Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23022
Gene name	Palladin, cytoskeletal associated protein
Gene symbol	PALLD
Synonyms (NCBI Gene)	CGI-151CGI151MYNPNCA1SIH002
Chromosome	4
Chromosome location	4q32.3
Summary	This gene encodes a cytoskeletal protein that is required for organizing the actin cytoskeleton. The protein is a component of actin-containing microfilaments, and it is involved in the control of cell shape, adhesion, and contraction. Polymorphisms in th

Show/Hide all (5)

SNP ID	Visualize variation	Clinical significance	Consequence
rs121908291	C>T	Risk-factor, uncertain-significance, benign	Missense variant, coding sequence variant, genic downstream transcript variant, intron variant
rs139375029	T>C,G	Conflicting-interpretations-of-pathogenicity, uncertain-significance	Missense variant, coding sequence variant, genic downstream transcript variant, 5 prime UTR variant
rs140454899	A>T	Likely-benign, conflicting-interpretations-of-pathogenicity	Missense variant, genic upstream transcript variant, coding sequence variant
rs587780760	T>G	Conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, missense variant, coding sequence variant, intron variant
rs753092219	C>T	Conflicting-interpretations-of-pathogenicity	Genic downstream transcript variant, synonymous variant, intron variant, coding sequence variant

272

Show/Hide all (272)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020550	hsa-miR-155-5p	Proteomics	18668040
MIRT022312	hsa-miR-124-3p	Microarray	18668037
MIRT030662	hsa-miR-21-5p	Microarray	18591254
MIRT031101	hsa-miR-19b-3p	Sequencing	20371350
MIRT048248	hsa-miR-196a-5p	CLASH	23622248
MIRT724502	hsa-miR-4694-5p	HITS-CLIP	19536157
MIRT724501	hsa-miR-4775	HITS-CLIP	19536157
MIRT649759	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649758	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649757	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT649756	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT649755	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT649754	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT649753	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT649752	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT649751	hsa-miR-4279	HITS-CLIP	23824327
MIRT649750	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT649749	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT531957	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT531956	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT531955	hsa-miR-4717-5p	PAR-CLIP	22012620
MIRT531954	hsa-miR-610	PAR-CLIP	22012620
MIRT531953	hsa-miR-6869-5p	PAR-CLIP	22012620
MIRT440053	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440053	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT724502	hsa-miR-4694-5p	HITS-CLIP	19536157
MIRT724501	hsa-miR-4775	HITS-CLIP	19536157
MIRT649759	hsa-miR-483-3p	HITS-CLIP	23824327
MIRT649758	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT649757	hsa-miR-3162-3p	HITS-CLIP	23824327
MIRT649756	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT649755	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT649754	hsa-miR-656-5p	HITS-CLIP	23824327
MIRT649753	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT649752	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT649751	hsa-miR-4279	HITS-CLIP	23824327
MIRT649750	hsa-miR-33a-5p	HITS-CLIP	23824327
MIRT649749	hsa-miR-33b-5p	HITS-CLIP	23824327
MIRT531957	hsa-miR-6758-5p	PAR-CLIP	22012620
MIRT531956	hsa-miR-6856-5p	PAR-CLIP	22012620
MIRT531955	hsa-miR-4717-5p	PAR-CLIP	22012620
MIRT531954	hsa-miR-610	PAR-CLIP	22012620
MIRT531953	hsa-miR-6869-5p	PAR-CLIP	22012620
MIRT1211692	hsa-miR-1	CLIP-seq
MIRT1211693	hsa-miR-1279	CLIP-seq
MIRT1211694	hsa-miR-1293	CLIP-seq
MIRT1211695	hsa-miR-206	CLIP-seq
MIRT1211696	hsa-miR-2116	CLIP-seq
MIRT1211697	hsa-miR-25	CLIP-seq
MIRT1211698	hsa-miR-3160-5p	CLIP-seq
MIRT1211699	hsa-miR-3163	CLIP-seq
MIRT1211700	hsa-miR-3190	CLIP-seq
MIRT1211701	hsa-miR-32	CLIP-seq
MIRT1211702	hsa-miR-320a	CLIP-seq
MIRT1211703	hsa-miR-320b	CLIP-seq
MIRT1211704	hsa-miR-320c	CLIP-seq
MIRT1211705	hsa-miR-320d	CLIP-seq
MIRT1211706	hsa-miR-342-5p	CLIP-seq
MIRT1211707	hsa-miR-34b	CLIP-seq
MIRT1211708	hsa-miR-3545-3p	CLIP-seq
MIRT1211709	hsa-miR-3607-5p	CLIP-seq
MIRT1211710	hsa-miR-3614-5p	CLIP-seq
MIRT1211711	hsa-miR-363	CLIP-seq
MIRT1211712	hsa-miR-367	CLIP-seq
MIRT1211713	hsa-miR-3673	CLIP-seq
MIRT1211714	hsa-miR-4282	CLIP-seq
MIRT1211715	hsa-miR-4325	CLIP-seq
MIRT1211716	hsa-miR-4429	CLIP-seq
MIRT1211717	hsa-miR-4483	CLIP-seq
MIRT1211718	hsa-miR-4651	CLIP-seq
MIRT1211719	hsa-miR-4652-3p	CLIP-seq
MIRT1211720	hsa-miR-4664-5p	CLIP-seq
MIRT1211721	hsa-miR-4666-5p	CLIP-seq
MIRT1211722	hsa-miR-4672	CLIP-seq
MIRT1211723	hsa-miR-4677-5p	CLIP-seq
MIRT1211724	hsa-miR-4718	CLIP-seq
MIRT1211725	hsa-miR-4793-5p	CLIP-seq
MIRT1211726	hsa-miR-520d-5p	CLIP-seq
MIRT1211727	hsa-miR-524-5p	CLIP-seq
MIRT1211728	hsa-miR-600	CLIP-seq
MIRT1211729	hsa-miR-608	CLIP-seq
MIRT1211730	hsa-miR-613	CLIP-seq
MIRT1211731	hsa-miR-659	CLIP-seq
MIRT1211732	hsa-miR-92a	CLIP-seq
MIRT1211733	hsa-miR-92b	CLIP-seq
MIRT1211734	hsa-miR-340	CLIP-seq
MIRT1211735	hsa-miR-3613-3p	CLIP-seq
MIRT1211736	hsa-miR-3974	CLIP-seq
MIRT1211737	hsa-miR-545	CLIP-seq
MIRT1211738	hsa-miR-548p	CLIP-seq
MIRT1552015	hsa-miR-186	CLIP-seq
MIRT1211696	hsa-miR-2116	CLIP-seq
MIRT1552016	hsa-miR-3133	CLIP-seq
MIRT1552017	hsa-miR-338-5p	CLIP-seq
MIRT1211734	hsa-miR-340	CLIP-seq
MIRT1552018	hsa-miR-4643	CLIP-seq
MIRT1552019	hsa-miR-466	CLIP-seq
MIRT1552020	hsa-miR-4666-3p	CLIP-seq
MIRT1211723	hsa-miR-4677-5p	CLIP-seq
MIRT1552021	hsa-miR-4789-3p	CLIP-seq
MIRT1552022	hsa-miR-4795-3p	CLIP-seq
MIRT1211726	hsa-miR-520d-5p	CLIP-seq
MIRT1211727	hsa-miR-524-5p	CLIP-seq
MIRT1552023	hsa-miR-570	CLIP-seq
MIRT1211728	hsa-miR-600	CLIP-seq
MIRT2060770	hsa-miR-182	CLIP-seq
MIRT2289410	hsa-miR-1226	CLIP-seq
MIRT2289411	hsa-miR-124	CLIP-seq
MIRT2289412	hsa-miR-1250	CLIP-seq
MIRT2289413	hsa-miR-1256	CLIP-seq
MIRT2289414	hsa-miR-1271	CLIP-seq
MIRT2289415	hsa-miR-1290	CLIP-seq
MIRT2289416	hsa-miR-153	CLIP-seq
MIRT2060770	hsa-miR-182	CLIP-seq
MIRT2289417	hsa-miR-217	CLIP-seq
MIRT2289418	hsa-miR-221	CLIP-seq
MIRT2289419	hsa-miR-222	CLIP-seq
MIRT2289420	hsa-miR-224	CLIP-seq
MIRT2289421	hsa-miR-28-3p	CLIP-seq
MIRT2289422	hsa-miR-31	CLIP-seq
MIRT2289423	hsa-miR-3120-3p	CLIP-seq
MIRT1211699	hsa-miR-3163	CLIP-seq
MIRT2289424	hsa-miR-3167	CLIP-seq
MIRT2289425	hsa-miR-323-3p	CLIP-seq
MIRT1211707	hsa-miR-34b	CLIP-seq
MIRT1211735	hsa-miR-3613-3p	CLIP-seq
MIRT2289426	hsa-miR-3617	CLIP-seq
MIRT2289427	hsa-miR-3674	CLIP-seq
MIRT2289428	hsa-miR-369-3p	CLIP-seq
MIRT2289429	hsa-miR-374c	CLIP-seq
MIRT2289430	hsa-miR-377	CLIP-seq
MIRT2289431	hsa-miR-3907	CLIP-seq
MIRT2289432	hsa-miR-3935	CLIP-seq
MIRT2289433	hsa-miR-4274	CLIP-seq
MIRT1211714	hsa-miR-4282	CLIP-seq
MIRT2289434	hsa-miR-4438	CLIP-seq
MIRT2289435	hsa-miR-4642	CLIP-seq
MIRT2289436	hsa-miR-4699-3p	CLIP-seq
MIRT2289437	hsa-miR-4703-3p	CLIP-seq
MIRT2289438	hsa-miR-4715-3p	CLIP-seq
MIRT2289439	hsa-miR-4727-5p	CLIP-seq
MIRT2289440	hsa-miR-4742-5p	CLIP-seq
MIRT2289441	hsa-miR-4769-3p	CLIP-seq
MIRT2289442	hsa-miR-4773	CLIP-seq
MIRT2289443	hsa-miR-4783-3p	CLIP-seq
MIRT2289444	hsa-miR-506	CLIP-seq
MIRT2289445	hsa-miR-5095	CLIP-seq
MIRT1211726	hsa-miR-520d-5p	CLIP-seq
MIRT1211727	hsa-miR-524-5p	CLIP-seq
MIRT2289446	hsa-miR-532-5p	CLIP-seq
MIRT2289447	hsa-miR-548v	CLIP-seq
MIRT2289448	hsa-miR-577	CLIP-seq
MIRT2289449	hsa-miR-586	CLIP-seq
MIRT2289450	hsa-miR-605	CLIP-seq
MIRT2289451	hsa-miR-634	CLIP-seq
MIRT2289452	hsa-miR-641	CLIP-seq
MIRT2289453	hsa-miR-655	CLIP-seq
MIRT2289454	hsa-miR-876-5p	CLIP-seq
MIRT2289455	hsa-miR-890	CLIP-seq
MIRT2289456	hsa-miR-96	CLIP-seq
MIRT2392060	hsa-miR-1236	CLIP-seq
MIRT1211693	hsa-miR-1279	CLIP-seq
MIRT1211697	hsa-miR-25	CLIP-seq
MIRT2392061	hsa-miR-3120-5p	CLIP-seq
MIRT1211701	hsa-miR-32	CLIP-seq
MIRT1211710	hsa-miR-3614-5p	CLIP-seq
MIRT1211711	hsa-miR-363	CLIP-seq
MIRT1211712	hsa-miR-367	CLIP-seq
MIRT1211715	hsa-miR-4325	CLIP-seq
MIRT2392062	hsa-miR-4659a-3p	CLIP-seq
MIRT2392063	hsa-miR-4659b-3p	CLIP-seq
MIRT2392064	hsa-miR-4778-3p	CLIP-seq
MIRT1211725	hsa-miR-4793-5p	CLIP-seq
MIRT1211731	hsa-miR-659	CLIP-seq
MIRT1211732	hsa-miR-92a	CLIP-seq
MIRT1211733	hsa-miR-92b	CLIP-seq
MIRT2289410	hsa-miR-1226	CLIP-seq
MIRT2289411	hsa-miR-124	CLIP-seq
MIRT2431840	hsa-miR-1278	CLIP-seq
MIRT2431841	hsa-miR-142-5p	CLIP-seq
MIRT1211696	hsa-miR-2116	CLIP-seq
MIRT2431842	hsa-miR-219-2-3p	CLIP-seq
MIRT2431843	hsa-miR-2964a-3p	CLIP-seq
MIRT2431844	hsa-miR-3065-3p	CLIP-seq
MIRT2431845	hsa-miR-3155	CLIP-seq
MIRT2431846	hsa-miR-3155b	CLIP-seq
MIRT1211699	hsa-miR-3163	CLIP-seq
MIRT1552017	hsa-miR-338-5p	CLIP-seq
MIRT1211734	hsa-miR-340	CLIP-seq
MIRT1211735	hsa-miR-3613-3p	CLIP-seq
MIRT2289427	hsa-miR-3674	CLIP-seq
MIRT2431847	hsa-miR-3688-5p	CLIP-seq
MIRT2289428	hsa-miR-369-3p	CLIP-seq
MIRT2431848	hsa-miR-3908	CLIP-seq
MIRT2289432	hsa-miR-3935	CLIP-seq
MIRT2431849	hsa-miR-3942-5p	CLIP-seq
MIRT2431850	hsa-miR-3973	CLIP-seq
MIRT2431851	hsa-miR-3976	CLIP-seq
MIRT2431852	hsa-miR-4264	CLIP-seq
MIRT2289433	hsa-miR-4274	CLIP-seq
MIRT2431853	hsa-miR-4276	CLIP-seq
MIRT1211714	hsa-miR-4282	CLIP-seq
MIRT2431854	hsa-miR-4302	CLIP-seq
MIRT2431855	hsa-miR-4307	CLIP-seq
MIRT2431856	hsa-miR-4470	CLIP-seq
MIRT2431857	hsa-miR-4484	CLIP-seq
MIRT1552020	hsa-miR-4666-3p	CLIP-seq
MIRT2431858	hsa-miR-4668-3p	CLIP-seq
MIRT1211722	hsa-miR-4672	CLIP-seq
MIRT1211723	hsa-miR-4677-5p	CLIP-seq
MIRT2431859	hsa-miR-4687-3p	CLIP-seq
MIRT2431860	hsa-miR-4703-5p	CLIP-seq
MIRT2431861	hsa-miR-4712-3p	CLIP-seq
MIRT2289439	hsa-miR-4727-5p	CLIP-seq
MIRT2431862	hsa-miR-4766-3p	CLIP-seq
MIRT1552022	hsa-miR-4795-3p	CLIP-seq
MIRT2431863	hsa-miR-484	CLIP-seq
MIRT2289444	hsa-miR-506	CLIP-seq
MIRT1211726	hsa-miR-520d-5p	CLIP-seq
MIRT1211727	hsa-miR-524-5p	CLIP-seq
MIRT2431864	hsa-miR-544	CLIP-seq
MIRT2431865	hsa-miR-548an	CLIP-seq
MIRT2431866	hsa-miR-548m	CLIP-seq
MIRT2431867	hsa-miR-567	CLIP-seq
MIRT2289448	hsa-miR-577	CLIP-seq
MIRT2431868	hsa-miR-581	CLIP-seq
MIRT2289449	hsa-miR-586	CLIP-seq
MIRT2431869	hsa-miR-587	CLIP-seq
MIRT1211728	hsa-miR-600	CLIP-seq
MIRT2431870	hsa-miR-622	CLIP-seq
MIRT2289451	hsa-miR-634	CLIP-seq
MIRT2431871	hsa-miR-656	CLIP-seq
MIRT2431872	hsa-miR-892a	CLIP-seq
MIRT2431873	hsa-miR-944	CLIP-seq
MIRT2289412	hsa-miR-1250	CLIP-seq
MIRT1211696	hsa-miR-2116	CLIP-seq
MIRT1211702	hsa-miR-320a	CLIP-seq
MIRT1211703	hsa-miR-320b	CLIP-seq
MIRT1211704	hsa-miR-320c	CLIP-seq
MIRT1211705	hsa-miR-320d	CLIP-seq
MIRT1211707	hsa-miR-34b	CLIP-seq
MIRT1211709	hsa-miR-3607-5p	CLIP-seq
MIRT2289431	hsa-miR-3907	CLIP-seq
MIRT1211716	hsa-miR-4429	CLIP-seq
MIRT1211721	hsa-miR-4666-5p	CLIP-seq
MIRT1211723	hsa-miR-4677-5p	CLIP-seq
MIRT2289438	hsa-miR-4715-3p	CLIP-seq
MIRT1211724	hsa-miR-4718	CLIP-seq
MIRT2289443	hsa-miR-4783-3p	CLIP-seq
MIRT1211726	hsa-miR-520d-5p	CLIP-seq
MIRT1211727	hsa-miR-524-5p	CLIP-seq
MIRT1211728	hsa-miR-600	CLIP-seq
MIRT2289412	hsa-miR-1250	CLIP-seq
MIRT2687035	hsa-miR-140-3p	CLIP-seq
MIRT1211696	hsa-miR-2116	CLIP-seq
MIRT1211702	hsa-miR-320a	CLIP-seq
MIRT1211703	hsa-miR-320b	CLIP-seq
MIRT1211704	hsa-miR-320c	CLIP-seq
MIRT1211705	hsa-miR-320d	CLIP-seq
MIRT1211707	hsa-miR-34b	CLIP-seq
MIRT2289431	hsa-miR-3907	CLIP-seq
MIRT1211716	hsa-miR-4429	CLIP-seq
MIRT1211723	hsa-miR-4677-5p	CLIP-seq
MIRT2289438	hsa-miR-4715-3p	CLIP-seq
MIRT1211724	hsa-miR-4718	CLIP-seq
MIRT2687036	hsa-miR-4729	CLIP-seq
MIRT2289443	hsa-miR-4783-3p	CLIP-seq
MIRT1211726	hsa-miR-520d-5p	CLIP-seq
MIRT1211727	hsa-miR-524-5p	CLIP-seq
MIRT2687037	hsa-miR-579	CLIP-seq
MIRT2687038	hsa-miR-590-3p	CLIP-seq
MIRT1211728	hsa-miR-600	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001725	Component	Stress fiber	IDA	11598191
GO:0001725	Component	Stress fiber	IEA
GO:0001726	Component	Ruffle	IEA
GO:0002102	Component	Podosome	IEA
GO:0003334	Process	Keratinocyte development	IEA
GO:0003382	Process	Epithelial cell morphogenesis	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	11598191, 16125169, 17537434, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	11598191
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005884	Component	Actin filament	IDA	11598191
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IDA	17322171
GO:0005925	Component	Focal adhesion	IEA
GO:0007010	Process	Cytoskeleton organization	NAS	11598191
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IBA
GO:0007411	Process	Axon guidance	IBA
GO:0015629	Component	Actin cytoskeleton	IDA
GO:0016477	Process	Cell migration	IEA
GO:0030018	Component	Z disc	IBA
GO:0030018	Component	Z disc	IDA	16125169
GO:0030018	Component	Z disc	IEA
GO:0030027	Component	Lamellipodium	IDA	17537434
GO:0030027	Component	Lamellipodium	IEA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030036	Process	Actin cytoskeleton organization	IEA
GO:0030424	Component	Axon	IBA
GO:0030424	Component	Axon	IEA
GO:0030426	Component	Growth cone	IEA
GO:0042995	Component	Cell projection	IEA
GO:0051371	Function	Muscle alpha-actinin binding	IEA
GO:0051371	Function	Muscle alpha-actinin binding	TAS	16125169
GO:0060076	Component	Excitatory synapse	ISS
GO:0070161	Component	Anchoring junction	IEA
GO:0070593	Process	Dendrite self-avoidance	IBA
GO:0098632	Function	Cell-cell adhesion mediator activity	IBA

MIM	HGNC	e!Ensembl
608092	17068	ENSG00000129116

Q8WX93

Protein name

Palladin (SIH002) (Sarcoma antigen NY-SAR-77)

Protein function

Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding mole

PDB

2DM2 , 2DM3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07679	I-set	271 → 361	Immunoglobulin I-set domain	Domain
PF07679	I-set	441 → 538	Immunoglobulin I-set domain	Domain
PF07679	I-set	1001 → 1092	Immunoglobulin I-set domain	Domain
PF07679	I-set	1135 → 1225	Immunoglobulin I-set domain	Domain
PF07679	I-set	1234 → 1325	Immunoglobulin I-set domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in both muscle and non-muscle tissues. High expression in prostate, ovary, colon, and kidney. Not detected in spleen, skeletal muscle, lung and peripheral blood lymphocytes (at protein level). Protein is overexpressed in FA6,

Sequence

MSGTSSHESFYDSLSDMQEESKNTDFFPGLSAFLSQEEINKSLDLARRAIADSETEDFDS
EKEISQIFSTSPASLCEHPSHKETKLGEHASRRPQDNRSTPVQPLAEKQTKSISSPVSKR
KPAMSPLLTRPSYIRSLRKAEKRGAKTPSTNVKPKTPHQRKGGPQSQLCDKAANLIEELT
SIFKAAKPRNRSPNGESSSPDSGYLSPKNQPSALLSASASQSPMEDQGEMEREVKSPGAR
HCYQDNQDLAVPHNRKSHPQPHSALHFPAAPRFIQKLRSQEVAEGSRVYLECRVTGNPTP
RVRWFCEGKELHNTPDIQIHCEGGDLHTLIIAEAFEDDTGRYTCLATNPSGSDTTSAEVF
IEGASSTDSDSESLAFKSRAGAMPQAQKKTTSVSLTIGSSSPKTGVTTAVIQPLSVPVQQ
VHSPTSYLCRPDGTTTAYFPPVFTKELQNTAVAEGQVVVLECRVRGAPPLQVQWFRQGSE
IQDSPDFRILQKKPRSTAEPEEICTLVIAETFPEDAGIFTCSARNDYGSATSTAQLVVTS
ANTENCSYESMGESNNDHFQHFPPPPPILETSSLELASKKPSEIQQVNNPELGLSRAALQ
MQFNAAERETNGVHPSRGVNGLINGKANSNKSLPTPAVLLSPTKEPPPLLAKPKLDPLKL
QQLQNQIRLEQEAGARQPPPAPRSAPPSPPFPPPPAFPELAACTPPASPEPMSALASRSA
PAMQSSGSFNYARPKQFIAAQNLGPASGHGTPASSPSSSSLPSPMSPTPRQFGRAPVPPF
AQPFGAEPEAPWGSSSPSPPPPPPPVFSPTAAFPVPDVFPLPPPPPPLPSPGQASHCSSP
ATRFGHSQTPAAFLSALLPSQPPPAAVNALGLPKGVTPAGFPKKASRTARIASDEEIQGT
KDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSATVFNIQEPEEETANQEYK
VSSCEQRLISEIEYRLERSPVDESGDEVQYGDVPVENGMAPFFEMKLKHYKIFEGMPVTF
TCRVAGNPKPKIYWFKDGKQISPKSDHYTIQRDLDGTCSLHTTASTLDDDGNYTIMAANP
QGRISCTGRLMVQAVNQRGRSPRSPSGHPHVRRPRSRSRDSGDENEPIQERFFRPHFLQA
PGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPVRPDSAHKMLVRENGVHSLIIEPVTS
RDAGIYTCIATNRAGQNSFSLELVVAAKEAHKPPVFIEKLQNTGVADGYPVRLECRVLGV
PPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCT
ARLDVYTQWHQQSQSTKPKKVRPSASRYAALSDQGLDIKAAFQPEANPSHLTLNTALVES
EDL

Sequence length

1383

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (36)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma of pancreas	Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cholangiocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY THROMBOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial pancreatic carcinoma	Benign	ClinVar Orphanet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Gastric cancer	Benign; Conflicting classifications of pathogenicity; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hereditary cancer-predisposing syndrome	Uncertain significance; Conflicting classifications of pathogenicity; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar GWAS catalog	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign; Conflicting classifications of pathogenicity	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PALLD-related disorder	Benign; Likely benign; Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatic adenocarcinoma	Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatic cancer, susceptibility to, 1	Conflicting classifications of pathogenicity; Benign; Likely benign; Uncertain significance	ClinVar ClinVar, GenCC	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
PANCREATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (67)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	LHGDN	17228136		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	17404500, 26333695		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of pancreas	Pancreatic adenocarcinoma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenomatous Polyposis Coli	Multiple polyposis syndrome	BEFREE	22368299		★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	28351381		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anorexia	Anorexia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	19205907, 21054356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	19205907, 21054356		★★★★★ ★☆☆☆☆ Found in Text Mining only
beta Thalassemia	beta Thalassemia	LHGDN	15310273		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	20471940, 21519185		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	20471940	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	21050850	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	21738681	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37960718	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	17404500, 27023252, 33764904	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	21738681	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	32631246	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Restrictive	Restrictive cardiomyopathy	Pubtator	36174041	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholestasis, Extrahepatic	Cholestasis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	20811713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic Neoplasms	BEFREE	20811713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	26973246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32859214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	GWASCAT_DG	29212778		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Coronary Disease	Coronary artery disease	Pubtator	18073581	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	21054356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	26915486	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	26915486		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	29720549		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dystonic Disorders	Dystonia	Pubtator	17194196	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Exocrine pancreatic insufficiency	Exocrine pancreatic insufficiency	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Familial pancreatic carcinoma	Pancreatic Carcinoma	Orphanet			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Intestinal Pseudo-Obstruction	Intestinal Pseudoobstruction	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney Disease	BEFREE	25573828		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	36047666	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	34166375	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	20471940, 21519185		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	17194196, 17404500, 17415588, 17992582, 18818508, 19336541, 19349734		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22291919, 26973246		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	20811713		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	HPO_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myocardial Infarction	Myocardial Infarction	BEFREE	19709766		★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	17194196, 18978809, 26333695		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephrolithiasis	Nephrolithiasis	Pubtator	40664942	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	23975165	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Oculocerebrorenal Syndrome	Oculocerebrorenal Syndrome	BEFREE	28739877		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Carcinoma	Ovarian Carcinoma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	17194196, 17404500, 17415588, 17992582, 18818508, 19336541, 19349734		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma, familial	Pancreatic carcinoma	BEFREE	17194196, 17415588, 19336541		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma, familial	Pancreatic carcinoma	ORPHANET_DG	17194196		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	LHGDN	17194196		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	BEFREE	20436683, 26333695		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasm	Pancreatic Neoplasm	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	17194196, 17404500, 21925511, 23076142, 33764904	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pancreatitis	Pancreatitis	Pubtator	22291919	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Patent ductus arteriosus	Patent ductus arteriosus	BEFREE	20436683		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stroke	Stroke	Pubtator	32980981	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vasculitis	Vasculitis	BEFREE	25573828		★★★★★ ★☆☆☆☆ Found in Text Mining only

PALLD (palladin, cytoskeletal associated protein)