Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23091
Gene name	Zinc finger CCCH-type containing 13
Gene symbol	ZC3H13
Synonyms (NCBI Gene)	KIAA0853Xio
Chromosome	13
Chromosome location	13q14.13

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments	Reference
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638005	hsa-miR-4744	HITS-CLIP	23824327
MIRT638004	hsa-miR-4509	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638005	hsa-miR-4744	HITS-CLIP	23824327
MIRT638004	hsa-miR-4509	HITS-CLIP	23824327
MIRT638003	hsa-miR-520f-5p	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT439252	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439252	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638005	hsa-miR-4744	HITS-CLIP	23824327
MIRT638004	hsa-miR-4509	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT638007	hsa-miR-4698	HITS-CLIP	23824327
MIRT638006	hsa-miR-4639-3p	HITS-CLIP	23824327
MIRT638005	hsa-miR-4744	HITS-CLIP	23824327
MIRT638004	hsa-miR-4509	HITS-CLIP	23824327
MIRT638003	hsa-miR-520f-5p	HITS-CLIP	23824327
MIRT638002	hsa-miR-412-3p	HITS-CLIP	23824327
MIRT638001	hsa-miR-6754-3p	HITS-CLIP	23824327
MIRT638000	hsa-miR-6837-3p	HITS-CLIP	23824327
MIRT637999	hsa-miR-6794-3p	HITS-CLIP	23824327
MIRT637998	hsa-miR-374b-3p	HITS-CLIP	23824327
MIRT1505654	hsa-miR-128	CLIP-seq
MIRT1505655	hsa-miR-129-5p	CLIP-seq
MIRT1505656	hsa-miR-198	CLIP-seq
MIRT1505657	hsa-miR-2117	CLIP-seq
MIRT1505658	hsa-miR-302a	CLIP-seq
MIRT1505659	hsa-miR-302b	CLIP-seq
MIRT1505660	hsa-miR-302c	CLIP-seq
MIRT1505661	hsa-miR-302d	CLIP-seq
MIRT1505662	hsa-miR-302e	CLIP-seq
MIRT1505663	hsa-miR-3672	CLIP-seq
MIRT1505664	hsa-miR-369-3p	CLIP-seq
MIRT1505665	hsa-miR-372	CLIP-seq
MIRT1505666	hsa-miR-373	CLIP-seq
MIRT1505667	hsa-miR-374c	CLIP-seq
MIRT1505668	hsa-miR-382	CLIP-seq
MIRT1505669	hsa-miR-3974	CLIP-seq
MIRT1505670	hsa-miR-4277	CLIP-seq
MIRT1505671	hsa-miR-4433	CLIP-seq
MIRT1505672	hsa-miR-4648	CLIP-seq
MIRT1505673	hsa-miR-4652-3p	CLIP-seq
MIRT1505674	hsa-miR-4653-3p	CLIP-seq
MIRT1505675	hsa-miR-4654	CLIP-seq
MIRT1505676	hsa-miR-4672	CLIP-seq
MIRT1505677	hsa-miR-4684-3p	CLIP-seq
MIRT1505678	hsa-miR-4684-5p	CLIP-seq
MIRT1505679	hsa-miR-4685-5p	CLIP-seq
MIRT1505680	hsa-miR-4720-3p	CLIP-seq
MIRT1505681	hsa-miR-4757-3p	CLIP-seq
MIRT1505682	hsa-miR-4769-5p	CLIP-seq
MIRT1505683	hsa-miR-4775	CLIP-seq
MIRT1505684	hsa-miR-4778-3p	CLIP-seq
MIRT1505685	hsa-miR-4804-3p	CLIP-seq
MIRT1505686	hsa-miR-499-3p	CLIP-seq
MIRT1505687	hsa-miR-499a-3p	CLIP-seq
MIRT1505688	hsa-miR-518a-5p	CLIP-seq
MIRT1505689	hsa-miR-519a	CLIP-seq
MIRT1505690	hsa-miR-519b-3p	CLIP-seq
MIRT1505691	hsa-miR-519c-3p	CLIP-seq
MIRT1505692	hsa-miR-520a-3p	CLIP-seq
MIRT1505693	hsa-miR-520b	CLIP-seq
MIRT1505694	hsa-miR-520c-3p	CLIP-seq
MIRT1505695	hsa-miR-520d-3p	CLIP-seq
MIRT1505696	hsa-miR-520e	CLIP-seq
MIRT1505697	hsa-miR-527	CLIP-seq
MIRT1505698	hsa-miR-548l	CLIP-seq
MIRT1505699	hsa-miR-618	CLIP-seq
MIRT1505700	hsa-miR-655	CLIP-seq
MIRT2152245	hsa-miR-1182	CLIP-seq
MIRT2152246	hsa-miR-1184	CLIP-seq
MIRT1505655	hsa-miR-129-5p	CLIP-seq
MIRT2152247	hsa-miR-193a-5p	CLIP-seq
MIRT2152248	hsa-miR-24	CLIP-seq
MIRT2152249	hsa-miR-2681	CLIP-seq
MIRT2152250	hsa-miR-3145-3p	CLIP-seq
MIRT2152251	hsa-miR-3194-3p	CLIP-seq
MIRT1505663	hsa-miR-3672	CLIP-seq
MIRT2152252	hsa-miR-4284	CLIP-seq
MIRT2152253	hsa-miR-431	CLIP-seq
MIRT2152254	hsa-miR-4418	CLIP-seq
MIRT2152255	hsa-miR-4705	CLIP-seq
MIRT2152256	hsa-miR-509-3-5p	CLIP-seq
MIRT2152257	hsa-miR-509-5p	CLIP-seq
MIRT2152258	hsa-miR-591	CLIP-seq
MIRT2152246	hsa-miR-1184	CLIP-seq
MIRT2372671	hsa-miR-1343	CLIP-seq
MIRT2152248	hsa-miR-24	CLIP-seq
MIRT2152249	hsa-miR-2681	CLIP-seq
MIRT2372672	hsa-miR-3074-5p	CLIP-seq
MIRT2372673	hsa-miR-338-3p	CLIP-seq
MIRT2372674	hsa-miR-378g	CLIP-seq
MIRT2152252	hsa-miR-4284	CLIP-seq
MIRT2372675	hsa-miR-4326	CLIP-seq
MIRT2152254	hsa-miR-4418	CLIP-seq
MIRT2372676	hsa-miR-4437	CLIP-seq
MIRT2372677	hsa-miR-4530	CLIP-seq
MIRT2372678	hsa-miR-4674	CLIP-seq
MIRT2152255	hsa-miR-4705	CLIP-seq
MIRT2372679	hsa-miR-4777-3p	CLIP-seq
MIRT2152256	hsa-miR-509-3-5p	CLIP-seq
MIRT2152257	hsa-miR-509-5p	CLIP-seq
MIRT2372680	hsa-miR-5096	CLIP-seq
MIRT2372681	hsa-miR-574-5p	CLIP-seq
MIRT2372682	hsa-miR-766	CLIP-seq
MIRT2152246	hsa-miR-1184	CLIP-seq
MIRT2397261	hsa-miR-122	CLIP-seq
MIRT2152248	hsa-miR-24	CLIP-seq
MIRT2152249	hsa-miR-2681	CLIP-seq
MIRT2152252	hsa-miR-4284	CLIP-seq
MIRT2152254	hsa-miR-4418	CLIP-seq
MIRT2152255	hsa-miR-4705	CLIP-seq
MIRT2152256	hsa-miR-509-3-5p	CLIP-seq
MIRT2152257	hsa-miR-509-5p	CLIP-seq
MIRT2372681	hsa-miR-574-5p	CLIP-seq
MIRT2152246	hsa-miR-1184	CLIP-seq
MIRT2152248	hsa-miR-24	CLIP-seq
MIRT2152249	hsa-miR-2681	CLIP-seq
MIRT2152252	hsa-miR-4284	CLIP-seq
MIRT2152254	hsa-miR-4418	CLIP-seq
MIRT2152255	hsa-miR-4705	CLIP-seq
MIRT2152256	hsa-miR-509-3-5p	CLIP-seq
MIRT2152257	hsa-miR-509-5p	CLIP-seq

Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005515	Function	Protein binding	IPI	20195357
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	29507755
GO:0005654	Component	Nucleoplasm	IDA	24100041
GO:0005654	Component	Nucleoplasm	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	IMP	29507755
GO:0008270	Function	Zinc ion binding	IEA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IBA
GO:0016607	Component	Nuclear speck	IDA	24100041
GO:0016607	Component	Nuclear speck	IEA
GO:0036396	Component	RNA N6-methyladenosine methyltransferase complex	IDA	29507755
GO:0036396	Component	RNA N6-methyladenosine methyltransferase complex	IPI	29507755
GO:0046872	Function	Metal ion binding	IEA
GO:2000036	Process	Regulation of stem cell population maintenance	ISS

MIM	HGNC	e!Ensembl
616453	20368	ENSG00000123200

Q5T200

Protein name

Zinc finger CCCH domain-containing protein 13

Protein function

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m

PDB

7VF2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00642	zf-CCCH	39 → 63	Zinc finger C-x8-C-x5-C-x3-H type (and similar)	Family

Sequence

MSKIRRKVTVENTKTISDSTSRRPSVFERLGPSTGSTAETQCRNWLKTGNCLYGNTCRFV
HGPSPRGKGYSSNYRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGR
HREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKL
EQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAV
SSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDR
GRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQ
RTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDT
RGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSR
EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSR
TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRS
SYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERR
EERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARERERERE
KERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERARER
DKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKR
RREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKE
SSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKA
KIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEE
AAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTE
AEHTATATTPGSTPSPLSSLLPPPPPVATATATTVPATLAATTAAAATSFSTSAITISTS
ATPTNTTNNTFANEDSHRKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRS
HTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPS
RSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQ
REWDRDADKDWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFE
SSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLE
GDDESKLDDAHSLGSGAGEGYEPISDDELDEILAGDAEKREDQQDEEKMPDPLDVIDVDW
SGLMPKHPKEPREPGAALLKFTPGAVMLRVGISKKLAGSELFAKVKETCQRLLEKPKDAD
NLFEHELGALNMAALLRKEERASLLSNLGPCCKALCFRRDSAIRKQLVKNEKGTIKQAYT
SAPMVDNELLRLSLRLFKRKTTCHAPGHEKTEDNKLSQSSIQQELCVS

Sequence length

1668

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
High myopia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ULCERATIVE COLITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (20)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32631107, 34312475, 35833147, 36222159, 37301543, 37469973	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32733931	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35278064, 35582419	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	38164857	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	31823961	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	21388066, 30311220		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	37194014	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	34230220, 34347888	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastrointestinal Neoplasms	Gastrointestinal neoplasm	Pubtator	35174637	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	21388066		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	21388066, 30548174		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30311220		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	37217897	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	33225598, 36545327	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	Pubtator	36133437	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	34531875, 36133437	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	21388066		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thalassemia	Thalassemia	Pubtator	34650160	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	36058934	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	36091006	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ZC3H13 (zinc finger CCCH-type containing 13)