Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	2230
Gene name	Ferredoxin 1
Gene symbol	FDX1
Synonyms (NCBI Gene)	ADXFDXLOH11CR1D
Chromosome	11
Chromosome location	11q22.3
Summary	This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chr

314

Show/Hide all (314)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028451	hsa-miR-30a-5p	Proteomics	18668040
MIRT037813	hsa-miR-455-3p	CLASH	23622248
MIRT626852	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT626851	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT626850	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT626849	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT626848	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT626847	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT626846	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT626845	hsa-miR-606	HITS-CLIP	23824327
MIRT626844	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT110977	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT626843	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT491030	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT491029	hsa-miR-3653-5p	PAR-CLIP	20371350
MIRT491028	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT491027	hsa-miR-4437	PAR-CLIP	20371350
MIRT491026	hsa-miR-4417	PAR-CLIP	20371350
MIRT491025	hsa-miR-4674	PAR-CLIP	20371350
MIRT491030	hsa-miR-101-5p	PAR-CLIP	23592263
MIRT491029	hsa-miR-3653-5p	PAR-CLIP	23592263
MIRT491028	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT491027	hsa-miR-4437	PAR-CLIP	23592263
MIRT491026	hsa-miR-4417	PAR-CLIP	23592263
MIRT491025	hsa-miR-4674	PAR-CLIP	23592263
MIRT491030	hsa-miR-101-5p	PAR-CLIP	27292025
MIRT491029	hsa-miR-3653-5p	PAR-CLIP	27292025
MIRT491026	hsa-miR-4417	PAR-CLIP	27292025
MIRT491027	hsa-miR-4437	PAR-CLIP	27292025
MIRT491025	hsa-miR-4674	PAR-CLIP	27292025
MIRT491028	hsa-miR-4795-5p	PAR-CLIP	27292025
MIRT626852	hsa-miR-548ae-3p	HITS-CLIP	23824327
MIRT626851	hsa-miR-548ah-3p	HITS-CLIP	23824327
MIRT626850	hsa-miR-548aj-3p	HITS-CLIP	23824327
MIRT626849	hsa-miR-548am-3p	HITS-CLIP	23824327
MIRT626848	hsa-miR-548aq-3p	HITS-CLIP	23824327
MIRT626847	hsa-miR-548j-3p	HITS-CLIP	23824327
MIRT626846	hsa-miR-548x-3p	HITS-CLIP	23824327
MIRT626845	hsa-miR-606	HITS-CLIP	23824327
MIRT626844	hsa-miR-888-5p	HITS-CLIP	23824327
MIRT110977	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT626843	hsa-miR-6826-5p	HITS-CLIP	23824327
MIRT491030	hsa-miR-101-5p	PAR-CLIP	20371350
MIRT491029	hsa-miR-3653-5p	PAR-CLIP	20371350
MIRT491028	hsa-miR-4795-5p	PAR-CLIP	20371350
MIRT491027	hsa-miR-4437	PAR-CLIP	20371350
MIRT491026	hsa-miR-4417	PAR-CLIP	20371350
MIRT491025	hsa-miR-4674	PAR-CLIP	20371350
MIRT491030	hsa-miR-101-5p	PAR-CLIP	23592263
MIRT491029	hsa-miR-3653-5p	PAR-CLIP	23592263
MIRT491028	hsa-miR-4795-5p	PAR-CLIP	23592263
MIRT491027	hsa-miR-4437	PAR-CLIP	23592263
MIRT491026	hsa-miR-4417	PAR-CLIP	23592263
MIRT491025	hsa-miR-4674	PAR-CLIP	23592263
MIRT994338	hsa-miR-1245b-3p	CLIP-seq
MIRT994339	hsa-miR-1263	CLIP-seq
MIRT994340	hsa-miR-127-5p	CLIP-seq
MIRT994341	hsa-miR-1293	CLIP-seq
MIRT994342	hsa-miR-138	CLIP-seq
MIRT994343	hsa-miR-1973	CLIP-seq
MIRT994344	hsa-miR-19a	CLIP-seq
MIRT994345	hsa-miR-19b	CLIP-seq
MIRT994346	hsa-miR-2117	CLIP-seq
MIRT994347	hsa-miR-24	CLIP-seq
MIRT994348	hsa-miR-30a	CLIP-seq
MIRT994349	hsa-miR-30b	CLIP-seq
MIRT994350	hsa-miR-30c	CLIP-seq
MIRT994351	hsa-miR-30d	CLIP-seq
MIRT994352	hsa-miR-30e	CLIP-seq
MIRT994353	hsa-miR-3122	CLIP-seq
MIRT994354	hsa-miR-3163	CLIP-seq
MIRT994355	hsa-miR-3165	CLIP-seq
MIRT994356	hsa-miR-323-5p	CLIP-seq
MIRT994357	hsa-miR-338-3p	CLIP-seq
MIRT994358	hsa-miR-340	CLIP-seq
MIRT994359	hsa-miR-3607-3p	CLIP-seq
MIRT994360	hsa-miR-3658	CLIP-seq
MIRT994361	hsa-miR-3670	CLIP-seq
MIRT994362	hsa-miR-3686	CLIP-seq
MIRT994363	hsa-miR-3689a-3p	CLIP-seq
MIRT994364	hsa-miR-3689c	CLIP-seq
MIRT994365	hsa-miR-3913-5p	CLIP-seq
MIRT994366	hsa-miR-3929	CLIP-seq
MIRT994367	hsa-miR-4273	CLIP-seq
MIRT994368	hsa-miR-4283	CLIP-seq
MIRT994369	hsa-miR-4284	CLIP-seq
MIRT994370	hsa-miR-4310	CLIP-seq
MIRT994371	hsa-miR-4419b	CLIP-seq
MIRT994372	hsa-miR-4478	CLIP-seq
MIRT994373	hsa-miR-4480	CLIP-seq
MIRT994374	hsa-miR-4483	CLIP-seq
MIRT994375	hsa-miR-4489	CLIP-seq
MIRT994376	hsa-miR-4524	CLIP-seq
MIRT994377	hsa-miR-4662a-5p	CLIP-seq
MIRT994378	hsa-miR-4668-3p	CLIP-seq
MIRT994379	hsa-miR-4675	CLIP-seq
MIRT994380	hsa-miR-4676-5p	CLIP-seq
MIRT994381	hsa-miR-4695-3p	CLIP-seq
MIRT994382	hsa-miR-4716-5p	CLIP-seq
MIRT994383	hsa-miR-4728-5p	CLIP-seq
MIRT994384	hsa-miR-4729	CLIP-seq
MIRT994385	hsa-miR-4741	CLIP-seq
MIRT994386	hsa-miR-4755-3p	CLIP-seq
MIRT994387	hsa-miR-485-5p	CLIP-seq
MIRT994388	hsa-miR-566	CLIP-seq
MIRT994389	hsa-miR-575	CLIP-seq
MIRT994390	hsa-miR-640	CLIP-seq
MIRT994391	hsa-miR-876-3p	CLIP-seq
MIRT994392	hsa-miR-891a	CLIP-seq
MIRT1556340	hsa-miR-1343	CLIP-seq
MIRT1556341	hsa-miR-3199	CLIP-seq
MIRT1556342	hsa-miR-4513	CLIP-seq
MIRT1556343	hsa-miR-4740-5p	CLIP-seq
MIRT1556344	hsa-miR-483-3p	CLIP-seq
MIRT1556345	hsa-miR-603	CLIP-seq
MIRT1556346	hsa-miR-642b	CLIP-seq
MIRT1994843	hsa-miR-1285	CLIP-seq
MIRT994341	hsa-miR-1293	CLIP-seq
MIRT1994844	hsa-miR-1323	CLIP-seq
MIRT1994845	hsa-miR-2053	CLIP-seq
MIRT1994846	hsa-miR-21	CLIP-seq
MIRT1994847	hsa-miR-223	CLIP-seq
MIRT994353	hsa-miR-3122	CLIP-seq
MIRT994355	hsa-miR-3165	CLIP-seq
MIRT1994848	hsa-miR-3177-5p	CLIP-seq
MIRT1994849	hsa-miR-3187-5p	CLIP-seq
MIRT994357	hsa-miR-338-3p	CLIP-seq
MIRT1994850	hsa-miR-34b	CLIP-seq
MIRT1994851	hsa-miR-3616-5p	CLIP-seq
MIRT1994852	hsa-miR-3617	CLIP-seq
MIRT1994853	hsa-miR-3647-5p	CLIP-seq
MIRT994361	hsa-miR-3670	CLIP-seq
MIRT994363	hsa-miR-3689a-3p	CLIP-seq
MIRT994364	hsa-miR-3689c	CLIP-seq
MIRT1994854	hsa-miR-369-3p	CLIP-seq
MIRT1994855	hsa-miR-371b-5p	CLIP-seq
MIRT1994856	hsa-miR-374c	CLIP-seq
MIRT994365	hsa-miR-3913-5p	CLIP-seq
MIRT994366	hsa-miR-3929	CLIP-seq
MIRT1994857	hsa-miR-412	CLIP-seq
MIRT1994858	hsa-miR-4297	CLIP-seq
MIRT994370	hsa-miR-4310	CLIP-seq
MIRT1994859	hsa-miR-4318	CLIP-seq
MIRT1994860	hsa-miR-4328	CLIP-seq
MIRT994371	hsa-miR-4419b	CLIP-seq
MIRT1994861	hsa-miR-4436a	CLIP-seq
MIRT994372	hsa-miR-4478	CLIP-seq
MIRT994374	hsa-miR-4483	CLIP-seq
MIRT1994862	hsa-miR-4503	CLIP-seq
MIRT1994863	hsa-miR-4539	CLIP-seq
MIRT1994864	hsa-miR-4643	CLIP-seq
MIRT1994865	hsa-miR-466	CLIP-seq
MIRT1994866	hsa-miR-4670-3p	CLIP-seq
MIRT1994867	hsa-miR-4693-5p	CLIP-seq
MIRT994383	hsa-miR-4728-5p	CLIP-seq
MIRT994384	hsa-miR-4729	CLIP-seq
MIRT1994868	hsa-miR-4789-3p	CLIP-seq
MIRT994387	hsa-miR-485-5p	CLIP-seq
MIRT1994869	hsa-miR-498	CLIP-seq
MIRT1994870	hsa-miR-548o	CLIP-seq
MIRT1994871	hsa-miR-573	CLIP-seq
MIRT1994872	hsa-miR-584	CLIP-seq
MIRT1994873	hsa-miR-590-5p	CLIP-seq
MIRT1994874	hsa-miR-612	CLIP-seq
MIRT1994875	hsa-miR-622	CLIP-seq
MIRT1994876	hsa-miR-641	CLIP-seq
MIRT1994877	hsa-miR-655	CLIP-seq
MIRT1994878	hsa-miR-661	CLIP-seq
MIRT1994879	hsa-miR-892a	CLIP-seq
MIRT994353	hsa-miR-3122	CLIP-seq
MIRT2228968	hsa-miR-3176	CLIP-seq
MIRT2228969	hsa-miR-3192	CLIP-seq
MIRT994357	hsa-miR-338-3p	CLIP-seq
MIRT2228970	hsa-miR-3667-5p	CLIP-seq
MIRT994361	hsa-miR-3670	CLIP-seq
MIRT994363	hsa-miR-3689a-3p	CLIP-seq
MIRT994364	hsa-miR-3689c	CLIP-seq
MIRT994365	hsa-miR-3913-5p	CLIP-seq
MIRT2228971	hsa-miR-3922-3p	CLIP-seq
MIRT994366	hsa-miR-3929	CLIP-seq
MIRT994370	hsa-miR-4310	CLIP-seq
MIRT994371	hsa-miR-4419b	CLIP-seq
MIRT994372	hsa-miR-4478	CLIP-seq
MIRT2228972	hsa-miR-4535	CLIP-seq
MIRT994383	hsa-miR-4728-5p	CLIP-seq
MIRT2228973	hsa-miR-4765	CLIP-seq
MIRT2228974	hsa-miR-4797-5p	CLIP-seq
MIRT994387	hsa-miR-485-5p	CLIP-seq
MIRT2228975	hsa-miR-492	CLIP-seq
MIRT2228976	hsa-miR-542-3p	CLIP-seq
MIRT994341	hsa-miR-1293	CLIP-seq
MIRT994353	hsa-miR-3122	CLIP-seq
MIRT994355	hsa-miR-3165	CLIP-seq
MIRT994357	hsa-miR-338-3p	CLIP-seq
MIRT994359	hsa-miR-3607-3p	CLIP-seq
MIRT994362	hsa-miR-3686	CLIP-seq
MIRT994363	hsa-miR-3689a-3p	CLIP-seq
MIRT994364	hsa-miR-3689c	CLIP-seq
MIRT994365	hsa-miR-3913-5p	CLIP-seq
MIRT994366	hsa-miR-3929	CLIP-seq
MIRT994370	hsa-miR-4310	CLIP-seq
MIRT994371	hsa-miR-4419b	CLIP-seq
MIRT994372	hsa-miR-4478	CLIP-seq
MIRT994374	hsa-miR-4483	CLIP-seq
MIRT994383	hsa-miR-4728-5p	CLIP-seq
MIRT994387	hsa-miR-485-5p	CLIP-seq
MIRT994341	hsa-miR-1293	CLIP-seq
MIRT994353	hsa-miR-3122	CLIP-seq
MIRT994355	hsa-miR-3165	CLIP-seq
MIRT994357	hsa-miR-338-3p	CLIP-seq
MIRT994359	hsa-miR-3607-3p	CLIP-seq
MIRT994362	hsa-miR-3686	CLIP-seq
MIRT994363	hsa-miR-3689a-3p	CLIP-seq
MIRT994364	hsa-miR-3689c	CLIP-seq
MIRT2449605	hsa-miR-380	CLIP-seq
MIRT994365	hsa-miR-3913-5p	CLIP-seq
MIRT994366	hsa-miR-3929	CLIP-seq
MIRT994370	hsa-miR-4310	CLIP-seq
MIRT994371	hsa-miR-4419b	CLIP-seq
MIRT994372	hsa-miR-4478	CLIP-seq
MIRT994374	hsa-miR-4483	CLIP-seq
MIRT2449606	hsa-miR-4495	CLIP-seq
MIRT994383	hsa-miR-4728-5p	CLIP-seq
MIRT994387	hsa-miR-485-5p	CLIP-seq
MIRT2449605	hsa-miR-380	CLIP-seq
MIRT2449606	hsa-miR-4495	CLIP-seq
MIRT2532537	hsa-miR-1178	CLIP-seq
MIRT2532538	hsa-miR-1184	CLIP-seq
MIRT994341	hsa-miR-1293	CLIP-seq
MIRT994344	hsa-miR-19a	CLIP-seq
MIRT994345	hsa-miR-19b	CLIP-seq
MIRT994353	hsa-miR-3122	CLIP-seq
MIRT2532539	hsa-miR-3123	CLIP-seq
MIRT994355	hsa-miR-3165	CLIP-seq
MIRT2532540	hsa-miR-3189-5p	CLIP-seq
MIRT994357	hsa-miR-338-3p	CLIP-seq
MIRT994359	hsa-miR-3607-3p	CLIP-seq
MIRT2532541	hsa-miR-3620	CLIP-seq
MIRT2532542	hsa-miR-362-5p	CLIP-seq
MIRT994362	hsa-miR-3686	CLIP-seq
MIRT994363	hsa-miR-3689a-3p	CLIP-seq
MIRT994364	hsa-miR-3689c	CLIP-seq
MIRT994365	hsa-miR-3913-5p	CLIP-seq
MIRT994366	hsa-miR-3929	CLIP-seq
MIRT994368	hsa-miR-4283	CLIP-seq
MIRT994370	hsa-miR-4310	CLIP-seq
MIRT2532543	hsa-miR-4323	CLIP-seq
MIRT2532544	hsa-miR-4418	CLIP-seq
MIRT994371	hsa-miR-4419b	CLIP-seq
MIRT994372	hsa-miR-4478	CLIP-seq
MIRT994374	hsa-miR-4483	CLIP-seq
MIRT994375	hsa-miR-4489	CLIP-seq
MIRT994379	hsa-miR-4675	CLIP-seq
MIRT2532545	hsa-miR-4690-3p	CLIP-seq
MIRT994383	hsa-miR-4728-5p	CLIP-seq
MIRT994385	hsa-miR-4741	CLIP-seq
MIRT994387	hsa-miR-485-5p	CLIP-seq
MIRT2532546	hsa-miR-500b	CLIP-seq
MIRT2532547	hsa-miR-502-5p	CLIP-seq
MIRT2532548	hsa-miR-509-3-5p	CLIP-seq
MIRT2532549	hsa-miR-509-5p	CLIP-seq
MIRT994388	hsa-miR-566	CLIP-seq
MIRT2532550	hsa-miR-596	CLIP-seq
MIRT1556345	hsa-miR-603	CLIP-seq
MIRT1556346	hsa-miR-642b	CLIP-seq
MIRT2532551	hsa-miR-652	CLIP-seq
MIRT2532552	hsa-miR-767-3p	CLIP-seq
MIRT994392	hsa-miR-891a	CLIP-seq
MIRT2532537	hsa-miR-1178	CLIP-seq
MIRT2532538	hsa-miR-1184	CLIP-seq
MIRT1994843	hsa-miR-1285	CLIP-seq
MIRT994341	hsa-miR-1293	CLIP-seq
MIRT994344	hsa-miR-19a	CLIP-seq
MIRT994345	hsa-miR-19b	CLIP-seq
MIRT994353	hsa-miR-3122	CLIP-seq
MIRT2532539	hsa-miR-3123	CLIP-seq
MIRT994355	hsa-miR-3165	CLIP-seq
MIRT1994849	hsa-miR-3187-5p	CLIP-seq
MIRT2532540	hsa-miR-3189-5p	CLIP-seq
MIRT994357	hsa-miR-338-3p	CLIP-seq
MIRT994359	hsa-miR-3607-3p	CLIP-seq
MIRT2532541	hsa-miR-3620	CLIP-seq
MIRT2532542	hsa-miR-362-5p	CLIP-seq
MIRT994362	hsa-miR-3686	CLIP-seq
MIRT994363	hsa-miR-3689a-3p	CLIP-seq
MIRT994364	hsa-miR-3689c	CLIP-seq
MIRT994365	hsa-miR-3913-5p	CLIP-seq
MIRT994366	hsa-miR-3929	CLIP-seq
MIRT994368	hsa-miR-4283	CLIP-seq
MIRT994370	hsa-miR-4310	CLIP-seq
MIRT2532543	hsa-miR-4323	CLIP-seq
MIRT2532544	hsa-miR-4418	CLIP-seq
MIRT994371	hsa-miR-4419b	CLIP-seq
MIRT994372	hsa-miR-4478	CLIP-seq
MIRT994374	hsa-miR-4483	CLIP-seq
MIRT994375	hsa-miR-4489	CLIP-seq
MIRT994379	hsa-miR-4675	CLIP-seq
MIRT2532545	hsa-miR-4690-3p	CLIP-seq
MIRT994383	hsa-miR-4728-5p	CLIP-seq
MIRT994385	hsa-miR-4741	CLIP-seq
MIRT994387	hsa-miR-485-5p	CLIP-seq
MIRT2532546	hsa-miR-500b	CLIP-seq
MIRT2532547	hsa-miR-502-5p	CLIP-seq
MIRT2532548	hsa-miR-509-3-5p	CLIP-seq
MIRT2532549	hsa-miR-509-5p	CLIP-seq
MIRT994388	hsa-miR-566	CLIP-seq
MIRT2532550	hsa-miR-596	CLIP-seq
MIRT1556345	hsa-miR-603	CLIP-seq
MIRT1994874	hsa-miR-612	CLIP-seq
MIRT1556346	hsa-miR-642b	CLIP-seq
MIRT2532551	hsa-miR-652	CLIP-seq
MIRT1994878	hsa-miR-661	CLIP-seq
MIRT2532552	hsa-miR-767-3p	CLIP-seq
MIRT994392	hsa-miR-891a	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005506	Function	Iron ion binding	TAS	2969697
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	2969697
GO:0005759	Component	Mitochondrial matrix	IEA
GO:0005759	Component	Mitochondrial matrix	ISS
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006694	Process	Steroid biosynthetic process	IEA
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008203	Process	Cholesterol metabolic process	IDA	21636783
GO:0008203	Process	Cholesterol metabolic process	IEA
GO:0009055	Function	Electron transfer activity	IBA
GO:0009055	Function	Electron transfer activity	IDA	21636783
GO:0009055	Function	Electron transfer activity	IEA
GO:0009055	Function	Electron transfer activity	TAS	1863359
GO:0022900	Process	Electron transport chain	IBA
GO:0042446	Process	Hormone biosynthetic process	IDA	21636783
GO:0046872	Function	Metal ion binding	IEA
GO:0051536	Function	Iron-sulfur cluster binding	IEA
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IDA	21636783
GO:0051537	Function	2 iron, 2 sulfur cluster binding	IEA
GO:0071320	Process	Cellular response to cAMP	IEA
GO:0140647	Process	P450-containing electron transport chain	IEA
GO:1904322	Process	Cellular response to forskolin	IEA

MIM	HGNC	e!Ensembl
103260	3638	ENSG00000137714

P10109

Protein name

Adrenodoxin, mitochondrial (Adrenal ferredoxin) (Ferredoxin-1) (Hepatoredoxin)

Protein function

Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodox

PDB

3N9Y , 3N9Z , 3NA0 , 3NA1 , 3P1M , 7M8I

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00111	Fer2	72 → 157	2Fe-2S iron-sulfur cluster binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highest levels in the adrenal gland (at protein level). Also detected in kidney and testis (at protein level). {ECO:0000269|PubMed:20547883}.

Sequence

MAAAGGARLLRAASAVLGGPAGRWLHHAGSRAGSSGLLRNRGPGGSAEASRSLSVSARAR
SSSEDKITVHFINRDGETLTTKGKVGDSLLDVVVENNLDIDGFGACEGTLACSTCHLIFE
DHIYEKLDAITDEENDMLDLAYGLTDRSRLGCQICLTKSMDNMTVRVPETVADARQSIDV
GKTS

Sequence length

184

Interactions

View interactions

	Reactome
			Mitochondrial iron-sulfur cluster biogenesis Pregnenolone biosynthesis Endogenous sterols Electron transport from NADPH to Ferredoxin Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (49)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adrenocortical Carcinoma	Adrenocortical carcinoma	Pubtator	37997497	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	Pubtator	32469254	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36312586	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35898502	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36611155	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	36826087	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36059510, 36105937, 36605188, 36611966, 36766692, 37193786, 37432054	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Renal cell carcinoma	Pubtator	36225932, 36292610	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Choriocarcinoma	Choriocarcinoma	BEFREE	1316854		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cirrhosis	Cirrhosis	BEFREE	24065354		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	37904461	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	36173462	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	32469254	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Crohn Disease	Crohn disease	Pubtator	36466876	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cushing Syndrome	Cushing`s Syndrome	BEFREE	30844071		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	37773841	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	37866660	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	36856182, 38114959, 40244269	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	36856182, 37301546, 40355831	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	36915038	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatolenticular Degeneration	Hepatolenticular degeneration	Pubtator	39809184	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	40244269	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
IGA Glomerulonephritis	Glomerulonephritis	BEFREE	26370181, 26431901		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune system disease	Pubtator	36605188, 37432054	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	37275904	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Iron Overload	Iron overload	Pubtator	22101253	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	24065354		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Liver Cirrhosis	BEFREE	24065354		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	37298135	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	36105937	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	36225932	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoproliferative Disorders	Lymphoproliferative syndrome	Pubtator	8876224	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	37298135	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	Pubtator	38018590	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30273606		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	24883309		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	36671512, 36817415	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoarthritis	Osteoarthritis	Pubtator	37809099	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	20340016	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	37405988	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	37144519	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	Pubtator	37215133	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	34130686, 37445796	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	37355762	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37036489	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	37505170	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Synovitis	Synovitis	Pubtator	36817415	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	37745716	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Vitamin D-dependent rickets, type 1	Vitamin D-Dependent Rickets	BEFREE	27399352		★★★★★ ★☆☆☆☆ Found in Text Mining only

FDX1 (ferredoxin 1)