Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23109
Gene name	Dendrin
Gene symbol	DDN
Synonyms (NCBI Gene)	-
Chromosome	12
Chromosome location	12q13.12

121

Show/Hide all (121)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018142	hsa-miR-335-5p	Microarray	18185580
MIRT051128	hsa-miR-16-5p	CLASH	23622248
MIRT478339	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT478338	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT478337	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT478336	hsa-miR-4496	PAR-CLIP	23592263
MIRT478334	hsa-miR-1321	PAR-CLIP	23592263
MIRT478335	hsa-miR-4739	PAR-CLIP	23592263
MIRT478333	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT478332	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT478331	hsa-miR-4270	PAR-CLIP	23592263
MIRT478330	hsa-miR-4441	PAR-CLIP	23592263
MIRT478329	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT478328	hsa-miR-1266-5p	PAR-CLIP	23592263
MIRT478327	hsa-miR-4518	PAR-CLIP	23592263
MIRT478326	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT478325	hsa-miR-4738-3p	PAR-CLIP	23592263
MIRT478324	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT478323	hsa-miR-3975	PAR-CLIP	23592263
MIRT478322	hsa-miR-2467-5p	PAR-CLIP	23592263
MIRT478321	hsa-miR-3188	PAR-CLIP	23592263
MIRT478319	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT478320	hsa-miR-4480	PAR-CLIP	23592263
MIRT478318	hsa-miR-3934-3p	PAR-CLIP	23592263
MIRT478317	hsa-miR-3689d	PAR-CLIP	23592263
MIRT478316	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT478315	hsa-miR-3926	PAR-CLIP	23592263
MIRT478314	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT478313	hsa-miR-663b	PAR-CLIP	23592263
MIRT478312	hsa-miR-3616-5p	PAR-CLIP	23592263
MIRT478311	hsa-miR-573	PAR-CLIP	23592263
MIRT478310	hsa-miR-548s	PAR-CLIP	23592263
MIRT478309	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT478339	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT478338	hsa-miR-6884-5p	PAR-CLIP	23592263
MIRT478337	hsa-miR-485-5p	PAR-CLIP	23592263
MIRT478336	hsa-miR-4496	PAR-CLIP	23592263
MIRT478334	hsa-miR-1321	PAR-CLIP	23592263
MIRT478335	hsa-miR-4739	PAR-CLIP	23592263
MIRT478333	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT478332	hsa-miR-211-3p	PAR-CLIP	23592263
MIRT478331	hsa-miR-4270	PAR-CLIP	23592263
MIRT478330	hsa-miR-4441	PAR-CLIP	23592263
MIRT478329	hsa-miR-6754-5p	PAR-CLIP	23592263
MIRT478328	hsa-miR-1266-5p	PAR-CLIP	23592263
MIRT478327	hsa-miR-4518	PAR-CLIP	23592263
MIRT478326	hsa-miR-4649-3p	PAR-CLIP	23592263
MIRT478325	hsa-miR-4738-3p	PAR-CLIP	23592263
MIRT478324	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT478323	hsa-miR-3975	PAR-CLIP	23592263
MIRT478322	hsa-miR-2467-5p	PAR-CLIP	23592263
MIRT478321	hsa-miR-3188	PAR-CLIP	23592263
MIRT478319	hsa-miR-7854-3p	PAR-CLIP	23592263
MIRT478320	hsa-miR-4480	PAR-CLIP	23592263
MIRT478318	hsa-miR-3934-3p	PAR-CLIP	23592263
MIRT478317	hsa-miR-3689d	PAR-CLIP	23592263
MIRT478316	hsa-miR-6851-5p	PAR-CLIP	23592263
MIRT478315	hsa-miR-3926	PAR-CLIP	23592263
MIRT478314	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT478313	hsa-miR-663b	PAR-CLIP	23592263
MIRT478312	hsa-miR-3616-5p	PAR-CLIP	23592263
MIRT478311	hsa-miR-573	PAR-CLIP	23592263
MIRT478310	hsa-miR-548s	PAR-CLIP	23592263
MIRT478309	hsa-miR-7108-5p	PAR-CLIP	23592263
MIRT929379	hsa-miR-1227	CLIP-seq
MIRT929380	hsa-miR-19a	CLIP-seq
MIRT929381	hsa-miR-19b	CLIP-seq
MIRT929382	hsa-miR-2682	CLIP-seq
MIRT929383	hsa-miR-300	CLIP-seq
MIRT929384	hsa-miR-3144-5p	CLIP-seq
MIRT929385	hsa-miR-3154	CLIP-seq
MIRT929386	hsa-miR-3179	CLIP-seq
MIRT929387	hsa-miR-3191	CLIP-seq
MIRT929388	hsa-miR-339-3p	CLIP-seq
MIRT929389	hsa-miR-34a	CLIP-seq
MIRT929390	hsa-miR-34c-5p	CLIP-seq
MIRT929391	hsa-miR-381	CLIP-seq
MIRT929392	hsa-miR-4271	CLIP-seq
MIRT929393	hsa-miR-4302	CLIP-seq
MIRT929394	hsa-miR-4318	CLIP-seq
MIRT929395	hsa-miR-4461	CLIP-seq
MIRT929396	hsa-miR-449a	CLIP-seq
MIRT929397	hsa-miR-449b	CLIP-seq
MIRT929398	hsa-miR-449c	CLIP-seq
MIRT929399	hsa-miR-4514	CLIP-seq
MIRT929400	hsa-miR-4645-5p	CLIP-seq
MIRT929401	hsa-miR-4651	CLIP-seq
MIRT929402	hsa-miR-4652-5p	CLIP-seq
MIRT929403	hsa-miR-4673	CLIP-seq
MIRT929404	hsa-miR-4692	CLIP-seq
MIRT929405	hsa-miR-4693-5p	CLIP-seq
MIRT929406	hsa-miR-4708-3p	CLIP-seq
MIRT929407	hsa-miR-4719	CLIP-seq
MIRT929408	hsa-miR-4725-3p	CLIP-seq
MIRT929409	hsa-miR-4747-5p	CLIP-seq
MIRT929410	hsa-miR-4755-3p	CLIP-seq
MIRT929411	hsa-miR-4760-5p	CLIP-seq
MIRT929412	hsa-miR-524-3p	CLIP-seq
MIRT929413	hsa-miR-525-3p	CLIP-seq
MIRT929414	hsa-miR-608	CLIP-seq
MIRT929415	hsa-miR-648	CLIP-seq
MIRT929416	hsa-miR-765	CLIP-seq
MIRT929417	hsa-miR-892a	CLIP-seq
MIRT1975202	hsa-miR-3664-5p	CLIP-seq
MIRT929401	hsa-miR-4651	CLIP-seq
MIRT929414	hsa-miR-608	CLIP-seq
MIRT2210572	hsa-miR-1254	CLIP-seq
MIRT2210573	hsa-miR-3116	CLIP-seq
MIRT929394	hsa-miR-4318	CLIP-seq
MIRT929405	hsa-miR-4693-5p	CLIP-seq
MIRT929417	hsa-miR-892a	CLIP-seq
MIRT2514522	hsa-miR-23a	CLIP-seq
MIRT2514523	hsa-miR-23b	CLIP-seq
MIRT2514524	hsa-miR-23c	CLIP-seq
MIRT2514525	hsa-miR-3647-5p	CLIP-seq
MIRT2514526	hsa-miR-4717-3p	CLIP-seq
MIRT2514522	hsa-miR-23a	CLIP-seq
MIRT2514523	hsa-miR-23b	CLIP-seq
MIRT2514524	hsa-miR-23c	CLIP-seq
MIRT2514525	hsa-miR-3647-5p	CLIP-seq
MIRT2514526	hsa-miR-4717-3p	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000978	Function	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IEA
GO:0005515	Function	Protein binding	IPI	16464232, 16751601
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IDA	16464232
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0030425	Component	Dendrite	IEA
GO:0032591	Component	Dendritic spine membrane	IEA
GO:0042995	Component	Cell projection	IDA	16464232
GO:0042995	Component	Cell projection	IEA
GO:0043204	Component	Perikaryon	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IEA
GO:0098793	Component	Presynapse	IEA
GO:0098794	Component	Postsynapse	IEA

MIM	HGNC	e!Ensembl
610588	24458	ENSG00000181418

O94850

Protein name

Dendrin

Protein function

Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein (By similarity).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15498	Dendrin	55 → 709	Nephrin and CD2AP-binding protein, Dendrin	Family

Tissue specificity

TISSUE SPECIFICITY: Specifically expressed in brain and kidney. Expressed in kidney glomerular capillary loops (at protein level). {ECO:0000269|PubMed:17251388, ECO:0000269|PubMed:18356187}.

Sequence

MLDGPLFSEGPDSPRELQDEESGSCLWVQKSKLLVIEVKTISCHYSRRAPSRQPMDFQAS
HWARGFQNRTCGPRPGSPQPPPRRPWASRVLQEATNWRAGPLAEVRAREQEKRKAASQER
EAKETERKRRKAGGARRSPPGRPRPEPRNAPRVAQLAGLPAPLRPERLAPVGRAPRPSAQ
PQSDPGSAWAGPWGGRRPGPPSYEAHLLLRGSAGTAPRRRWDRPPPYVAPPSYEGPHRTL
GTKRGPGNSQVPTSSAPAATPARTDGGRTKKRLDPRIYRDVLGAWGLRQGQGLLGGSPGC
GAARARPEPGKGVVEKSLGLAAADLNSGSDSHPQAKATGSAGTEIAPAGSATAAPCAPHP
APRSRHHLKGSREGKEGEQIWFPKCWIPSPKKQPPRHSQTLPRPWAPGGTGWRESLGLGE
GAGPETLEGWKATRRAHTLPRSSQGLSRGEGVFVIDATCVVIRSQYVPTPRTQQVQLLPS
GVTRVVGDSPSQSKPGKEEGEGATVFPSPCQKRLSSSRLLHQPGGGRGGEAEGGRPGDST
LEERTFRILGLPAPEVNLRDAPTQPGSPEHQALGPAASGAQGRAEGSEVAVVQRRAGRGW
ARTPGPYAGALREAVSRIRRHTAPDSDTDEAEELSVHSGSSDGSDTEAPGASWRNERTLP
EVGNSSPEEDGKTAELSDSVGEILDVISQTEEVLFGVRDIRGTQQGNRKRQ

Sequence length

711

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BONE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOPOROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (12)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Atrophy	Atrophy	Pubtator	30458823	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	GWASCAT_DG	27329760		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Focal glomerulosclerosis	Glomerulosclerosis	BEFREE	30458823		★★★★★ ★☆☆☆☆ Found in Text Mining only
IGA Glomerulonephritis	Glomerulonephritis	BEFREE	30458823		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	17537921		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	23667252, 30458823	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lipoid nephrosis	Lipoid Nephrosis	BEFREE	30458823		★★★★★ ★☆☆☆☆ Found in Text Mining only
Macular dystrophy, corneal type 1	Macular corneal dystrophy	BEFREE	30458823		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephrotic Syndrome	Nephrotic Syndrome	LHGDN	18356187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephrotic Syndrome, Minimal Change	Nephrotic Syndrome	BEFREE	18356187		★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal glomerular disease	Renal Glomerular Disease	BEFREE	30458823		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	31374203		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

DDN (dendrin)