RRAS2 (RAS related 2)

Gene

• Entrez ID: 22800
• Gene name: RAS related 2
• Gene symbol: RRAS2
• Synonyms (NCBI Gene): NS12, TC21
• Chromosome: 11
• Chromosome location: 11p15.2
• Summary: This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathway

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs113954997	T>A,C	Pathogenic	Missense variant, 5 prime UTR variant, coding sequence variant
rs782457908	C>T	Pathogenic	Missense variant, coding sequence variant, 5 prime UTR variant
rs1591495767	->ACGCCGCCC	Pathogenic	Genic upstream transcript variant, coding sequence variant, inframe insertion, upstream transcript variant, intron variant
rs1591495776	->CCCCCGCCG	Pathogenic	Genic upstream transcript variant, coding sequence variant, inframe insertion, upstream transcript variant, intron variant
rs1591495779	C>A	Pathogenic	Genic upstream transcript variant, coding sequence variant, upstream transcript variant, missense variant, intron variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022861	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT025875	hsa-miR-7-5p	Sequencing	20371350
MIRT028141	hsa-miR-93-5p	Sequencing	20371350
MIRT029816	hsa-miR-26b-5p	Microarray	19088304
MIRT031260	hsa-miR-19b-3p	Sequencing	20371350
MIRT053416	hsa-miR-624-3p	Microarray	23807165
MIRT438004	hsa-miR-23b-3p	Luciferase reporter assay	24391759
MIRT438004	hsa-miR-23b-3p	Luciferase reporter assay	24391759
MIRT468899	hsa-miR-223-3p	HITS-CLIP	21572407
MIRT468898	hsa-miR-548n	HITS-CLIP	21572407
MIRT468897	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT468896	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT485131	hsa-miR-3609	HITS-CLIP	21572407
MIRT485132	hsa-miR-548ah-5p	HITS-CLIP	21572407
MIRT468895	hsa-miR-935	HITS-CLIP	21572407
MIRT468894	hsa-miR-4697-3p	HITS-CLIP	21572407
MIRT468893	hsa-miR-580-3p	HITS-CLIP	21572407
MIRT468899	hsa-miR-223-3p	PAR-CLIP	20371350
MIRT468898	hsa-miR-548n	PAR-CLIP	20371350
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT468895	hsa-miR-935	PAR-CLIP	20371350
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT468893	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT485131	hsa-miR-3609	PAR-CLIP	20371350
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT571685	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT571684	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT571683	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT571682	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT571681	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT571680	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT571679	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT028141	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT571678	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT571677	hsa-miR-1255b-2-3p	PAR-CLIP	20371350
MIRT571676	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT571675	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT571674	hsa-miR-549a	PAR-CLIP	20371350
MIRT571673	hsa-miR-4504	PAR-CLIP	20371350
MIRT571672	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT031260	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT571671	hsa-miR-3161	PAR-CLIP	20371350
MIRT571670	hsa-miR-599	PAR-CLIP	20371350
MIRT468899	hsa-miR-223-3p	PAR-CLIP	20371350
MIRT468898	hsa-miR-548n	PAR-CLIP	20371350
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT468895	hsa-miR-935	PAR-CLIP	20371350
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT468893	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT025875	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT265276	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT554576	hsa-miR-944	PAR-CLIP	20371350
MIRT554575	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT025875	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT265276	hsa-miR-651-3p	PAR-CLIP	21572407
MIRT554576	hsa-miR-944	PAR-CLIP	21572407
MIRT554575	hsa-miR-1252-5p	PAR-CLIP	21572407
MIRT554574	hsa-miR-7848-3p	PAR-CLIP	21572407
MIRT554573	hsa-miR-2681-5p	PAR-CLIP	21572407
MIRT468899	hsa-miR-223-3p	PAR-CLIP	21572407
MIRT468898	hsa-miR-548n	PAR-CLIP	21572407
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT468895	hsa-miR-935	PAR-CLIP	21572407
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT468893	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT468899	hsa-miR-223-3p	PAR-CLIP	21572407
MIRT468898	hsa-miR-548n	PAR-CLIP	21572407
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT485131	hsa-miR-3609	PAR-CLIP	21572407
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT468895	hsa-miR-935	PAR-CLIP	21572407
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT468893	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT534558	hsa-miR-3662	PAR-CLIP	22012620
MIRT534557	hsa-miR-106a-3p	PAR-CLIP	22012620
MIRT468899	hsa-miR-223-3p	PAR-CLIP	22012620
MIRT468898	hsa-miR-548n	PAR-CLIP	22012620
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT468895	hsa-miR-935	PAR-CLIP	22012620
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	22012620
MIRT468893	hsa-miR-580-3p	PAR-CLIP	22012620
MIRT468899	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468898	hsa-miR-548n	PAR-CLIP	23592263
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT485131	hsa-miR-3609	PAR-CLIP	23592263
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT468895	hsa-miR-935	PAR-CLIP	23592263
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468893	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT468899	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468898	hsa-miR-548n	PAR-CLIP	23592263
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT485131	hsa-miR-3609	PAR-CLIP	23592263
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT468895	hsa-miR-935	PAR-CLIP	23592263
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468893	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT468899	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468898	hsa-miR-548n	PAR-CLIP	23592263
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT468895	hsa-miR-935	PAR-CLIP	23592263
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468893	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT468899	hsa-miR-223-3p	PAR-CLIP	26701625
MIRT485131	hsa-miR-3609	PAR-CLIP	26701625
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	26701625
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	26701625
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	26701625
MIRT468898	hsa-miR-548n	PAR-CLIP	26701625
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	26701625
MIRT468893	hsa-miR-580-3p	PAR-CLIP	26701625
MIRT468895	hsa-miR-935	PAR-CLIP	26701625
MIRT468899	hsa-miR-223-3p	PAR-CLIP	27292025
MIRT485131	hsa-miR-3609	PAR-CLIP	27292025
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	27292025
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	27292025
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	27292025
MIRT468898	hsa-miR-548n	PAR-CLIP	27292025
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	27292025
MIRT468893	hsa-miR-580-3p	PAR-CLIP	27292025
MIRT468895	hsa-miR-935	PAR-CLIP	27292025
MIRT468899	hsa-miR-223-3p	HITS-CLIP	21572407
MIRT468898	hsa-miR-548n	HITS-CLIP	21572407
MIRT468897	hsa-miR-548az-5p	HITS-CLIP	21572407
MIRT468896	hsa-miR-548t-5p	HITS-CLIP	21572407
MIRT485131	hsa-miR-3609	HITS-CLIP	21572407
MIRT485132	hsa-miR-548ah-5p	HITS-CLIP	21572407
MIRT468895	hsa-miR-935	HITS-CLIP	21572407
MIRT468894	hsa-miR-4697-3p	HITS-CLIP	21572407
MIRT468893	hsa-miR-580-3p	HITS-CLIP	21572407
MIRT468899	hsa-miR-223-3p	PAR-CLIP	20371350
MIRT468898	hsa-miR-548n	PAR-CLIP	20371350
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT468895	hsa-miR-935	PAR-CLIP	20371350
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT468893	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT485131	hsa-miR-3609	PAR-CLIP	20371350
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	20371350
MIRT571685	hsa-miR-106a-5p	PAR-CLIP	20371350
MIRT571684	hsa-miR-106b-5p	PAR-CLIP	20371350
MIRT571683	hsa-miR-17-5p	PAR-CLIP	20371350
MIRT571682	hsa-miR-20a-5p	PAR-CLIP	20371350
MIRT571681	hsa-miR-20b-5p	PAR-CLIP	20371350
MIRT571680	hsa-miR-519d-3p	PAR-CLIP	20371350
MIRT571679	hsa-miR-526b-3p	PAR-CLIP	20371350
MIRT028141	hsa-miR-93-5p	PAR-CLIP	20371350
MIRT571678	hsa-miR-4796-3p	PAR-CLIP	20371350
MIRT571677	hsa-miR-1255b-2-3p	PAR-CLIP	20371350
MIRT571676	hsa-miR-142-5p	PAR-CLIP	20371350
MIRT571675	hsa-miR-5590-3p	PAR-CLIP	20371350
MIRT571674	hsa-miR-549a	PAR-CLIP	20371350
MIRT571673	hsa-miR-4504	PAR-CLIP	20371350
MIRT571672	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT031260	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT571671	hsa-miR-3161	PAR-CLIP	20371350
MIRT571670	hsa-miR-599	PAR-CLIP	20371350
MIRT468899	hsa-miR-223-3p	PAR-CLIP	20371350
MIRT468898	hsa-miR-548n	PAR-CLIP	20371350
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	20371350
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	20371350
MIRT468895	hsa-miR-935	PAR-CLIP	20371350
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	20371350
MIRT468893	hsa-miR-580-3p	PAR-CLIP	20371350
MIRT025875	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT265276	hsa-miR-651-3p	PAR-CLIP	20371350
MIRT554576	hsa-miR-944	PAR-CLIP	20371350
MIRT554575	hsa-miR-1252-5p	PAR-CLIP	20371350
MIRT025875	hsa-miR-7-5p	PAR-CLIP	21572407
MIRT265276	hsa-miR-651-3p	PAR-CLIP	21572407
MIRT554576	hsa-miR-944	PAR-CLIP	21572407
MIRT554575	hsa-miR-1252-5p	PAR-CLIP	21572407
MIRT554574	hsa-miR-7848-3p	PAR-CLIP	21572407
MIRT554573	hsa-miR-2681-5p	PAR-CLIP	21572407
MIRT468899	hsa-miR-223-3p	PAR-CLIP	21572407
MIRT468898	hsa-miR-548n	PAR-CLIP	21572407
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT468895	hsa-miR-935	PAR-CLIP	21572407
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT468893	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT468899	hsa-miR-223-3p	PAR-CLIP	21572407
MIRT468898	hsa-miR-548n	PAR-CLIP	21572407
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	21572407
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	21572407
MIRT485131	hsa-miR-3609	PAR-CLIP	21572407
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	21572407
MIRT468895	hsa-miR-935	PAR-CLIP	21572407
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	21572407
MIRT468893	hsa-miR-580-3p	PAR-CLIP	21572407
MIRT534558	hsa-miR-3662	PAR-CLIP	22012620
MIRT534557	hsa-miR-106a-3p	PAR-CLIP	22012620
MIRT468899	hsa-miR-223-3p	PAR-CLIP	22012620
MIRT468898	hsa-miR-548n	PAR-CLIP	22012620
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	22012620
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	22012620
MIRT468895	hsa-miR-935	PAR-CLIP	22012620
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	22012620
MIRT468893	hsa-miR-580-3p	PAR-CLIP	22012620
MIRT468899	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468898	hsa-miR-548n	PAR-CLIP	23592263
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT485131	hsa-miR-3609	PAR-CLIP	23592263
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT468895	hsa-miR-935	PAR-CLIP	23592263
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468893	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT468899	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468898	hsa-miR-548n	PAR-CLIP	23592263
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT485131	hsa-miR-3609	PAR-CLIP	23592263
MIRT485132	hsa-miR-548ah-5p	PAR-CLIP	23592263
MIRT468895	hsa-miR-935	PAR-CLIP	23592263
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468893	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT468899	hsa-miR-223-3p	PAR-CLIP	23592263
MIRT468898	hsa-miR-548n	PAR-CLIP	23592263
MIRT468897	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT468896	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT468895	hsa-miR-935	PAR-CLIP	23592263
MIRT468894	hsa-miR-4697-3p	PAR-CLIP	23592263
MIRT468893	hsa-miR-580-3p	PAR-CLIP	23592263
MIRT1319421	hsa-miR-1225-5p	CLIP-seq
MIRT1319422	hsa-miR-1276	CLIP-seq
MIRT1319423	hsa-miR-134	CLIP-seq
MIRT1319424	hsa-miR-140-3p	CLIP-seq
MIRT1319425	hsa-miR-193a-3p	CLIP-seq
MIRT1319426	hsa-miR-193b	CLIP-seq
MIRT1319427	hsa-miR-3118	CLIP-seq
MIRT1319428	hsa-miR-3168	CLIP-seq
MIRT1319429	hsa-miR-3646	CLIP-seq
MIRT1319430	hsa-miR-3926	CLIP-seq
MIRT1319431	hsa-miR-3978	CLIP-seq
MIRT1319432	hsa-miR-4308	CLIP-seq
MIRT1319433	hsa-miR-4426	CLIP-seq
MIRT1319434	hsa-miR-4521	CLIP-seq
MIRT1319435	hsa-miR-4647	CLIP-seq
MIRT1319436	hsa-miR-4662b	CLIP-seq
MIRT1319437	hsa-miR-4725-5p	CLIP-seq
MIRT1319438	hsa-miR-504	CLIP-seq
MIRT1319439	hsa-miR-548m	CLIP-seq
MIRT1319440	hsa-miR-548s	CLIP-seq
MIRT1319441	hsa-miR-548t	CLIP-seq
MIRT1319442	hsa-miR-587	CLIP-seq
MIRT1319443	hsa-miR-634	CLIP-seq
MIRT1319444	hsa-miR-654-3p	CLIP-seq
MIRT1319445	hsa-miR-875-3p	CLIP-seq
MIRT1319446	hsa-miR-1244	CLIP-seq
MIRT1319423	hsa-miR-134	CLIP-seq
MIRT1319425	hsa-miR-193a-3p	CLIP-seq
MIRT1319426	hsa-miR-193b	CLIP-seq
MIRT1319447	hsa-miR-223	CLIP-seq
MIRT1319427	hsa-miR-3118	CLIP-seq
MIRT1319448	hsa-miR-3137	CLIP-seq
MIRT1319449	hsa-miR-3164	CLIP-seq
MIRT1319450	hsa-miR-3187-3p	CLIP-seq
MIRT1319451	hsa-miR-3686	CLIP-seq
MIRT1319452	hsa-miR-3692	CLIP-seq
MIRT1319453	hsa-miR-382	CLIP-seq
MIRT1319430	hsa-miR-3926	CLIP-seq
MIRT1319431	hsa-miR-3978	CLIP-seq
MIRT1319432	hsa-miR-4308	CLIP-seq
MIRT1319454	hsa-miR-4328	CLIP-seq
MIRT1319433	hsa-miR-4426	CLIP-seq
MIRT1319455	hsa-miR-4435	CLIP-seq
MIRT1319456	hsa-miR-4436b-5p	CLIP-seq
MIRT1319457	hsa-miR-4501	CLIP-seq
MIRT1319458	hsa-miR-4529-5p	CLIP-seq
MIRT1319435	hsa-miR-4647	CLIP-seq
MIRT1319459	hsa-miR-4652-3p	CLIP-seq
MIRT1319436	hsa-miR-4662b	CLIP-seq
MIRT1319460	hsa-miR-4701-5p	CLIP-seq
MIRT1319461	hsa-miR-4703-3p	CLIP-seq
MIRT1319437	hsa-miR-4725-5p	CLIP-seq
MIRT1319438	hsa-miR-504	CLIP-seq
MIRT1319462	hsa-miR-520d-5p	CLIP-seq
MIRT1319463	hsa-miR-524-5p	CLIP-seq
MIRT1319464	hsa-miR-548ah	CLIP-seq
MIRT1319440	hsa-miR-548s	CLIP-seq
MIRT1319441	hsa-miR-548t	CLIP-seq
MIRT1319465	hsa-miR-570	CLIP-seq
MIRT1319466	hsa-miR-580	CLIP-seq
MIRT1319442	hsa-miR-587	CLIP-seq
MIRT1319467	hsa-miR-588	CLIP-seq
MIRT1319468	hsa-miR-656	CLIP-seq
MIRT1319445	hsa-miR-875-3p	CLIP-seq
MIRT1319441	hsa-miR-548t	CLIP-seq
MIRT2094915	hsa-miR-3591-5p	CLIP-seq
MIRT2094916	hsa-miR-4255	CLIP-seq
MIRT2094917	hsa-miR-513a-3p	CLIP-seq
MIRT1319447	hsa-miR-223	CLIP-seq
MIRT2319313	hsa-miR-3613-5p	CLIP-seq
MIRT1319464	hsa-miR-548ah	CLIP-seq
MIRT1319441	hsa-miR-548t	CLIP-seq
MIRT1319466	hsa-miR-580	CLIP-seq
MIRT1319441	hsa-miR-548t	CLIP-seq
MIRT1319447	hsa-miR-223	CLIP-seq
MIRT2393894	hsa-miR-526b	CLIP-seq
MIRT1319464	hsa-miR-548ah	CLIP-seq
MIRT1319441	hsa-miR-548t	CLIP-seq
MIRT2393895	hsa-miR-578	CLIP-seq
MIRT1319466	hsa-miR-580	CLIP-seq
MIRT1319422	hsa-miR-1276	CLIP-seq
MIRT2614971	hsa-miR-200b	CLIP-seq
MIRT2614972	hsa-miR-200c	CLIP-seq
MIRT2614973	hsa-miR-203	CLIP-seq
MIRT2614974	hsa-miR-3675-3p	CLIP-seq
MIRT2614975	hsa-miR-374c	CLIP-seq
MIRT2614976	hsa-miR-429	CLIP-seq
MIRT1319444	hsa-miR-654-3p	CLIP-seq
MIRT2614977	hsa-miR-655	CLIP-seq
MIRT1319444	hsa-miR-654-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
BTF3	Repression	17312387

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	31130282
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS	10777492
GO:0005515	Function	Protein binding	IPI	12620389, 19060904, 28514442, 31515488, 32296183, 33961781
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005783	Component	Endoplasmic reticulum	NAS	10777492
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	28406396
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	NAS	10777492
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0007165	Process	Signal transduction	IEA
GO:0007265	Process	Ras protein signal transduction	IDA	31130282
GO:0007265	Process	Ras protein signal transduction	IEA
GO:0007265	Process	Ras protein signal transduction	IEA
GO:0016020	Component	Membrane	HDA	16210410
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0019003	Function	GDP binding	IBA
GO:0036135	Process	Schwann cell migration	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:1900149	Process	Positive regulation of Schwann cell migration	IEA

Other IDs

• MIM: 600098
• HGNC: 17271
• e!Ensembl: ENSG00000133818

Protein

• UniProt ID: P62070
• Protein name: Ras-related protein R-Ras2 (EC 3.6.5.2) (Ras-like protein TC21) (Teratocarcinoma oncogene)
• Protein function: GTP-binding protein with GTPase activity, involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes (PubMed:31130282, PubMed:31130285, PubMed:39809765). Regulates craniofacial development (PubMed:31
• PDB: 2ERY, 9B4Q, 9B4S
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00071	Ras	16 → 177	Ras family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver; low levels in brain, kidney, and pancreas. {ECO:0000269|PubMed:8052619}.
• Sequence:

  MAAAGWRDGSGQEKYRLVVVGGGGVGKSALTIQFIQSYFVTDYDPTIEDSYTKQCVIDDR
  AARLDILDTAGQEEFGAMREQYMRTGEGFLLVFSVTDRGSFEEIYKFQRQILRVKDRDEF
  PMILIGNKADLDHQRQVTQEEGQQLARQLKVTYMEASAKIRMNVDQAFHELVRVIRKFQE
  QECPPSPEPTRKEKDKKGCHCVIF

• Sequence length: 204

Pathways

KEGG:

MAPK signaling pathway
Ras signaling pathway
cAMP signaling pathway
Phospholipase D signaling pathway
Mitophagy - animal
Autophagy - animal
Cellular senescence
Apelin signaling pathway
C-type lectin receptor signaling pathway
Regulation of actin cytoskeleton
Proteoglycans in cancer

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Adenocarcinoma of the large intestine	Likely pathogenic; Pathogenic	rs2493951813	RCV006254361	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Central nervous system germ cell tumor	Pathogenic	rs1591495779	RCV006254325	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Germinoma	Likely pathogenic; Pathogenic	rs2134048726, rs1591495779	RCV006254311 RCV006254148	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Noonan syndrome	Likely pathogenic; Pathogenic	rs2134048726, rs113954997, rs782457908, rs1591495767, rs1591495776, rs1591495779	RCV003153250 RCV000852398 RCV000852397 RCV000852399 RCV000852395 RCV000852396	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan syndrome 12	Pathogenic; Likely pathogenic	rs1591495779, rs2493951813, rs113954997, rs782457908, rs1591495767	RCV002272974 RCV005254745 RCV000010054 RCV000853183 RCV000853184	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Ovarian neoplasm	Pathogenic	rs113954997	RCV001072115	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
RASopathy	Likely pathogenic	rs782457908	RCV004760768	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
RRAS2-related disorder	Likely pathogenic	rs782457908	RCV003411705	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DESBUQUOIS SYNDROME	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Embryonal rhabdomyosarcoma	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER NEOPLASMS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Astrocytoma	Astrocytoma	Pubtator	24148564	Stimulate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	10557073, 19047159, 9703274		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	24148564	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	20811707, 24148564		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	GENOMICS_ENGLAND_DG			★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	37942564	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal carcinoma	Esophageal Carcinoma	BEFREE	22919244		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophagus Neoplasm	BEFREE	22919244		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	22919244	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	22919244	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	24148564	Stimulate	★☆☆☆☆ Found in Text Mining only
Hydrops Fetalis	Hydrops fetalis	Pubtator	33686258	Associate	★☆☆☆☆ Found in Text Mining only
Hyperplasia	Hyperplasia	Pubtator	24148564	Stimulate	★☆☆☆☆ Found in Text Mining only
Juvenile Myelomonocytic Leukemia	Myelomonocytic Leukemia	CTD_human_DG	26457647		★☆☆☆☆ Found in Text Mining only
leiomyosarcoma	Leiomyosarcoma	BEFREE	7478545, 9703274		★☆☆☆☆ Found in Text Mining only
Leiomyosarcoma	Leiomyosarcoma	Pubtator	9703274	Associate	★☆☆☆☆ Found in Text Mining only
Leukoplakia	Leukoplakia	BEFREE	20040018		★☆☆☆☆ Found in Text Mining only
Lip and Oral Cavity Carcinoma	Lip and Oral Cavity Carcinoma	BEFREE	20040018		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	20811707, 22912832		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	24148564		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	24148564	Stimulate	★☆☆☆☆ Found in Text Mining only
Macrocephaly	Macrocephaly	BEFREE	31130285		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	10557073, 19047159, 9703274		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	22919244		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of mouth	Malignant neoplasm of mouth	BEFREE	20040018		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	CGI_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	GENOMICS_ENGLAND_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	24391759		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	20040018		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	19047159, 9703274		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10557073, 19047159, 8196649		★☆☆☆☆ Found in Text Mining only
Nervous System Diseases	Nervous system disease	Pubtator	24148564	Associate	★☆☆☆☆ Found in Text Mining only
Neurofibrosarcoma	Neurofibrosarcoma	Pubtator	34530870	Associate	★☆☆☆☆ Found in Text Mining only
Noonan Syndrome	Noonan Syndrome	GENOMICS_ENGLAND_DG	24705357		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan Syndrome	Noonan Syndrome	BEFREE	31130282, 31130285		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan Syndrome	Noonan Syndrome	CLINGEN_DG	31130282, 31130285		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan Syndrome	Noonan syndrome	Pubtator	31130282, 33686258, 37942564	Associate	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan Syndrome	Noonan Syndrome	ORPHANET_DG	31130285		★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan syndrome	Noonan Syndrome	Orphanet			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Noonan Syndrome 1	Noonan Syndrome	CLINVAR_DG			★☆☆☆☆ Found in Text Mining only
Oligodendroglioma	Oligodendroglioma	Pubtator	24148564	Stimulate	★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	31517733		★☆☆☆☆ Found in Text Mining only
Ovarian Carcinoma	Ovarian Carcinoma	GENOMICS_ENGLAND_DG			★☆☆☆☆ Found in Text Mining only
Ovarian Carcinoma	Ovarian Carcinoma	CGI_DG			★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	CGI_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
ovarian neoplasm	Ovarian neoplasm	CLINVAR_DG			★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	8052619, 9703274	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	21085126		★☆☆☆☆ Found in Text Mining only
Pediatric Obesity	Childhood obesity	BEFREE	31622249		★☆☆☆☆ Found in Text Mining only
Rhabdomyosarcoma Embryonal	Rhabdomyosarcoma	Pubtator	37942564	Associate	★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin neoplasm	Pubtator	24391759	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	20040018		★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	22919244		★☆☆☆☆ Found in Text Mining only