NFASC (neurofascin)

Gene

• Entrez ID: 23114
• Gene name: Neurofascin
• Gene symbol: NFASC
• Synonyms (NCBI Gene): NEDCPMD, NF, NRCAML
• Chromosome: 1
• Chromosome location: 1q32.1
• Summary: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs754724304	T>A,G	Pathogenic	Coding sequence variant, genic downstream transcript variant, missense variant
rs755160624	C>T	Pathogenic	Intron variant, coding sequence variant, stop gained, genic downstream transcript variant
rs767453033	G>A,C	Pathogenic	Non coding transcript variant, 5 prime UTR variant, coding sequence variant, missense variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT725328	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT725326	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT725325	hsa-miR-4496	HITS-CLIP	19536157
MIRT725324	hsa-miR-5088-5p	HITS-CLIP	19536157
MIRT725323	hsa-miR-4446-3p	HITS-CLIP	19536157
MIRT725322	hsa-miR-3158-3p	HITS-CLIP	19536157
MIRT725321	hsa-miR-4656	HITS-CLIP	19536157
MIRT725319	hsa-miR-1296-5p	HITS-CLIP	19536157
MIRT725320	hsa-miR-2909	HITS-CLIP	19536157
MIRT655882	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT655881	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT655880	hsa-miR-4640-3p	HITS-CLIP	23824327
MIRT655879	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT655878	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT655877	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT655876	hsa-miR-5695	HITS-CLIP	23824327
MIRT655875	hsa-miR-3184-5p	HITS-CLIP	23824327
MIRT655874	hsa-miR-423-5p	HITS-CLIP	23824327
MIRT655872	hsa-miR-4290	HITS-CLIP	23824327
MIRT655873	hsa-miR-6825-5p	HITS-CLIP	23824327
MIRT487202	hsa-miR-490-3p	PAR-CLIP	20371350
MIRT487201	hsa-miR-7851-3p	PAR-CLIP	20371350
MIRT487200	hsa-miR-6798-5p	PAR-CLIP	20371350
MIRT487199	hsa-miR-204-3p	PAR-CLIP	20371350
MIRT487198	hsa-miR-4646-5p	PAR-CLIP	20371350
MIRT487197	hsa-miR-4487	PAR-CLIP	20371350
MIRT487196	hsa-miR-6132	PAR-CLIP	20371350
MIRT487195	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT487194	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT487192	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT487193	hsa-miR-4327	PAR-CLIP	20371350
MIRT487191	hsa-miR-1292-5p	PAR-CLIP	20371350
MIRT487190	hsa-miR-4471	PAR-CLIP	20371350
MIRT487189	hsa-miR-8059	PAR-CLIP	20371350
MIRT487188	hsa-miR-4300	PAR-CLIP	20371350
MIRT487187	hsa-miR-5591-5p	PAR-CLIP	20371350
MIRT487185	hsa-miR-6726-5p	PAR-CLIP	20371350
MIRT487186	hsa-miR-920	PAR-CLIP	20371350
MIRT487184	hsa-miR-1343-5p	PAR-CLIP	20371350
MIRT487183	hsa-miR-939-5p	PAR-CLIP	20371350
MIRT487181	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT487182	hsa-miR-5698	PAR-CLIP	20371350
MIRT487180	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT487179	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT487178	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT487177	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT487176	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT487175	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT487174	hsa-miR-8082	PAR-CLIP	20371350
MIRT487202	hsa-miR-490-3p	PAR-CLIP	23592263
MIRT487201	hsa-miR-7851-3p	PAR-CLIP	23592263
MIRT487200	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT487199	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT487198	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT487197	hsa-miR-4487	PAR-CLIP	23592263
MIRT487196	hsa-miR-6132	PAR-CLIP	23592263
MIRT487195	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT487194	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT487192	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT487193	hsa-miR-4327	PAR-CLIP	23592263
MIRT487191	hsa-miR-1292-5p	PAR-CLIP	23592263
MIRT487190	hsa-miR-4471	PAR-CLIP	23592263
MIRT487189	hsa-miR-8059	PAR-CLIP	23592263
MIRT487188	hsa-miR-4300	PAR-CLIP	23592263
MIRT487187	hsa-miR-5591-5p	PAR-CLIP	23592263
MIRT487185	hsa-miR-6726-5p	PAR-CLIP	23592263
MIRT487186	hsa-miR-920	PAR-CLIP	23592263
MIRT487184	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT487183	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT487181	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT487182	hsa-miR-5698	PAR-CLIP	23592263
MIRT487180	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT487179	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT487178	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT487177	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT487176	hsa-miR-6511b-5p	PAR-CLIP	23592263
MIRT487175	hsa-miR-6811-5p	PAR-CLIP	23592263
MIRT487174	hsa-miR-8082	PAR-CLIP	23592263
MIRT725328	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT725326	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT725325	hsa-miR-4496	HITS-CLIP	19536157
MIRT725324	hsa-miR-5088-5p	HITS-CLIP	19536157
MIRT725323	hsa-miR-4446-3p	HITS-CLIP	19536157
MIRT725322	hsa-miR-3158-3p	HITS-CLIP	19536157
MIRT725321	hsa-miR-4656	HITS-CLIP	19536157
MIRT725319	hsa-miR-1296-5p	HITS-CLIP	19536157
MIRT725320	hsa-miR-2909	HITS-CLIP	19536157
MIRT655882	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT655881	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT655880	hsa-miR-4640-3p	HITS-CLIP	23824327
MIRT655879	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT655878	hsa-miR-7113-5p	HITS-CLIP	23824327
MIRT655877	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT655876	hsa-miR-5695	HITS-CLIP	23824327
MIRT655875	hsa-miR-3184-5p	HITS-CLIP	23824327
MIRT655874	hsa-miR-423-5p	HITS-CLIP	23824327
MIRT655872	hsa-miR-4290	HITS-CLIP	23824327
MIRT655873	hsa-miR-6825-5p	HITS-CLIP	23824327
MIRT487202	hsa-miR-490-3p	PAR-CLIP	20371350
MIRT487201	hsa-miR-7851-3p	PAR-CLIP	20371350
MIRT487200	hsa-miR-6798-5p	PAR-CLIP	20371350
MIRT487199	hsa-miR-204-3p	PAR-CLIP	20371350
MIRT487198	hsa-miR-4646-5p	PAR-CLIP	20371350
MIRT487197	hsa-miR-4487	PAR-CLIP	20371350
MIRT487196	hsa-miR-6132	PAR-CLIP	20371350
MIRT487195	hsa-miR-6836-5p	PAR-CLIP	20371350
MIRT487194	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT487192	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT487193	hsa-miR-4327	PAR-CLIP	20371350
MIRT487191	hsa-miR-1292-5p	PAR-CLIP	20371350
MIRT487190	hsa-miR-4471	PAR-CLIP	20371350
MIRT487189	hsa-miR-8059	PAR-CLIP	20371350
MIRT487188	hsa-miR-4300	PAR-CLIP	20371350
MIRT487187	hsa-miR-5591-5p	PAR-CLIP	20371350
MIRT487185	hsa-miR-6726-5p	PAR-CLIP	20371350
MIRT487186	hsa-miR-920	PAR-CLIP	20371350
MIRT487184	hsa-miR-1343-5p	PAR-CLIP	20371350
MIRT487183	hsa-miR-939-5p	PAR-CLIP	20371350
MIRT487181	hsa-miR-4723-5p	PAR-CLIP	20371350
MIRT487182	hsa-miR-5698	PAR-CLIP	20371350
MIRT487180	hsa-miR-6870-5p	PAR-CLIP	20371350
MIRT487179	hsa-miR-7111-5p	PAR-CLIP	20371350
MIRT487178	hsa-miR-6795-5p	PAR-CLIP	20371350
MIRT487177	hsa-miR-6887-5p	PAR-CLIP	20371350
MIRT487176	hsa-miR-6511b-5p	PAR-CLIP	20371350
MIRT487175	hsa-miR-6811-5p	PAR-CLIP	20371350
MIRT487174	hsa-miR-8082	PAR-CLIP	20371350
MIRT487202	hsa-miR-490-3p	PAR-CLIP	23592263
MIRT487201	hsa-miR-7851-3p	PAR-CLIP	23592263
MIRT487200	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT487199	hsa-miR-204-3p	PAR-CLIP	23592263
MIRT487198	hsa-miR-4646-5p	PAR-CLIP	23592263
MIRT487197	hsa-miR-4487	PAR-CLIP	23592263
MIRT487196	hsa-miR-6132	PAR-CLIP	23592263
MIRT487195	hsa-miR-6836-5p	PAR-CLIP	23592263
MIRT487194	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT487192	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT487193	hsa-miR-4327	PAR-CLIP	23592263
MIRT487191	hsa-miR-1292-5p	PAR-CLIP	23592263
MIRT487190	hsa-miR-4471	PAR-CLIP	23592263
MIRT487189	hsa-miR-8059	PAR-CLIP	23592263
MIRT487188	hsa-miR-4300	PAR-CLIP	23592263
MIRT487187	hsa-miR-5591-5p	PAR-CLIP	23592263
MIRT487185	hsa-miR-6726-5p	PAR-CLIP	23592263
MIRT487186	hsa-miR-920	PAR-CLIP	23592263
MIRT487184	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT487183	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT487181	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT487182	hsa-miR-5698	PAR-CLIP	23592263
MIRT487180	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT487179	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT487178	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT487177	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT487176	hsa-miR-6511b-5p	PAR-CLIP	23592263
MIRT487175	hsa-miR-6811-5p	PAR-CLIP	23592263
MIRT487174	hsa-miR-8082	PAR-CLIP	23592263
MIRT1181794	hsa-miR-1197	CLIP-seq
MIRT1181795	hsa-miR-1207-5p	CLIP-seq
MIRT1181796	hsa-miR-122	CLIP-seq
MIRT1181797	hsa-miR-1286	CLIP-seq
MIRT1181798	hsa-miR-1301	CLIP-seq
MIRT1181799	hsa-miR-1322	CLIP-seq
MIRT1181800	hsa-miR-3074-5p	CLIP-seq
MIRT1181801	hsa-miR-3124-3p	CLIP-seq
MIRT1181802	hsa-miR-3135b	CLIP-seq
MIRT1181803	hsa-miR-3160-3p	CLIP-seq
MIRT1181804	hsa-miR-370	CLIP-seq
MIRT1181805	hsa-miR-4436a	CLIP-seq
MIRT1181806	hsa-miR-4436b-5p	CLIP-seq
MIRT1181807	hsa-miR-4477a	CLIP-seq
MIRT1181808	hsa-miR-4660	CLIP-seq
MIRT1181809	hsa-miR-4663	CLIP-seq
MIRT1181810	hsa-miR-4736	CLIP-seq
MIRT1181811	hsa-miR-4763-3p	CLIP-seq
MIRT1181812	hsa-miR-4797-5p	CLIP-seq
MIRT1181813	hsa-miR-5047	CLIP-seq
MIRT1181814	hsa-miR-558	CLIP-seq
MIRT1181815	hsa-miR-759	CLIP-seq
MIRT1181816	hsa-miR-1270	CLIP-seq
MIRT1181817	hsa-miR-1976	CLIP-seq
MIRT1181818	hsa-miR-3690	CLIP-seq
MIRT1181819	hsa-miR-4254	CLIP-seq
MIRT1181820	hsa-miR-4683	CLIP-seq
MIRT1181821	hsa-miR-4719	CLIP-seq
MIRT1181822	hsa-miR-620	CLIP-seq
MIRT1181823	hsa-miR-3664-3p	CLIP-seq
MIRT1181824	hsa-miR-4433	CLIP-seq
MIRT1181825	hsa-miR-4459	CLIP-seq
MIRT1181826	hsa-miR-4768-3p	CLIP-seq
MIRT1181827	hsa-miR-510	CLIP-seq
MIRT1181828	hsa-miR-649	CLIP-seq
MIRT1181794	hsa-miR-1197	CLIP-seq
MIRT1181829	hsa-miR-1207-3p	CLIP-seq
MIRT1181795	hsa-miR-1207-5p	CLIP-seq
MIRT1181796	hsa-miR-122	CLIP-seq
MIRT1181797	hsa-miR-1286	CLIP-seq
MIRT1181830	hsa-miR-1470	CLIP-seq
MIRT1181831	hsa-miR-223	CLIP-seq
MIRT1181832	hsa-miR-3065-3p	CLIP-seq
MIRT1181800	hsa-miR-3074-5p	CLIP-seq
MIRT1181801	hsa-miR-3124-3p	CLIP-seq
MIRT1181802	hsa-miR-3135b	CLIP-seq
MIRT1181833	hsa-miR-3140-5p	CLIP-seq
MIRT1181834	hsa-miR-3157-5p	CLIP-seq
MIRT1181803	hsa-miR-3160-3p	CLIP-seq
MIRT1181835	hsa-miR-3620	CLIP-seq
MIRT1181836	hsa-miR-3670	CLIP-seq
MIRT1181804	hsa-miR-370	CLIP-seq
MIRT1181837	hsa-miR-4267	CLIP-seq
MIRT1181838	hsa-miR-4328	CLIP-seq
MIRT1181805	hsa-miR-4436a	CLIP-seq
MIRT1181806	hsa-miR-4436b-5p	CLIP-seq
MIRT1181839	hsa-miR-4469	CLIP-seq
MIRT1181808	hsa-miR-4660	CLIP-seq
MIRT1181809	hsa-miR-4663	CLIP-seq
MIRT1181840	hsa-miR-4667-3p	CLIP-seq
MIRT1181841	hsa-miR-4691-3p	CLIP-seq
MIRT1181842	hsa-miR-4712-3p	CLIP-seq
MIRT1181810	hsa-miR-4736	CLIP-seq
MIRT1181843	hsa-miR-4738-3p	CLIP-seq
MIRT1181811	hsa-miR-4763-3p	CLIP-seq
MIRT1181844	hsa-miR-4790-3p	CLIP-seq
MIRT1181812	hsa-miR-4797-5p	CLIP-seq
MIRT1181845	hsa-miR-486-3p	CLIP-seq
MIRT1181814	hsa-miR-558	CLIP-seq
MIRT1181846	hsa-miR-628-5p	CLIP-seq
MIRT1181847	hsa-miR-766	CLIP-seq
MIRT1551735	hsa-miR-3150a-3p	CLIP-seq
MIRT1181795	hsa-miR-1207-5p	CLIP-seq
MIRT1181811	hsa-miR-4763-3p	CLIP-seq
MIRT1181837	hsa-miR-4267	CLIP-seq
MIRT1181809	hsa-miR-4663	CLIP-seq
MIRT1181840	hsa-miR-4667-3p	CLIP-seq
MIRT1181796	hsa-miR-122	CLIP-seq
MIRT1181800	hsa-miR-3074-5p	CLIP-seq
MIRT1181801	hsa-miR-3124-3p	CLIP-seq
MIRT1181802	hsa-miR-3135b	CLIP-seq
MIRT1181803	hsa-miR-3160-3p	CLIP-seq
MIRT1181804	hsa-miR-370	CLIP-seq
MIRT2052642	hsa-miR-3714	CLIP-seq
MIRT2052643	hsa-miR-4279	CLIP-seq
MIRT1181806	hsa-miR-4436b-5p	CLIP-seq
MIRT2052644	hsa-miR-4481	CLIP-seq
MIRT1181809	hsa-miR-4663	CLIP-seq
MIRT2052645	hsa-miR-4745-5p	CLIP-seq
MIRT1181814	hsa-miR-558	CLIP-seq
MIRT2052646	hsa-miR-607	CLIP-seq
MIRT2052647	hsa-miR-940	CLIP-seq
MIRT2281977	hsa-miR-1184	CLIP-seq
MIRT2281978	hsa-miR-1205	CLIP-seq
MIRT1181796	hsa-miR-122	CLIP-seq
MIRT2281979	hsa-miR-1226	CLIP-seq
MIRT1181797	hsa-miR-1286	CLIP-seq
MIRT1181799	hsa-miR-1322	CLIP-seq
MIRT2281980	hsa-miR-140-5p	CLIP-seq
MIRT2281981	hsa-miR-1913	CLIP-seq
MIRT2281982	hsa-miR-200b	CLIP-seq
MIRT2281983	hsa-miR-200c	CLIP-seq
MIRT2281984	hsa-miR-2467-3p	CLIP-seq
MIRT1181800	hsa-miR-3074-5p	CLIP-seq
MIRT1181801	hsa-miR-3124-3p	CLIP-seq
MIRT2281985	hsa-miR-3126-5p	CLIP-seq
MIRT1181802	hsa-miR-3135b	CLIP-seq
MIRT2281986	hsa-miR-3150b-3p	CLIP-seq
MIRT2281987	hsa-miR-3158-5p	CLIP-seq
MIRT1181803	hsa-miR-3160-3p	CLIP-seq
MIRT2281988	hsa-miR-3180-5p	CLIP-seq
MIRT2281989	hsa-miR-3186-5p	CLIP-seq
MIRT2281990	hsa-miR-3201	CLIP-seq
MIRT2281991	hsa-miR-324-3p	CLIP-seq
MIRT2281992	hsa-miR-3612	CLIP-seq
MIRT2281993	hsa-miR-3652	CLIP-seq
MIRT1181804	hsa-miR-370	CLIP-seq
MIRT2281994	hsa-miR-3922-5p	CLIP-seq
MIRT2281995	hsa-miR-3934	CLIP-seq
MIRT2281996	hsa-miR-429	CLIP-seq
MIRT2281997	hsa-miR-4326	CLIP-seq
MIRT2281998	hsa-miR-4430	CLIP-seq
MIRT1181805	hsa-miR-4436a	CLIP-seq
MIRT1181806	hsa-miR-4436b-5p	CLIP-seq
MIRT2281999	hsa-miR-4443	CLIP-seq
MIRT1181807	hsa-miR-4477a	CLIP-seq
MIRT2052644	hsa-miR-4481	CLIP-seq
MIRT2282000	hsa-miR-4492	CLIP-seq
MIRT2282001	hsa-miR-4498	CLIP-seq
MIRT2282002	hsa-miR-4505	CLIP-seq
MIRT2282003	hsa-miR-4527	CLIP-seq
MIRT1181809	hsa-miR-4663	CLIP-seq
MIRT2282004	hsa-miR-4667-5p	CLIP-seq
MIRT2282005	hsa-miR-4689	CLIP-seq
MIRT2282006	hsa-miR-4695-5p	CLIP-seq
MIRT2282007	hsa-miR-4700-5p	CLIP-seq
MIRT2282008	hsa-miR-4713-5p	CLIP-seq
MIRT2282009	hsa-miR-4731-5p	CLIP-seq
MIRT2282010	hsa-miR-4733-3p	CLIP-seq
MIRT2052645	hsa-miR-4745-5p	CLIP-seq
MIRT2282011	hsa-miR-4773	CLIP-seq
MIRT2282012	hsa-miR-4784	CLIP-seq
MIRT2282013	hsa-miR-4791	CLIP-seq
MIRT1181845	hsa-miR-486-3p	CLIP-seq
MIRT1181814	hsa-miR-558	CLIP-seq
MIRT2282014	hsa-miR-650	CLIP-seq
MIRT2282015	hsa-miR-762	CLIP-seq
MIRT2282016	hsa-miR-939	CLIP-seq
MIRT2282017	hsa-miR-942	CLIP-seq
MIRT1181800	hsa-miR-3074-5p	CLIP-seq
MIRT1181801	hsa-miR-3124-3p	CLIP-seq
MIRT1181809	hsa-miR-4663	CLIP-seq
MIRT2455085	hsa-miR-3127-3p	CLIP-seq
MIRT1181840	hsa-miR-4667-3p	CLIP-seq
MIRT2282008	hsa-miR-4713-5p	CLIP-seq
MIRT2455086	hsa-miR-532-3p	CLIP-seq
MIRT2580063	hsa-miR-101	CLIP-seq
MIRT1181796	hsa-miR-122	CLIP-seq
MIRT2580064	hsa-miR-1276	CLIP-seq
MIRT2580065	hsa-miR-1287	CLIP-seq
MIRT2580066	hsa-miR-155	CLIP-seq
MIRT2580067	hsa-miR-182	CLIP-seq
MIRT2281981	hsa-miR-1913	CLIP-seq
MIRT2580068	hsa-miR-193a-3p	CLIP-seq
MIRT2580069	hsa-miR-193b	CLIP-seq
MIRT2580070	hsa-miR-302f	CLIP-seq
MIRT2580071	hsa-miR-3121-5p	CLIP-seq
MIRT2580072	hsa-miR-3128	CLIP-seq
MIRT2580073	hsa-miR-3133	CLIP-seq
MIRT1181802	hsa-miR-3135b	CLIP-seq
MIRT2580074	hsa-miR-3136-3p	CLIP-seq
MIRT2580075	hsa-miR-3182	CLIP-seq
MIRT2281991	hsa-miR-324-3p	CLIP-seq
MIRT2580076	hsa-miR-3591-3p	CLIP-seq
MIRT2580077	hsa-miR-3611	CLIP-seq
MIRT2580078	hsa-miR-3613-3p	CLIP-seq
MIRT2580079	hsa-miR-3622a-3p	CLIP-seq
MIRT2580080	hsa-miR-3622b-3p	CLIP-seq
MIRT2580081	hsa-miR-3622b-5p	CLIP-seq
MIRT2580082	hsa-miR-3907	CLIP-seq
MIRT2580083	hsa-miR-4420	CLIP-seq
MIRT1181806	hsa-miR-4436b-5p	CLIP-seq
MIRT2580084	hsa-miR-4470	CLIP-seq
MIRT2580085	hsa-miR-4645-3p	CLIP-seq
MIRT2580086	hsa-miR-4653-3p	CLIP-seq
MIRT2580087	hsa-miR-4659a-3p	CLIP-seq
MIRT2580088	hsa-miR-4659b-3p	CLIP-seq
MIRT2580089	hsa-miR-4661-3p	CLIP-seq
MIRT2580090	hsa-miR-4709-3p	CLIP-seq
MIRT2580091	hsa-miR-4720-5p	CLIP-seq
MIRT2580092	hsa-miR-4731-3p	CLIP-seq
MIRT2580093	hsa-miR-4776-3p	CLIP-seq
MIRT2580094	hsa-miR-4799-3p	CLIP-seq
MIRT2580095	hsa-miR-4801	CLIP-seq
MIRT2580096	hsa-miR-485-3p	CLIP-seq
MIRT2580097	hsa-miR-501-5p	CLIP-seq
MIRT2580098	hsa-miR-569	CLIP-seq
MIRT2580099	hsa-miR-574-5p	CLIP-seq
MIRT2580100	hsa-miR-624	CLIP-seq
MIRT2580101	hsa-miR-626	CLIP-seq
MIRT2580102	hsa-miR-938	CLIP-seq
MIRT2580066	hsa-miR-155	CLIP-seq
MIRT2580073	hsa-miR-3133	CLIP-seq
MIRT2580078	hsa-miR-3613-3p	CLIP-seq
MIRT2580098	hsa-miR-569	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23897819, 32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	30850329
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007155	Process	Cell adhesion	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0007420	Process	Brain development	IBA
GO:0007422	Process	Peripheral nervous system development	ISS
GO:0016020	Component	Membrane	IEA
GO:0030424	Component	Axon	IBA
GO:0033010	Component	Paranodal junction	IEA
GO:0033268	Component	Node of Ranvier	ISS
GO:0033268	Component	Node of Ranvier	TAS	16652168
GO:0042552	Process	Myelination	ISS
GO:0043194	Component	Axon initial segment	ISS
GO:0070161	Component	Anchoring junction	IEA
GO:0098609	Process	Cell-cell adhesion	IBA
GO:0098632	Function	Cell-cell adhesion mediator activity	IBA
GO:0101003	Component	Ficolin-1-rich granule membrane	TAS

Other IDs

• MIM: 609145
• HGNC: 29866
• e!Ensembl: ENSG00000163531

Protein

• UniProt ID: O94856
• Protein name: Neurofascin
• Protein function: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions.
• PDB: 3P3Y, 3P40
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13927	Ig_3	40 → 122		Domain
  PF00047	ig	146 → 222	Immunoglobulin domain	Domain
  PF13927	Ig_3	243 → 320		Domain
  PF13927	Ig_3	340 → 412		Domain
  PF07679	I-set	434 → 518	Immunoglobulin I-set domain	Domain
  PF07679	I-set	522 → 609	Immunoglobulin I-set domain	Domain
  PF00041	fn3	629 → 714	Fibronectin type III domain	Domain
  PF00041	fn3	729 → 813	Fibronectin type III domain	Domain
  PF00041	fn3	827 → 920	Fibronectin type III domain	Domain
  PF00041	fn3	933 → 1018	Fibronectin type III domain	Domain
  PF00041	fn3	1118 → 1195	Fibronectin type III domain	Domain
  PF13882	Bravo_FIGEY	1239 → 1323	Bravo-like intracellular region	Domain

• Sequence:

  MARQPPPPWVHAAFLLCLLSLGGAIEIPMDPSIQNELTQPPTITKQSAKDHIVDPRDNIL
  IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA
  RNKFGTALSNRIRLQVSKSPLWPKENLDPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSSM
  EPITQDKRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRGVA
  ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKA
  LRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDEPKNLILAPGEDGRLVCRA
  NGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLAN
  AFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHV
  YENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVARRGTTVQ
  LECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQ
  DLAKAYLTVLADQATPTNRLAALPKGRPDRPRDLELTDLAERSVRLTWIPGDANNSPITD
  YVVQFEEDQFQPGVWHDHSKYPGSVNSAVLRLSPYVNYQFRVIAINEVGSSHPSLPSERY
  RTSGAPPESNPGDVKGEGTRKNNMEITWTPMNATSAFGPNLRYIVKWRRRETREAWNNVT
  VWGSRYVVGQTPVYVPYEIRVQAENDFGKGPEPESVIGYSGEDYPRAAPTEVKVRVMNST
  AISLQWNRVYSDTVQGQLREYRAYYWRESSLLKNLWVSQKRQQASFPGDRLRGVVSRLFP
  YSNYKLEMVVVNGRGDGPRSETKEFTTPEGVPSAPRRFRVRQPNLETINLEWDHPEHPNG
  IMIGYTLKYVAFNGTKVGKQIVENFSPNQTKFTVQRTDPVSRYRFTLSARTQVGSGEAVT
  EESPAPPNEATPTAAPPTLPPTTVGATGAVSSTDATAIAATTEATTVPIIPTVAPTTIAT
  TTTVATTTTTTAAATTTTESPPTTTSGTKIHESAPDEQSIWNVTVLPNSKWANITWKHNF
  GPGTDFVVEYIDSNHTKKTVPVKAQAQPIQLTDLYPGMTYTLRVYSRDNEGISSTVITFM
  TSTAYTNNQADIATQGWFIGLMCAIALLVLILLIVCFIKRSRGGKYPVREKKDVPLGPED
  PKEEDGSFDYSDEDNKPLQGSQTSLDGTIKQQESDDSLVDYGEGGEGQFNEDGSFIGQYT
  VKKDKEETEGNESSEATSPVNAIYSLA

• Sequence length: 1347

Pathways

KEGG:

Cell adhesion molecules

Reactome:

Neurofascin interactions
Neutrophil degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Neurodevelopmental disorder with central and peripheral motor dysfunction	Likely pathogenic; Pathogenic	rs758701595, rs767453033, rs755160624, rs754724304, rs765387808, rs773245304	RCV001331937 RCV000761195 RCV000761196 RCV000761197 RCV001253764 RCV001253765	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONOTRUNCAL HEART MALFORMATIONS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENTAL CARIES	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESSENTIAL TREMOR	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Germ cell tumor of testis	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEPROSY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROMUSCULAR DISEASES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NFASC-related disorder	Benign; Conflicting classifications of pathogenicity; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIODONTITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPORADIC AMYOTROPHIC LATERAL SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis	Pubtator	12730211, 24704493, 29959860, 30029677, 32515902	Associate	★☆☆☆☆ Found in Text Mining only
Anxiety	Anxiety Disorder	HPO_DG			★☆☆☆☆ Found in Text Mining only
Ataxias, Hereditary	Ataxia	BEFREE	30850329		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	29187518	Associate	★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases of the Nervous System	Autoimmune nervous system disorder	Pubtator	29187518	Associate	★☆☆☆☆ Found in Text Mining only
Basal Ganglia Diseases	Basal ganglia disease	Pubtator	21278408	Associate	★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	40123161	Associate	★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25169499, 35403930	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	31163018	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Merkel Cell	Merkel cell carcinoma	Pubtator	30349028	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	28418179		★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	32631246	Associate	★☆☆☆☆ Found in Text Mining only
Cerebellar Ataxia	Cerebellar ataxia	Pubtator	30850329	Associate	★☆☆☆☆ Found in Text Mining only
Demyelinating Diseases	Demyelinating Diseases	LHGDN	17405145		★☆☆☆☆ Found in Text Mining only
Demyelinating Diseases	Demyelinating diseases	Pubtator	30850329, 31501903	Associate	★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	30850329, 31501903	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	28573768		★☆☆☆☆ Found in Text Mining only
Diabetic Neuropathies	Diabetic Nephropathy	BEFREE	28573768		★☆☆☆☆ Found in Text Mining only
Dysarthria	Dysarthria	HPO_DG			★☆☆☆☆ Found in Text Mining only
Endometriosis	Endometriosis	Pubtator	37555920	Associate	★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	34169995	Associate	★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Glossoptosis	Glossoptosis	HPO_DG			★☆☆☆☆ Found in Text Mining only
Guillain-Barre Syndrome	Guillain-Barre Syndrome	BEFREE	29187518, 29945879		★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Intellectual developmental disorder	Pubtator	31501903, 9804856	Associate	★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	19368910	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	31163018		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	28418179	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	28418179		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	Pubtator	2478022	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	LHGDN	17405145		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	20129933		★☆☆☆☆ Found in Text Mining only
Muscular Atrophy Spinal	Spinal muscular atrophy	Pubtator	37458045	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28418179		★☆☆☆☆ Found in Text Mining only
Nephrotic Syndrome	Nephrotic Syndrome	BEFREE	31306213		★☆☆☆☆ Found in Text Mining only
Nervous System Diseases	Nervous system disease	Pubtator	30850329, 31501903	Associate	★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	2123747	Associate	★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	37848414	Associate	★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	BEFREE	30850329		★☆☆☆☆ Found in Text Mining only
Neuropathy	Neuropathy	BEFREE	28573768, 29130507, 29187518, 30850329, 31657126		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	28418179		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	24971005	Associate	★☆☆☆☆ Found in Text Mining only
Peripheral demyelinating neuropathy	Demyelinating neuropathy	BEFREE	30850329, 31501903		★☆☆☆☆ Found in Text Mining only
Peripheral Nervous System Diseases	Nervous System Diseases	BEFREE	28819062, 29187518		★☆☆☆☆ Found in Text Mining only
Peripheral Nervous System Diseases	Peripheral nervous system disease	Pubtator	29187518	Associate	★☆☆☆☆ Found in Text Mining only
Progressive cerebellar ataxia	Cerebellar Ataxia	BEFREE	31608123		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	26979803	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	20218926		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Schizophrenia	Schizophrenia	PSYGENET_DG	20218926		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sensorimotor neuropathy	Sensorimotor neuropathy	BEFREE	29130507		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	29719198	Associate	★☆☆☆☆ Found in Text Mining only
Tremor	Tremor	Pubtator	30850329	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	33720323	Associate	★☆☆☆☆ Found in Text Mining only