Gene Gene information from NCBI Gene database.
Entrez ID 22862
Gene name Fibronectin type III domain containing 3A
Gene symbol FNDC3A
Synonyms (NCBI Gene)
FNDC3HUGObA203I16.1bA203I16.5
Chromosome 13
Chromosome location 13q14.2
miRNA miRNA information provided by mirtarbase database.
715
miRTarBase ID miRNA Experiments Reference
MIRT001631 hsa-let-7b-5p pSILAC 18668040
MIRT023556 hsa-miR-1-3p Microarray 18668037
MIRT023556 hsa-miR-1-3p Proteomics 18668040
MIRT027515 hsa-miR-98-5p Microarray 19088304
MIRT001631 hsa-let-7b-5p Proteomics;Other 18668040
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0001669 Component Acrosomal vesicle IEA
GO:0003723 Function RNA binding HDA 22658674
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
615794 20296 ENSG00000102531
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9Y2H6
Protein name Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts)
Protein function Mediates spermatid-Sertoli adhesion during spermatogenesis.
PDB 1WK0 , 1X3D , 1X4X , 1X5X , 2CRM , 2CRZ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00041 fn3 267 359 Fibronectin type III domain Domain
PF00041 fn3 372 455 Fibronectin type III domain Domain
PF00041 fn3 468 552 Fibronectin type III domain Domain
PF00041 fn3 567 650 Fibronectin type III domain Domain
PF00041 fn3 667 747 Fibronectin type III domain Domain
PF00041 fn3 760 841 Fibronectin type III domain Domain
PF00041 fn3 865 940 Fibronectin type III domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the odontoblast and nerves in the dental pulp. Also expressed in trachea and to a lesser extent in the brain, liver, lung and kidney. {ECO:0000269|PubMed:18218838}.
Sequence
MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEAFTIRREDGQFQCITGP
AQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPEFHPGSHTVLHRSPHPPLP
GFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVYGDVDAHSTHGRSNFRDERSS
KTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEHNGLIKGQIAGGINTGSAKIKSG
KGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASDIQARTVVLTWSPPSSLINGETDES
SVPELYGYEVLISSTGKDGKYKSVYVGEETNITLNDLKPAMDYHAKVQAEYNSIKGTPS
E
AEIFTTLSCEPDIPNPPRIANRTKNSLTLQWKAPSDNGSKIQNFVLEWDEGKGNGEFCQC
YMGSQKQFKITKLSPAMGCKFRLSARNDYGTSGFS
EEVLYYTSGCAPSMPASPVLTKAGI
TWLSLQWSKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKV
IAYNSEGKSNPS
EVVEFTTCPDKPGIPVKPSVKGKIHSHSFKITWDPPKDNGGATINKYV
VEMAEGSNGNKWEMIYSGATREHLCDRLNPGCFYRLRVYCISDGGQSAVS
ESLLVQTPAV
PPGPCLPPRLQGRPKAKEIQLRWGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVEC
TVSSLLPGKTYSFRLRAANKMGFGPFS
EKCDITTAPGPPDQCKPPQVTCRSATCAQVNWE
VPLSNGTDVTEYRLEWGGVEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPF
S
EVVACVTPPSVPGIVTCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFG
DKQSLTVGKVTSYIINNLQPDTTYRIRIQALNSLGAGPFS
HMIKLKTKPLPPDPPRLECV
AFSHQNLKLKWGEGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYK
FCIQACNEAGEGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIY
SLQVMLGKDSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTT
VLFISQRTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFVIK
Sequence length 1198
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
19
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANKYLOSING SPONDYLITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FNDC3A-related disorder Benign; Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 22217803
★☆☆☆☆
Found in Text Mining only
Albinism, Ocular Ocular albinism BEFREE 16550551
★☆☆☆☆
Found in Text Mining only
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 24094577, 30394813
★☆☆☆☆
Found in Text Mining only
Ankylosing spondylitis Ankylosing Spondylitis GWASCAT_DG 26974007
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Autism Spectrum Disorders Autism Spectrum Disorder BEFREE 23639254
★☆☆☆☆
Found in Text Mining only
Bipolar Disorder Bipolar Disorder BEFREE 15768394
★☆☆☆☆
Found in Text Mining only
Carcinoma of lung Lung carcinoma BEFREE 19887610
★☆☆☆☆
Found in Text Mining only
Carcinoma, Ovarian Epithelial Ovarian Epithelial carcinoma BEFREE 30394813
★☆☆☆☆
Found in Text Mining only
Cholangitis, Sclerosing Cholangitis GWASCAT_DG 26974007
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 27080994 Associate
★☆☆☆☆
Found in Text Mining only