Gene Gene information from NCBI Gene database.
Entrez ID 23142
Gene name Defective in cullin neddylation 1 domain containing 4
Gene symbol DCUN1D4
Synonyms (NCBI Gene)
DCNL4
Chromosome 4
Chromosome location 4q12
miRNA miRNA information provided by mirtarbase database.
671
miRTarBase ID miRNA Experiments Reference
MIRT019951 hsa-miR-375 Microarray 20215506
MIRT050924 hsa-miR-17-5p CLASH 23622248
MIRT164842 hsa-miR-27a-3p HITS-CLIP 22473208
MIRT164846 hsa-miR-27b-3p HITS-CLIP 22473208
MIRT927926 hsa-miR-1179 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IBA
GO:0005515 Function Protein binding IPI 21911577, 23201271, 26906416
GO:0005634 Component Nucleus IDA
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus IMP 26906416
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612977 28998 ENSG00000109184
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92564
Protein name DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4)
Protein function Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which are necessary for the activation of cullin-RING E3 ubiquitin
PDB 5V89
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03556 Cullin_binding 175 285 Cullin binding Family
Sequence
MHSDAAAVNFQLNSHLSTLANIHKIYHTLNKLNLTEDIGQDDHQTGSLRSCSSSDCFNKV
MPPRKKRRPASGDDLSAKKSRHDSMYRKYDSTRIKTEEEAFSSKRCLEWFYEYAGTDDVV
GPEGMEKFCEDIGVEPENVVMLVLAWKLDAQNMGYFTLQEWLKGMTSLQCDTTEKLRNTL
DYLRSFLNDSTNFKLIYRYAFDFAREKDQRSLDINTAKCMLGLLLGKIWPLFPVFHQFLE
QSKYKVINKDQWCNVLEFSRTINLDLSNYDEDGAWPVLLDEFVEW
YKDKQMS
Sequence length 292
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neddylation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Squamous cell carcinoma of lung Lung carcinoma GWASCAT_DG 29924316
★☆☆☆☆
Found in Text Mining only