Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	22985
Gene name	Apoptotic chromatin condensation inducer 1
Gene symbol	ACIN1
Synonyms (NCBI Gene)	ACINUSACNfSAP152
Chromosome	14
Chromosome location	14q11.2
Summary	Apoptosis is defined by several morphologic nuclear changes, including chromatin condensation and nuclear fragmentation. This gene encodes a nuclear protein that induces apoptotic chromatin condensation after activation by caspase-3, without inducing DNA

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019549	hsa-miR-340-5p	Sequencing	20371350
MIRT027955	hsa-miR-93-5p	Sequencing	20371350
MIRT031335	hsa-miR-18a-5p	Sequencing	20371350
MIRT046954	hsa-miR-221-3p	CLASH	23622248
MIRT044279	hsa-miR-106b-5p	CLASH	23622248
MIRT043129	hsa-miR-324-5p	CLASH	23622248
MIRT038741	hsa-miR-93-3p	CLASH	23622248
MIRT036443	hsa-miR-1226-3p	CLASH	23622248
MIRT715885	hsa-miR-4640-3p	HITS-CLIP	19536157
MIRT715884	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT715883	hsa-miR-4292	HITS-CLIP	19536157
MIRT715882	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT715881	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT715880	hsa-miR-7114-5p	HITS-CLIP	19536157
MIRT715879	hsa-miR-134-3p	HITS-CLIP	19536157
MIRT715878	hsa-miR-4529-5p	HITS-CLIP	19536157
MIRT715877	hsa-miR-6877-5p	HITS-CLIP	19536157
MIRT715876	hsa-miR-6762-5p	HITS-CLIP	19536157
MIRT715875	hsa-miR-6845-5p	HITS-CLIP	19536157
MIRT715874	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT715873	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT715872	hsa-miR-663b	HITS-CLIP	19536157
MIRT715871	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT715870	hsa-miR-1227-5p	HITS-CLIP	19536157
MIRT715869	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT441292	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441292	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT715885	hsa-miR-4640-3p	HITS-CLIP	19536157
MIRT715884	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT715883	hsa-miR-4292	HITS-CLIP	19536157
MIRT715882	hsa-miR-6791-5p	HITS-CLIP	19536157
MIRT715881	hsa-miR-6852-5p	HITS-CLIP	19536157
MIRT715880	hsa-miR-7114-5p	HITS-CLIP	19536157
MIRT715879	hsa-miR-134-3p	HITS-CLIP	19536157
MIRT715878	hsa-miR-4529-5p	HITS-CLIP	19536157
MIRT715877	hsa-miR-6877-5p	HITS-CLIP	19536157
MIRT715876	hsa-miR-6762-5p	HITS-CLIP	19536157
MIRT715875	hsa-miR-6845-5p	HITS-CLIP	19536157
MIRT715874	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT715873	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT715872	hsa-miR-663b	HITS-CLIP	19536157
MIRT715871	hsa-miR-3187-3p	HITS-CLIP	19536157
MIRT715870	hsa-miR-1227-5p	HITS-CLIP	19536157
MIRT715869	hsa-miR-7108-5p	HITS-CLIP	19536157
MIRT762685	hsa-miR-4729	CLIP-seq
MIRT762686	hsa-miR-587	CLIP-seq
MIRT762687	hsa-miR-224	CLIP-seq
MIRT762688	hsa-miR-548a-3p	CLIP-seq
MIRT762689	hsa-miR-548e	CLIP-seq
MIRT762690	hsa-miR-548f	CLIP-seq
MIRT1924839	hsa-miR-154	CLIP-seq
MIRT1924840	hsa-miR-1910	CLIP-seq
MIRT1924841	hsa-miR-3130-5p	CLIP-seq
MIRT1924842	hsa-miR-4482	CLIP-seq
MIRT1924843	hsa-miR-4687-3p	CLIP-seq
MIRT1924844	hsa-miR-4707-5p	CLIP-seq
MIRT2166054	hsa-miR-1205	CLIP-seq
MIRT1924840	hsa-miR-1910	CLIP-seq
MIRT1924841	hsa-miR-3130-5p	CLIP-seq
MIRT1924842	hsa-miR-4482	CLIP-seq
MIRT1924843	hsa-miR-4687-3p	CLIP-seq
MIRT1924844	hsa-miR-4707-5p	CLIP-seq
MIRT2166054	hsa-miR-1205	CLIP-seq
MIRT2383818	hsa-miR-1291	CLIP-seq
MIRT2383819	hsa-miR-1292	CLIP-seq
MIRT2383820	hsa-miR-1909	CLIP-seq
MIRT2383821	hsa-miR-3199	CLIP-seq
MIRT2383822	hsa-miR-4418	CLIP-seq
MIRT2383823	hsa-miR-4471	CLIP-seq
MIRT2383824	hsa-miR-509-3-5p	CLIP-seq
MIRT2383825	hsa-miR-509-5p	CLIP-seq
MIRT2166054	hsa-miR-1205	CLIP-seq
MIRT2468554	hsa-miR-1286	CLIP-seq
MIRT2468555	hsa-miR-1321	CLIP-seq
MIRT1924840	hsa-miR-1910	CLIP-seq
MIRT2468556	hsa-miR-1912	CLIP-seq
MIRT2468557	hsa-miR-1915	CLIP-seq
MIRT2468558	hsa-miR-2355-5p	CLIP-seq
MIRT2468559	hsa-miR-2392	CLIP-seq
MIRT2468560	hsa-miR-3064-5p	CLIP-seq
MIRT1924841	hsa-miR-3130-5p	CLIP-seq
MIRT2468561	hsa-miR-3148	CLIP-seq
MIRT2468562	hsa-miR-3169	CLIP-seq
MIRT2468563	hsa-miR-3176	CLIP-seq
MIRT2468564	hsa-miR-326	CLIP-seq
MIRT2468565	hsa-miR-330-5p	CLIP-seq
MIRT2468566	hsa-miR-3689d	CLIP-seq
MIRT2468567	hsa-miR-3922-3p	CLIP-seq
MIRT2468568	hsa-miR-3926	CLIP-seq
MIRT2468569	hsa-miR-4257	CLIP-seq
MIRT2468570	hsa-miR-4270	CLIP-seq
MIRT2468571	hsa-miR-4436a	CLIP-seq
MIRT2468572	hsa-miR-4441	CLIP-seq
MIRT2468573	hsa-miR-4446-3p	CLIP-seq
MIRT1924842	hsa-miR-4482	CLIP-seq
MIRT2468574	hsa-miR-4515	CLIP-seq
MIRT2468575	hsa-miR-4534	CLIP-seq
MIRT1924843	hsa-miR-4687-3p	CLIP-seq
MIRT1924844	hsa-miR-4707-5p	CLIP-seq
MIRT2468576	hsa-miR-4722-5p	CLIP-seq
MIRT2468577	hsa-miR-4739	CLIP-seq
MIRT2468578	hsa-miR-4756-5p	CLIP-seq
MIRT2468579	hsa-miR-4802-5p	CLIP-seq
MIRT2468580	hsa-miR-486-3p	CLIP-seq
MIRT2468581	hsa-miR-548c-3p	CLIP-seq
MIRT2468582	hsa-miR-548s	CLIP-seq
MIRT2468583	hsa-miR-765	CLIP-seq
MIRT2468555	hsa-miR-1321	CLIP-seq
MIRT1924840	hsa-miR-1910	CLIP-seq
MIRT2468556	hsa-miR-1912	CLIP-seq
MIRT2468557	hsa-miR-1915	CLIP-seq
MIRT2468559	hsa-miR-2392	CLIP-seq
MIRT1924841	hsa-miR-3130-5p	CLIP-seq
MIRT2468561	hsa-miR-3148	CLIP-seq
MIRT2468562	hsa-miR-3169	CLIP-seq
MIRT2468566	hsa-miR-3689d	CLIP-seq
MIRT2468569	hsa-miR-4257	CLIP-seq
MIRT2468570	hsa-miR-4270	CLIP-seq
MIRT2468572	hsa-miR-4441	CLIP-seq
MIRT1924842	hsa-miR-4482	CLIP-seq
MIRT2468574	hsa-miR-4515	CLIP-seq
MIRT2468575	hsa-miR-4534	CLIP-seq
MIRT1924843	hsa-miR-4687-3p	CLIP-seq
MIRT1924844	hsa-miR-4707-5p	CLIP-seq
MIRT2468577	hsa-miR-4739	CLIP-seq
MIRT2468578	hsa-miR-4756-5p	CLIP-seq
MIRT2468579	hsa-miR-4802-5p	CLIP-seq
MIRT2468580	hsa-miR-486-3p	CLIP-seq
MIRT2468581	hsa-miR-548c-3p	CLIP-seq
MIRT2468583	hsa-miR-765	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003676	Function	Nucleic acid binding	NAS	10490026
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	17332742, 18951082, 19387494, 20195357, 22365833, 22388736, 23602568, 28514442, 30021884, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	10490026
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IDA
GO:0006397	Process	MRNA processing	IEA
GO:0006915	Process	Apoptotic process	IEA
GO:0008380	Process	RNA splicing	IBA
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IDA	20966198
GO:0016607	Component	Nuclear speck	IEA
GO:0016887	Function	ATP hydrolysis activity	NAS	10490026
GO:0019899	Function	Enzyme binding	NAS	10490026
GO:0030218	Process	Erythrocyte differentiation	IEP	11208865
GO:0030263	Process	Apoptotic chromosome condensation	IDA	10490026
GO:0031981	Component	Nuclear lumen	IEA
GO:0035145	Component	Exon-exon junction complex	IDA	16314458
GO:0043065	Process	Positive regulation of apoptotic process	IDA	12665594
GO:0045657	Process	Positive regulation of monocyte differentiation	IEP	12393560
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	IDA	12665594
GO:0061574	Component	ASAP complex	IBA
GO:0061574	Component	ASAP complex	IDA	12665594

MIM	HGNC	e!Ensembl
604562	17066	ENSG00000100813

Q9UKV3

Protein name

Apoptotic chromatin condensation inducer in the nucleus (Acinus)

Protein function

Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated fa

PDB

6G6S

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02037	SAP	72 → 106	SAP domain	Family
PF16294	RSB_motif	1129 → 1247	RNSP1-SAP18 binding (RSB) motif	Motif

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies.

Sequence

MWRRKHPRTSGGTRGVLSGNRGVEYGSGRGHLGTFEGRWRKLPKMPEAVGTDPSTSRKMA
ELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGALMLENLQKHSTPHAA
FQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEASAESEDEMIHPEGVA
SLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGERRSSRVRQARAAKLS
EGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEEGDDEGQKSREAPI
LKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEARKSHLARQQQEKE
MKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVALPEQTASEEETPPPLLT
KEASSPPPHPQLHSEEEIEPMEGPAPAVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPL
SSPSDTKAESPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAK
GITEECLKQPSLEQKEGRRASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSG
SRSHSPLRSKQRDVAQARTHANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGV
SRDSSTSYTETKDPSSGQEVATPPVPQLQVCEPKERTSTSSSSVQARRLSQPESAEKHVT
QRLQPERGSPKKCEAEEAEPPAATQPQTSETQTSHLPESERIHHTVEEKEEVTMDTSENR
PENDVPEPPMPIADQVSNDDRPEGSVEDEEKKESSLPKSFKRKISVVSATKGVPAGNSDT
EGGQPGRKRRWGASTATTQKKPSISITTESLKSLIPDIKPLAGQEAVVDLHADDSRISED
ETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVAL
PPPAEHEVKKVTLGDTLTRRSISQQKSGVSITIDDPVRTAQVPSPPRGKISNIVHISNLV
RPFTLGQLKELLGRTGTLVEEAFWIDKIKSHCFVTYSTVEEAVATRTALHGVKWPQSNPK
FLCADYAEQDELDYHRGLLVDRPSETKTEEQGIPRPLHPPPPPPVQPPQHPRAEQREQER
AVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAKSKEKKSEKKE
KAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQ
KEREKEAERERNRQLEREKRREHSRERDRERERERERDRGDRDRDRERDRERGRERDRRD
TKRHSRSRSRSTPVRDRGGRR

Sequence length

1341

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport mRNA surveillance pathway Spliceosome		Apoptotic cleavage of cellular proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma	Adenocarcinoma	BEFREE	17409846		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	LHGDN	17409846		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	17409846		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	30282520		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bronchioloalveolar Adenocarcinoma	Lung adenocarcinoma	BEFREE	17409846		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30282520		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33142236	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	16721359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	GENOMICS_ENGLAND_DG	26350204		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	18559500	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	18559500	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	26615145		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30282520		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	12402304, 16721359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroma, Acoustic, Bilateral	Bilateral vestibular Schwannoma	BEFREE	16721359		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	22629410	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	37143720	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	35255776	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ACIN1 (apoptotic chromatin condensation inducer 1)