR-3960	PAR-CLIP	20371350
MIRT500205	hsa-miR-8072	PAR-CLIP	20371350
MIRT500204	hsa-miR-5580-5p	PAR-CLIP	20371350
MIRT500203	hsa-miR-566	PAR-CLIP	20371350
MIRT500202	hsa-miR-4467	PAR-CLIP	20371350
MIRT500201	hsa-miR-3652	PAR-CLIP	20371350
MIRT500200	hsa-miR-4430	PAR-CLIP	20371350
MIRT500198	hsa-miR-4505	PAR-CLIP	20371350
MIRT500199	hsa-miR-5787	PAR-CLIP	20371350
MIRT500197	hsa-miR-3180	PAR-CLIP	20371350
MIRT500196	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT500195	hsa-miR-3196	PAR-CLIP	20371350
MIRT500194	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT500193	hsa-miR-6842-3p	PAR-CLIP	20371350
MIRT375251	hsa-miR-5197-3p	PAR-CLIP	24398324
MIRT500211	hsa-miR-3064-5p	PAR-CLIP	24398324
MIRT500210	hsa-miR-6504-5p	PAR-CLIP	24398324
MIRT500209	hsa-miR-3184-5p	PAR-CLIP	24398324
MIRT500208	hsa-miR-423-5p	PAR-CLIP	24398324
MIRT500207	hsa-miR-6720-3p	PAR-CLIP	24398324
MIRT500206	hsa-miR-3960	PAR-CLIP	24398324
MIRT500205	hsa-miR-8072	PAR-CLIP	24398324
MIRT500204	hsa-miR-5580-5p	PAR-CLIP	24398324
MIRT500203	hsa-miR-566	PAR-CLIP	24398324
MIRT500202	hsa-miR-4467	PAR-CLIP	24398324
MIRT500201	hsa-miR-3652	PAR-CLIP	24398324
MIRT500200	hsa-miR-4430	PAR-CLIP	24398324
MIRT500198	hsa-miR-4505	PAR-CLIP	24398324
MIRT500199	hsa-miR-5787	PAR-CLIP	24398324
MIRT500197	hsa-miR-3180	PAR-CLIP	24398324
MIRT500196	hsa-miR-3180-3p	PAR-CLIP	24398324
MIRT500195	hsa-miR-3196	PAR-CLIP	24398324
MIRT500194	hsa-miR-6816-5p	PAR-CLIP	24398324
MIRT500193	hsa-miR-6842-3p	PAR-CLIP	24398324
MIRT500211	hsa-miR-3064-5p	PAR-CLIP	26701625
MIRT500196	hsa-miR-3180-3p	PAR-CLIP	26701625
MIRT500197	hsa-miR-3180	PAR-CLIP	26701625
MIRT500209	hsa-miR-3184-5p	PAR-CLIP	26701625
MIRT500195	hsa-miR-3196	PAR-CLIP	26701625
MIRT500201	hsa-miR-3652	PAR-CLIP	26701625
MIRT500206	hsa-miR-3960	PAR-CLIP	26701625
MIRT500208	hsa-miR-423-5p	PAR-CLIP	26701625
MIRT500200	hsa-miR-4430	PAR-CLIP	26701625
MIRT500202	hsa-miR-4467	PAR-CLIP	26701625
MIRT500198	hsa-miR-4505	PAR-CLIP	26701625
MIRT375251	hsa-miR-5197-3p	PAR-CLIP	26701625
MIRT500203	hsa-miR-566	PAR-CLIP	26701625
MIRT500199	hsa-miR-5787	PAR-CLIP	26701625
MIRT500210	hsa-miR-6504-5p	PAR-CLIP	26701625
MIRT500207	hsa-miR-6720-3p	PAR-CLIP	26701625
MIRT500194	hsa-miR-6816-5p	PAR-CLIP	26701625
MIRT500193	hsa-miR-6842-3p	PAR-CLIP	26701625
MIRT500205	hsa-miR-8072	PAR-CLIP	26701625
MIRT711827	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT711826	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT711825	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT711824	hsa-miR-1248	HITS-CLIP	19536157
MIRT711823	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711822	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT724681	hsa-miR-378a-5p	HITS-CLIP	19536157
MIRT724680	hsa-miR-1200	HITS-CLIP	19536157
MIRT711821	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT711827	hsa-miR-3127-3p	HITS-CLIP	19536157
MIRT711826	hsa-miR-6756-3p	HITS-CLIP	19536157
MIRT711825	hsa-miR-5088-3p	HITS-CLIP	19536157
MIRT711824	hsa-miR-1248	HITS-CLIP	19536157
MIRT711823	hsa-miR-4778-3p	HITS-CLIP	19536157
MIRT711822	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT711821	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT375251	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT500211	hsa-miR-3064-5p	PAR-CLIP	20371350
MIRT500210	hsa-miR-6504-5p	PAR-CLIP	20371350
MIRT500209	hsa-miR-3184-5p	PAR-CLIP	20371350
MIRT500208	hsa-miR-423-5p	PAR-CLIP	20371350
MIRT500207	hsa-miR-6720-3p	PAR-CLIP	20371350
MIRT500206	hsa-miR-3960	PAR-CLIP	20371350
MIRT500205	hsa-miR-8072	PAR-CLIP	20371350
MIRT500203	hsa-miR-566	PAR-CLIP	20371350
MIRT500202	hsa-miR-4467	PAR-CLIP	20371350
MIRT500201	hsa-miR-3652	PAR-CLIP	20371350
MIRT500200	hsa-miR-4430	PAR-CLIP	20371350
MIRT500198	hsa-miR-4505	PAR-CLIP	20371350
MIRT500199	hsa-miR-5787	PAR-CLIP	20371350
MIRT500197	hsa-miR-3180	PAR-CLIP	20371350
MIRT500196	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT500195	hsa-miR-3196	PAR-CLIP	20371350
MIRT500194	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT500193	hsa-miR-6842-3p	PAR-CLIP	20371350
MIRT375251	hsa-miR-5197-3p	PAR-CLIP	20371350
MIRT500211	hsa-miR-3064-5p	PAR-CLIP	20371350
MIRT500210	hsa-miR-6504-5p	PAR-CLIP	20371350
MIRT500209	hsa-miR-3184-5p	PAR-CLIP	20371350
MIRT500208	hsa-miR-423-5p	PAR-CLIP	20371350
MIRT500207	hsa-miR-6720-3p	PAR-CLIP	20371350
MIRT500206	hsa-miR-3960	PAR-CLIP	20371350
MIRT500205	hsa-miR-8072	PAR-CLIP	20371350
MIRT500204	hsa-miR-5580-5p	PAR-CLIP	20371350
MIRT500203	hsa-miR-566	PAR-CLIP	20371350
MIRT500202	hsa-miR-4467	PAR-CLIP	20371350
MIRT500201	hsa-miR-3652	PAR-CLIP	20371350
MIRT500200	hsa-miR-4430	PAR-CLIP	20371350
MIRT500198	hsa-miR-4505	PAR-CLIP	20371350
MIRT500199	hsa-miR-5787	PAR-CLIP	20371350
MIRT500197	hsa-miR-3180	PAR-CLIP	20371350
MIRT500196	hsa-miR-3180-3p	PAR-CLIP	20371350
MIRT500195	hsa-miR-3196	PAR-CLIP	20371350
MIRT500194	hsa-miR-6816-5p	PAR-CLIP	20371350
MIRT500193	hsa-miR-6842-3p	PAR-CLIP	20371350
MIRT375251	hsa-miR-5197-3p	PAR-CLIP	24398324
MIRT500211	hsa-miR-3064-5p	PAR-CLIP	24398324
MIRT500210	hsa-miR-6504-5p	PAR-CLIP	24398324
MIRT500209	hsa-miR-3184-5p	PAR-CLIP	24398324
MIRT500208	hsa-miR-423-5p	PAR-CLIP	24398324
MIRT500207	hsa-miR-6720-3p	PAR-CLIP	24398324
MIRT500206	hsa-miR-3960	PAR-CLIP	24398324
MIRT500205	hsa-miR-8072	PAR-CLIP	24398324
MIRT500204	hsa-miR-5580-5p	PAR-CLIP	24398324
MIRT500203	hsa-miR-566	PAR-CLIP	24398324
MIRT500202	hsa-miR-4467	PAR-CLIP	24398324
MIRT500201	hsa-miR-3652	PAR-CLIP	24398324
MIRT500200	hsa-miR-4430	PAR-CLIP	24398324
MIRT500198	hsa-miR-4505	PAR-CLIP	24398324
MIRT500199	hsa-miR-5787	PAR-CLIP	24398324
MIRT500197	hsa-miR-3180	PAR-CLIP	24398324
MIRT500196	hsa-miR-3180-3p	PAR-CLIP	24398324
MIRT500195	hsa-miR-3196	PAR-CLIP	24398324
MIRT500194	hsa-miR-6816-5p	PAR-CLIP	24398324
MIRT500193	hsa-miR-6842-3p	PAR-CLIP	24398324
MIRT1131171	hsa-miR-1207-5p	CLIP-seq
MIRT1131172	hsa-miR-1224-3p	CLIP-seq
MIRT1131173	hsa-miR-1260	CLIP-seq
MIRT1131174	hsa-miR-1260b	CLIP-seq
MIRT1131175	hsa-miR-1273e	CLIP-seq
MIRT1131176	hsa-miR-1275	CLIP-seq
MIRT1131177	hsa-miR-1280	CLIP-seq
MIRT1131178	hsa-miR-1324	CLIP-seq
MIRT1131179	hsa-miR-1343	CLIP-seq
MIRT1131180	hsa-miR-146b-3p	CLIP-seq
MIRT1131181	hsa-miR-1827	CLIP-seq
MIRT1131182	hsa-miR-1908	CLIP-seq
MIRT1131183	hsa-miR-1909	CLIP-seq
MIRT1131184	hsa-miR-208a	CLIP-seq
MIRT1131185	hsa-miR-208b	CLIP-seq
MIRT1131186	hsa-miR-22	CLIP-seq
MIRT1131187	hsa-miR-2392	CLIP-seq
MIRT1131188	hsa-miR-2467-5p	CLIP-seq
MIRT1131189	hsa-miR-28-5p	CLIP-seq
MIRT1131190	hsa-miR-3126-5p	CLIP-seq
MIRT1131191	hsa-miR-3139	CLIP-seq
MIRT1131192	hsa-miR-3173-5p	CLIP-seq
MIRT1131193	hsa-miR-3188	CLIP-seq
MIRT1131194	hsa-miR-3189-5p	CLIP-seq
MIRT1131195	hsa-miR-3192	CLIP-seq
MIRT1131196	hsa-miR-320e	CLIP-seq
MIRT1131197	hsa-miR-3612	CLIP-seq
MIRT1131198	hsa-miR-3616-3p	CLIP-seq
MIRT1131199	hsa-miR-3617	CLIP-seq
MIRT1131200	hsa-miR-3620	CLIP-seq
MIRT1131201	hsa-miR-3689a-3p	CLIP-seq
MIRT1131202	hsa-miR-3689c	CLIP-seq
MIRT1131203	hsa-miR-3918	CLIP-seq
MIRT1131204	hsa-miR-3926	CLIP-seq
MIRT1131205	hsa-miR-3929	CLIP-seq
MIRT1131206	hsa-miR-3975	CLIP-seq
MIRT1131207	hsa-miR-4251	CLIP-seq
MIRT1131208	hsa-miR-4274	CLIP-seq
MIRT1131209	hsa-miR-4292	CLIP-seq
MIRT1131210	hsa-miR-4293	CLIP-seq
MIRT1131211	hsa-miR-4314	CLIP-seq
MIRT1131212	hsa-miR-4324	CLIP-seq
MIRT1131213	hsa-miR-4327	CLIP-seq
MIRT1131214	hsa-miR-4419b	CLIP-seq
MIRT1131215	hsa-miR-4433	CLIP-seq
MIRT1131216	hsa-miR-4435	CLIP-seq
MIRT1131217	hsa-miR-4459	CLIP-seq
MIRT1131218	hsa-miR-4478	CLIP-seq
MIRT1131219	hsa-miR-4488	CLIP-seq
MIRT1131220	hsa-miR-4512	CLIP-seq
MIRT1131221	hsa-miR-4519	CLIP-seq
MIRT1131222	hsa-miR-4525	CLIP-seq
MIRT1131223	hsa-miR-4646-5p	CLIP-seq
MIRT1131224	hsa-miR-4649-3p	CLIP-seq
MIRT1131225	hsa-miR-4663	CLIP-seq
MIRT1131226	hsa-miR-4665-5p	CLIP-seq
MIRT1131227	hsa-miR-4685-5p	CLIP-seq
MIRT1131228	hsa-miR-4691-5p	CLIP-seq
MIRT1131229	hsa-miR-4695-5p	CLIP-seq
MIRT1131230	hsa-miR-4697-5p	CLIP-seq
MIRT1131231	hsa-miR-4700-3p	CLIP-seq
MIRT1131232	hsa-miR-4714-3p	CLIP-seq
MIRT1131233	hsa-miR-4721	CLIP-seq
MIRT1131234	hsa-miR-4723-5p	CLIP-seq
MIRT1131235	hsa-miR-4728-5p	CLIP-seq
MIRT1131236	hsa-miR-4729	CLIP-seq
MIRT1131237	hsa-miR-4761-5p	CLIP-seq
MIRT1131238	hsa-miR-4763-3p	CLIP-seq
MIRT1131239	hsa-miR-4763-5p	CLIP-seq
MIRT1131240	hsa-miR-4787-5p	CLIP-seq
MIRT1131241	hsa-miR-483-3p	CLIP-seq
MIRT1131242	hsa-miR-485-5p	CLIP-seq
MIRT1131243	hsa-miR-499-5p	CLIP-seq
MIRT1131244	hsa-miR-539	CLIP-seq
MIRT1131245	hsa-miR-544b	CLIP-seq
MIRT1131246	hsa-miR-558	CLIP-seq
MIRT1131247	hsa-miR-593	CLIP-seq
MIRT1131248	hsa-miR-605	CLIP-seq
MIRT1131249	hsa-miR-625	CLIP-seq
MIRT1131250	hsa-miR-629	CLIP-seq
MIRT1131251	hsa-miR-637	CLIP-seq
MIRT1131252	hsa-miR-641	CLIP-seq
MIRT1131253	hsa-miR-650	CLIP-seq
MIRT1131254	hsa-miR-663	CLIP-seq
MIRT1131255	hsa-miR-663b	CLIP-seq
MIRT1131256	hsa-miR-665	CLIP-seq
MIRT1131257	hsa-miR-671-5p	CLIP-seq
MIRT1131258	hsa-miR-708	CLIP-seq
MIRT1131259	hsa-miR-759	CLIP-seq
MIRT1131260	hsa-miR-874	CLIP-seq
MIRT1131261	hsa-miR-885-3p	CLIP-seq
MIRT1131262	hsa-miR-940	CLIP-seq
MIRT1131171	hsa-miR-1207-5p	CLIP-seq
MIRT1131181	hsa-miR-1827	CLIP-seq
MIRT1131197	hsa-miR-3612	CLIP-seq
MIRT1131217	hsa-miR-4459	CLIP-seq
MIRT1131227	hsa-miR-4685-5p	CLIP-seq
MIRT1131229	hsa-miR-4695-5p	CLIP-seq
MIRT1131238	hsa-miR-4763-3p	CLIP-seq
MIRT1131253	hsa-miR-650	CLIP-seq
MIRT1131262	hsa-miR-940	CLIP-seq
MIRT2267285	hsa-miR-1207-3p	CLIP-seq
MIRT1131171	hsa-miR-1207-5p	CLIP-seq
MIRT2267286	hsa-miR-1285	CLIP-seq
MIRT1131178	hsa-miR-1324	CLIP-seq
MIRT2267287	hsa-miR-2278	CLIP-seq
MIRT2267288	hsa-miR-3144-5p	CLIP-seq
MIRT2267289	hsa-miR-3187-5p	CLIP-seq
MIRT2267290	hsa-miR-3191	CLIP-seq
MIRT2267291	hsa-miR-342-5p	CLIP-seq
MIRT2267292	hsa-miR-4270	CLIP-seq
MIRT2267293	hsa-miR-4441	CLIP-seq
MIRT2267294	hsa-miR-4651	CLIP-seq
MIRT2267295	hsa-miR-4652-5p	CLIP-seq
MIRT2267296	hsa-miR-4664-5p	CLIP-seq
MIRT2267297	hsa-miR-4731-5p	CLIP-seq
MIRT1131238	hsa-miR-4763-3p	CLIP-seq
MIRT2267298	hsa-miR-491-5p	CLIP-seq
MIRT2267299	hsa-miR-608	CLIP-seq
MIRT2267300	hsa-miR-612	CLIP-seq
MIRT1131251	hsa-miR-637	CLIP-seq
MIRT2267285	hsa-miR-1207-3p	CLIP-seq
MIRT1131183	hsa-miR-1909	CLIP-seq
MIRT2267288	hsa-miR-3144-5p	CLIP-seq
MIRT2267290	hsa-miR-3191	CLIP-seq
MIRT2267291	hsa-miR-342-5p	CLIP-seq
MIRT2267294	hsa-miR-4651	CLIP-seq
MIRT2267295	hsa-miR-4652-5p	CLIP-seq
MIRT2267296	hsa-miR-4664-5p	CLIP-seq
MIRT2267297	hsa-miR-4731-5p	CLIP-seq
MIRT2267298	hsa-miR-491-5p	CLIP-seq
MIRT2267299	hsa-miR-608	CLIP-seq
MIRT1131260	hsa-miR-874	CLIP-seq
MIRT2567031	hsa-miR-1224-5p	CLIP-seq
MIRT1131180	hsa-miR-146b-3p	CLIP-seq
MIRT2567032	hsa-miR-18a	CLIP-seq
MIRT2567033	hsa-miR-18b	CLIP-seq
MIRT2567034	hsa-miR-2682	CLIP-seq
MIRT2567035	hsa-miR-3136-3p	CLIP-seq
MIRT1131192	hsa-miR-3173-5p	CLIP-seq
MIRT2567036	hsa-miR-3690	CLIP-seq
MIRT2567037	hsa-miR-371-3p	CLIP-seq
MIRT2567038	hsa-miR-371b-3p	CLIP-seq
MIRT2567039	hsa-miR-378	CLIP-seq
MIRT2567040	hsa-miR-378b	CLIP-seq
MIRT2567041	hsa-miR-378c	CLIP-seq
MIRT2567042	hsa-miR-378d	CLIP-seq
MIRT2567043	hsa-miR-378e	CLIP-seq
MIRT2567044	hsa-miR-378f	CLIP-seq
MIRT2567045	hsa-miR-378h	CLIP-seq
MIRT2567046	hsa-miR-378i	CLIP-seq
MIRT2567047	hsa-miR-3915	CLIP-seq
MIRT2567048	hsa-miR-422a	CLIP-seq
MIRT2567049	hsa-miR-4267	CLIP-seq
MIRT2567050	hsa-miR-4308	CLIP-seq
MIRT2567051	hsa-miR-449c	CLIP-seq
MIRT2567052	hsa-miR-4522	CLIP-seq
MIRT2567053	hsa-miR-4689	CLIP-seq
MIRT2567054	hsa-miR-4735-3p	CLIP-seq
MIRT2567055	hsa-miR-4751	CLIP-seq
MIRT1131237	hsa-miR-4761-5p	CLIP-seq
MIRT2567056	hsa-miR-515-3p	CLIP-seq
MIRT2567057	hsa-miR-519e	CLIP-seq
MIRT2567058	hsa-miR-550a	CLIP-seq
MIRT2567059	hsa-miR-661	CLIP-seq
MIRT1131260	hsa-miR-874	CLIP-seq
MIRT1131262	hsa-miR-940	CLIP-seq
MIRT2684591	hsa-miR-1915	CLIP-seq
MIRT2684592	hsa-miR-2467-3p	CLIP-seq
MIRT2567034	hsa-miR-2682	CLIP-seq
MIRT2684593	hsa-miR-296-5p	CLIP-seq
MIRT2567035	hsa-miR-3136-3p	CLIP-seq
MIRT2684594	hsa-miR-3678-3p	CLIP-seq
MIRT2567037	hsa-miR-371-3p	CLIP-seq
MIRT2567038	hsa-miR-371b-3p	CLIP-seq
MIRT2684595	hsa-miR-4257	CLIP-seq
MIRT2567049	hsa-miR-4267	CLIP-seq
MIRT2684596	hsa-miR-4436b-3p	CLIP-seq
MIRT2567051	hsa-miR-449c	CLIP-seq
MIRT2684597	hsa-miR-4514	CLIP-seq
MIRT1131227	hsa-miR-4685-5p	CLIP-seq
MIRT2684598	hsa-miR-4692	CLIP-seq
MIRT2567056	hsa-miR-515-3p	CLIP-seq
MIRT2567057	hsa-miR-519e	CLIP-seq
MIRT2684599	hsa-miR-541	CLIP-seq
MIRT2567058	hsa-miR-550a	CLIP-seq
MIRT2684600	hsa-miR-654-5p	CLIP-seq
MIRT2567059	hsa-miR-661	CLIP-seq
MIRT1131262	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	ISS
GO:0000165	Process	MAPK cascade	IEA
GO:0005078	Function	MAP-kinase scaffold activity	IBA
GO:0005078	Function	MAP-kinase scaffold activity	IEA
GO:0005078	Function	MAP-kinase scaffold activity	ISS
GO:0005515	Function	Protein binding	IPI	27107012, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0008432	Function	JUN kinase binding	IBA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0016192	Process	Vesicle-mediated transport	ISS
GO:0019894	Function	Kinesin binding	IBA
GO:0019894	Function	Kinesin binding	ISS
GO:0030159	Function	Signaling receptor complex adaptor activity	IBA
GO:0030424	Component	Axon	IEA
GO:0030424	Component	Axon	ISS
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0030426	Component	Growth cone	IEA
GO:0031103	Process	Axon regeneration	ISS
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IMP	33022230
GO:0044297	Component	Cell body	ISS
GO:0046328	Process	Regulation of JNK cascade	ISS
GO:0046330	Process	Positive regulation of JNK cascade	ISS
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	ISS
GO:0050821	Process	Protein stabilization	IMP	33022230
GO:0061564	Process	Axon development	ISS
GO:0099641	Process	Anterograde axonal protein transport	ISS
GO:1904115	Component	Axon cytoplasm	IEA

Other IDs

• MIM: 605431
• HGNC: 6884
• e!Ensembl: ENSG00000138834

Protein

• UniProt ID: Q9UPT6
• Protein name: C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
• Protein function: The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12189133). May function as a regulator of ve
• PDB: 4PXJ, 8PR2, 8PR3, 8PR4, 8PTK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF09744	Jnk-SapK_ap_N	29 → 184	JNK_SAPK-associated protein-1	Family
  PF16471	JIP_LZII	414 → 484	JNK-interacting protein leucine zipper II	Coiled-coil
  PF19056	WD40_2	943 → 1174		Repeat

• Sequence:

  MMEIQMDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVV
  NVLENLDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKK
  ELQIQVEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIE
  RSKMQQVGGNSQTESSLPGRRKERPTSLNVFPLADGTVRAQIGGKLVPAGDHWHLSDLGQ
  LQSSSSYQCPQDEMSESGQSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDYGV
  GSKNSKRAREKRDSRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPETRLD
  RTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMGKEV
  GNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELE
  EELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKE
  RLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHY
  KSPTTAGFSQRRNHAMCPISAGSRPLEFFPDDDCTSSARREQKREQYRQVREHVRNDDGR
  LQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWRP
  NEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEKKKAKELPEMDATSSRVWILTSTL
  TTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSDVNPEDPGAD
  GVLAGITLVGCATRCNVPRSNCSSRGDTPVLDKGQGEVATIANGKVNPSQSTEEATEATE
  VPDPGPSEPETATLRPGPLTEHVFTDPAPTPSSGPQPGSENGPEPDSSSTRPEPEPSGDP
  TGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLHSIKLKDSVLSLVHVKGRVLVALADGT
  LAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKS
  FDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLYHAHTHQHLQDVDIEPYVSKMLGTGKL
  GFSFVRITALLVAGSRLWVGTGNGVVISIPLTETVVLHRGQLLGLRANKTSPTSGEGARP
  GGIIHVYGDDSSDRAASSFIPYCSMAQAQLCFHGHRDAVKFFVSVPGNVLATLNGSVLDS
  PAEGPGPAAPASEVEGQKLRNVLVLSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSK
  AERSHIIVWQVSYTPE

• Sequence length: 1336

Pathways

KEGG:

MAPK signaling pathway

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
MAPK8IP3-related disorder	Likely pathogenic	rs770703007	RCV000735203	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental disorder	Likely pathogenic; Pathogenic	rs1567203083	RCV002470976	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Neurodevelopmental disorder with or without variable brain abnormalities; NEDBA	Likely pathogenic; Pathogenic	rs2547945615, rs2548090655, rs2547945307, rs770703007, rs1567128142, rs1567198751, rs1567203083, rs1567214097, rs1479142047, rs2037399601, rs1596766963	RCV002470481 RCV003148576 RCV003321468 RCV000779602 RCV000779601 RCV000779603 RCV000779604 RCV000779605 RCV000993678 RCV001172334 RCV001172335	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
2-3 finger cutaneous syndactyly	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL DISABILITIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Global developmental delay	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT VARIABLE BRAIN ABNORMALITIES	—	Disgenet, HPO Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDER WITH OR WITHOUT VARIABLE BRAIN ABNORMALITIES, NEDBA	—	CTD, ClinGen, ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-SPECIFIC SYNDROMIC INTELLECTUAL DISABILITY	—	Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
POLYCYSTIC OVARY SYNDROME	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uveal melanoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	33788575	Inhibit	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	12105094		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	16141199		★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain neoplasms	Pubtator	16141199	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26504170	Associate	★☆☆☆☆ Found in Text Mining only
Cerebellar Hypoplasia	Cerebellar Hypoplasia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Cerebral atrophy	Cerebral Atrophy	HPO_DG			★☆☆☆☆ Found in Text Mining only
Clinodactyly of the 5th finger	Camptodactyly of fingers	HPO_DG			★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	37330543	Associate	★☆☆☆☆ Found in Text Mining only
Dysarthria	Dysarthria	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Edema	Edema	Pubtator	35013510	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	26002316		★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	26002316		★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	GENOMICS_ENGLAND_DG	28135719		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Global developmental delay	Developmental Delay	HPO_DG			★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Global developmental delay	Developmental Delay	CLINVAR_DG			★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Hypertrophic Cardiomyopathy	Hypertrophic cardiomyopathy	BEFREE	29604277		★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	28135719		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	30612693		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	16141199, 26504170		★☆☆☆☆ Found in Text Mining only
Microstomia	Microstomia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Neonatal Hypotonia	Hypotonia	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	37330543	Associate	★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	CTD_human_DG	21411543		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	BEFREE	12105094		★☆☆☆☆ Found in Text Mining only
Sclerocystic Ovaries	Sclerocystic Ovaries	CTD_human_DG	21411543		★☆☆☆☆ Found in Text Mining only
Scoliosis, unspecified	Scoliosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Severe intellectual disability	Mental retardation	BEFREE	30612693		★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★☆☆☆☆ Found in Text Mining only
Subarachnoid Hemorrhage	Subarachnoid hemorrhage	BEFREE	28396258		★☆☆☆☆ Found in Text Mining only