Gene Gene information from NCBI Gene database.
Entrez ID 2274
Gene name Four and a half LIM domains 2
Gene symbol FHL2
Synonyms (NCBI Gene)
AAG11DRALFHL-2SLIM-3SLIM3
Chromosome 2
Chromosome location 2q12.2
Summary This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is th
miRNA miRNA information provided by mirtarbase database.
456
miRTarBase ID miRNA Experiments Reference
MIRT023214 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT643969 hsa-miR-4639-3p HITS-CLIP 19536157
MIRT643970 hsa-miR-6515-3p HITS-CLIP 19536157
MIRT643968 hsa-miR-1236-3p HITS-CLIP 19536157
MIRT643967 hsa-miR-412-3p HITS-CLIP 19536157
Transcription factors Transcription factors information provided by TRRUST V2 database.
5
Transcription factor Regulation Reference
PAX5 Activation 21540083
RUNX1 Unknown 18768464
SKI Activation 14583455
SRF Unknown 22456196
ZBTB14 Activation 21540083
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IBA
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IDA 15692560
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0001649 Process Osteoblast differentiation IEA
GO:0003714 Function Transcription corepressor activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602633 3703 ENSG00000115641
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14192
Protein name Four and a half LIM domains protein 2 (FHL-2) (LIM domain protein DRAL) (Skeletal muscle LIM-protein 3) (SLIM-3)
Protein function May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and
PDB 1X4K , 1X4L , 2D8Z , 2MIU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 40 97 LIM domain Domain
PF00412 LIM 101 158 LIM domain Domain
PF00412 LIM 162 217 LIM domain Domain
PF00412 LIM 221 278 LIM domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11813260}.
Sequence
Sequence length 279
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Osteoclast differentiation
Cytoskeleton in muscle cells
  PPARA activates gene expression
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
37
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Arrhythmogenic right ventricular cardiomyopathy Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Myeloid Leukemia (AML-M2) Leukemia CTD_human_DG 17330099
★☆☆☆☆
Found in Text Mining only
Acute Myeloid Leukemia, M1 Myeloid Leukemia CTD_human_DG 17330099
★☆☆☆☆
Found in Text Mining only
Adenoma Adenoma BEFREE 20442768, 28349819
★☆☆☆☆
Found in Text Mining only
Adult Type Ovarian Granulosa Cell Tumor Ovarian Tumor BEFREE 27415427
★☆☆☆☆
Found in Text Mining only
Amenorrhea Amenorrhea Pubtator 25747126 Associate
★☆☆☆☆
Found in Text Mining only
Anaplasia Anaplasia BEFREE 25855776
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 25917075
★☆☆☆☆
Found in Text Mining only
Aortic Valve Stenosis Aortic valve stenosis Pubtator 37175670 Associate
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 31714683
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 25125695
★☆☆☆☆
Found in Text Mining only