ERP44 (endoplasmic reticulum protein 44)

Gene

• Entrez ID: 23071
• Gene name: Endoplasmic reticulum protein 44
• Gene symbol: ERP44
• Synonyms (NCBI Gene): PDIA10, TXNDC4
• Chromosome: 9
• Chromosome location: 9q31.1
• Summary: This gene encodes a member of the protein disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an inferred N-terminal signal peptide, a catalytically active thioredoxin (TRX) domain, two TRX-like domains and a C-terminal ER-rete

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019815	hsa-miR-375	Microarray	20215506
MIRT049949	hsa-miR-30a-5p	CLASH	23622248
MIRT719615	hsa-miR-548p	HITS-CLIP	19536157
MIRT719614	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT719613	hsa-miR-5695	HITS-CLIP	19536157
MIRT719612	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT719611	hsa-miR-6740-3p	HITS-CLIP	19536157
MIRT719610	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT719609	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT668527	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT447696	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT668526	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT658533	hsa-miR-548n	HITS-CLIP	23824327
MIRT658532	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT658531	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT658530	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT658529	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT658528	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT658527	hsa-miR-587	HITS-CLIP	23824327
MIRT447715	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447714	hsa-miR-21-5p	PAR-CLIP	22100165
MIRT447713	hsa-miR-590-5p	PAR-CLIP	22100165
MIRT447712	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT447711	hsa-miR-5701	PAR-CLIP	22100165
MIRT447710	hsa-miR-4503	PAR-CLIP	22100165
MIRT447709	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT447708	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT447707	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT447706	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT447705	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT447704	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT447703	hsa-miR-6838-3p	PAR-CLIP	22100165
MIRT447702	hsa-miR-3617-3p	PAR-CLIP	22100165
MIRT447701	hsa-miR-4310	PAR-CLIP	22100165
MIRT447700	hsa-miR-7157-5p	PAR-CLIP	22100165
MIRT447699	hsa-miR-361-5p	PAR-CLIP	22100165
MIRT450440	hsa-miR-4795-3p	PAR-CLIP	22100165
MIRT447698	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT447697	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT447696	hsa-miR-374a-3p	PAR-CLIP	22100165
MIRT447695	hsa-miR-8081	PAR-CLIP	22100165
MIRT447715	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447714	hsa-miR-21-5p	PAR-CLIP	22100165
MIRT447713	hsa-miR-590-5p	PAR-CLIP	22100165
MIRT447712	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT447711	hsa-miR-5701	PAR-CLIP	22100165
MIRT447710	hsa-miR-4503	PAR-CLIP	22100165
MIRT447709	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT447708	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT447707	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT447706	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT447705	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT447704	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT447703	hsa-miR-6838-3p	PAR-CLIP	22100165
MIRT447702	hsa-miR-3617-3p	PAR-CLIP	22100165
MIRT447701	hsa-miR-4310	PAR-CLIP	22100165
MIRT447700	hsa-miR-7157-5p	PAR-CLIP	22100165
MIRT447699	hsa-miR-361-5p	PAR-CLIP	22100165
MIRT447698	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT447697	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT447696	hsa-miR-374a-3p	PAR-CLIP	22100165
MIRT447695	hsa-miR-8081	PAR-CLIP	22100165
MIRT719615	hsa-miR-548p	HITS-CLIP	19536157
MIRT719614	hsa-miR-519d-5p	HITS-CLIP	19536157
MIRT719613	hsa-miR-5695	HITS-CLIP	19536157
MIRT719612	hsa-miR-942-5p	HITS-CLIP	19536157
MIRT719611	hsa-miR-6740-3p	HITS-CLIP	19536157
MIRT719610	hsa-miR-515-5p	HITS-CLIP	19536157
MIRT719609	hsa-miR-519e-5p	HITS-CLIP	19536157
MIRT668527	hsa-miR-136-3p	HITS-CLIP	23824327
MIRT447696	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT668526	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT658533	hsa-miR-548n	HITS-CLIP	23824327
MIRT658532	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT658531	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT658530	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT658529	hsa-miR-501-5p	HITS-CLIP	23824327
MIRT658528	hsa-miR-584-5p	HITS-CLIP	23824327
MIRT658527	hsa-miR-587	HITS-CLIP	23824327
MIRT447715	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447714	hsa-miR-21-5p	PAR-CLIP	22100165
MIRT447713	hsa-miR-590-5p	PAR-CLIP	22100165
MIRT447712	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT447711	hsa-miR-5701	PAR-CLIP	22100165
MIRT447710	hsa-miR-4503	PAR-CLIP	22100165
MIRT447709	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT447708	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT447707	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT447706	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT447705	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT447704	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT447703	hsa-miR-6838-3p	PAR-CLIP	22100165
MIRT447702	hsa-miR-3617-3p	PAR-CLIP	22100165
MIRT447701	hsa-miR-4310	PAR-CLIP	22100165
MIRT447700	hsa-miR-7157-5p	PAR-CLIP	22100165
MIRT447699	hsa-miR-361-5p	PAR-CLIP	22100165
MIRT450440	hsa-miR-4795-3p	PAR-CLIP	22100165
MIRT447698	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT447697	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT447696	hsa-miR-374a-3p	PAR-CLIP	22100165
MIRT447695	hsa-miR-8081	PAR-CLIP	22100165
MIRT447715	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT447714	hsa-miR-21-5p	PAR-CLIP	22100165
MIRT447713	hsa-miR-590-5p	PAR-CLIP	22100165
MIRT447712	hsa-miR-27b-5p	PAR-CLIP	22100165
MIRT447711	hsa-miR-5701	PAR-CLIP	22100165
MIRT447710	hsa-miR-4503	PAR-CLIP	22100165
MIRT447709	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT447708	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT447707	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT447706	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT447705	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT447704	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT447703	hsa-miR-6838-3p	PAR-CLIP	22100165
MIRT447702	hsa-miR-3617-3p	PAR-CLIP	22100165
MIRT447701	hsa-miR-4310	PAR-CLIP	22100165
MIRT447700	hsa-miR-7157-5p	PAR-CLIP	22100165
MIRT447699	hsa-miR-361-5p	PAR-CLIP	22100165
MIRT447698	hsa-miR-937-5p	PAR-CLIP	22100165
MIRT447697	hsa-miR-627-5p	PAR-CLIP	22100165
MIRT447696	hsa-miR-374a-3p	PAR-CLIP	22100165
MIRT447695	hsa-miR-8081	PAR-CLIP	22100165
MIRT969877	hsa-miR-1207-5p	CLIP-seq
MIRT969878	hsa-miR-128	CLIP-seq
MIRT969879	hsa-miR-200b	CLIP-seq
MIRT969880	hsa-miR-200c	CLIP-seq
MIRT969881	hsa-miR-2355-3p	CLIP-seq
MIRT969882	hsa-miR-27a	CLIP-seq
MIRT969883	hsa-miR-27b	CLIP-seq
MIRT969884	hsa-miR-300	CLIP-seq
MIRT969885	hsa-miR-3163	CLIP-seq
MIRT969886	hsa-miR-3164	CLIP-seq
MIRT969887	hsa-miR-340	CLIP-seq
MIRT969888	hsa-miR-3606	CLIP-seq
MIRT969889	hsa-miR-3647-3p	CLIP-seq
MIRT969890	hsa-miR-369-3p	CLIP-seq
MIRT969891	hsa-miR-381	CLIP-seq
MIRT969892	hsa-miR-3909	CLIP-seq
MIRT969893	hsa-miR-4276	CLIP-seq
MIRT969894	hsa-miR-4282	CLIP-seq
MIRT969895	hsa-miR-429	CLIP-seq
MIRT969896	hsa-miR-4639-5p	CLIP-seq
MIRT969897	hsa-miR-4666-3p	CLIP-seq
MIRT969898	hsa-miR-4724-5p	CLIP-seq
MIRT969899	hsa-miR-4736	CLIP-seq
MIRT969900	hsa-miR-4762-5p	CLIP-seq
MIRT969901	hsa-miR-4763-3p	CLIP-seq
MIRT969902	hsa-miR-4778-5p	CLIP-seq
MIRT969903	hsa-miR-4789-5p	CLIP-seq
MIRT969904	hsa-miR-513a-5p	CLIP-seq
MIRT969905	hsa-miR-539	CLIP-seq
MIRT969906	hsa-miR-580	CLIP-seq
MIRT969907	hsa-miR-586	CLIP-seq
MIRT969908	hsa-miR-617	CLIP-seq
MIRT969909	hsa-miR-676	CLIP-seq
MIRT969910	hsa-miR-921	CLIP-seq
MIRT1921430	hsa-miR-1248	CLIP-seq
MIRT1921431	hsa-miR-3614-3p	CLIP-seq
MIRT1921432	hsa-miR-526b	CLIP-seq
MIRT1987489	hsa-miR-1267	CLIP-seq
MIRT1987490	hsa-miR-1273e	CLIP-seq
MIRT969879	hsa-miR-200b	CLIP-seq
MIRT969880	hsa-miR-200c	CLIP-seq
MIRT969885	hsa-miR-3163	CLIP-seq
MIRT969887	hsa-miR-340	CLIP-seq
MIRT969888	hsa-miR-3606	CLIP-seq
MIRT1987491	hsa-miR-3622a-5p	CLIP-seq
MIRT969892	hsa-miR-3909	CLIP-seq
MIRT1987492	hsa-miR-3920	CLIP-seq
MIRT969894	hsa-miR-4282	CLIP-seq
MIRT969895	hsa-miR-429	CLIP-seq
MIRT1987493	hsa-miR-4327	CLIP-seq
MIRT1987494	hsa-miR-4423-3p	CLIP-seq
MIRT1987495	hsa-miR-4690-5p	CLIP-seq
MIRT1987496	hsa-miR-4700-3p	CLIP-seq
MIRT1987497	hsa-miR-502-5p	CLIP-seq
MIRT1987498	hsa-miR-5095	CLIP-seq
MIRT1987499	hsa-miR-579	CLIP-seq
MIRT1987500	hsa-miR-656	CLIP-seq
MIRT969910	hsa-miR-921	CLIP-seq
MIRT2221892	hsa-miR-1244	CLIP-seq
MIRT1987489	hsa-miR-1267	CLIP-seq
MIRT2221893	hsa-miR-130a	CLIP-seq
MIRT2221894	hsa-miR-130b	CLIP-seq
MIRT2221895	hsa-miR-301a	CLIP-seq
MIRT2221896	hsa-miR-301b	CLIP-seq
MIRT2221897	hsa-miR-3064-3p	CLIP-seq
MIRT2221898	hsa-miR-3128	CLIP-seq
MIRT2221899	hsa-miR-3162-3p	CLIP-seq
MIRT2221900	hsa-miR-325	CLIP-seq
MIRT2221901	hsa-miR-3666	CLIP-seq
MIRT2221902	hsa-miR-4295	CLIP-seq
MIRT2221903	hsa-miR-454	CLIP-seq
MIRT2221904	hsa-miR-4671-3p	CLIP-seq
MIRT2221905	hsa-miR-4720-5p	CLIP-seq
MIRT2221906	hsa-miR-4799-3p	CLIP-seq
MIRT2221907	hsa-miR-488	CLIP-seq
MIRT2221908	hsa-miR-511	CLIP-seq
MIRT2221909	hsa-miR-569	CLIP-seq
MIRT1987499	hsa-miR-579	CLIP-seq
MIRT2221910	hsa-miR-653	CLIP-seq
MIRT969892	hsa-miR-3909	CLIP-seq
MIRT2387534	hsa-miR-4684-5p	CLIP-seq
MIRT2387535	hsa-miR-4768-5p	CLIP-seq
MIRT969907	hsa-miR-586	CLIP-seq
MIRT2448952	hsa-miR-3919	CLIP-seq
MIRT2448953	hsa-miR-4756-3p	CLIP-seq
MIRT2448954	hsa-miR-490-3p	CLIP-seq
MIRT2448955	hsa-miR-549	CLIP-seq
MIRT2448952	hsa-miR-3919	CLIP-seq
MIRT2448953	hsa-miR-4756-3p	CLIP-seq
MIRT2448954	hsa-miR-490-3p	CLIP-seq
MIRT2448955	hsa-miR-549	CLIP-seq
MIRT2525533	hsa-miR-1182	CLIP-seq
MIRT2525534	hsa-miR-1183	CLIP-seq
MIRT2525535	hsa-miR-1205	CLIP-seq
MIRT2525536	hsa-miR-1298	CLIP-seq
MIRT2525537	hsa-miR-1304	CLIP-seq
MIRT969879	hsa-miR-200b	CLIP-seq
MIRT969880	hsa-miR-200c	CLIP-seq
MIRT2525538	hsa-miR-2110	CLIP-seq
MIRT2525539	hsa-miR-3117-5p	CLIP-seq
MIRT2525540	hsa-miR-3183	CLIP-seq
MIRT2525541	hsa-miR-331-5p	CLIP-seq
MIRT2525542	hsa-miR-339-5p	CLIP-seq
MIRT2525543	hsa-miR-34a	CLIP-seq
MIRT2525544	hsa-miR-34c-5p	CLIP-seq
MIRT2525545	hsa-miR-3663-5p	CLIP-seq
MIRT969890	hsa-miR-369-3p	CLIP-seq
MIRT2525546	hsa-miR-374a	CLIP-seq
MIRT2525547	hsa-miR-374b	CLIP-seq
MIRT969892	hsa-miR-3909	CLIP-seq
MIRT2525548	hsa-miR-3938	CLIP-seq
MIRT2525549	hsa-miR-3973	CLIP-seq
MIRT2525550	hsa-miR-4270	CLIP-seq
MIRT2525551	hsa-miR-4271	CLIP-seq
MIRT2525552	hsa-miR-4287	CLIP-seq
MIRT969895	hsa-miR-429	CLIP-seq
MIRT2525553	hsa-miR-4292	CLIP-seq
MIRT2525554	hsa-miR-4308	CLIP-seq
MIRT2525555	hsa-miR-4441	CLIP-seq
MIRT2525556	hsa-miR-4461	CLIP-seq
MIRT2525557	hsa-miR-4469	CLIP-seq
MIRT2525558	hsa-miR-449a	CLIP-seq
MIRT2525559	hsa-miR-449b	CLIP-seq
MIRT2525560	hsa-miR-4650-5p	CLIP-seq
MIRT2525561	hsa-miR-4667-5p	CLIP-seq
MIRT2525562	hsa-miR-4678	CLIP-seq
MIRT2525563	hsa-miR-4685-3p	CLIP-seq
MIRT2525564	hsa-miR-4693-5p	CLIP-seq
MIRT2525565	hsa-miR-4700-5p	CLIP-seq
MIRT2525566	hsa-miR-4723-3p	CLIP-seq
MIRT2525567	hsa-miR-4725-3p	CLIP-seq
MIRT2525568	hsa-miR-4728-3p	CLIP-seq
MIRT2525569	hsa-miR-4760-3p	CLIP-seq
MIRT2525570	hsa-miR-518d-5p	CLIP-seq
MIRT2525571	hsa-miR-519b-5p	CLIP-seq
MIRT2525572	hsa-miR-519c-5p	CLIP-seq
MIRT2525573	hsa-miR-520c-5p	CLIP-seq
MIRT2525574	hsa-miR-520g	CLIP-seq
MIRT2525575	hsa-miR-520h	CLIP-seq
MIRT2525576	hsa-miR-526a	CLIP-seq
MIRT2525577	hsa-miR-550b	CLIP-seq
MIRT2525578	hsa-miR-561	CLIP-seq
MIRT2525579	hsa-miR-578	CLIP-seq
MIRT1987499	hsa-miR-579	CLIP-seq
MIRT2525580	hsa-miR-642a	CLIP-seq
MIRT2525581	hsa-miR-661	CLIP-seq
MIRT2525582	hsa-miR-664	CLIP-seq
MIRT2525583	hsa-miR-670	CLIP-seq
MIRT2525584	hsa-miR-711	CLIP-seq
MIRT2680286	hsa-miR-105	CLIP-seq
MIRT2525534	hsa-miR-1183	CLIP-seq
MIRT2680287	hsa-miR-1291	CLIP-seq
MIRT2525536	hsa-miR-1298	CLIP-seq
MIRT2680288	hsa-miR-146b-3p	CLIP-seq
MIRT969879	hsa-miR-200b	CLIP-seq
MIRT969880	hsa-miR-200c	CLIP-seq
MIRT2680289	hsa-miR-2355-5p	CLIP-seq
MIRT2221897	hsa-miR-3064-3p	CLIP-seq
MIRT2525539	hsa-miR-3117-5p	CLIP-seq
MIRT2525540	hsa-miR-3183	CLIP-seq
MIRT2525541	hsa-miR-331-5p	CLIP-seq
MIRT2525542	hsa-miR-339-5p	CLIP-seq
MIRT2525543	hsa-miR-34a	CLIP-seq
MIRT2525544	hsa-miR-34c-5p	CLIP-seq
MIRT969890	hsa-miR-369-3p	CLIP-seq
MIRT969892	hsa-miR-3909	CLIP-seq
MIRT2680290	hsa-miR-3922-5p	CLIP-seq
MIRT2525548	hsa-miR-3938	CLIP-seq
MIRT2525549	hsa-miR-3973	CLIP-seq
MIRT2680291	hsa-miR-4267	CLIP-seq
MIRT2525552	hsa-miR-4287	CLIP-seq
MIRT969895	hsa-miR-429	CLIP-seq
MIRT2525553	hsa-miR-4292	CLIP-seq
MIRT2525554	hsa-miR-4308	CLIP-seq
MIRT2680292	hsa-miR-4457	CLIP-seq
MIRT2525557	hsa-miR-4469	CLIP-seq
MIRT2525558	hsa-miR-449a	CLIP-seq
MIRT2525559	hsa-miR-449b	CLIP-seq
MIRT2525562	hsa-miR-4678	CLIP-seq
MIRT2525563	hsa-miR-4685-3p	CLIP-seq
MIRT2525564	hsa-miR-4693-5p	CLIP-seq
MIRT2525566	hsa-miR-4723-3p	CLIP-seq
MIRT2680293	hsa-miR-4731-3p	CLIP-seq
MIRT2525569	hsa-miR-4760-3p	CLIP-seq
MIRT2680294	hsa-miR-4801	CLIP-seq
MIRT2525574	hsa-miR-520g	CLIP-seq
MIRT2525575	hsa-miR-520h	CLIP-seq
MIRT2680295	hsa-miR-532-5p	CLIP-seq
MIRT2525577	hsa-miR-550b	CLIP-seq
MIRT2525578	hsa-miR-561	CLIP-seq
MIRT2525580	hsa-miR-642a	CLIP-seq
MIRT2525582	hsa-miR-664	CLIP-seq
MIRT2525583	hsa-miR-670	CLIP-seq
MIRT2525584	hsa-miR-711	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
PPARG	Activation	20484463
PPARG	Repression	20484463

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003756	Function	Protein disulfide isomerase activity	IBA
GO:0003756	Function	Protein disulfide isomerase activity	IDA	11847130
GO:0005515	Function	Protein binding	IPI	17805346, 29858230, 32814053
GO:0005576	Component	Extracellular region	TAS
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IDA	11847130
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	11847130
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IBA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IDA	15308636
GO:0006457	Process	Protein folding	IBA
GO:0006457	Process	Protein folding	IDA	11847130
GO:0006986	Process	Response to unfolded protein	IDA	11847130
GO:0009100	Process	Glycoprotein metabolic process	IDA	11847130
GO:0009986	Component	Cell surface	IDA	19995400
GO:0009986	Component	Cell surface	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IDA	11847130
GO:0035580	Component	Specific granule lumen	TAS
GO:0045454	Process	Cell redox homeostasis	TAS	11847130
GO:0070062	Component	Extracellular exosome	HDA	19199708

Other IDs

• MIM: 609170
• HGNC: 18311
• e!Ensembl: ENSG00000023318

Protein

• UniProt ID: Q9BS26
• Protein name: Endoplasmic reticulum resident protein 44 (ER protein 44) (ERp44) (Thioredoxin domain-containing protein 4)
• Protein function: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652
• PDB: 2R2J, 5GU6, 5GU7, 5HQP, 5XWM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00085	Thioredoxin	30 → 138	Thioredoxin	Domain
  PF13848	Thioredoxin_6	167 → 350		Domain

• Sequence:

  MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRF
  SQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMK
  REYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFER
  VANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDK
  CVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHAD
  CDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREF
  HHGPDPTDTAPGEQAQDVASSPPESSFQKLAPSEYRYTLLRDRDEL

• Sequence length: 406

Pathways

Reactome:

Neutrophil degranulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CYSTIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OCULAR SARCOIDOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PREECLAMPSIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	27347718		★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	27347718		★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	25512553, 35689735	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	28945274, 30224065, 31283909		★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	30224065		★☆☆☆☆ Found in Text Mining only
Fatty Liver Disease	Fatty Liver	BEFREE	28968997		★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	25512553	Associate	★☆☆☆☆ Found in Text Mining only
insulinoma	Insulinoma	BEFREE	29507125		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	27347718	Inhibit	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	27347718		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	17013881		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	27347718		★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	17013881		★★☆☆☆ Found in Text Mining + Unknown/Other Associations