Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	22873
Gene name	DAZ interacting zinc finger protein 1
Gene symbol	DZIP1
Synonyms (NCBI Gene)	DZIPDZIPt1MMVP3MVP3SPGF47
Chromosome	13
Chromosome location	13q32.1

204

Show/Hide all (204)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005040	hsa-let-7b-5p	Microarray	17699775
MIRT022498	hsa-miR-124-3p	Microarray	18668037
MIRT051692	hsa-let-7e-5p	CLASH	23622248
MIRT038523	hsa-miR-99b-3p	CLASH	23622248
MIRT949932	hsa-miR-1227	CLIP-seq
MIRT949933	hsa-miR-1243	CLIP-seq
MIRT949934	hsa-miR-1261	CLIP-seq
MIRT949935	hsa-miR-1273f	CLIP-seq
MIRT949936	hsa-miR-128	CLIP-seq
MIRT949937	hsa-miR-1285	CLIP-seq
MIRT949938	hsa-miR-1293	CLIP-seq
MIRT949939	hsa-miR-1304	CLIP-seq
MIRT949940	hsa-miR-137	CLIP-seq
MIRT949941	hsa-miR-142-3p	CLIP-seq
MIRT949942	hsa-miR-150	CLIP-seq
MIRT949943	hsa-miR-186	CLIP-seq
MIRT949944	hsa-miR-1915	CLIP-seq
MIRT949945	hsa-miR-27a	CLIP-seq
MIRT949946	hsa-miR-27b	CLIP-seq
MIRT949947	hsa-miR-3122	CLIP-seq
MIRT949948	hsa-miR-3133	CLIP-seq
MIRT949949	hsa-miR-3146	CLIP-seq
MIRT949950	hsa-miR-3174	CLIP-seq
MIRT949951	hsa-miR-3176	CLIP-seq
MIRT949952	hsa-miR-3187-5p	CLIP-seq
MIRT949953	hsa-miR-3192	CLIP-seq
MIRT949954	hsa-miR-3607-5p	CLIP-seq
MIRT949955	hsa-miR-3688-5p	CLIP-seq
MIRT949956	hsa-miR-3689a-3p	CLIP-seq
MIRT949957	hsa-miR-3689c	CLIP-seq
MIRT949958	hsa-miR-3913-5p	CLIP-seq
MIRT949959	hsa-miR-3922-3p	CLIP-seq
MIRT949960	hsa-miR-3926	CLIP-seq
MIRT949961	hsa-miR-4252	CLIP-seq
MIRT949962	hsa-miR-4261	CLIP-seq
MIRT949963	hsa-miR-4269	CLIP-seq
MIRT949964	hsa-miR-4314	CLIP-seq
MIRT949965	hsa-miR-4433	CLIP-seq
MIRT949966	hsa-miR-4459	CLIP-seq
MIRT949967	hsa-miR-4477b	CLIP-seq
MIRT949968	hsa-miR-4483	CLIP-seq
MIRT949969	hsa-miR-4506	CLIP-seq
MIRT949970	hsa-miR-4514	CLIP-seq
MIRT949971	hsa-miR-4537	CLIP-seq
MIRT949972	hsa-miR-4646-5p	CLIP-seq
MIRT949973	hsa-miR-4692	CLIP-seq
MIRT949974	hsa-miR-4694-3p	CLIP-seq
MIRT949975	hsa-miR-4709-5p	CLIP-seq
MIRT949976	hsa-miR-4726-3p	CLIP-seq
MIRT949977	hsa-miR-4728-5p	CLIP-seq
MIRT949978	hsa-miR-4742-5p	CLIP-seq
MIRT949979	hsa-miR-4760-3p	CLIP-seq
MIRT949980	hsa-miR-4768-3p	CLIP-seq
MIRT949981	hsa-miR-4786-5p	CLIP-seq
MIRT949982	hsa-miR-4795-3p	CLIP-seq
MIRT949983	hsa-miR-485-3p	CLIP-seq
MIRT949984	hsa-miR-522	CLIP-seq
MIRT949985	hsa-miR-548m	CLIP-seq
MIRT949986	hsa-miR-548s	CLIP-seq
MIRT949987	hsa-miR-562	CLIP-seq
MIRT949988	hsa-miR-577	CLIP-seq
MIRT949989	hsa-miR-579	CLIP-seq
MIRT949990	hsa-miR-582-3p	CLIP-seq
MIRT949991	hsa-miR-612	CLIP-seq
MIRT949992	hsa-miR-622	CLIP-seq
MIRT949993	hsa-miR-656	CLIP-seq
MIRT949994	hsa-miR-658	CLIP-seq
MIRT949995	hsa-miR-661	CLIP-seq
MIRT949996	hsa-miR-921	CLIP-seq
MIRT1548108	hsa-miR-24	CLIP-seq
MIRT1548109	hsa-miR-320a	CLIP-seq
MIRT1548110	hsa-miR-320b	CLIP-seq
MIRT1548111	hsa-miR-320c	CLIP-seq
MIRT1548112	hsa-miR-320d	CLIP-seq
MIRT1548113	hsa-miR-330-3p	CLIP-seq
MIRT1548114	hsa-miR-4284	CLIP-seq
MIRT1548115	hsa-miR-4429	CLIP-seq
MIRT1548116	hsa-miR-4501	CLIP-seq
MIRT1548117	hsa-miR-4504	CLIP-seq
MIRT1548118	hsa-miR-542-3p	CLIP-seq
MIRT1548119	hsa-miR-582-5p	CLIP-seq
MIRT1548120	hsa-miR-600	CLIP-seq
MIRT949956	hsa-miR-3689a-3p	CLIP-seq
MIRT949957	hsa-miR-3689c	CLIP-seq
MIRT949977	hsa-miR-4728-5p	CLIP-seq
MIRT949979	hsa-miR-4760-3p	CLIP-seq
MIRT2216411	hsa-miR-1224-3p	CLIP-seq
MIRT949932	hsa-miR-1227	CLIP-seq
MIRT2216412	hsa-miR-1260	CLIP-seq
MIRT2216413	hsa-miR-1260b	CLIP-seq
MIRT949935	hsa-miR-1273f	CLIP-seq
MIRT949936	hsa-miR-128	CLIP-seq
MIRT2216414	hsa-miR-1280	CLIP-seq
MIRT949937	hsa-miR-1285	CLIP-seq
MIRT2216415	hsa-miR-139-5p	CLIP-seq
MIRT949942	hsa-miR-150	CLIP-seq
MIRT949945	hsa-miR-27a	CLIP-seq
MIRT949946	hsa-miR-27b	CLIP-seq
MIRT949951	hsa-miR-3176	CLIP-seq
MIRT949952	hsa-miR-3187-5p	CLIP-seq
MIRT2216416	hsa-miR-323-5p	CLIP-seq
MIRT2216417	hsa-miR-3617	CLIP-seq
MIRT2216418	hsa-miR-3622b-5p	CLIP-seq
MIRT2216419	hsa-miR-3688-3p	CLIP-seq
MIRT949956	hsa-miR-3689a-3p	CLIP-seq
MIRT949957	hsa-miR-3689c	CLIP-seq
MIRT949959	hsa-miR-3922-3p	CLIP-seq
MIRT949960	hsa-miR-3926	CLIP-seq
MIRT2216420	hsa-miR-3936	CLIP-seq
MIRT2216421	hsa-miR-3945	CLIP-seq
MIRT2216422	hsa-miR-3978	CLIP-seq
MIRT949961	hsa-miR-4252	CLIP-seq
MIRT2216423	hsa-miR-4253	CLIP-seq
MIRT949965	hsa-miR-4433	CLIP-seq
MIRT949966	hsa-miR-4459	CLIP-seq
MIRT2216424	hsa-miR-4509	CLIP-seq
MIRT2216425	hsa-miR-4645-5p	CLIP-seq
MIRT2216426	hsa-miR-4673	CLIP-seq
MIRT2216427	hsa-miR-4688	CLIP-seq
MIRT2216428	hsa-miR-4700-3p	CLIP-seq
MIRT949975	hsa-miR-4709-5p	CLIP-seq
MIRT2216429	hsa-miR-4711-5p	CLIP-seq
MIRT949977	hsa-miR-4728-5p	CLIP-seq
MIRT2216430	hsa-miR-4755-3p	CLIP-seq
MIRT949980	hsa-miR-4768-3p	CLIP-seq
MIRT949981	hsa-miR-4786-5p	CLIP-seq
MIRT2216431	hsa-miR-4803	CLIP-seq
MIRT949983	hsa-miR-485-3p	CLIP-seq
MIRT2216432	hsa-miR-532-3p	CLIP-seq
MIRT2216433	hsa-miR-541	CLIP-seq
MIRT949985	hsa-miR-548m	CLIP-seq
MIRT949986	hsa-miR-548s	CLIP-seq
MIRT949987	hsa-miR-562	CLIP-seq
MIRT2216434	hsa-miR-607	CLIP-seq
MIRT949991	hsa-miR-612	CLIP-seq
MIRT949992	hsa-miR-622	CLIP-seq
MIRT2216435	hsa-miR-641	CLIP-seq
MIRT2216436	hsa-miR-654-5p	CLIP-seq
MIRT949995	hsa-miR-661	CLIP-seq
MIRT2216437	hsa-miR-876-3p	CLIP-seq
MIRT2216438	hsa-miR-890	CLIP-seq
MIRT2520376	hsa-miR-129-5p	CLIP-seq
MIRT2520377	hsa-miR-1299	CLIP-seq
MIRT2520378	hsa-miR-141	CLIP-seq
MIRT2520379	hsa-miR-200a	CLIP-seq
MIRT2520380	hsa-miR-200b	CLIP-seq
MIRT2520381	hsa-miR-200c	CLIP-seq
MIRT2520382	hsa-miR-3065-5p	CLIP-seq
MIRT2520383	hsa-miR-3143	CLIP-seq
MIRT2520384	hsa-miR-3145-5p	CLIP-seq
MIRT2520385	hsa-miR-3170	CLIP-seq
MIRT2520386	hsa-miR-342-5p	CLIP-seq
MIRT2520387	hsa-miR-3613-3p	CLIP-seq
MIRT2520388	hsa-miR-3675-3p	CLIP-seq
MIRT2520389	hsa-miR-3689a-5p	CLIP-seq
MIRT2520390	hsa-miR-3689b	CLIP-seq
MIRT2520391	hsa-miR-3689e	CLIP-seq
MIRT2520392	hsa-miR-3689f	CLIP-seq
MIRT2520393	hsa-miR-4260	CLIP-seq
MIRT2520394	hsa-miR-429	CLIP-seq
MIRT2520395	hsa-miR-4455	CLIP-seq
MIRT2520396	hsa-miR-4535	CLIP-seq
MIRT2520397	hsa-miR-4651	CLIP-seq
MIRT2520398	hsa-miR-4664-5p	CLIP-seq
MIRT2520399	hsa-miR-4679	CLIP-seq
MIRT2520400	hsa-miR-4684-5p	CLIP-seq
MIRT2520401	hsa-miR-4724-5p	CLIP-seq
MIRT2520402	hsa-miR-4762-5p	CLIP-seq
MIRT2520403	hsa-miR-4776-5p	CLIP-seq
MIRT2520404	hsa-miR-4782-5p	CLIP-seq
MIRT2520405	hsa-miR-492	CLIP-seq
MIRT2520406	hsa-miR-494	CLIP-seq
MIRT2520407	hsa-miR-500a	CLIP-seq
MIRT2520408	hsa-miR-508-5p	CLIP-seq
MIRT2520409	hsa-miR-516b	CLIP-seq
MIRT2520410	hsa-miR-543	CLIP-seq
MIRT2520411	hsa-miR-548aa	CLIP-seq
MIRT2520412	hsa-miR-548c-3p	CLIP-seq
MIRT2520413	hsa-miR-576-5p	CLIP-seq
MIRT2520414	hsa-miR-608	CLIP-seq
MIRT2520415	hsa-miR-665	CLIP-seq
MIRT2520416	hsa-miR-875-3p	CLIP-seq
MIRT2520378	hsa-miR-141	CLIP-seq
MIRT2520379	hsa-miR-200a	CLIP-seq
MIRT2520380	hsa-miR-200b	CLIP-seq
MIRT2520381	hsa-miR-200c	CLIP-seq
MIRT2520382	hsa-miR-3065-5p	CLIP-seq
MIRT2520387	hsa-miR-3613-3p	CLIP-seq
MIRT2679627	hsa-miR-3646	CLIP-seq
MIRT2520388	hsa-miR-3675-3p	CLIP-seq
MIRT2520389	hsa-miR-3689a-5p	CLIP-seq
MIRT2520390	hsa-miR-3689b	CLIP-seq
MIRT2520391	hsa-miR-3689e	CLIP-seq
MIRT2520392	hsa-miR-3689f	CLIP-seq
MIRT2520394	hsa-miR-429	CLIP-seq
MIRT2679628	hsa-miR-4311	CLIP-seq
MIRT2520399	hsa-miR-4679	CLIP-seq
MIRT2520400	hsa-miR-4684-5p	CLIP-seq
MIRT2520401	hsa-miR-4724-5p	CLIP-seq
MIRT2520402	hsa-miR-4762-5p	CLIP-seq
MIRT2520406	hsa-miR-494	CLIP-seq
MIRT2520411	hsa-miR-548aa	CLIP-seq
MIRT2520412	hsa-miR-548c-3p	CLIP-seq
MIRT2216438	hsa-miR-890	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15081113, 21878643, 23955340, 32296183
GO:0005634	Component	Nucleus	IDA	15081113
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	15081113
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA
GO:0005814	Component	Centriole	IDA	19852954
GO:0005814	Component	Centriole	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005929	Component	Cilium	IEA
GO:0007224	Process	Smoothened signaling pathway	IEA
GO:0007281	Process	Germ cell development	IEP	15081113
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	IMP	32051257
GO:0007507	Process	Heart development	IEA
GO:0007507	Process	Heart development	IMP	31118289
GO:0008270	Function	Zinc ion binding	IEA
GO:0016607	Component	Nuclear speck	IEA
GO:0030030	Process	Cell projection organization	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0032053	Process	Ciliary basal body organization	IMP	32051257
GO:0033365	Process	Protein localization to organelle	IEA
GO:0034451	Component	Centriolar satellite	IDA	27979967
GO:0034451	Component	Centriolar satellite	IEA
GO:0036064	Component	Ciliary basal body	IBA
GO:0036064	Component	Ciliary basal body	IDA	19852954
GO:0036064	Component	Ciliary basal body	IEA
GO:0042995	Component	Cell projection	IEA
GO:0044782	Process	Cilium organization	IEA
GO:0045184	Process	Establishment of protein localization	IEA
GO:0045724	Process	Positive regulation of cilium assembly	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051649	Process	Establishment of localization in cell	IEA
GO:0060090	Function	Molecular adaptor activity	IMP	27979967
GO:0060271	Process	Cilium assembly	IBA
GO:0060271	Process	Cilium assembly	IEA
GO:0060271	Process	Cilium assembly	IEA
GO:0060271	Process	Cilium assembly	IMP	19852954
GO:0061512	Process	Protein localization to cilium	IEA
GO:0062063	Function	BBSome binding	IDA	27979967
GO:0062063	Function	BBSome binding	IEA
GO:0097539	Component	Ciliary transition fiber	IEA
GO:0097546	Component	Ciliary base	IEA
GO:0120316	Process	Sperm flagellum assembly	IMP	32051257
GO:0140706	Process	Protein-containing complex localization to centriolar satellite	IDA	27979967
GO:1903566	Process	Positive regulation of protein localization to cilium	IEA

MIM	HGNC	e!Ensembl
608671	20908	ENSG00000134874

Q86YF9

Protein name

Cilium assembly protein DZIP1 (DAZ-interacting protein 1/2) (DAZ-interacting zinc finger protein 1)

Protein function

Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:19852954, PubMed:23955340, PubMed:27979967, PubMed:32051257). At the exit of mitosis, localizes to the basal body and ci

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13815	Dzip-like_N	58 → 178	Iguana/Dzip1-like DAZ-interacting protein N-terminal	Family

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in testis (at protein level) (PubMed:15081113, PubMed:32051257). Also expressed in fetal brain, adult oocytes and ovary (PubMed:15081113). Expressed in undifferentiated ES cells (PubMed:15081113). In testis, it

Sequence

MQAEAADWFSSMPFQKHVYYPLASGPEGPDVAVAAAAAGAASMACAPPSAASGPLPFFQF
RPRLESVDWRRLSAIDVDKVAGAVDVLTLQENIMNITFCKLEDEKCPHCQSGVDPVLLKL
IRLAQFTIEYLLHSQEFLTSQLHTLEERLRLSHCDGEQSKKLLTKQAGEIKTLKEECKRR
KKMISTQQLMIEAKANYYQCHFCDKAFMNQAFLQSHIQRRHTEENSHFEYQKNAQIEKLR
SEIVVLKEELQLTRSELEAAHHASAVRFSKEYEMQKTKEEDFLKLFDRWKEEEKEKLVDE
MEKVKEMFMKEFKELTSKNSALEYQLSEIQKSNMQIKSNIGTLKDAHEFKEDRSPYPQDF
HNVMQLLDSQESKWTARVQAIHQEHKKEKGRLLSHIEKLRTSMIDDLNASNVFYKKRIEE
LGQRLQEQNELIITQRQQIKDFTCNPLNSISEPKGNPLAWQAFESQPAAPAVPMNAPALH
TLETKSSLPMVHEQAFSSHILEPIEELSEEEKGRENEQKLNNNKMHLRKALKSNSSLTKG
LRTMVEQNLMEKLETLGINADIRGISSDQLHRVLKSVESERHKQEREIPNFHQIREFLEH
QVSCKIEEKALLSSDQCSVSQMDTLSTGEVPKMIQLPSKNRQLIRQKAVSTDRTSVPKIK
KNVMEDPFPRKSSTITTPPFSSEEEQEDDDLIRAYASPGPLPVPPPQNKGSFGKNTVKSD
ADGTEGSEIEDTDDSPKPAGVAVKTPTEKVEKMFPHRKNVNKPVGGTNVPEMFIKKEELQ
ELKCADVEDEDWDISSLEEEISLGKKSGKEQKEPPPAKNEPHFAHVLNAWGAFNPKGPKG
EGLQENESSTLKSSLVTVTDWSDTSDV

Sequence length

867

Interactions

View interactions

	Reactome
			Hedgehog 'on' state

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Spermatogenic failure 47	Pathogenic	rs1877018344, rs1878524886	RCV001265625 RCV001265626	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DZIP1-related disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INTELLECTUAL DEVELOPMENTAL DISORDER, AUTOSOMAL DOMINANT 61	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITRAL VALVE PROLAPSE 3	—	HPO	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MITRAL VALVE PROLAPSE SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mitral valve prolapse, myxomatous 3	Uncertain significance	ClinVar CTD, ClinVar, Disgenet CTD, ClinVar, Disgenet CTD, ClinVar, Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
TETRALOGY OF FALLOT	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Azoospermia	Azoospermia	Pubtator	37854191	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	22433712		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	22433712		★★★★★ ★☆☆☆☆ Found in Text Mining only

DZIP1 (DAZ interacting zinc finger protein 1)