EPN2 (epsin 2)

Gene

• Entrez ID: 22905
• Gene name: Epsin 2
• Gene symbol: EPN2
• Synonyms (NCBI Gene): EHB21
• Chromosome: 17
• Chromosome location: 17p11.2
• Summary: This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The p

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018537	hsa-miR-335-5p	Reporter assay;Western blot	21618216
MIRT040434	hsa-miR-615-3p	CLASH	23622248
MIRT647896	hsa-miR-4282	HITS-CLIP	23824327
MIRT647895	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647894	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647893	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT647896	hsa-miR-4282	HITS-CLIP	23824327
MIRT647895	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647894	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647893	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT727759	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT727758	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT647896	hsa-miR-4282	HITS-CLIP	23824327
MIRT647895	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647894	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647893	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT647896	hsa-miR-4282	HITS-CLIP	23824327
MIRT647895	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT647894	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT647893	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT967063	hsa-miR-1233	CLIP-seq
MIRT967064	hsa-miR-1321	CLIP-seq
MIRT967065	hsa-miR-148a	CLIP-seq
MIRT967066	hsa-miR-148b	CLIP-seq
MIRT967067	hsa-miR-152	CLIP-seq
MIRT967068	hsa-miR-3173-5p	CLIP-seq
MIRT967069	hsa-miR-3692	CLIP-seq
MIRT967070	hsa-miR-3922-5p	CLIP-seq
MIRT967071	hsa-miR-4257	CLIP-seq
MIRT967072	hsa-miR-4293	CLIP-seq
MIRT967073	hsa-miR-4419a	CLIP-seq
MIRT967074	hsa-miR-4443	CLIP-seq
MIRT967075	hsa-miR-4473	CLIP-seq
MIRT967076	hsa-miR-4510	CLIP-seq
MIRT967077	hsa-miR-4659a-3p	CLIP-seq
MIRT967078	hsa-miR-4659b-3p	CLIP-seq
MIRT967079	hsa-miR-4662a-5p	CLIP-seq
MIRT967080	hsa-miR-4671-3p	CLIP-seq
MIRT967081	hsa-miR-4705	CLIP-seq
MIRT967082	hsa-miR-4722-3p	CLIP-seq
MIRT967083	hsa-miR-4739	CLIP-seq
MIRT967084	hsa-miR-4756-5p	CLIP-seq
MIRT967085	hsa-miR-4766-5p	CLIP-seq
MIRT967086	hsa-miR-4769-3p	CLIP-seq
MIRT967087	hsa-miR-520f	CLIP-seq
MIRT967088	hsa-miR-596	CLIP-seq
MIRT967089	hsa-miR-7	CLIP-seq
MIRT967090	hsa-miR-765	CLIP-seq
MIRT967091	hsa-miR-1224-5p	CLIP-seq
MIRT967092	hsa-miR-1262	CLIP-seq
MIRT967093	hsa-miR-1290	CLIP-seq
MIRT967094	hsa-miR-1294	CLIP-seq
MIRT967095	hsa-miR-132	CLIP-seq
MIRT967064	hsa-miR-1321	CLIP-seq
MIRT967096	hsa-miR-155	CLIP-seq
MIRT967097	hsa-miR-186	CLIP-seq
MIRT967098	hsa-miR-197	CLIP-seq
MIRT967099	hsa-miR-200b	CLIP-seq
MIRT967100	hsa-miR-200c	CLIP-seq
MIRT967101	hsa-miR-212	CLIP-seq
MIRT967102	hsa-miR-28-5p	CLIP-seq
MIRT967103	hsa-miR-3133	CLIP-seq
MIRT967104	hsa-miR-3139	CLIP-seq
MIRT967105	hsa-miR-3159	CLIP-seq
MIRT967106	hsa-miR-3612	CLIP-seq
MIRT967107	hsa-miR-3975	CLIP-seq
MIRT967108	hsa-miR-421	CLIP-seq
MIRT967109	hsa-miR-429	CLIP-seq
MIRT967073	hsa-miR-4419a	CLIP-seq
MIRT967074	hsa-miR-4443	CLIP-seq
MIRT967076	hsa-miR-4510	CLIP-seq
MIRT967110	hsa-miR-4633-3p	CLIP-seq
MIRT967111	hsa-miR-4701-3p	CLIP-seq
MIRT967112	hsa-miR-4709-5p	CLIP-seq
MIRT967113	hsa-miR-4731-3p	CLIP-seq
MIRT967083	hsa-miR-4739	CLIP-seq
MIRT967114	hsa-miR-4744	CLIP-seq
MIRT967115	hsa-miR-4751	CLIP-seq
MIRT967084	hsa-miR-4756-5p	CLIP-seq
MIRT967116	hsa-miR-4760-3p	CLIP-seq
MIRT967117	hsa-miR-4801	CLIP-seq
MIRT967118	hsa-miR-505	CLIP-seq
MIRT967119	hsa-miR-541	CLIP-seq
MIRT967120	hsa-miR-548an	CLIP-seq
MIRT967121	hsa-miR-582-5p	CLIP-seq
MIRT967122	hsa-miR-610	CLIP-seq
MIRT967123	hsa-miR-650	CLIP-seq
MIRT967124	hsa-miR-654-5p	CLIP-seq
MIRT967089	hsa-miR-7	CLIP-seq
MIRT967125	hsa-miR-708	CLIP-seq
MIRT1986461	hsa-miR-1207-3p	CLIP-seq
MIRT1986462	hsa-miR-1293	CLIP-seq
MIRT967095	hsa-miR-132	CLIP-seq
MIRT1986463	hsa-miR-1323	CLIP-seq
MIRT1986464	hsa-miR-1343	CLIP-seq
MIRT1986465	hsa-miR-1915	CLIP-seq
MIRT967101	hsa-miR-212	CLIP-seq
MIRT967068	hsa-miR-3173-5p	CLIP-seq
MIRT1986466	hsa-miR-3192	CLIP-seq
MIRT1986467	hsa-miR-3194-3p	CLIP-seq
MIRT1986468	hsa-miR-3199	CLIP-seq
MIRT1986469	hsa-miR-326	CLIP-seq
MIRT1986470	hsa-miR-330-5p	CLIP-seq
MIRT1986471	hsa-miR-3661	CLIP-seq
MIRT1986472	hsa-miR-3907	CLIP-seq
MIRT967108	hsa-miR-421	CLIP-seq
MIRT1986473	hsa-miR-4251	CLIP-seq
MIRT1986474	hsa-miR-4305	CLIP-seq
MIRT1986475	hsa-miR-4314	CLIP-seq
MIRT1986476	hsa-miR-433	CLIP-seq
MIRT1986477	hsa-miR-4462	CLIP-seq
MIRT1986478	hsa-miR-4483	CLIP-seq
MIRT1986479	hsa-miR-4646-5p	CLIP-seq
MIRT1986480	hsa-miR-4680-5p	CLIP-seq
MIRT1986481	hsa-miR-4691-3p	CLIP-seq
MIRT967112	hsa-miR-4709-5p	CLIP-seq
MIRT1986482	hsa-miR-4726-3p	CLIP-seq
MIRT967113	hsa-miR-4731-3p	CLIP-seq
MIRT1986483	hsa-miR-4740-5p	CLIP-seq
MIRT1986484	hsa-miR-4757-5p	CLIP-seq
MIRT967117	hsa-miR-4801	CLIP-seq
MIRT967118	hsa-miR-505	CLIP-seq
MIRT1986485	hsa-miR-539	CLIP-seq
MIRT1986486	hsa-miR-548aa	CLIP-seq
MIRT1986487	hsa-miR-548o	CLIP-seq
MIRT1986488	hsa-miR-548u	CLIP-seq
MIRT1986489	hsa-miR-618	CLIP-seq
MIRT1986490	hsa-miR-631	CLIP-seq
MIRT1986491	hsa-miR-764	CLIP-seq
MIRT1986492	hsa-miR-873	CLIP-seq
MIRT1986463	hsa-miR-1323	CLIP-seq
MIRT2220986	hsa-miR-3184	CLIP-seq
MIRT1986468	hsa-miR-3199	CLIP-seq
MIRT2220987	hsa-miR-423-5p	CLIP-seq
MIRT1986474	hsa-miR-4305	CLIP-seq
MIRT967113	hsa-miR-4731-3p	CLIP-seq
MIRT967117	hsa-miR-4801	CLIP-seq
MIRT1986487	hsa-miR-548o	CLIP-seq
MIRT2220988	hsa-miR-1254	CLIP-seq
MIRT2220989	hsa-miR-1288	CLIP-seq
MIRT2220990	hsa-miR-187	CLIP-seq
MIRT2220991	hsa-miR-3116	CLIP-seq
MIRT2220992	hsa-miR-3158-3p	CLIP-seq
MIRT2220993	hsa-miR-3169	CLIP-seq
MIRT2220994	hsa-miR-342-5p	CLIP-seq
MIRT2220995	hsa-miR-3657	CLIP-seq
MIRT2220996	hsa-miR-3944-3p	CLIP-seq
MIRT2220997	hsa-miR-4278	CLIP-seq
MIRT2220998	hsa-miR-4446-3p	CLIP-seq
MIRT2220999	hsa-miR-4492	CLIP-seq
MIRT2221000	hsa-miR-4498	CLIP-seq
MIRT2221001	hsa-miR-4505	CLIP-seq
MIRT2221002	hsa-miR-4651	CLIP-seq
MIRT2221003	hsa-miR-4656	CLIP-seq
MIRT2221004	hsa-miR-4664-5p	CLIP-seq
MIRT2221005	hsa-miR-4688	CLIP-seq
MIRT2221006	hsa-miR-4731-5p	CLIP-seq
MIRT2221007	hsa-miR-608	CLIP-seq
MIRT2221008	hsa-miR-637	CLIP-seq
MIRT2221009	hsa-miR-661	CLIP-seq
MIRT2221010	hsa-miR-762	CLIP-seq
MIRT2524740	hsa-miR-1252	CLIP-seq
MIRT2524741	hsa-miR-1285	CLIP-seq
MIRT2524742	hsa-miR-1291	CLIP-seq
MIRT2524743	hsa-miR-224	CLIP-seq
MIRT2524744	hsa-miR-25	CLIP-seq
MIRT2524745	hsa-miR-3130-3p	CLIP-seq
MIRT2524746	hsa-miR-3136-3p	CLIP-seq
MIRT2524747	hsa-miR-3147	CLIP-seq
MIRT967068	hsa-miR-3173-5p	CLIP-seq
MIRT2524748	hsa-miR-3187-5p	CLIP-seq
MIRT2524749	hsa-miR-32	CLIP-seq
MIRT2524750	hsa-miR-363	CLIP-seq
MIRT1986471	hsa-miR-3661	CLIP-seq
MIRT2524751	hsa-miR-367	CLIP-seq
MIRT2524752	hsa-miR-3679-3p	CLIP-seq
MIRT2524753	hsa-miR-378g	CLIP-seq
MIRT2524754	hsa-miR-3973	CLIP-seq
MIRT2524755	hsa-miR-4260	CLIP-seq
MIRT2524756	hsa-miR-4286	CLIP-seq
MIRT1986475	hsa-miR-4314	CLIP-seq
MIRT2524757	hsa-miR-4425	CLIP-seq
MIRT2524758	hsa-miR-4486	CLIP-seq
MIRT2524759	hsa-miR-4707-5p	CLIP-seq
MIRT967082	hsa-miR-4722-3p	CLIP-seq
MIRT2524760	hsa-miR-4781-3p	CLIP-seq
MIRT2524761	hsa-miR-4786-5p	CLIP-seq
MIRT2524762	hsa-miR-4793-5p	CLIP-seq
MIRT2524763	hsa-miR-520g	CLIP-seq
MIRT2524764	hsa-miR-520h	CLIP-seq
MIRT2524765	hsa-miR-554	CLIP-seq
MIRT2524766	hsa-miR-612	CLIP-seq
MIRT1986490	hsa-miR-631	CLIP-seq
MIRT2524767	hsa-miR-92a	CLIP-seq
MIRT2524768	hsa-miR-92b	CLIP-seq
MIRT2524769	hsa-miR-934	CLIP-seq
MIRT2524740	hsa-miR-1252	CLIP-seq
MIRT2524741	hsa-miR-1285	CLIP-seq
MIRT2524742	hsa-miR-1291	CLIP-seq
MIRT2524744	hsa-miR-25	CLIP-seq
MIRT2524745	hsa-miR-3130-3p	CLIP-seq
MIRT2524746	hsa-miR-3136-3p	CLIP-seq
MIRT967068	hsa-miR-3173-5p	CLIP-seq
MIRT2524748	hsa-miR-3187-5p	CLIP-seq
MIRT2524749	hsa-miR-32	CLIP-seq
MIRT2524750	hsa-miR-363	CLIP-seq
MIRT1986471	hsa-miR-3661	CLIP-seq
MIRT2524751	hsa-miR-367	CLIP-seq
MIRT2524753	hsa-miR-378g	CLIP-seq
MIRT2524756	hsa-miR-4286	CLIP-seq
MIRT1986475	hsa-miR-4314	CLIP-seq
MIRT2524758	hsa-miR-4486	CLIP-seq
MIRT967082	hsa-miR-4722-3p	CLIP-seq
MIRT2524762	hsa-miR-4793-5p	CLIP-seq
MIRT2524765	hsa-miR-554	CLIP-seq
MIRT2524766	hsa-miR-612	CLIP-seq
MIRT1986490	hsa-miR-631	CLIP-seq
MIRT2524767	hsa-miR-92a	CLIP-seq
MIRT2524768	hsa-miR-92b	CLIP-seq
MIRT2524769	hsa-miR-934	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	18199683, 32296183, 37207277
GO:0005543	Function	Phospholipid binding	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IBA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0006897	Process	Endocytosis	IBA
GO:0006897	Process	Endocytosis	IEA
GO:0008289	Function	Lipid binding	IEA
GO:0030125	Component	Clathrin vesicle coat	IBA
GO:0030136	Component	Clathrin-coated vesicle	IEA
GO:0030276	Function	Clathrin binding	IBA
GO:0030948	Process	Negative regulation of vascular endothelial growth factor receptor signaling pathway	IMP	28717225
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0045747	Process	Positive regulation of Notch signaling pathway	IMP	28717225
GO:1903671	Process	Negative regulation of sprouting angiogenesis	IMP	28717225

Other IDs

• MIM: 607263
• HGNC: 18639
• e!Ensembl: ENSG00000072134

Protein

• UniProt ID: O95208
• Protein name: Epsin-2 (EPS-15-interacting protein 2)
• Protein function: Plays a role in the formation of clathrin-coated invaginations and endocytosis.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01417	ENTH	17 → 140	ENTH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highest expression is found in brain. Detected at lower levels in lung and liver. {ECO:0000269|PubMed:10567358}.
• Sequence:

  MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMV
  WKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQG
  INVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTS
  HSEQEYGKAGGSPASYHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLASRPN
  GDWSQPCLTCDRAARATSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRRG
  DDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSAST
  NQTNPWGGPAAPASTSDPWPSFGTKPAASIDPWGVPTGATVQSVPKNSDPWAASQQPASS
  AGKRASDAWGAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFDNLRTSKKTAESVTSLPSQ
  NNGTTSPDPFESQPLTVASSKPSSARKTPESFLGPNAALVNLDSLVTRPAPPAQSLNPFL
  APGAPATSAPVNPFQVNQPQPLTLNQLRGSPVLGTSTSFGPGPGVESMAVASMTSAAPQP
  ALGATGSSLTPLGPAMMNMVGSVGIPPSAAQATGTTNPFLL

• Sequence length: 641

Pathways

KEGG:

Endocytosis

Reactome:

Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Cholangiocarcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Dementia Vascular	Vascular dementia	Pubtator	39909351	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	GWASCAT_DG	26198764, 31374203		★★☆☆☆ Found in Text Mining + Unknown/Other Associations