DCUN1D4 (defective in cullin neddylation 1 domain containing 4)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 23142 |
| Gene name | Defective in cullin neddylation 1 domain containing 4 |
| Gene symbol | DCUN1D4 |
| Synonyms (NCBI Gene) |
DCNL4
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| Chromosome | 4 |
| Chromosome location | 4q12 |
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miRNA
miRNA information provided by mirtarbase database.
671
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q92564 | ||||||||||
| Protein name | DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4) | ||||||||||
| Protein function | Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin | ||||||||||
| PDB | 5V89 | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 292 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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