Gene Gene information from NCBI Gene database.
Entrez ID 23136
Gene name Erythrocyte membrane protein band 4.1 like 3
Gene symbol EPB41L3
Synonyms (NCBI Gene)
4.1BDAL-1DAL1
Chromosome 18
Chromosome location 18p11.31
miRNA miRNA information provided by mirtarbase database.
141
miRTarBase ID miRNA Experiments Reference
MIRT006374 hsa-miR-223-3p Luciferase reporter assayWestern blot 21628394
MIRT006374 hsa-miR-223-3p Luciferase reporter assayWestern blot 21628394
MIRT006374 hsa-miR-223-3p Luciferase reporter assayWestern blot 21628394
MIRT051992 hsa-let-7b-5p CLASH 23622248
MIRT049330 hsa-miR-92a-3p CLASH 23622248
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
ERG Repression 20860828
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
40
GO ID Ontology Definition Evidence Reference
GO:0002175 Process Protein localization to paranode region of axon ISS
GO:0003779 Function Actin binding IEA
GO:0005198 Function Structural molecule activity IEA
GO:0005200 Function Structural constituent of cytoskeleton TAS 21966409
GO:0005515 Function Protein binding IPI 12234973, 20936779, 24366813, 25416956, 32296183, 33961781, 36931259
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605331 3380 ENSG00000082397
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y2J2
Protein name Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]
Protein function Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. {ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:1
PDB 2HE7 , 3BIN , 5RYM , 5RYN , 5RYO , 5RYP , 5RYQ , 5RYR , 5RYS , 5RYT , 5RYU , 5RYV , 5RYW , 5RYX , 5RYY , 5RYZ , 5RZ0 , 5RZ1 , 5RZ2 , 5RZ3 , 5RZ4 , 5RZ5 , 5RZ6 , 5RZ7 , 5RZ8 , 5RZ9 , 5RZA , 5RZB , 5RZC , 5RZD , 5RZE , 5RZF , 5RZG , 5RZH , 5RZI , 5RZJ , 5RZK , 5RZL , 5RZM , 5RZN , 5RZO , 5RZP , 5RZQ , 5RZR , 5RZS , 5RZT , 5RZU , 5RZV , 5RZW , 5RZX , 5RZY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09379 FERM_N 114 177 FERM N-terminal domain Domain
PF00373 FERM_M 192 301 FERM central domain Domain
PF09380 FERM_C 305 395 FERM C-terminal PH-like domain Domain
PF08736 FA 398 441 FERM adjacent (FA) Family
PF04382 SAB 717 765 SAB domain Domain
PF05902 4_1_CTD 973 1079 4.1 protein C-terminal domain (CTD) Domain
Tissue specificity TISSUE SPECIFICITY: Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung. {ECO:0000269|PubMed:9892180}.
Sequence
MTTESGSDSESKPDQEAEPQEAAGAQGRAGAPVPEPPKEEQQQALEQFAAAAAHSTPVRR
EVTDKEQEFAARAAKQLEYQQLEDDKLSQKSSSSKLSRSPLKIVKKPKSMQCKVILLDGS
EYTCDVEKRSRGQVLFDKVCEHLNLLEKDYFGLTYRDAENQKNWLDPAKEIKKQVRS
GAW
HFSFNVKFYPPDPAQLSEDITRYYLCLQLRDDIVSGRLPCSFVTLALLGSYTVQSELGDY
DPDECGSDYISEFRFAPNHTKELEDKVIELHKSHRGMTPAEAEMHFLENAKKLSMYGVDL
H
HAKDSEGVEIMLGVCASGLLIYRDRLRINRFAWPKVLKISYKRNNFYIKIRPGEFEQFE
STIGFKLPNHRAAKRLWKVCVEHHTFFRLLLPEAP
PKKFLTLGSKFRYSGRTQAQTRRAS
ALIDRPAPYFERSSSKRYTMS
RSLDGEVGTGQYATTKGISQTNLITTVTPEKKAEEERDE
EEDKRRKGEEVTPISAIRHEGKSPGLGTDSCPLSPPSTHCAPTSPTELRRRCKENDCKLP
GYEPSRAEHLPGEPALDSDGPGRPYLGDQDVAFSYRQQTGKGTTLFSFSLQLPESFPSLL
DDDGYLSFPNLSETNLLPQSLQHYLPIRSPSLVPCFLFIFFFLLSASFSVPYALTLSFPL
ALCLCYLEPKAASLSASLDNDPSDSSEEETDSERTDTAADGETTATESDQEEDAELKAQE
LEKTQDDLMKHQTNISELKRTFLETSTDTAVTNEWEKRLSTSPVR
LAARQEDAPMIEPLV
PEETKQSSGEKLMDGSEIFSLLESARKPTEFIGGVTSTSQSWVQKMETKTESSGIETEPT
VHHLPLSTEKVVQETVLVEERRVVHASGDASYSAGDSGDAAAQPAFTGIKGKEGSALTEG
AKEEGGEEVAKAVLEQEETAAASRERQEEQSAAIHISETLEQKPHFESSTVKTETISFGS
VSPGGVKLEISTKEVPVVHTETKTITYESSQVDPGTDLEPGVLMSAQTITSETTSTTTTT
HITKTVKGGISETRIEKRIVITGDADIDHDQALAQAIKEAKEQHPDMSVTKVVVHKETE
I
TPEDGED
Sequence length 1087
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Neurexins and neuroligins
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BREAST CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BREAST NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Adenocarcinoma BEFREE 15837747, 26222671
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 10888600, 15116094, 15837747, 16142420, 19846932, 26300315, 29048640, 9892180
★☆☆☆☆
Found in Text Mining only
Anaplasia Anaplasia Pubtator 14601094 Associate
★☆☆☆☆
Found in Text Mining only
Anodontia Anodontia Pubtator 31828581 Associate
★☆☆☆☆
Found in Text Mining only
Azoospermia Azoospermia Pubtator 37283758 Associate
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain Neoplasms BEFREE 10888600
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain neoplasms Pubtator 15731777 Inhibit
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 17260099, 19846932
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Carcinoma Breast Carcinoma CTD_human_DG 17260099
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Breast Neoplasms Breast neoplasm Pubtator 11996670 Inhibit
★★☆☆☆
Found in Text Mining + Unknown/Other Associations