Gene Gene information from NCBI Gene database.
Entrez ID 222484
Gene name Ligand of numb-protein X 2
Gene symbol LNX2
Synonyms (NCBI Gene)
PDZRN1
Chromosome 13
Chromosome location 13q12.2
miRNA miRNA information provided by mirtarbase database.
426
miRTarBase ID miRNA Experiments Reference
MIRT020558 hsa-miR-155-5p Reporter assay;Other 20584899
MIRT022212 hsa-miR-124-3p Microarray 18668037
MIRT385082 hsa-miR-543 HITS-CLIP 19536157
MIRT718654 hsa-miR-3143 HITS-CLIP 19536157
MIRT385082 hsa-miR-543 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0004842 Function Ubiquitin-protein transferase activity IBA
GO:0005515 Function Protein binding IPI 21516116, 22458338, 23088713, 27107012, 29892012, 31515488, 32814053, 33864728
GO:0005886 Component Plasma membrane IEA
GO:0007399 Process Nervous system development IEA
GO:0008270 Function Zinc ion binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609733 20421 ENSG00000139517
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N448
Protein name Ligand of Numb protein X 2 (Numb-binding protein 2) (PDZ domain-containing RING finger protein 1)
PDB 2VWR , 5DIN , 5E11 , 5E1Y , 5E21 , 5E22 , 7QCT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13923 zf-C3HC4_2 49 86 Domain
PF00595 PDZ 233 315 PDZ domain Domain
PF00595 PDZ 339 419 PDZ domain Domain
PF00595 PDZ 468 553 PDZ domain Domain
PF00595 PDZ 600 683 PDZ domain Domain
Sequence
MGTTSDEMVSVEQTSSSSLNPLCFECGQQHWTRENHLYNYQNEVDDDLVCHICLQPLLQP
LDTPCGHTFCYKCLRNFLQEKDFCPL
DRKRLHFKLCKKSSILVHKLLDKLLVLCPFSSVC
KDVMQRCDLEAHLKNRCPGASHRRVALERRKTSRTQAEIENENGPTLLDPAGTLSPEADC
LGTGAVPVERHLTSASLSTWSEEPGLDNPAFEESAGADTTQQPLSLPEGEITTIEIHRSN
PYIQLGISIVGGNETPLINIVIQEVYRDGVIARDGRLLAGDQILQVNNYNISNVSHNYAR
AVLSQPCNTLHLTVL
RERRFGNRAHNHSDSNSPREEIFQVALHKRDSGEQLGIKLVRRTD
EPGVFILDLLEGGLAAQDGRLSSNDRVLAINGHDLKYGTPELAAQIIQASGERVNLTIA
R
PGKPQPGNTIREAGNHSSSSQHHTPPPYYSRPSSHKDLTQCVTCQEKHITVKKEPHESLG
MTVAGGRGSKSGELPIFVTSVPPHGCLARDGRIKRGDVLLNINGIDLTNLSHSEAVAMLK
ASAASPAVALKAL
EVQIVEEATQNAEEQPSTFSENEYDASWSPSWVMWLGLPSTLHSCHD
IVLRRSYLGSWGFSIVGGYEENHTNQPFFIKTIVLGTPAYYDGRLKCGDMIVAVNGLSTV
GMSHSALVPMLKEQRNKVTLTVI
CWPGSLV
Sequence length 690
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
DENTAL CARIES GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PRIMARY DENTAL CARIES GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Anemia Sickle Cell Sickle cell anemia Pubtator 37553354 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Basal Cell Basal cell carcinoma Pubtator 32631335 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 23319804
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 23319804 Associate
★☆☆☆☆
Found in Text Mining only
Lymphoma Lymphoma BEFREE 21471979
★☆☆☆☆
Found in Text Mining only