Gene Gene information from NCBI Gene database.
Entrez ID 23042
Gene name Pyridoxal dependent decarboxylase domain containing 1
Gene symbol PDXDC1
Synonyms (NCBI Gene)
LP8165
Chromosome 16
Chromosome location 16p13.11
miRNA miRNA information provided by mirtarbase database.
489
miRTarBase ID miRNA Experiments Reference
MIRT016276 hsa-miR-193b-3p Proteomics 21512034
MIRT046621 hsa-miR-222-3p CLASH 23622248
MIRT040072 hsa-miR-615-3p CLASH 23622248
MIRT040072 hsa-miR-615-3p CLASH 23622248
MIRT1223473 hsa-miR-1197 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0005794 Component Golgi apparatus IDA
GO:0016829 Function Lyase activity IEA
GO:0016830 Function Carbon-carbon lyase activity IEA
GO:0016831 Function Carboxy-lyase activity IEA
GO:0019752 Process Carboxylic acid metabolic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
614244 28995 ENSG00000179889
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6P996
Protein name Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-)
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00282 Pyridoxal_deC 167 318 Pyridoxal-dependent decarboxylase conserved domain Domain
Sequence
MDASLEKIADPTLAEMGKNLKEAVKMLEDSQRRTEEENGKKLISGDIPGPLQGSGQDMVS
ILQLVQNLMHGDEDEEPQSPRIQNIGEQGHMALLGHSLGAYISTLDKEKLRKLTTRILSD
TTLWLCRIFRYENGCAYFHEEEREGLAKICRLAIHSRYEDFVVDGFNVLYNKKPVIYLSA
AARPGLGQYLCNQLGLPFPCLCRVPCNTVFGSQHQMDVAFLEKLIKDDIERGRLPLLLVA
NAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALGYVSSSVLAAAKCDSMTMTPG
PWLGLPAVPAVTLYKHDD
PALTLVAGLTSNKPTDKLRALPLWLSLQYLGLDGFVERIKHA
CQLSQRLQESLKKVNYIKILVEDELSSPVVVFRFFQELPGSDPVFKAVPVPNMTPSGVGR
ERHSCDALNRWLGEQLKQLVPASGLTVMDLEAEGTCLRFSPLMTAAVLGTRGEDVDQLVA
CIESKLPVLCCTLQLREEFKQEVEATAGLLYVDDPNWSGIGVVRYEHANDDKSSLKSDPE
GENIHAGLLKKLNELESDLTFKIGPEYKSMKSCLYVGMASDNVDAAELVETIAATAREIE
ENSRLLENMTEVVRKGIQEAQVELQKASEERLLEEGVLRQIPVVGSVLNWFSPVQALQKG
RTFNLTAGSLESTEPIYVYKAQGAGVTLPPTPSGSRTKQRLPGQKPFKRSLRGSDALSET
SSVSHIEDLEKVERLSSGPEQITLEASSTEGHPGAPSPQHTDQTEAFQKGVPHPEDDHSQ
VEGPESLR
Sequence length 788
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
8
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CARCINOMA, RENAL CELL CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CLONAL HEMATOPOIESIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
INSOMNIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Brain Neoplasms Brain neoplasms Pubtator 32644145 Associate
★☆☆☆☆
Found in Text Mining only
Chromophobe Renal Cell Carcinoma Chromophobe Carcinoma CTD_human_DG 25401301
★☆☆☆☆
Found in Text Mining only
Chronic Kidney Diseases Kidney Disease GWASCAT_DG 29545352
★☆☆☆☆
Found in Text Mining only
Collecting Duct Carcinoma of the Kidney Renal Carcinoma CTD_human_DG 25401301
★☆☆☆☆
Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma Renal Carcinoma CTD_human_DG 25401301
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 32644145 Associate
★☆☆☆☆
Found in Text Mining only
Glioma Glioma BEFREE 28339748
★☆☆☆☆
Found in Text Mining only
Glioma Glioma Pubtator 28339748 Associate
★☆☆☆☆
Found in Text Mining only
Hearing Loss Hearing loss Pubtator 25528277 Associate
★☆☆☆☆
Found in Text Mining only
Kidney Failure, Chronic Kidney Failure GWASCAT_DG 29545352
★☆☆☆☆
Found in Text Mining only