Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	230
Gene name	Aldolase, fructose-bisphosphate C
Gene symbol	ALDOC
Synonyms (NCBI Gene)	ALDC
Chromosome	17
Chromosome location	17q11.2
Summary	This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fruc

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016877	hsa-miR-335-5p	Microarray	18185580
MIRT040405	hsa-miR-615-3p	CLASH	23622248
MIRT644456	hsa-miR-6085	HITS-CLIP	23824327
MIRT644455	hsa-miR-6813-5p	HITS-CLIP	23824327
MIRT644454	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT644453	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT644452	hsa-miR-3184-5p	HITS-CLIP	23824327
MIRT644451	hsa-miR-423-5p	HITS-CLIP	23824327
MIRT644450	hsa-miR-1914-3p	HITS-CLIP	23824327
MIRT644449	hsa-miR-5194	HITS-CLIP	23824327
MIRT644448	hsa-miR-6738-5p	HITS-CLIP	23824327
MIRT644447	hsa-miR-7106-3p	HITS-CLIP	23824327
MIRT644446	hsa-miR-4283	HITS-CLIP	23824327
MIRT644445	hsa-miR-4281	HITS-CLIP	23824327
MIRT644444	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT644443	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT644442	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT644441	hsa-miR-6734-5p	HITS-CLIP	23824327
MIRT644440	hsa-miR-133a-3p	HITS-CLIP	23824327
MIRT644456	hsa-miR-6085	HITS-CLIP	23824327
MIRT644455	hsa-miR-6813-5p	HITS-CLIP	23824327
MIRT644454	hsa-miR-454-5p	HITS-CLIP	23824327
MIRT644453	hsa-miR-2116-3p	HITS-CLIP	23824327
MIRT644452	hsa-miR-3184-5p	HITS-CLIP	23824327
MIRT644451	hsa-miR-423-5p	HITS-CLIP	23824327
MIRT644450	hsa-miR-1914-3p	HITS-CLIP	23824327
MIRT644449	hsa-miR-5194	HITS-CLIP	23824327
MIRT644448	hsa-miR-6738-5p	HITS-CLIP	23824327
MIRT644447	hsa-miR-7106-3p	HITS-CLIP	23824327
MIRT644446	hsa-miR-4283	HITS-CLIP	23824327
MIRT644445	hsa-miR-4281	HITS-CLIP	23824327
MIRT644444	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT644443	hsa-miR-202-5p	HITS-CLIP	23824327
MIRT644442	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT644441	hsa-miR-6734-5p	HITS-CLIP	23824327
MIRT644440	hsa-miR-133a-3p	HITS-CLIP	23824327
MIRT777897	hsa-miR-31	CLIP-seq
MIRT777898	hsa-miR-4436b-3p	CLIP-seq
MIRT777899	hsa-miR-4742-5p	CLIP-seq
MIRT777900	hsa-miR-4768-3p	CLIP-seq
MIRT777901	hsa-miR-665	CLIP-seq
MIRT1929631	hsa-miR-3187-3p	CLIP-seq
MIRT1929632	hsa-miR-4529-5p	CLIP-seq
MIRT1929633	hsa-miR-4726-3p	CLIP-seq
MIRT1929634	hsa-miR-4796-3p	CLIP-seq
MIRT1929635	hsa-miR-548p	CLIP-seq
MIRT1929636	hsa-miR-548t	CLIP-seq
MIRT2170471	hsa-miR-3910	CLIP-seq
MIRT2170472	hsa-miR-3922-5p	CLIP-seq
MIRT2170473	hsa-miR-888	CLIP-seq
MIRT2170471	hsa-miR-3910	CLIP-seq
MIRT2170472	hsa-miR-3922-5p	CLIP-seq
MIRT2384081	hsa-miR-4718	CLIP-seq
MIRT2170473	hsa-miR-888	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0004332	Function	Fructose-bisphosphate aldolase activity	IBA
GO:0004332	Function	Fructose-bisphosphate aldolase activity	IDA	9244396, 15537755
GO:0004332	Function	Fructose-bisphosphate aldolase activity	IEA
GO:0005515	Function	Protein binding	IPI	11399750, 25416956, 25910212, 26496610, 28514442, 29924966, 31515488, 32296183, 33961781, 35156780, 36012204
GO:0005576	Component	Extracellular region	TAS
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IC	9244396
GO:0006000	Process	Fructose metabolic process	TAS	3105602
GO:0006094	Process	Gluconeogenesis	IEA
GO:0006096	Process	Glycolytic process	IBA
GO:0006096	Process	Glycolytic process	IEA
GO:0008092	Function	Cytoskeletal protein binding	IDA	9244396
GO:0016829	Function	Lyase activity	IEA
GO:0030388	Process	Fructose 1,6-bisphosphate metabolic process	IBA
GO:0030388	Process	Fructose 1,6-bisphosphate metabolic process	IDA	9244396, 15537755
GO:0030855	Process	Epithelial cell differentiation	IEP	21492153
GO:0034774	Component	Secretory granule lumen	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:1904724	Component	Tertiary granule lumen	TAS
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
103870	418	ENSG00000109107

P09972

Protein name

Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase)

PDB

1XFB

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00274	Glycolytic	15 → 364	Fructose-bisphosphate aldolase class-I	Domain

Sequence

MPHSYPALSAEQKKELSDIALRIVAPGKGILAADESVGSMAKRLSQIGVENTEENRRLYR
QVLFSADDRVKKCIGGVIFFHETLYQKDDNGVPFVRTIQDKGIVVGIKVDKGVVPLAGTD
GETTTQGLDGLSERCAQYKKDGADFAKWRCVLKISERTPSALAILENANVLARYASICQQ
NGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHAC
PIKYTPEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASFNLNAINRCPLPRPWALTF
SYGRALQASALNAWRGQRDNAGAATEEFIKRAEVNGLAAQGKYEGSGEDGGAAAQSLYIA
NHAY

Sequence length

364

Interactions

View interactions

	KEGG		Reactome
	Glycolysis / Gluconeogenesis Pentose phosphate pathway Fructose and mannose metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids HIF-1 signaling pathway		Neutrophil degranulation Glycolysis Gluconeogenesis

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (14)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	33664453	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33737938	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Disease	Coronary artery disease	Pubtator	33904367	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Cardiomyopathies	Diabetic cardiomyopathy	Pubtator	30246236	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic retinopathy	Pubtator	38274229	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Gallbladder neoplasm	Pubtator	32502493	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	33607293	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	30396920	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	9173889		★★★★★ ★☆☆☆☆ Found in Text Mining only
Raynaud Disease	Raynaud disease	Pubtator	33904367	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	LHGDN	19034380, 19110265		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	19405953	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	35922788	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	34456184	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ALDOC (aldolase, fructose-bisphosphate C)