Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	22981
Gene name	Ninein like
Gene symbol	NINL
Synonyms (NCBI Gene)	NLP
Chromosome	20
Chromosome location	20p11.21

135

Show/Hide all (135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018701	hsa-miR-335-5p	Microarray	18185580
MIRT1185176	hsa-miR-101	CLIP-seq
MIRT1185177	hsa-miR-137	CLIP-seq
MIRT1185178	hsa-miR-144	CLIP-seq
MIRT1185179	hsa-miR-199a-3p	CLIP-seq
MIRT1185180	hsa-miR-199b-3p	CLIP-seq
MIRT1185181	hsa-miR-2277-3p	CLIP-seq
MIRT1185182	hsa-miR-25	CLIP-seq
MIRT1185183	hsa-miR-29a	CLIP-seq
MIRT1185184	hsa-miR-29b	CLIP-seq
MIRT1185185	hsa-miR-29c	CLIP-seq
MIRT1185186	hsa-miR-3129-5p	CLIP-seq
MIRT1185187	hsa-miR-3148	CLIP-seq
MIRT1185188	hsa-miR-3153	CLIP-seq
MIRT1185189	hsa-miR-3157-5p	CLIP-seq
MIRT1185190	hsa-miR-3164	CLIP-seq
MIRT1185191	hsa-miR-3187-3p	CLIP-seq
MIRT1185192	hsa-miR-32	CLIP-seq
MIRT1185193	hsa-miR-363	CLIP-seq
MIRT1185194	hsa-miR-3660	CLIP-seq
MIRT1185195	hsa-miR-367	CLIP-seq
MIRT1185196	hsa-miR-450b-5p	CLIP-seq
MIRT1185197	hsa-miR-4526	CLIP-seq
MIRT1185198	hsa-miR-4529-5p	CLIP-seq
MIRT1185199	hsa-miR-4639-3p	CLIP-seq
MIRT1185200	hsa-miR-4668-5p	CLIP-seq
MIRT1185201	hsa-miR-4691-3p	CLIP-seq
MIRT1185202	hsa-miR-4714-5p	CLIP-seq
MIRT1185203	hsa-miR-518a-5p	CLIP-seq
MIRT1185204	hsa-miR-527	CLIP-seq
MIRT1185205	hsa-miR-582-5p	CLIP-seq
MIRT1185206	hsa-miR-656	CLIP-seq
MIRT1185207	hsa-miR-92a	CLIP-seq
MIRT1185208	hsa-miR-92b	CLIP-seq
MIRT2053652	hsa-miR-1323	CLIP-seq
MIRT1185187	hsa-miR-3148	CLIP-seq
MIRT1185188	hsa-miR-3153	CLIP-seq
MIRT2053653	hsa-miR-3938	CLIP-seq
MIRT2053654	hsa-miR-4470	CLIP-seq
MIRT1185200	hsa-miR-4668-5p	CLIP-seq
MIRT2053655	hsa-miR-548o	CLIP-seq
MIRT1185187	hsa-miR-3148	CLIP-seq
MIRT1185188	hsa-miR-3153	CLIP-seq
MIRT1185196	hsa-miR-450b-5p	CLIP-seq
MIRT1185200	hsa-miR-4668-5p	CLIP-seq
MIRT2455197	hsa-miR-1245b-3p	CLIP-seq
MIRT2455198	hsa-miR-1915	CLIP-seq
MIRT2455199	hsa-miR-2964a-5p	CLIP-seq
MIRT2455200	hsa-miR-4330	CLIP-seq
MIRT2455201	hsa-miR-4726-3p	CLIP-seq
MIRT2581049	hsa-miR-124	CLIP-seq
MIRT2581050	hsa-miR-128	CLIP-seq
MIRT2053652	hsa-miR-1323	CLIP-seq
MIRT2581051	hsa-miR-149	CLIP-seq
MIRT2455198	hsa-miR-1915	CLIP-seq
MIRT1185181	hsa-miR-2277-3p	CLIP-seq
MIRT2581052	hsa-miR-3064-5p	CLIP-seq
MIRT2581053	hsa-miR-3126-3p	CLIP-seq
MIRT2581054	hsa-miR-3688-5p	CLIP-seq
MIRT2581055	hsa-miR-3714	CLIP-seq
MIRT2581056	hsa-miR-3910	CLIP-seq
MIRT2053654	hsa-miR-4470	CLIP-seq
MIRT2581057	hsa-miR-4521	CLIP-seq
MIRT2581058	hsa-miR-4646-5p	CLIP-seq
MIRT2581059	hsa-miR-4693-3p	CLIP-seq
MIRT2455201	hsa-miR-4726-3p	CLIP-seq
MIRT2581060	hsa-miR-4794	CLIP-seq
MIRT2581061	hsa-miR-506	CLIP-seq
MIRT2581062	hsa-miR-520a-5p	CLIP-seq
MIRT2581063	hsa-miR-525-5p	CLIP-seq
MIRT2581064	hsa-miR-548a-3p	CLIP-seq
MIRT2581065	hsa-miR-548e	CLIP-seq
MIRT2581066	hsa-miR-548f	CLIP-seq
MIRT2053655	hsa-miR-548o	CLIP-seq
MIRT2686319	hsa-miR-106a	CLIP-seq
MIRT2686320	hsa-miR-106b	CLIP-seq
MIRT2686321	hsa-miR-1178	CLIP-seq
MIRT2581049	hsa-miR-124	CLIP-seq
MIRT2581050	hsa-miR-128	CLIP-seq
MIRT2053652	hsa-miR-1323	CLIP-seq
MIRT2581051	hsa-miR-149	CLIP-seq
MIRT2686322	hsa-miR-17	CLIP-seq
MIRT2455198	hsa-miR-1915	CLIP-seq
MIRT2686323	hsa-miR-20a	CLIP-seq
MIRT2686324	hsa-miR-20b	CLIP-seq
MIRT1185181	hsa-miR-2277-3p	CLIP-seq
MIRT1185183	hsa-miR-29a	CLIP-seq
MIRT1185184	hsa-miR-29b	CLIP-seq
MIRT1185185	hsa-miR-29c	CLIP-seq
MIRT2686325	hsa-miR-302a	CLIP-seq
MIRT2686326	hsa-miR-302b	CLIP-seq
MIRT2686327	hsa-miR-302c	CLIP-seq
MIRT2686328	hsa-miR-302d	CLIP-seq
MIRT2686329	hsa-miR-302e	CLIP-seq
MIRT2581052	hsa-miR-3064-5p	CLIP-seq
MIRT2581053	hsa-miR-3126-3p	CLIP-seq
MIRT2686330	hsa-miR-3664-3p	CLIP-seq
MIRT2686331	hsa-miR-3688-3p	CLIP-seq
MIRT2581054	hsa-miR-3688-5p	CLIP-seq
MIRT2581055	hsa-miR-3714	CLIP-seq
MIRT2686332	hsa-miR-372	CLIP-seq
MIRT2686333	hsa-miR-373	CLIP-seq
MIRT2581056	hsa-miR-3910	CLIP-seq
MIRT2686334	hsa-miR-3978	CLIP-seq
MIRT2686335	hsa-miR-4436a	CLIP-seq
MIRT2053654	hsa-miR-4470	CLIP-seq
MIRT2686336	hsa-miR-4480	CLIP-seq
MIRT2581057	hsa-miR-4521	CLIP-seq
MIRT2581058	hsa-miR-4646-5p	CLIP-seq
MIRT2581059	hsa-miR-4693-3p	CLIP-seq
MIRT2686337	hsa-miR-4717-3p	CLIP-seq
MIRT2455201	hsa-miR-4726-3p	CLIP-seq
MIRT2686338	hsa-miR-4775	CLIP-seq
MIRT2686339	hsa-miR-4776-3p	CLIP-seq
MIRT2581060	hsa-miR-4794	CLIP-seq
MIRT2686340	hsa-miR-4802-3p	CLIP-seq
MIRT2581061	hsa-miR-506	CLIP-seq
MIRT2686341	hsa-miR-510	CLIP-seq
MIRT2686342	hsa-miR-512-3p	CLIP-seq
MIRT2686343	hsa-miR-512-5p	CLIP-seq
MIRT2686344	hsa-miR-519d	CLIP-seq
MIRT2686345	hsa-miR-520a-3p	CLIP-seq
MIRT2581062	hsa-miR-520a-5p	CLIP-seq
MIRT2686346	hsa-miR-520b	CLIP-seq
MIRT2686347	hsa-miR-520c-3p	CLIP-seq
MIRT2686348	hsa-miR-520d-3p	CLIP-seq
MIRT2686349	hsa-miR-520e	CLIP-seq
MIRT2581063	hsa-miR-525-5p	CLIP-seq
MIRT2581064	hsa-miR-548a-3p	CLIP-seq
MIRT2581065	hsa-miR-548e	CLIP-seq
MIRT2581066	hsa-miR-548f	CLIP-seq
MIRT2053655	hsa-miR-548o	CLIP-seq
MIRT2686350	hsa-miR-626	CLIP-seq
MIRT2686351	hsa-miR-767-3p	CLIP-seq
MIRT2686352	hsa-miR-93	CLIP-seq

Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	16189514, 21516116, 25416956, 26485514
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	26485514
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0034454	Process	Microtubule anchoring at centrosome	IBA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
609580	29163	ENSG00000101004

Q9Y2I6

Protein name

Ninein-like protein

Protein function

Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicl

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13499	EF-hand_7	198 → 260	EF-hand domain pair	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in KYSE-150 esophageal carcinoma, HeLa cervical carcinoma and U2OS osteosarcoma cells. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase (at protein level). Expressed in fetal heart, skeleta

Sequence

MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFAR
VNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCDA
ATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQTWDS
EDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELED
LFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTS
SLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLELT
WALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKE
MDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQ
AEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAEL
LAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGL
GPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKD
MEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALC
GLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLE
LERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQ
EGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASH
GPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEP
PLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRG
SLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRE
NDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNR
QNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQK
LRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVA
ELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQF
EKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAAL
SV

Sequence length

1382

Interactions

View interactions

	Reactome
			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Autism spectrum disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioma susceptibility 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NINL-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (23)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Acute pancreatitis	Pancreatitis	BEFREE	29575044		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adult Hodgkin Lymphoma	Hodgkin Lymphoma	BEFREE	12115499, 15160902		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	31535693		★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain atrophy	Brain atrophy	BEFREE	25731621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	21505454, 25901761		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	22353935, 25901761	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	21505454, 29855732		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral atrophy	Cerebral Atrophy	BEFREE	25731621		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ciliopathies	Ciliopathies	BEFREE	26485645		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hodgkin Disease	Hodgkin Disease	BEFREE	12115499, 15160902		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leber Congenital Amaurosis	Leber Congenital Amaurosis	BEFREE	18826961		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	20093778, 21505454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	21505454, 25901761		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	20093778, 22353935, 29855732		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30637711		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	19724857, 21505454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	18538832, 19724857, 20093778		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nodular Sclerosis Classical Hodgkin Lymphoma	Classical Hodgkin lymphoma	BEFREE	10362793		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	BEFREE	16518657		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30637711		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma	Carcinoma	BEFREE	19724857		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	19724857		★★★★★ ★☆☆☆☆ Found in Text Mining only
Usher Syndrome	Usher Syndrome	BEFREE	18826961		★★★★★ ★☆☆☆☆ Found in Text Mining only

NINL (ninein like)