Gene Gene information from NCBI Gene database.
Entrez ID 22824
Gene name Heat shock protein family A (Hsp70) member 4 like
Gene symbol HSPA4L
Synonyms (NCBI Gene)
APG-1APG1HSPH3Osp94
Chromosome 4
Chromosome location 4q28.1
Summary The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a goo
miRNA miRNA information provided by mirtarbase database.
370
miRTarBase ID miRNA Experiments Reference
MIRT020685 hsa-miR-155-5p Proteomics 18668040
MIRT031642 hsa-miR-16-5p Proteomics 18668040
MIRT714604 hsa-miR-320a HITS-CLIP 19536157
MIRT714603 hsa-miR-320b HITS-CLIP 19536157
MIRT714602 hsa-miR-320c HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
GO ID Ontology Definition Evidence Reference
GO:0000166 Function Nucleotide binding IEA
GO:0000774 Function Adenyl-nucleotide exchange factor activity IBA
GO:0005524 Function ATP binding IEA
GO:0005524 Function ATP binding ISS
GO:0005634 Component Nucleus IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
619077 17041 ENSG00000164070
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O95757
Protein name Heat shock 70 kDa protein 4L (Heat shock 70-related protein APG-1) (Heat shock protein family H member 3) (Heat-shock protein family A member 4-like protein) (HSPA4-like protein) (Osmotic stress protein 94)
Protein function Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00012 HSP70 3 588 Hsp70 protein Family
PF00012 HSP70 571 694 Hsp70 protein Family
Sequence
MSVVGIDLGFLNCYIAVARSGGIETIANEYSDRCTPACISLGSRTRAIGNAAKSQIVTNV
RNTIHGFKKLHGRSFDDPIVQTERIRLPYELQKMPNGSAGVKVRYLEEERPFAIEQVTGM
LLAKLKETSENALKKPVADCVISIPSFFTDAERRSVMAAAQVAGLNCLRLMNETTAVALA
YGIYKQDLPPLDEKPRNVVFIDMGHSAYQVLVCAFNKGKLKVLATTFDPYLGGRNFDEAL
VDYFCDEFKTKYKINVKENSRALLRLYQECEKLKKLMSANASDLPLNIECFMNDLDVSSK
MNRAQFEQLCASLLARVEPPLKAVMEQANLQREDISSIEIVGGATRIPAVKEQITKFFLK
DISTTLNADEAVARGCALQCAILSPAFKVREFSITDLVPYSITLRWKTSFEDGSGECEVF
CKNHPAPFSKVITFHKKEPFELEAFYTNLHEVPYPDARIGSFTIQNVFPQSDGDSSKVKV
KVRVNIHGIFSVASASVIEKQNLEGDHSDAPMETETSFKNENKDNMDKMQVDQEEGHQKC
HAEHTPEEEIDHTGAKTKSAVSDKQDRLNQ
TLKKGKVKSIDLPIQSSLCRQLGQDLLNSY
IENEGKMIMQDKLEKERNDAKNAVEEYVYDFRDRLGTVYEKFITPEDLSKLSAVLEDTEN
WLYEDGEDQPKQVYVDKLQELKKYGQPIQMKYME
HEERPKALNDLGKKIQLVMKVIEAYR
NKDERYDHLDPTEMEKVEKCISDAMSWLNSKMNAQNKLSLTQDPVVKVSEIVAKSKELDN
FCNPIIYKPKPKAEVPEDKPKANSEHNGPMDGQSGTETKSDSTKDSSQHTKSSGEMEVD
Sequence length 839
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Protein processing in endoplasmic reticulum   Regulation of HSF1-mediated heat shock response
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
MAJOR DEPRESSIVE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinogenesis Carcinogenesis Pubtator 36068491 Associate
★☆☆☆☆
Found in Text Mining only
leukemia Leukemia BEFREE 17588478
★☆☆☆☆
Found in Text Mining only
Leukemia Leukemia Pubtator 17588478 Stimulate
★☆☆☆☆
Found in Text Mining only
Leukemia Myeloid Acute Myeloid leukemia Pubtator 17588478 Associate
★☆☆☆☆
Found in Text Mining only
Multiple Myeloma Multiple myeloma Pubtator 31899217 Associate
★☆☆☆☆
Found in Text Mining only
Multiple Sclerosis Multiple sclerosis Pubtator 32503176 Associate
★☆☆☆☆
Found in Text Mining only
Nasopharyngeal carcinoma Nasopharyngeal Carcinoma BEFREE 26486082
★☆☆☆☆
Found in Text Mining only
Periodontitis Periodontitis BEFREE 29516510
★☆☆☆☆
Found in Text Mining only
Testicular Germ Cell Tumor Testicular Germ Cell Tumor BEFREE 11389747
★☆☆☆☆
Found in Text Mining only