Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	22837
Gene name	Cordon-bleu WH2 repeat protein like 1
Gene symbol	COBLL1
Synonyms (NCBI Gene)	COBLR1
Chromosome	2
Chromosome location	2q24.3

150

Show/Hide all (150)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024539	hsa-miR-215-5p	Microarray	19074876
MIRT026290	hsa-miR-192-5p	Microarray	19074876
MIRT030747	hsa-miR-21-5p	Microarray	18591254
MIRT717215	hsa-miR-4694-3p	HITS-CLIP	19536157
MIRT717214	hsa-miR-224-3p	HITS-CLIP	19536157
MIRT717213	hsa-miR-522-3p	HITS-CLIP	19536157
MIRT717212	hsa-miR-200a-5p	HITS-CLIP	19536157
MIRT717211	hsa-miR-200b-5p	HITS-CLIP	19536157
MIRT717210	hsa-miR-600	HITS-CLIP	19536157
MIRT717209	hsa-miR-520d-5p	HITS-CLIP	19536157
MIRT717208	hsa-miR-524-5p	HITS-CLIP	19536157
MIRT717207	hsa-miR-6768-5p	HITS-CLIP	19536157
MIRT717206	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT717205	hsa-miR-4424	HITS-CLIP	19536157
MIRT613875	hsa-miR-8485	HITS-CLIP	23313552
MIRT692429	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT692428	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT692427	hsa-miR-603	HITS-CLIP	23313552
MIRT613874	hsa-miR-3943	HITS-CLIP	23313552
MIRT692426	hsa-miR-6793-3p	HITS-CLIP	23313552
MIRT692425	hsa-miR-3941	HITS-CLIP	23313552
MIRT613875	hsa-miR-8485	HITS-CLIP	23824327
MIRT613874	hsa-miR-3943	HITS-CLIP	23824327
MIRT613875	hsa-miR-8485	HITS-CLIP	23824327
MIRT613874	hsa-miR-3943	HITS-CLIP	23824327
MIRT613875	hsa-miR-8485	HITS-CLIP	23824327
MIRT613874	hsa-miR-3943	HITS-CLIP	23824327
MIRT613875	hsa-miR-8485	HITS-CLIP	23824327
MIRT613874	hsa-miR-3943	HITS-CLIP	23824327
MIRT613874	hsa-miR-3943	HITS-CLIP	27418678
MIRT613875	hsa-miR-8485	HITS-CLIP	27418678
MIRT613875	hsa-miR-8485	HITS-CLIP	27418678
MIRT717215	hsa-miR-4694-3p	HITS-CLIP	19536157
MIRT717214	hsa-miR-224-3p	HITS-CLIP	19536157
MIRT717213	hsa-miR-522-3p	HITS-CLIP	19536157
MIRT717212	hsa-miR-200a-5p	HITS-CLIP	19536157
MIRT717211	hsa-miR-200b-5p	HITS-CLIP	19536157
MIRT717210	hsa-miR-600	HITS-CLIP	19536157
MIRT717209	hsa-miR-520d-5p	HITS-CLIP	19536157
MIRT717208	hsa-miR-524-5p	HITS-CLIP	19536157
MIRT717207	hsa-miR-6768-5p	HITS-CLIP	19536157
MIRT717206	hsa-miR-627-3p	HITS-CLIP	19536157
MIRT717205	hsa-miR-4424	HITS-CLIP	19536157
MIRT613875	hsa-miR-8485	HITS-CLIP	23313552
MIRT692429	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT692428	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT692427	hsa-miR-603	HITS-CLIP	23313552
MIRT613874	hsa-miR-3943	HITS-CLIP	23313552
MIRT692426	hsa-miR-6793-3p	HITS-CLIP	23313552
MIRT692425	hsa-miR-3941	HITS-CLIP	23313552
MIRT613875	hsa-miR-8485	HITS-CLIP	23824327
MIRT613874	hsa-miR-3943	HITS-CLIP	23824327
MIRT613875	hsa-miR-8485	HITS-CLIP	23824327
MIRT613874	hsa-miR-3943	HITS-CLIP	23824327
MIRT613875	hsa-miR-8485	HITS-CLIP	23824327
MIRT613874	hsa-miR-3943	HITS-CLIP	23824327
MIRT613875	hsa-miR-8485	HITS-CLIP	23824327
MIRT613874	hsa-miR-3943	HITS-CLIP	23824327
MIRT902017	hsa-miR-103a	CLIP-seq
MIRT902018	hsa-miR-107	CLIP-seq
MIRT902019	hsa-miR-138	CLIP-seq
MIRT902020	hsa-miR-15a	CLIP-seq
MIRT902021	hsa-miR-15b	CLIP-seq
MIRT902022	hsa-miR-16	CLIP-seq
MIRT902023	hsa-miR-195	CLIP-seq
MIRT902024	hsa-miR-224	CLIP-seq
MIRT902025	hsa-miR-3123	CLIP-seq
MIRT902026	hsa-miR-3168	CLIP-seq
MIRT902027	hsa-miR-3190	CLIP-seq
MIRT902028	hsa-miR-3616-5p	CLIP-seq
MIRT902029	hsa-miR-3647-5p	CLIP-seq
MIRT902030	hsa-miR-3674	CLIP-seq
MIRT902031	hsa-miR-3925-5p	CLIP-seq
MIRT902032	hsa-miR-424	CLIP-seq
MIRT902033	hsa-miR-4272	CLIP-seq
MIRT902034	hsa-miR-4422	CLIP-seq
MIRT902035	hsa-miR-4427	CLIP-seq
MIRT902036	hsa-miR-4490	CLIP-seq
MIRT902037	hsa-miR-4509	CLIP-seq
MIRT902038	hsa-miR-4527	CLIP-seq
MIRT902039	hsa-miR-4670-3p	CLIP-seq
MIRT902040	hsa-miR-4680-3p	CLIP-seq
MIRT902041	hsa-miR-4698	CLIP-seq
MIRT902042	hsa-miR-4732-5p	CLIP-seq
MIRT902043	hsa-miR-4744	CLIP-seq
MIRT902044	hsa-miR-4776-3p	CLIP-seq
MIRT902045	hsa-miR-4795-5p	CLIP-seq
MIRT902046	hsa-miR-4799-5p	CLIP-seq
MIRT902047	hsa-miR-497	CLIP-seq
MIRT902048	hsa-miR-519a	CLIP-seq
MIRT902049	hsa-miR-519b-3p	CLIP-seq
MIRT902050	hsa-miR-519c-3p	CLIP-seq
MIRT902051	hsa-miR-573	CLIP-seq
MIRT902052	hsa-miR-885-5p	CLIP-seq
MIRT1546538	hsa-miR-3647-3p	CLIP-seq
MIRT1546538	hsa-miR-3647-3p	CLIP-seq
MIRT1546538	hsa-miR-3647-3p	CLIP-seq
MIRT1546538	hsa-miR-3647-3p	CLIP-seq
MIRT1546538	hsa-miR-3647-3p	CLIP-seq
MIRT1967575	hsa-miR-1256	CLIP-seq
MIRT1967576	hsa-miR-1827	CLIP-seq
MIRT902024	hsa-miR-224	CLIP-seq
MIRT1967577	hsa-miR-27a	CLIP-seq
MIRT1967578	hsa-miR-27b	CLIP-seq
MIRT1967579	hsa-miR-3074-3p	CLIP-seq
MIRT902025	hsa-miR-3123	CLIP-seq
MIRT1967580	hsa-miR-3128	CLIP-seq
MIRT1967581	hsa-miR-3155	CLIP-seq
MIRT1967582	hsa-miR-3155b	CLIP-seq
MIRT1967583	hsa-miR-3163	CLIP-seq
MIRT1967584	hsa-miR-338-5p	CLIP-seq
MIRT1967585	hsa-miR-3591-3p	CLIP-seq
MIRT1967586	hsa-miR-3662	CLIP-seq
MIRT902030	hsa-miR-3674	CLIP-seq
MIRT902031	hsa-miR-3925-5p	CLIP-seq
MIRT1967587	hsa-miR-3945	CLIP-seq
MIRT1967588	hsa-miR-4253	CLIP-seq
MIRT1967589	hsa-miR-4305	CLIP-seq
MIRT1967590	hsa-miR-4310	CLIP-seq
MIRT1967591	hsa-miR-4438	CLIP-seq
MIRT1967592	hsa-miR-4477b	CLIP-seq
MIRT1967593	hsa-miR-4504	CLIP-seq
MIRT1967594	hsa-miR-4652-3p	CLIP-seq
MIRT1967595	hsa-miR-4720-5p	CLIP-seq
MIRT902042	hsa-miR-4732-5p	CLIP-seq
MIRT1967596	hsa-miR-4799-3p	CLIP-seq
MIRT1967597	hsa-miR-484	CLIP-seq
MIRT1967598	hsa-miR-5096	CLIP-seq
MIRT1967599	hsa-miR-513a-5p	CLIP-seq
MIRT1967600	hsa-miR-542-3p	CLIP-seq
MIRT1967601	hsa-miR-579	CLIP-seq
MIRT1967602	hsa-miR-944	CLIP-seq
MIRT902024	hsa-miR-224	CLIP-seq
MIRT1546538	hsa-miR-3647-3p	CLIP-seq
MIRT1967581	hsa-miR-3155	CLIP-seq
MIRT1967582	hsa-miR-3155b	CLIP-seq
MIRT1967585	hsa-miR-3591-3p	CLIP-seq
MIRT1967591	hsa-miR-4438	CLIP-seq
MIRT1967597	hsa-miR-484	CLIP-seq
MIRT1967602	hsa-miR-944	CLIP-seq
MIRT1967577	hsa-miR-27a	CLIP-seq
MIRT1967578	hsa-miR-27b	CLIP-seq
MIRT1967590	hsa-miR-4310	CLIP-seq
MIRT1967592	hsa-miR-4477b	CLIP-seq
MIRT1967593	hsa-miR-4504	CLIP-seq
MIRT1967594	hsa-miR-4652-3p	CLIP-seq
MIRT1967598	hsa-miR-5096	CLIP-seq
MIRT1967599	hsa-miR-513a-5p	CLIP-seq
MIRT1967600	hsa-miR-542-3p	CLIP-seq
MIRT1967602	hsa-miR-944	CLIP-seq

Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IEA
GO:0003785	Function	Actin monomer binding	IEA
GO:0005515	Function	Protein binding	IPI	20936779, 33961781
GO:0005938	Component	Cell cortex	IEA
GO:0016020	Component	Membrane	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070062	Component	Extracellular exosome	HDA	19056867

MIM	HGNC	e!Ensembl
610318	23571	ENSG00000082438

Q53SF7

Protein name

Cordon-bleu protein-like 1

PDB

2DAJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09469	Cobl	136 → 227	Cordon-bleu ubiquitin-like domain	Domain

Sequence

MDGRTPRPQDAPARRKPKAKAPLPPAETKYTDVSSAADSVESTAFIMEQKENMIDKDVEL
SVVLPGDIIKSTTVHGSKPMMDLLIFLCAQYHLNPSSYTIDLLSAEQNHIKFKPNTPIGM
LEVEKVILKPKMLDKKKPTPIIPEKTVRVVINFKKTQKTIVRVSPHASLQELAPIICSKC
EFDPLHTLLLKDYQSQEPLDLTKSLNDLGLRELYAMDVNRESCQISQNLDIMKEKENKGF
FSFFQRSKKKRDQTASAPATPLVNKHRPTFTRSNTISKPYISNTLPSDAPKKRRAPLPPM
PASQSVPQDLAHIQERPASCIVKSMSVDETDKSPCEAGRVRAGSLQLSSMSAGNSSLRRT
KRKAPSPPSKIPPHQSDENSRVTALQPVDGVPPDSASEANSPEELSSPAGISSDYSLEEI
DEKEELSEVPKVEAENISPKSQDIPFVSTDIINTLKNDPDSALGNGSGEFSQNSMEEKQE
TKSTDGQEPHSVVYDTSNGKKVVDSIRNLKSLGPNQENVVQNEIIVYPENTEDNMKNGVK
KTEINVEGVAKNNNIDMEVERPSNSEAHETDTAISYKENHLAASSVPDQKLNQPSAEKTK
DAAIQTTPSCNSFDGKHQDHNLSDSKVEECVQTSNNNISTQHSCLSSQDSVNTSREFRSQ
GTLIIHSEDPLTVKDPICAHGNDDLLPPVDRIDKNSTASYLKNYPLYRQDYNPKPKPSNE
ITREYIPKIGMTTYKIVPPKSLEISKDWQSETIEYKDDQDMHALGKKHTHENVKETAIQT
EDSAISESPEEPLPNLKPKPNLRTEHQVPSSVSSPDDAMVSPLKPAPKMTRDTGTAPFAP
NLEEINNILESKFKSRASNAQAKPSSFFLQMQKRVSGHYVTSAAAKSVHAAPNPAPKELT
NKEAERDMLPSPEQTLSPLSKMPHSVPQPLVEKTDDDVIGQAPAEASPPPIAPKPVTIPA
SQVSTQNLKTLKTFGAPRPYSSSGPSPFALAVVKRSQSFSKERTESPSASALVQPPANTE
EGKTHSVNKFVDIPQLGVSDKENNSAHNEQNSQIPTPTDGPSFTVMRQSSLTFQSSDPEQ
MRQSLLTAIRSGEAAAKLKRVTIPSNTISVNGRSRLSHSMSPDAQDGH

Sequence length

1128

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (20)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CLEFT PALATE WITH CLEFT LIP	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ATHEROSCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC EYE DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETIC RETINOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL HYPERLIPIDEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERLIPIDEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL ISCHEMIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NONALCOHOLIC STEATOHEPATITIS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (21)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Autism Spectrum Disorder	Autism	Pubtator	30071822	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autism Spectrum Disorders	Autism Spectrum Disorder	BEFREE	30071822		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blast Crisis	Blast crisis	Pubtator	35352878	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Blast Phase	Blast phase chronic myelogenous leukemia	BEFREE	28232743		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	36068491	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	35718636	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cleft Lip	Cleft lip	Pubtator	36493769	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cleft Palate	Cleft palate	Pubtator	36493769	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Gestational	Gestational diabetes	Pubtator	36313769	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	23160641	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASCAT_DG	22885922, 28869590, 29632382, 30054458, 30718926, 31118516		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	GWASDB_DG	22885922		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	23160641, 28258026		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gilles de la Tourette syndrome	Tourette Syndrome	BEFREE	30071822		★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	23463496, 30089489	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	29686105		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mesothelioma	Mesothelioma	Pubtator	21569526	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myeloid Leukemia, Chronic	Myeloid Leukemia	BEFREE	28232743, 28397868		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	23463496, 35955692, 36835164	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	29686105		★★★★★ ★☆☆☆☆ Found in Text Mining only
Tourette Syndrome	Tourette syndrome	Pubtator	30071822	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

COBLL1 (cordon-bleu WH2 repeat protein like 1)