Gene Gene information from NCBI Gene database.
Entrez ID 22863
Gene name Autophagy related 14
Gene symbol ATG14
Synonyms (NCBI Gene)
ATG14LBARKORKIAA0831
Chromosome 14
Chromosome location 14q22.3
miRNA miRNA information provided by mirtarbase database.
482
miRTarBase ID miRNA Experiments Reference
MIRT027109 hsa-miR-103a-3p Sequencing 20371350
MIRT031793 hsa-miR-16-5p Sequencing 20371350
MIRT054904 hsa-miR-195-5p ImmunofluorescenceLuciferase reporter assayqRT-PCR 23361941
MIRT054904 hsa-miR-195-5p ImmunofluorescenceLuciferase reporter assayqRT-PCR 23361941
MIRT138595 hsa-miR-6890-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
62
GO ID Ontology Definition Evidence Reference
GO:0000045 Process Autophagosome assembly IBA
GO:0000045 Process Autophagosome assembly IDA 25891078, 33637724
GO:0000045 Process Autophagosome assembly IDA 20713597
GO:0000045 Process Autophagosome assembly IMP 19270696
GO:0000407 Component Phagophore assembly site IDA 20713597
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613515 19962 ENSG00000126775
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6ZNE5
Protein name Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L)
Protein function Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosph
PDB 6HOL , 8SOR , 9C82 , 9MHF , 9MHG , 9MHH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10186 Atg14 43 391 Vacuolar sorting 38 and autophagy-related subunit 14 Family
Sequence
Sequence length 492
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Autophagy - animal
Alzheimer disease
Amyotrophic lateral sclerosis
Huntington disease
Spinocerebellar ataxia
Pathways of neurodegeneration - multiple diseases
Shigellosis
Kaposi sarcoma-associated herpesvirus infection
  Macroautophagy
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TESTICULAR CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TESTICULAR GERM CELL TUMOR GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 30669930
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 33378015 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 31704614
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 36333388 Associate
★☆☆☆☆
Found in Text Mining only
Congenital disorder of glycosylation type 1A Congenital disorder of glycosylation Pubtator 28214880 Associate
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Diabetes mellitus, type 2 Pubtator 28252104 Associate
★☆☆☆☆
Found in Text Mining only
Fibrosis, Liver Liver Fibrosis BEFREE 29414645
★☆☆☆☆
Found in Text Mining only
Intracranial Aneurysm Intracranial Aneurysm BEFREE 28214880
★☆☆☆☆
Found in Text Mining only
Intracranial Aneurysm Intracranial aneurysm Pubtator 28214880 Associate
★☆☆☆☆
Found in Text Mining only
Ketosis Ketosis BEFREE 31179571
★☆☆☆☆
Found in Text Mining only