Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	222962
Gene name	Solute carrier family 29 member 4
Gene symbol	SLC29A4
Synonyms (NCBI Gene)	ENT4PMAT
Chromosome	7
Chromosome location	7p22.1
Summary	This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been sho

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miRTarBase ID	miRNA	Experiments	Reference
MIRT030404	hsa-miR-24-3p	Microarray	19748357
MIRT670167	hsa-miR-1321	HITS-CLIP	23824327
MIRT670166	hsa-miR-4739	HITS-CLIP	23824327
MIRT670165	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT670164	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT670163	hsa-miR-6087	HITS-CLIP	23824327
MIRT670162	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT670161	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT670160	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT670159	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT670158	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT670157	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT670156	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT670155	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT670154	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT670153	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT670152	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT670151	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT670150	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT670149	hsa-miR-3689c	HITS-CLIP	23824327
MIRT670148	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT670147	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT670146	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT670145	hsa-miR-3122	HITS-CLIP	23824327
MIRT670144	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT670143	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT670142	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT662297	hsa-miR-4445-3p	HITS-CLIP	23824327
MIRT662296	hsa-miR-548al	HITS-CLIP	23824327
MIRT662295	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662294	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662293	hsa-miR-940	HITS-CLIP	23824327
MIRT662292	hsa-miR-3929	HITS-CLIP	23824327
MIRT662291	hsa-miR-4419b	HITS-CLIP	23824327
MIRT662290	hsa-miR-4478	HITS-CLIP	23824327
MIRT662289	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT662288	hsa-miR-665	HITS-CLIP	23824327
MIRT662287	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662286	hsa-miR-1827	HITS-CLIP	23824327
MIRT662285	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT662284	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT670167	hsa-miR-1321	HITS-CLIP	23824327
MIRT670166	hsa-miR-4739	HITS-CLIP	23824327
MIRT670165	hsa-miR-4756-5p	HITS-CLIP	23824327
MIRT670164	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT670163	hsa-miR-6087	HITS-CLIP	23824327
MIRT670162	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT670161	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT670160	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT670159	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT670158	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT670157	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT670156	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT670155	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT670154	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT670153	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT670152	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT670151	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT670150	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT670149	hsa-miR-3689c	HITS-CLIP	23824327
MIRT670148	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT670147	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT670146	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT670145	hsa-miR-3122	HITS-CLIP	23824327
MIRT670144	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT670143	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT670142	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT662297	hsa-miR-4445-3p	HITS-CLIP	23824327
MIRT662296	hsa-miR-548al	HITS-CLIP	23824327
MIRT662295	hsa-miR-6808-5p	HITS-CLIP	23824327
MIRT662294	hsa-miR-6893-5p	HITS-CLIP	23824327
MIRT662293	hsa-miR-940	HITS-CLIP	23824327
MIRT662292	hsa-miR-3929	HITS-CLIP	23824327
MIRT662291	hsa-miR-4419b	HITS-CLIP	23824327
MIRT662290	hsa-miR-4478	HITS-CLIP	23824327
MIRT662289	hsa-miR-4768-3p	HITS-CLIP	23824327
MIRT662288	hsa-miR-665	HITS-CLIP	23824327
MIRT662287	hsa-miR-4649-3p	HITS-CLIP	23824327
MIRT662286	hsa-miR-1827	HITS-CLIP	23824327
MIRT662285	hsa-miR-4722-5p	HITS-CLIP	23824327
MIRT662284	hsa-miR-7160-5p	HITS-CLIP	23824327
MIRT1358343	hsa-miR-125a-5p	CLIP-seq
MIRT1358344	hsa-miR-125b	CLIP-seq
MIRT1358345	hsa-miR-1307	CLIP-seq
MIRT1358346	hsa-miR-148a	CLIP-seq
MIRT1358347	hsa-miR-148b	CLIP-seq
MIRT1358348	hsa-miR-152	CLIP-seq
MIRT1358349	hsa-miR-1910	CLIP-seq
MIRT1358350	hsa-miR-298	CLIP-seq
MIRT1358351	hsa-miR-3126-5p	CLIP-seq
MIRT1358352	hsa-miR-3151	CLIP-seq
MIRT1358353	hsa-miR-34a	CLIP-seq
MIRT1358354	hsa-miR-34c-5p	CLIP-seq
MIRT1358355	hsa-miR-3622b-5p	CLIP-seq
MIRT1358356	hsa-miR-3652	CLIP-seq
MIRT1358357	hsa-miR-3678-3p	CLIP-seq
MIRT1358358	hsa-miR-3681	CLIP-seq
MIRT1358359	hsa-miR-371-3p	CLIP-seq
MIRT1358360	hsa-miR-3937	CLIP-seq
MIRT1358361	hsa-miR-4253	CLIP-seq
MIRT1358362	hsa-miR-4283	CLIP-seq
MIRT1358363	hsa-miR-4292	CLIP-seq
MIRT1358364	hsa-miR-4308	CLIP-seq
MIRT1358365	hsa-miR-4319	CLIP-seq
MIRT1358366	hsa-miR-4419a	CLIP-seq
MIRT1358367	hsa-miR-4430	CLIP-seq
MIRT1358368	hsa-miR-4460	CLIP-seq
MIRT1358369	hsa-miR-4466	CLIP-seq
MIRT1358370	hsa-miR-4481	CLIP-seq
MIRT1358371	hsa-miR-4489	CLIP-seq
MIRT1358372	hsa-miR-449a	CLIP-seq
MIRT1358373	hsa-miR-449b	CLIP-seq
MIRT1358374	hsa-miR-4505	CLIP-seq
MIRT1358375	hsa-miR-4510	CLIP-seq
MIRT1358376	hsa-miR-455-3p	CLIP-seq
MIRT1358377	hsa-miR-4685-5p	CLIP-seq
MIRT1358378	hsa-miR-4725-5p	CLIP-seq
MIRT1358379	hsa-miR-4727-3p	CLIP-seq
MIRT1358380	hsa-miR-4743	CLIP-seq
MIRT1358381	hsa-miR-4745-5p	CLIP-seq
MIRT1358382	hsa-miR-4746-3p	CLIP-seq
MIRT1358383	hsa-miR-4755-3p	CLIP-seq
MIRT1358384	hsa-miR-486-3p	CLIP-seq
MIRT1358385	hsa-miR-504	CLIP-seq
MIRT1358386	hsa-miR-544b	CLIP-seq
MIRT1358387	hsa-miR-582-5p	CLIP-seq
MIRT1358388	hsa-miR-675	CLIP-seq
MIRT1358389	hsa-miR-711	CLIP-seq
MIRT1358358	hsa-miR-3681	CLIP-seq
MIRT1358368	hsa-miR-4460	CLIP-seq
MIRT1358369	hsa-miR-4466	CLIP-seq
MIRT1358379	hsa-miR-4727-3p	CLIP-seq
MIRT1358380	hsa-miR-4743	CLIP-seq
MIRT1358387	hsa-miR-582-5p	CLIP-seq
MIRT1358388	hsa-miR-675	CLIP-seq
MIRT2106179	hsa-miR-1266	CLIP-seq
MIRT2106180	hsa-miR-3127-5p	CLIP-seq
MIRT1358352	hsa-miR-3151	CLIP-seq
MIRT2106181	hsa-miR-3918	CLIP-seq
MIRT1358360	hsa-miR-3937	CLIP-seq
MIRT1358362	hsa-miR-4283	CLIP-seq
MIRT1358364	hsa-miR-4308	CLIP-seq
MIRT1358370	hsa-miR-4481	CLIP-seq
MIRT1358371	hsa-miR-4489	CLIP-seq
MIRT1358374	hsa-miR-4505	CLIP-seq
MIRT2106182	hsa-miR-4518	CLIP-seq
MIRT2106183	hsa-miR-4716-3p	CLIP-seq
MIRT1358381	hsa-miR-4745-5p	CLIP-seq
MIRT2330437	hsa-miR-296-5p	CLIP-seq
MIRT2330438	hsa-miR-4650-5p	CLIP-seq
MIRT2330439	hsa-miR-4274	CLIP-seq
MIRT2330440	hsa-miR-4307	CLIP-seq
MIRT2330441	hsa-miR-4434	CLIP-seq
MIRT2330442	hsa-miR-4516	CLIP-seq
MIRT2330443	hsa-miR-494	CLIP-seq
MIRT2330444	hsa-miR-523	CLIP-seq
MIRT1358356	hsa-miR-3652	CLIP-seq
MIRT1358367	hsa-miR-4430	CLIP-seq
MIRT2394703	hsa-miR-4492	CLIP-seq
MIRT2394704	hsa-miR-4498	CLIP-seq
MIRT2394705	hsa-miR-762	CLIP-seq
MIRT2459645	hsa-miR-1587	CLIP-seq
MIRT2459646	hsa-miR-3064-5p	CLIP-seq
MIRT2459647	hsa-miR-3135b	CLIP-seq
MIRT1358356	hsa-miR-3652	CLIP-seq
MIRT2459648	hsa-miR-378g	CLIP-seq
MIRT1358367	hsa-miR-4430	CLIP-seq
MIRT2394703	hsa-miR-4492	CLIP-seq
MIRT2394704	hsa-miR-4498	CLIP-seq
MIRT1358374	hsa-miR-4505	CLIP-seq
MIRT2459649	hsa-miR-4656	CLIP-seq
MIRT2459650	hsa-miR-4675	CLIP-seq
MIRT2459651	hsa-miR-4741	CLIP-seq
MIRT2394705	hsa-miR-762	CLIP-seq

Show/Hide all (71)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001692	Process	Histamine metabolic process	TAS	23505051
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IDA	15448143, 17018840, 17121826, 20592246, 20858707, 22396231
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IEA
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	IMP	23505051
GO:0005326	Function	Neurotransmitter transmembrane transporter activity	ISS
GO:0005337	Function	Nucleoside transmembrane transporter activity	IEA
GO:0005337	Function	Nucleoside transmembrane transporter activity	TAS
GO:0005342	Function	Organic acid transmembrane transporter activity	IDA	26376205
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	20858707
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006836	Process	Neurotransmitter transport	IDA	20858707
GO:0006836	Process	Neurotransmitter transport	IEA
GO:0006836	Process	Neurotransmitter transport	ISS
GO:0006837	Process	Serotonin transport	IDA	15448143, 17121826, 20592246, 20858707
GO:0006837	Process	Serotonin transport	IEA
GO:0008324	Function	Monoatomic cation transmembrane transporter activity	IEA
GO:0008324	Function	Monoatomic cation transmembrane transporter activity	ISS
GO:0008504	Function	Monoamine transmembrane transporter activity	IBA
GO:0008504	Function	Monoamine transmembrane transporter activity	IDA	15448143, 16099839, 17018840, 17121826, 20592246, 20858707, 22396231
GO:0008504	Function	Monoamine transmembrane transporter activity	IEA
GO:0008504	Function	Monoamine transmembrane transporter activity	IMP	23505051
GO:0008504	Function	Monoamine transmembrane transporter activity	ISS
GO:0015101	Function	Organic cation transmembrane transporter activity	IDA	16099839, 26376205
GO:0015562	Function	Efflux transmembrane transporter activity	IDA	16099839, 31537831
GO:0015562	Function	Efflux transmembrane transporter activity	IMP	31842924
GO:0015695	Process	Organic cation transport	IDA	26376205
GO:0015844	Process	Monoamine transport	IEA
GO:0015844	Process	Monoamine transport	IMP	23505051
GO:0015872	Process	Dopamine transport	IDA	15448143, 17121826, 20858707
GO:0015872	Process	Dopamine transport	IEA
GO:0015874	Process	Norepinephrine transport	IDA	15448143, 20858707
GO:0016020	Component	Membrane	IEA
GO:0016323	Component	Basolateral plasma membrane	IDA	26376205
GO:0016323	Component	Basolateral plasma membrane	IEA
GO:0016324	Component	Apical plasma membrane	IDA	17018840, 23255610, 26376205
GO:0016324	Component	Apical plasma membrane	IEA
GO:0019534	Function	Toxin transmembrane transporter activity	IEA
GO:0019534	Function	Toxin transmembrane transporter activity	ISS
GO:0032238	Process	Adenosine transport	IDA	16873718, 20592246, 31537831
GO:0032238	Process	Adenosine transport	IEA
GO:0042908	Process	Xenobiotic transport	IDA	20858707, 26376205
GO:0042908	Process	Xenobiotic transport	IEA
GO:0042908	Process	Xenobiotic transport	IMP	31842924
GO:0042908	Process	Xenobiotic transport	ISS
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IDA	26376205
GO:0042910	Function	Xenobiotic transmembrane transporter activity	IMP	31842924
GO:0048241	Process	Epinephrine transport	IDA	15448143, 20858707
GO:0051608	Process	Histamine transport	IDA	16099839, 17018840, 20858707, 22396231
GO:0051610	Process	Serotonin uptake	IDA	20858707
GO:0051610	Process	Serotonin uptake	IEA
GO:0051610	Process	Serotonin uptake	ISS
GO:0051615	Process	Histamine uptake	IDA	20858707
GO:0051615	Process	Histamine uptake	IMP	23505051
GO:0051620	Process	Norepinephrine uptake	IDA	20858707
GO:0051620	Process	Norepinephrine uptake	IEA
GO:0051620	Process	Norepinephrine uptake	ISS
GO:0051625	Process	Epinephrine uptake	IDA	20858707
GO:0090494	Process	Dopamine uptake	IDA	20858707
GO:0090494	Process	Dopamine uptake	IEA
GO:0090494	Process	Dopamine uptake	ISS
GO:0098655	Process	Monoatomic cation transmembrane transport	IEA
GO:0098655	Process	Monoatomic cation transmembrane transport	ISS
GO:0098793	Component	Presynapse	IEA
GO:0140115	Process	Export across plasma membrane	IMP	31842924
GO:0150104	Process	Transport across blood-brain barrier	NAS	26590417, 30280653
GO:1901642	Process	Nucleoside transmembrane transport	IEA
GO:1903825	Process	Organic acid transmembrane transport	IDA	26376205
GO:1990748	Process	Cellular detoxification	IEA
GO:1990748	Process	Cellular detoxification	ISS

MIM	HGNC	e!Ensembl
609149	23097	ENSG00000164638

Q7RTT9

Protein name

Equilibrative nucleoside transporter 4 (hENT4) (Plasma membrane monoamine transporter) (PMAT) (Solute carrier family 29 member 4)

Protein function

Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:15448143, PubMed:16099839, PubMed:16873718, PubMed:17018840, PubMed:17121826, PubMed:20592

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01733	Nucleoside_tran	170 → 506	Nucleoside transporter	Family

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in brain and skeletal muscle (PubMed:15448143, PubMed:16873718, PubMed:20592246, PubMed:20858707). In brain, expressed in cerebellum, cerebral cortex, medulla oblongata, occipital pole, frontal and temporal lobes putam

Sequence

MGSVGSQRLEEPSVAGTPDPGVVMSFTFDSHQLEEAAEAAQGQGLRARGVPAFTDTTLDE
PVPDDRYHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSIVFDMSLTYILVALAAV
LLNNVLVERLTLHTRITAGYLLALGPLLFISICDVWLQLFSRDQAYAINLAAVGTVAFGC
TVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTLIFFLVSVA
LELLCFLLHLLVRRSRFVLFYTTRPRDSHRGRPGLGRGYGYRVHHDVVAGDVHFEHPAPA
LAPNESPKDSPAHEVTGSGGAYMRFDVPRPRVQRSWPTFRALLLHRYVVARVIWADMLSI
AVTYFITLCLFPGLESEIRHCILGEWLPILIMAVFNLSDFVGKILAALPVDWRGTHLLAC
SCLRVVFIPLFILCVYPSGMPALRHPAWPCIFSLLMGISNGYFGSVPMILAAGKVSPKQR
ELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHGSCLHASTANGSILAGL

Sequence length

530

Interactions

View interactions

	Reactome
			Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BRAIN INFARCTION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CEREBRAL AMYLOID ANGIOPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEWY BODY DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SLC29A4-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Desmoplastic Small Round Cell Tumor	Desmoplastic Tumor	BEFREE	18523561		★★★★★ ★☆☆☆☆ Found in Text Mining only
Desmoplastic Small Round Cell Tumor	Desmoplastic small round cell tumor	Pubtator	18523561	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	30885951		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	30357508		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	37541765	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	17711502		★★★★★ ★☆☆☆☆ Found in Text Mining only

SLC29A4 (solute carrier family 29 member 4)