ITGA11 (integrin subunit alpha 11)

Gene

• Entrez ID: 22801
• Gene name: Integrin subunit alpha 11
• Gene symbol: ITGA11
• Synonyms (NCBI Gene): HsT18964
• Chromosome: 15
• Chromosome location: 15q23
• Summary: This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005675	hsa-miR-29a-3p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	20971881
MIRT005675	hsa-miR-29a-3p	Luciferase reporter assay, Microarray, Northern blot, qRT-PCR	20971881
MIRT608811	hsa-miR-2682-5p	HITS-CLIP	23313552
MIRT608810	hsa-miR-34b-5p	HITS-CLIP	23313552
MIRT608809	hsa-miR-449c-5p	HITS-CLIP	23313552
MIRT608808	hsa-miR-4302	HITS-CLIP	23313552
MIRT608807	hsa-miR-1827	HITS-CLIP	23313552
MIRT608246	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT608806	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT608805	hsa-miR-3612	HITS-CLIP	23313552
MIRT608804	hsa-miR-650	HITS-CLIP	23313552
MIRT608803	hsa-miR-34a-5p	HITS-CLIP	23313552
MIRT608802	hsa-miR-34c-5p	HITS-CLIP	23313552
MIRT608801	hsa-miR-449a	HITS-CLIP	23313552
MIRT608800	hsa-miR-449b-5p	HITS-CLIP	23313552
MIRT608249	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT608799	hsa-miR-2278	HITS-CLIP	23313552
MIRT608798	hsa-miR-6757-5p	HITS-CLIP	23313552
MIRT608811	hsa-miR-2682-5p	HITS-CLIP	24906430
MIRT608810	hsa-miR-34b-5p	HITS-CLIP	24906430
MIRT608809	hsa-miR-449c-5p	HITS-CLIP	24906430
MIRT608808	hsa-miR-4302	HITS-CLIP	24906430
MIRT608807	hsa-miR-1827	HITS-CLIP	24906430
MIRT608806	hsa-miR-6499-3p	HITS-CLIP	24906430
MIRT608805	hsa-miR-3612	HITS-CLIP	24906430
MIRT608804	hsa-miR-650	HITS-CLIP	24906430
MIRT608803	hsa-miR-34a-5p	HITS-CLIP	24906430
MIRT608802	hsa-miR-34c-5p	HITS-CLIP	24906430
MIRT608801	hsa-miR-449a	HITS-CLIP	24906430
MIRT608800	hsa-miR-449b-5p	HITS-CLIP	24906430
MIRT608249	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608799	hsa-miR-2278	HITS-CLIP	24906430
MIRT608246	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT608798	hsa-miR-6757-5p	HITS-CLIP	24906430
MIRT608257	hsa-miR-6760-5p	HITS-CLIP	24906430
MIRT608256	hsa-miR-1321	HITS-CLIP	24906430
MIRT608254	hsa-miR-4739	HITS-CLIP	24906430
MIRT608255	hsa-miR-4756-5p	HITS-CLIP	24906430
MIRT608253	hsa-miR-149-3p	HITS-CLIP	24906430
MIRT608252	hsa-miR-4728-5p	HITS-CLIP	24906430
MIRT608251	hsa-miR-6785-5p	HITS-CLIP	24906430
MIRT608250	hsa-miR-6883-5p	HITS-CLIP	24906430
MIRT608249	hsa-miR-6867-5p	HITS-CLIP	24906430
MIRT608247	hsa-miR-3162-5p	HITS-CLIP	24906430
MIRT608248	hsa-miR-135b-3p	HITS-CLIP	24906430
MIRT608246	hsa-miR-574-5p	HITS-CLIP	24906430
MIRT576458	hsa-miR-1321	PAR-CLIP	26701625
MIRT576445	hsa-miR-135b-3p	PAR-CLIP	26701625
MIRT576454	hsa-miR-149-3p	PAR-CLIP	26701625
MIRT576446	hsa-miR-3162-5p	PAR-CLIP	26701625
MIRT576453	hsa-miR-4728-5p	PAR-CLIP	26701625
MIRT576457	hsa-miR-4739	PAR-CLIP	26701625
MIRT576456	hsa-miR-4756-5p	PAR-CLIP	26701625
MIRT576444	hsa-miR-574-5p	PAR-CLIP	26701625
MIRT576455	hsa-miR-6732-5p	PAR-CLIP	26701625
MIRT576450	hsa-miR-6752-5p	PAR-CLIP	26701625
MIRT576459	hsa-miR-6760-5p	PAR-CLIP	26701625
MIRT576452	hsa-miR-6785-5p	PAR-CLIP	26701625
MIRT576449	hsa-miR-6842-5p	PAR-CLIP	26701625
MIRT576447	hsa-miR-6867-5p	PAR-CLIP	26701625
MIRT576451	hsa-miR-6883-5p	PAR-CLIP	26701625
MIRT576448	hsa-miR-7110-5p	PAR-CLIP	26701625
MIRT576458	hsa-miR-1321	PAR-CLIP	27292025
MIRT576445	hsa-miR-135b-3p	PAR-CLIP	27292025
MIRT576454	hsa-miR-149-3p	PAR-CLIP	27292025
MIRT576446	hsa-miR-3162-5p	PAR-CLIP	27292025
MIRT576453	hsa-miR-4728-5p	PAR-CLIP	27292025
MIRT576457	hsa-miR-4739	PAR-CLIP	27292025
MIRT576456	hsa-miR-4756-5p	PAR-CLIP	27292025
MIRT576444	hsa-miR-574-5p	PAR-CLIP	27292025
MIRT576459	hsa-miR-6760-5p	PAR-CLIP	27292025
MIRT576452	hsa-miR-6785-5p	PAR-CLIP	27292025
MIRT576447	hsa-miR-6867-5p	PAR-CLIP	27292025
MIRT576451	hsa-miR-6883-5p	PAR-CLIP	27292025
MIRT576458	hsa-miR-1321	HITS-CLIP	27418678
MIRT576445	hsa-miR-135b-3p	HITS-CLIP	27418678
MIRT608807	hsa-miR-1827	HITS-CLIP	27418678
MIRT608807	hsa-miR-1827	HITS-CLIP	27418678
MIRT608799	hsa-miR-2278	HITS-CLIP	27418678
MIRT608799	hsa-miR-2278	HITS-CLIP	27418678
MIRT608811	hsa-miR-2682-5p	HITS-CLIP	27418678
MIRT608811	hsa-miR-2682-5p	HITS-CLIP	27418678
MIRT576446	hsa-miR-3162-5p	HITS-CLIP	27418678
MIRT608803	hsa-miR-34a-5p	HITS-CLIP	27418678
MIRT608803	hsa-miR-34a-5p	HITS-CLIP	27418678
MIRT608810	hsa-miR-34b-5p	HITS-CLIP	27418678
MIRT608810	hsa-miR-34b-5p	HITS-CLIP	27418678
MIRT608802	hsa-miR-34c-5p	HITS-CLIP	27418678
MIRT608802	hsa-miR-34c-5p	HITS-CLIP	27418678
MIRT608805	hsa-miR-3612	HITS-CLIP	27418678
MIRT608805	hsa-miR-3612	HITS-CLIP	27418678
MIRT608808	hsa-miR-4302	HITS-CLIP	27418678
MIRT608808	hsa-miR-4302	HITS-CLIP	27418678
MIRT608801	hsa-miR-449a	HITS-CLIP	27418678
MIRT608801	hsa-miR-449a	HITS-CLIP	27418678
MIRT608800	hsa-miR-449b-5p	HITS-CLIP	27418678
MIRT608800	hsa-miR-449b-5p	HITS-CLIP	27418678
MIRT608809	hsa-miR-449c-5p	HITS-CLIP	27418678
MIRT608809	hsa-miR-449c-5p	HITS-CLIP	27418678
MIRT576457	hsa-miR-4739	HITS-CLIP	27418678
MIRT576456	hsa-miR-4756-5p	HITS-CLIP	27418678
MIRT576444	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT576444	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT608806	hsa-miR-6499-3p	HITS-CLIP	27418678
MIRT608806	hsa-miR-6499-3p	HITS-CLIP	27418678
MIRT608804	hsa-miR-650	HITS-CLIP	27418678
MIRT608804	hsa-miR-650	HITS-CLIP	27418678
MIRT608798	hsa-miR-6757-5p	HITS-CLIP	27418678
MIRT608798	hsa-miR-6757-5p	HITS-CLIP	27418678
MIRT576459	hsa-miR-6760-5p	HITS-CLIP	27418678
MIRT576447	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT576447	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT735539	hsa-miR-516b-5p	Luciferase reporter assay, Western blotting, Microarray, Immunoprecipitaion (IP), qRT-PCR	33174014
MIRT608811	hsa-miR-2682-5p	HITS-CLIP	23313552
MIRT608810	hsa-miR-34b-5p	HITS-CLIP	23313552
MIRT608809	hsa-miR-449c-5p	HITS-CLIP	23313552
MIRT608808	hsa-miR-4302	HITS-CLIP	23313552
MIRT608807	hsa-miR-1827	HITS-CLIP	23313552
MIRT576444	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT608806	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT608805	hsa-miR-3612	HITS-CLIP	23313552
MIRT608804	hsa-miR-650	HITS-CLIP	23313552
MIRT608803	hsa-miR-34a-5p	HITS-CLIP	23313552
MIRT608802	hsa-miR-34c-5p	HITS-CLIP	23313552
MIRT608801	hsa-miR-449a	HITS-CLIP	23313552
MIRT608800	hsa-miR-449b-5p	HITS-CLIP	23313552
MIRT576447	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT608799	hsa-miR-2278	HITS-CLIP	23313552
MIRT608798	hsa-miR-6757-5p	HITS-CLIP	23313552
MIRT1073377	hsa-miR-1184	CLIP-seq
MIRT1073378	hsa-miR-2682	CLIP-seq
MIRT1073379	hsa-miR-29a	CLIP-seq
MIRT1073380	hsa-miR-29b	CLIP-seq
MIRT1073381	hsa-miR-29c	CLIP-seq
MIRT1073382	hsa-miR-34a	CLIP-seq
MIRT1073383	hsa-miR-370	CLIP-seq
MIRT1073384	hsa-miR-384	CLIP-seq
MIRT1073385	hsa-miR-449b	CLIP-seq
MIRT1073386	hsa-miR-449c	CLIP-seq
MIRT1073387	hsa-miR-4755-3p	CLIP-seq
MIRT1073377	hsa-miR-1184	CLIP-seq
MIRT1550252	hsa-miR-1207-3p	CLIP-seq
MIRT1550253	hsa-miR-122	CLIP-seq
MIRT1550254	hsa-miR-1225-3p	CLIP-seq
MIRT1550255	hsa-miR-1237	CLIP-seq
MIRT1550256	hsa-miR-1254	CLIP-seq
MIRT1550257	hsa-miR-1262	CLIP-seq
MIRT1550258	hsa-miR-1299	CLIP-seq
MIRT1550259	hsa-miR-134	CLIP-seq
MIRT1550260	hsa-miR-143	CLIP-seq
MIRT1550261	hsa-miR-1915	CLIP-seq
MIRT1550262	hsa-miR-2110	CLIP-seq
MIRT1550263	hsa-miR-2277-3p	CLIP-seq
MIRT1550264	hsa-miR-2355-3p	CLIP-seq
MIRT1550265	hsa-miR-3116	CLIP-seq
MIRT1550266	hsa-miR-3118	CLIP-seq
MIRT1550267	hsa-miR-3164	CLIP-seq
MIRT1550268	hsa-miR-3202	CLIP-seq
MIRT1550269	hsa-miR-3664-3p	CLIP-seq
MIRT1550270	hsa-miR-3675-5p	CLIP-seq
MIRT1550271	hsa-miR-3689a-3p	CLIP-seq
MIRT1550272	hsa-miR-3689c	CLIP-seq
MIRT1550273	hsa-miR-3944-5p	CLIP-seq
MIRT1550274	hsa-miR-423-3p	CLIP-seq
MIRT1550275	hsa-miR-4254	CLIP-seq
MIRT1550276	hsa-miR-4271	CLIP-seq
MIRT1550277	hsa-miR-4323	CLIP-seq
MIRT1550278	hsa-miR-4419a	CLIP-seq
MIRT1550279	hsa-miR-4436a	CLIP-seq
MIRT1550280	hsa-miR-4481	CLIP-seq
MIRT1550281	hsa-miR-4510	CLIP-seq
MIRT1550282	hsa-miR-4651	CLIP-seq
MIRT1550283	hsa-miR-4654	CLIP-seq
MIRT1550284	hsa-miR-4690-5p	CLIP-seq
MIRT1550285	hsa-miR-4701-3p	CLIP-seq
MIRT1550286	hsa-miR-4725-3p	CLIP-seq
MIRT1550287	hsa-miR-4745-5p	CLIP-seq
MIRT1550288	hsa-miR-4747-5p	CLIP-seq
MIRT1550289	hsa-miR-4769-5p	CLIP-seq
MIRT1550290	hsa-miR-4770	CLIP-seq
MIRT1550291	hsa-miR-4782-5p	CLIP-seq
MIRT1550292	hsa-miR-4802-5p	CLIP-seq
MIRT1550293	hsa-miR-486-3p	CLIP-seq
MIRT1550294	hsa-miR-516a-3p	CLIP-seq
MIRT1550295	hsa-miR-516b	CLIP-seq
MIRT1550296	hsa-miR-608	CLIP-seq
MIRT1550297	hsa-miR-648	CLIP-seq
MIRT1550298	hsa-miR-676	CLIP-seq
MIRT1550299	hsa-miR-875-3p	CLIP-seq
MIRT1550258	hsa-miR-1299	CLIP-seq
MIRT2018093	hsa-miR-1305	CLIP-seq
MIRT2018094	hsa-miR-3613-3p	CLIP-seq
MIRT1550278	hsa-miR-4419a	CLIP-seq
MIRT1550281	hsa-miR-4510	CLIP-seq
MIRT1550284	hsa-miR-4690-5p	CLIP-seq
MIRT2018095	hsa-miR-4742-3p	CLIP-seq
MIRT2018096	hsa-miR-4775	CLIP-seq
MIRT1550291	hsa-miR-4782-5p	CLIP-seq
MIRT1550295	hsa-miR-516b	CLIP-seq
MIRT2018097	hsa-miR-590-3p	CLIP-seq
MIRT2018098	hsa-miR-607	CLIP-seq
MIRT1550257	hsa-miR-1262	CLIP-seq
MIRT2249965	hsa-miR-1301	CLIP-seq
MIRT2249966	hsa-miR-4436b-3p	CLIP-seq
MIRT2249967	hsa-miR-4660	CLIP-seq
MIRT1550285	hsa-miR-4701-3p	CLIP-seq
MIRT2249968	hsa-miR-5047	CLIP-seq
MIRT1073378	hsa-miR-2682	CLIP-seq
MIRT1073382	hsa-miR-34a	CLIP-seq
MIRT1550271	hsa-miR-3689a-3p	CLIP-seq
MIRT1550272	hsa-miR-3689c	CLIP-seq
MIRT1073385	hsa-miR-449b	CLIP-seq
MIRT1073386	hsa-miR-449c	CLIP-seq
MIRT1073377	hsa-miR-1184	CLIP-seq
MIRT1550254	hsa-miR-1225-3p	CLIP-seq
MIRT2553426	hsa-miR-124	CLIP-seq
MIRT2553427	hsa-miR-129-3p	CLIP-seq
MIRT2553428	hsa-miR-1298	CLIP-seq
MIRT2553429	hsa-miR-1323	CLIP-seq
MIRT1550261	hsa-miR-1915	CLIP-seq
MIRT1550264	hsa-miR-2355-3p	CLIP-seq
MIRT2553430	hsa-miR-2392	CLIP-seq
MIRT2553431	hsa-miR-2467-5p	CLIP-seq
MIRT2553432	hsa-miR-3145-5p	CLIP-seq
MIRT2553433	hsa-miR-3162-3p	CLIP-seq
MIRT2553434	hsa-miR-3178	CLIP-seq
MIRT2553435	hsa-miR-3189-3p	CLIP-seq
MIRT2553436	hsa-miR-326	CLIP-seq
MIRT2553437	hsa-miR-330-5p	CLIP-seq
MIRT2553438	hsa-miR-33a	CLIP-seq
MIRT2553439	hsa-miR-33b	CLIP-seq
MIRT2553440	hsa-miR-34c-3p	CLIP-seq
MIRT2553441	hsa-miR-3605-5p	CLIP-seq
MIRT2553442	hsa-miR-3607-5p	CLIP-seq
MIRT2553443	hsa-miR-3622a-5p	CLIP-seq
MIRT2553444	hsa-miR-3657	CLIP-seq
MIRT1073383	hsa-miR-370	CLIP-seq
MIRT2553445	hsa-miR-3714	CLIP-seq
MIRT2553446	hsa-miR-371b-5p	CLIP-seq
MIRT2553447	hsa-miR-3910	CLIP-seq
MIRT2553448	hsa-miR-3940-5p	CLIP-seq
MIRT2553449	hsa-miR-4260	CLIP-seq
MIRT2553450	hsa-miR-4269	CLIP-seq
MIRT2553451	hsa-miR-4270	CLIP-seq
MIRT1550277	hsa-miR-4323	CLIP-seq
MIRT2553452	hsa-miR-4441	CLIP-seq
MIRT2553453	hsa-miR-4450	CLIP-seq
MIRT2553454	hsa-miR-4486	CLIP-seq
MIRT2553455	hsa-miR-4507	CLIP-seq
MIRT2553456	hsa-miR-4645-5p	CLIP-seq
MIRT2553457	hsa-miR-4669	CLIP-seq
MIRT2553458	hsa-miR-4673	CLIP-seq
MIRT1073387	hsa-miR-4755-3p	CLIP-seq
MIRT2553459	hsa-miR-4768-5p	CLIP-seq
MIRT2553460	hsa-miR-4777-3p	CLIP-seq
MIRT1550293	hsa-miR-486-3p	CLIP-seq
MIRT2553461	hsa-miR-506	CLIP-seq
MIRT2553462	hsa-miR-508-5p	CLIP-seq
MIRT1550295	hsa-miR-516b	CLIP-seq
MIRT2553463	hsa-miR-532-5p	CLIP-seq
MIRT2553464	hsa-miR-548o	CLIP-seq
MIRT2553465	hsa-miR-635	CLIP-seq
MIRT1550298	hsa-miR-676	CLIP-seq
MIRT2553466	hsa-miR-765	CLIP-seq
MIRT2553426	hsa-miR-124	CLIP-seq
MIRT2553427	hsa-miR-129-3p	CLIP-seq
MIRT2553428	hsa-miR-1298	CLIP-seq
MIRT2553429	hsa-miR-1323	CLIP-seq
MIRT1550264	hsa-miR-2355-3p	CLIP-seq
MIRT2553430	hsa-miR-2392	CLIP-seq
MIRT2553432	hsa-miR-3145-5p	CLIP-seq
MIRT2553434	hsa-miR-3178	CLIP-seq
MIRT2553435	hsa-miR-3189-3p	CLIP-seq
MIRT2553436	hsa-miR-326	CLIP-seq
MIRT2553437	hsa-miR-330-5p	CLIP-seq
MIRT2553438	hsa-miR-33a	CLIP-seq
MIRT2553439	hsa-miR-33b	CLIP-seq
MIRT2553440	hsa-miR-34c-3p	CLIP-seq
MIRT2553441	hsa-miR-3605-5p	CLIP-seq
MIRT2553442	hsa-miR-3607-5p	CLIP-seq
MIRT2553443	hsa-miR-3622a-5p	CLIP-seq
MIRT2553444	hsa-miR-3657	CLIP-seq
MIRT2553445	hsa-miR-3714	CLIP-seq
MIRT2553446	hsa-miR-371b-5p	CLIP-seq
MIRT2553447	hsa-miR-3910	CLIP-seq
MIRT2553448	hsa-miR-3940-5p	CLIP-seq
MIRT2553449	hsa-miR-4260	CLIP-seq
MIRT2553450	hsa-miR-4269	CLIP-seq
MIRT2553453	hsa-miR-4450	CLIP-seq
MIRT2553454	hsa-miR-4486	CLIP-seq
MIRT2553455	hsa-miR-4507	CLIP-seq
MIRT2553456	hsa-miR-4645-5p	CLIP-seq
MIRT2553457	hsa-miR-4669	CLIP-seq
MIRT2553458	hsa-miR-4673	CLIP-seq
MIRT1073387	hsa-miR-4755-3p	CLIP-seq
MIRT2553459	hsa-miR-4768-5p	CLIP-seq
MIRT2553460	hsa-miR-4777-3p	CLIP-seq
MIRT1550293	hsa-miR-486-3p	CLIP-seq
MIRT2553461	hsa-miR-506	CLIP-seq
MIRT2553462	hsa-miR-508-5p	CLIP-seq
MIRT1550295	hsa-miR-516b	CLIP-seq
MIRT2553463	hsa-miR-532-5p	CLIP-seq
MIRT2553464	hsa-miR-548o	CLIP-seq
MIRT2553465	hsa-miR-635	CLIP-seq
MIRT1550298	hsa-miR-676	CLIP-seq
MIRT2553466	hsa-miR-765	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0005518	Function	Collagen binding	IMP	11518510
GO:0005518	Function	Collagen binding	TAS	10464311
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IDA	11518510
GO:0006929	Process	Substrate-dependent cell migration	IEA
GO:0006929	Process	Substrate-dependent cell migration	IMP	11518510
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	TAS	10486209
GO:0007160	Process	Cell-matrix adhesion	IBA
GO:0007160	Process	Cell-matrix adhesion	IMP	11518510, 24823363
GO:0007160	Process	Cell-matrix adhesion	TAS	10464311
GO:0007229	Process	Integrin-mediated signaling pathway	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	IMP	24823363
GO:0007517	Process	Muscle organ development	TAS	10464311
GO:0008305	Component	Integrin complex	IEA
GO:0008305	Component	Integrin complex	TAS	10486209
GO:0009986	Component	Cell surface	IBA
GO:0016020	Component	Membrane	HDA	16210410
GO:0016020	Component	Membrane	IEA
GO:0033627	Process	Cell adhesion mediated by integrin	IMP	11518510
GO:0034681	Component	Integrin alpha11-beta1 complex	IBA
GO:0034681	Component	Integrin alpha11-beta1 complex	IDA	24823363
GO:0038023	Function	Signaling receptor activity	IBA
GO:0038064	Function	Collagen receptor activity	IMP	11518510
GO:0038065	Process	Collagen-activated signaling pathway	IMP	11518510
GO:0046872	Function	Metal ion binding	IEA
GO:0098609	Process	Cell-cell adhesion	IBA
GO:0098639	Function	Collagen binding involved in cell-matrix adhesion	IEA
GO:0098639	Function	Collagen binding involved in cell-matrix adhesion	IMP	24823363

Other IDs

• MIM: 604789
• HGNC: 6136
• e!Ensembl: ENSG00000137809

Protein

• UniProt ID: Q9UKX5
• Protein name: Integrin alpha-11
• Protein function: Integrin alpha-11/beta-1 is a receptor for collagen.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00092	VWA	164 → 344	von Willebrand factor type A domain	Domain
  PF01839	FG-GAP	480 → 518	FG-GAP repeat	Repeat
  PF01839	FG-GAP	542 → 577	FG-GAP repeat	Repeat
  PF08441	Integrin_alpha2	635 → 1067	Integrin alpha	Family

• Tissue specificity: TISSUE SPECIFICITY: According to PubMed:10464311, highest levels of expression in uterus and heart, intermediate levels in skeletal muscle and intermediate to low levels in pancreas, kidney and placenta. According to PubMed:10486209, also found in brain,
• Sequence:

  MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTAFFGYTVQQHDISGNKWLVVGA
  PLETNGYQKTGDVYKCPVIHGNCTKLNLGRVTLSNVSERKDNMRLGLSLATNPKDNSFLA
  CSPLWSHECGSSYYTTGMCSRVNSNFRFSKTVAPALQRCQTYMDIVIVLDGSNSIYPWVE
  VQHFLINILKKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTET
  RTAFGIEFARSEAFQKGGRKGAKKVMIVITDGESHDSPDLEKVIQQSERDNVTRYAVAVL
  GYYNRRGINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEGTNKNET
  SFGLEMSQTGFSSHVVEDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKEFPEELKN
  HGAYLGYTVTSVVSSRQGRVYVAGAPRFNHTGKVILFTMHNNRSLTIHQAMRGQQIGSYF
  GSEITSVDIDGDGVTDVLLVGAPMYFNEGRERGKVYVYELRQNLFVYNGTLKDSHSYQNA
  RFGSSIASVRDLNQDSYNDVVVGAPLEDNHAGAIYIFHGFRGSILKTPKQRITASELATG
  LQYFGCSIHGQLDLNEDGLIDLAVGALGNAVILWSRPVVQINASLHFEPSKINIFHRDCK
  RSGRDATCLAAFLCFTPIFLAPHFQTTTVGIRYNATMDERRYTPRAHLDEGGDRFTNRAV
  LLSSGQELCERINFHVLDTADYVKPVTFSVEYSLEDPDHGPMLDDGWPTTLRVSVPFWNG
  CNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFDTTVFIIESTRQRVAV
  EATLENRGENAYSTVLNISQSANLQFASLIQKEDSDGSIECVNEERRLQKQVCNVSYPFF
  RAKAKVAFRLDFEFSKSIFLHHLEIELAAGSDSNERDSTKEDNVAPLRFHLKYEADVLFT
  RSSSLSHYEVKPNSSLERYDGIGPPFSCIFRIQNLGLFPIHGMMMKITIPIATRSGNRLL
  KLRDFLTDEANTSCNIWGNSTEYRPTPVEEDLRRAPQLNHSNSDVVSINCNIRLVPNQEI
  NFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHSPFIFREEDPSRQIVFEISKQEDWQV
  PIWIIVGSTLGGLLLLALLVLALWKLGFFRSARRRREPGLDPTPKVLE

• Sequence length: 1188

Pathways

KEGG:

PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Regulation of actin cytoskeleton
Cytoskeleton in muscle cells
Human papillomavirus infection
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy

Reactome:

Integrin cell surface interactions

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DUPUYTREN CONTRACTURE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	31121900		★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	30808244, 31159419		★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm Abdominal	Aortic aneurysm	Pubtator	40275351	Associate	★☆☆☆☆ Found in Text Mining only
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	GWASCAT_DG	18839057		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Attention deficit hyperactivity disorder	Attention Deficit Hyperactivity Disorder	GWASDB_DG	18839057		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Breast Carcinoma	Breast Carcinoma	BEFREE	29383106, 30876468, 31287804		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	31605508	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	27121382, 31778288		★☆☆☆☆ Found in Text Mining only
Carotid Artery Diseases	Carotid artery disease	Pubtator	29595698	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Periodontitis	Periodontitis	BEFREE	19641149		★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	36737481	Associate	★☆☆☆☆ Found in Text Mining only
Dupuytren Contracture	Dupuytren Contracture	GWASCAT_DG	28886342		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	35813220	Associate	★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	29147013		★☆☆☆☆ Found in Text Mining only
Intracranial Aneurysm	Intracranial aneurysm	Pubtator	40275351	Associate	★☆☆☆☆ Found in Text Mining only
Left Ventricular Hypertrophy	Left Ventricular Hypertrophy	BEFREE	28771943		★☆☆☆☆ Found in Text Mining only
Leiomyoma	Leiomyoma	Pubtator	24520080	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	27121382, 31778288	Associate	★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASDB_DG	23377640		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Major Depressive Disorder	Mental Depression	GWASCAT_DG	23377640		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of breast	Breast Cancer	BEFREE	29383106, 30876468, 31287804		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	27121382, 31778288		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	30808244		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	31610176, 31778288		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	30876468		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	31610176		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	25881608	Associate	★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	33054494	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27699902, 30808244, 30876468, 31121900, 31159419, 31778288		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	17016581, 17600088, 31121900, 31778288		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32878513	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	30808244		★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	31159419		★☆☆☆☆ Found in Text Mining only
Spinal Muscular Atrophy	Spinal Muscular Atrophy	BEFREE	27699902		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	27699902	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of the head and neck	Carcinoma Of The Head And Neck	BEFREE	27699902		★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Triple Negative Breast Neoplasms	BEFREE	30876468		★☆☆☆☆ Found in Text Mining only