Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	22993
Gene name	HMG-box containing 3
Gene symbol	HMGXB3
Synonyms (NCBI Gene)	HMGX3SMF
Chromosome	5
Chromosome location	5q32
Summary	This gene is one of the non-canonical high mobility group (HMG) genes. The encoded protein contains an HMG-box domain found in DNA binding proteins such as transcription factors and chromosomal proteins. [provided by RefSeq, Aug 2011]

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Show/Hide all (142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT049848	hsa-miR-92a-3p	CLASH	23622248
MIRT043043	hsa-miR-324-5p	CLASH	23622248
MIRT041726	hsa-miR-484	CLASH	23622248
MIRT040316	hsa-miR-615-3p	CLASH	23622248
MIRT039237	hsa-miR-454-3p	CLASH	23622248
MIRT452505	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT452504	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT452503	hsa-miR-4476	PAR-CLIP	23592263
MIRT452502	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT452501	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT452500	hsa-miR-3677-5p	PAR-CLIP	23592263
MIRT452499	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT452498	hsa-miR-3179	PAR-CLIP	23592263
MIRT452497	hsa-miR-3202	PAR-CLIP	23592263
MIRT452496	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT452495	hsa-miR-3153	PAR-CLIP	23592263
MIRT452494	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT452493	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT452492	hsa-miR-4435	PAR-CLIP	23592263
MIRT452505	hsa-miR-3173-3p	PAR-CLIP	23592263
MIRT452504	hsa-miR-6891-5p	PAR-CLIP	23592263
MIRT452503	hsa-miR-4476	PAR-CLIP	23592263
MIRT452502	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT452501	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT452500	hsa-miR-3677-5p	PAR-CLIP	23592263
MIRT452499	hsa-miR-7113-5p	PAR-CLIP	23592263
MIRT452498	hsa-miR-3179	PAR-CLIP	23592263
MIRT452497	hsa-miR-3202	PAR-CLIP	23592263
MIRT452496	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT452495	hsa-miR-3153	PAR-CLIP	23592263
MIRT452494	hsa-miR-6733-5p	PAR-CLIP	23592263
MIRT452493	hsa-miR-6739-5p	PAR-CLIP	23592263
MIRT452492	hsa-miR-4435	PAR-CLIP	23592263
MIRT1050013	hsa-miR-1287	CLIP-seq
MIRT1050014	hsa-miR-133a	CLIP-seq
MIRT1050015	hsa-miR-133b	CLIP-seq
MIRT1050016	hsa-miR-135a	CLIP-seq
MIRT1050017	hsa-miR-135b	CLIP-seq
MIRT1050018	hsa-miR-1910	CLIP-seq
MIRT1050019	hsa-miR-3135b	CLIP-seq
MIRT1050020	hsa-miR-4269	CLIP-seq
MIRT1050021	hsa-miR-4512	CLIP-seq
MIRT1050022	hsa-miR-4514	CLIP-seq
MIRT1050023	hsa-miR-455-3p	CLIP-seq
MIRT1050024	hsa-miR-4692	CLIP-seq
MIRT1050025	hsa-miR-4742-5p	CLIP-seq
MIRT1050026	hsa-miR-512-3p	CLIP-seq
MIRT1050027	hsa-miR-548aa	CLIP-seq
MIRT1050028	hsa-miR-671-5p	CLIP-seq
MIRT1050029	hsa-miR-7	CLIP-seq
MIRT1050030	hsa-miR-9	CLIP-seq
MIRT2011436	hsa-miR-103a	CLIP-seq
MIRT2011437	hsa-miR-107	CLIP-seq
MIRT2011438	hsa-miR-1184	CLIP-seq
MIRT2011439	hsa-miR-136	CLIP-seq
MIRT2011440	hsa-miR-15a	CLIP-seq
MIRT2011441	hsa-miR-15b	CLIP-seq
MIRT2011442	hsa-miR-16	CLIP-seq
MIRT2011443	hsa-miR-185	CLIP-seq
MIRT2011444	hsa-miR-1915	CLIP-seq
MIRT2011445	hsa-miR-195	CLIP-seq
MIRT2011446	hsa-miR-424	CLIP-seq
MIRT2011447	hsa-miR-4306	CLIP-seq
MIRT2011448	hsa-miR-4446-5p	CLIP-seq
MIRT2011449	hsa-miR-4519	CLIP-seq
MIRT2011450	hsa-miR-4644	CLIP-seq
MIRT2011451	hsa-miR-4726-3p	CLIP-seq
MIRT2011452	hsa-miR-4755-5p	CLIP-seq
MIRT2011453	hsa-miR-497	CLIP-seq
MIRT2011454	hsa-miR-604	CLIP-seq
MIRT2011455	hsa-miR-642a	CLIP-seq
MIRT2011456	hsa-miR-647	CLIP-seq
MIRT2011457	hsa-miR-885-5p	CLIP-seq
MIRT2011436	hsa-miR-103a	CLIP-seq
MIRT2011437	hsa-miR-107	CLIP-seq
MIRT2011438	hsa-miR-1184	CLIP-seq
MIRT2243653	hsa-miR-154	CLIP-seq
MIRT2011440	hsa-miR-15a	CLIP-seq
MIRT2011441	hsa-miR-15b	CLIP-seq
MIRT2011442	hsa-miR-16	CLIP-seq
MIRT2011445	hsa-miR-195	CLIP-seq
MIRT2243654	hsa-miR-205	CLIP-seq
MIRT2243655	hsa-miR-335	CLIP-seq
MIRT2243656	hsa-miR-3685	CLIP-seq
MIRT2243657	hsa-miR-384	CLIP-seq
MIRT2011446	hsa-miR-424	CLIP-seq
MIRT2243658	hsa-miR-4270	CLIP-seq
MIRT2243659	hsa-miR-4441	CLIP-seq
MIRT2011449	hsa-miR-4519	CLIP-seq
MIRT2011453	hsa-miR-497	CLIP-seq
MIRT2011454	hsa-miR-604	CLIP-seq
MIRT2011456	hsa-miR-647	CLIP-seq
MIRT2243658	hsa-miR-4270	CLIP-seq
MIRT2243659	hsa-miR-4441	CLIP-seq
MIRT2546854	hsa-miR-1224-3p	CLIP-seq
MIRT2546855	hsa-miR-1224-5p	CLIP-seq
MIRT2546856	hsa-miR-1260	CLIP-seq
MIRT2546857	hsa-miR-1260b	CLIP-seq
MIRT2546858	hsa-miR-1266	CLIP-seq
MIRT2546859	hsa-miR-1280	CLIP-seq
MIRT1050014	hsa-miR-133a	CLIP-seq
MIRT1050015	hsa-miR-133b	CLIP-seq
MIRT2546860	hsa-miR-146a	CLIP-seq
MIRT2546861	hsa-miR-146b-5p	CLIP-seq
MIRT2546862	hsa-miR-296-3p	CLIP-seq
MIRT2546863	hsa-miR-331-3p	CLIP-seq
MIRT2546864	hsa-miR-4254	CLIP-seq
MIRT2243658	hsa-miR-4270	CLIP-seq
MIRT2546865	hsa-miR-4292	CLIP-seq
MIRT2546866	hsa-miR-4308	CLIP-seq
MIRT2243659	hsa-miR-4441	CLIP-seq
MIRT2546867	hsa-miR-4518	CLIP-seq
MIRT2546868	hsa-miR-4725-5p	CLIP-seq
MIRT2546869	hsa-miR-4751	CLIP-seq
MIRT2546870	hsa-miR-504	CLIP-seq
MIRT2546871	hsa-miR-580	CLIP-seq
MIRT2546872	hsa-miR-589	CLIP-seq
MIRT1050028	hsa-miR-671-5p	CLIP-seq
MIRT1050030	hsa-miR-9	CLIP-seq
MIRT2546854	hsa-miR-1224-3p	CLIP-seq
MIRT2546855	hsa-miR-1224-5p	CLIP-seq
MIRT2546856	hsa-miR-1260	CLIP-seq
MIRT2546857	hsa-miR-1260b	CLIP-seq
MIRT2546858	hsa-miR-1266	CLIP-seq
MIRT2546859	hsa-miR-1280	CLIP-seq
MIRT2546860	hsa-miR-146a	CLIP-seq
MIRT2546861	hsa-miR-146b-5p	CLIP-seq
MIRT2546862	hsa-miR-296-3p	CLIP-seq
MIRT2546863	hsa-miR-331-3p	CLIP-seq
MIRT2546864	hsa-miR-4254	CLIP-seq
MIRT2243658	hsa-miR-4270	CLIP-seq
MIRT2546865	hsa-miR-4292	CLIP-seq
MIRT2546866	hsa-miR-4308	CLIP-seq
MIRT2243659	hsa-miR-4441	CLIP-seq
MIRT2546867	hsa-miR-4518	CLIP-seq
MIRT2546868	hsa-miR-4725-5p	CLIP-seq
MIRT2546869	hsa-miR-4751	CLIP-seq
MIRT2546870	hsa-miR-504	CLIP-seq
MIRT2546871	hsa-miR-580	CLIP-seq
MIRT2546872	hsa-miR-589	CLIP-seq
MIRT1050028	hsa-miR-671-5p	CLIP-seq
MIRT1050030	hsa-miR-9	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence
GO:0003677	Function	DNA binding	IEA
GO:0005575	Component	Cellular_component	ND
GO:0005634	Component	Nucleus	IEA
GO:0008150	Process	Biological_process	ND

MIM	HGNC	e!Ensembl
619800	28982	ENSG00000113716

Q12766

Protein name

HMG domain-containing protein 3 (HMG box-containing protein 3) (Protein SMF)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09011	HMG_box_2	285 → 354	HMG-box domain	Domain
PF18717	CxC4	979 → 1109	CxC4 like cysteine cluster associated with KDZ transposases	Domain

Sequence

MQRTQPRPCYLNAPQQCPGAERPGRPTAGSHSFLLRPGPLAGSSPFALLDPLQAFEQFVW
VRSQARAGLLRLRQGSHAVTRCRPLPVRREGRRDGSPWRSVVCRYCRCSRQTGASVTTVS
LPSSSSSPGLDPRGPRQASVRSLRSEPVLLFLPFRTPYRDSEEGKREGLSRLRAVCRRAG
PRGRGSFSPRDARASPRLHFLVAAVTTGAASRRQRGARVRQPSPSSSRRAKRLRECERRS
LHAPPAMDASYDGTEVTVVMEEIEEAYCYTSPGPPKKKKKYKIHGEKTKKPRSAYLLYYY
DIYLKVQQELPHLPQSEINKKISESWRLLSVAERSYYLEKAKLEKEGLDPNSKLSALTAV
VPDIPGFRKILPRSDYIIIPKSSLQEDRSCPQLELCVAQNQMSPKGPPLVSNTAPETVPS
HAGMAEQCLAVEALAEEVGALTQSGAVQEIATSEILSQDVLLEDASLEVGESHQPYQTSL
VIEETLVNGSPDLPTGSLAVPHPQVGESVSVVTVMRDSSESSSSAPATQFIMLPLPAYSV
VENPTSIKLTTTYTRRGHGTCTSPGCSFTYVTRHKPPKCPTCGNFLGGKWIPKEKPAKVK
VELASGVSSKGSVVKRNQQPVTTEQNSSKENASKLTLENSEAVSQLLNVAPPREVGEESE
WEEVIISDAHVLVKEAPGNCGTAVTKTPVVKSGVQPEVTLGTTDNDSPGADVPTPSEGTS
TSSPLPAPKKPTGADLLTPGSRAPELKGRARGKPSLLAAARPMRAILPAPVNVGRGSSMG
LPRARQAFSLSDKTPSVRTCGLKPSTLKQLGQPIQQPSGPGEVKLPSGPSNRTSQVKVVE
VKPDMFPPYKYSCTVTLDLGLATSRGRGKCKNPSCSYVYTNRHKPRICPSCGVNLAKDRT
EKTTKAIEVSSPLPDVLNATEPLSTAQREIQRQSTLQLLRKVLQIPENESELAEVFALIH
ELNSSRLILSNVSEETVTIEQTSWSNYYESPSTQCLLCSSPLFKGGQNSLAGPQECWLLT
ASRLQTVTAQVKMCLNPHCLALHSFIDIYTGLFNVGNKLLVSLDLLFAIRNQIKLGEDPR
VSINVVLKSVQEQTEKTLTSEELSQLQELLCNGYWAFECLTVRDYNDMICGICGVAPKVE
MAQRSEENVLALKSVEFTWPEFLGSNEVNVEDFWATMETEVIEQVAFPASIPITKFDASV
IAPFFPPLMRGAVVVNTEKDKNLDVQPVPGSGSALVRLLQEGTCKLDEIGSYSEEKLQHL
LRQCGIPFGAEDSKDQLCFSLLALYESVQNGARAIRPPRHFTGGKIYKVCPHQVVCGSKY
LVRGESARDHVDLLASSRHWPPVYVVDMATSVALCADLCYPELTNQMWGRNQGCFSSPTE
PPVSVSCPELLDQHYTVDMTETEHSIQHPVTKTATRRIVHAGLQPNPGDPSAGHHSLALC
PELAPYATILASIVDSKPNGVRQRPIAFDNATHYYLYNRLMDFLTSREIVNRQIHDIVQS
CQPGEVVIRDTLYRLGVAQIKTETEEEGEEEEVAAVAE

Sequence length

1538

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
GILLES DE LA TOURETTE SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TOURETTE SYNDROME	—	GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	34155128	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	19801673, 23106139		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary Myelofibrosis	Myelofibrosis	BEFREE	29713873		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma	Rhabdomyosarcoma	BEFREE	7543834		★★★★★ ★☆☆☆☆ Found in Text Mining only

HMGXB3 (HMG-box containing 3)