Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	222256
Gene name	Cadherin related family member 3
Gene symbol	CDHR3
Synonyms (NCBI Gene)	CDH28
Chromosome	7
Chromosome location	7q22.3

206

Show/Hide all (206)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043326	hsa-miR-331-3p	CLASH	23622248
MIRT880028	hsa-miR-1178	CLIP-seq
MIRT880029	hsa-miR-1200	CLIP-seq
MIRT880030	hsa-miR-1224-3p	CLIP-seq
MIRT880031	hsa-miR-1245b-3p	CLIP-seq
MIRT880032	hsa-miR-1253	CLIP-seq
MIRT880033	hsa-miR-125a-3p	CLIP-seq
MIRT880034	hsa-miR-1273f	CLIP-seq
MIRT880035	hsa-miR-129-5p	CLIP-seq
MIRT880036	hsa-miR-1343	CLIP-seq
MIRT880037	hsa-miR-1913	CLIP-seq
MIRT880038	hsa-miR-197	CLIP-seq
MIRT880039	hsa-miR-27a	CLIP-seq
MIRT880040	hsa-miR-27b	CLIP-seq
MIRT880041	hsa-miR-3117-5p	CLIP-seq
MIRT880042	hsa-miR-3140-3p	CLIP-seq
MIRT880043	hsa-miR-3149	CLIP-seq
MIRT880044	hsa-miR-3152-5p	CLIP-seq
MIRT880045	hsa-miR-3156-3p	CLIP-seq
MIRT880046	hsa-miR-3187-3p	CLIP-seq
MIRT880047	hsa-miR-323-3p	CLIP-seq
MIRT880048	hsa-miR-324-3p	CLIP-seq
MIRT880049	hsa-miR-338-3p	CLIP-seq
MIRT880050	hsa-miR-3545-3p	CLIP-seq
MIRT880051	hsa-miR-3663-5p	CLIP-seq
MIRT880052	hsa-miR-371-5p	CLIP-seq
MIRT880053	hsa-miR-371b-5p	CLIP-seq
MIRT880054	hsa-miR-3934	CLIP-seq
MIRT880055	hsa-miR-3938	CLIP-seq
MIRT880056	hsa-miR-411	CLIP-seq
MIRT880057	hsa-miR-4274	CLIP-seq
MIRT880058	hsa-miR-4301	CLIP-seq
MIRT880059	hsa-miR-4317	CLIP-seq
MIRT880060	hsa-miR-4324	CLIP-seq
MIRT880061	hsa-miR-4419a	CLIP-seq
MIRT880062	hsa-miR-4435	CLIP-seq
MIRT880063	hsa-miR-4506	CLIP-seq
MIRT880064	hsa-miR-450b-5p	CLIP-seq
MIRT880065	hsa-miR-4510	CLIP-seq
MIRT880066	hsa-miR-4519	CLIP-seq
MIRT880067	hsa-miR-4530	CLIP-seq
MIRT880068	hsa-miR-4635	CLIP-seq
MIRT880069	hsa-miR-4659a-5p	CLIP-seq
MIRT880070	hsa-miR-4659b-5p	CLIP-seq
MIRT880071	hsa-miR-4680-5p	CLIP-seq
MIRT880072	hsa-miR-4701-5p	CLIP-seq
MIRT880073	hsa-miR-4716-5p	CLIP-seq
MIRT880074	hsa-miR-4727-5p	CLIP-seq
MIRT880075	hsa-miR-4729	CLIP-seq
MIRT880076	hsa-miR-4753-3p	CLIP-seq
MIRT880077	hsa-miR-4755-3p	CLIP-seq
MIRT880078	hsa-miR-4763-5p	CLIP-seq
MIRT880079	hsa-miR-4776-3p	CLIP-seq
MIRT880080	hsa-miR-4781-3p	CLIP-seq
MIRT880081	hsa-miR-498	CLIP-seq
MIRT880082	hsa-miR-507	CLIP-seq
MIRT880083	hsa-miR-5095	CLIP-seq
MIRT880084	hsa-miR-5096	CLIP-seq
MIRT880085	hsa-miR-513a-5p	CLIP-seq
MIRT880086	hsa-miR-518a-5p	CLIP-seq
MIRT880087	hsa-miR-520d-5p	CLIP-seq
MIRT880088	hsa-miR-524-5p	CLIP-seq
MIRT880089	hsa-miR-527	CLIP-seq
MIRT880090	hsa-miR-544b	CLIP-seq
MIRT880091	hsa-miR-548s	CLIP-seq
MIRT880092	hsa-miR-550a	CLIP-seq
MIRT880093	hsa-miR-552	CLIP-seq
MIRT880094	hsa-miR-557	CLIP-seq
MIRT880095	hsa-miR-580	CLIP-seq
MIRT880096	hsa-miR-588	CLIP-seq
MIRT880097	hsa-miR-640	CLIP-seq
MIRT880098	hsa-miR-764	CLIP-seq
MIRT880099	hsa-miR-766	CLIP-seq
MIRT880100	hsa-miR-885-5p	CLIP-seq
MIRT880101	hsa-miR-891b	CLIP-seq
MIRT880033	hsa-miR-125a-3p	CLIP-seq
MIRT880038	hsa-miR-197	CLIP-seq
MIRT880046	hsa-miR-3187-3p	CLIP-seq
MIRT880051	hsa-miR-3663-5p	CLIP-seq
MIRT880052	hsa-miR-371-5p	CLIP-seq
MIRT880053	hsa-miR-371b-5p	CLIP-seq
MIRT880054	hsa-miR-3934	CLIP-seq
MIRT880062	hsa-miR-4435	CLIP-seq
MIRT880072	hsa-miR-4701-5p	CLIP-seq
MIRT880073	hsa-miR-4716-5p	CLIP-seq
MIRT880077	hsa-miR-4755-3p	CLIP-seq
MIRT880080	hsa-miR-4781-3p	CLIP-seq
MIRT880084	hsa-miR-5096	CLIP-seq
MIRT880091	hsa-miR-548s	CLIP-seq
MIRT880096	hsa-miR-588	CLIP-seq
MIRT880097	hsa-miR-640	CLIP-seq
MIRT880098	hsa-miR-764	CLIP-seq
MIRT880029	hsa-miR-1200	CLIP-seq
MIRT880033	hsa-miR-125a-3p	CLIP-seq
MIRT880036	hsa-miR-1343	CLIP-seq
MIRT1960748	hsa-miR-182	CLIP-seq
MIRT880038	hsa-miR-197	CLIP-seq
MIRT1960749	hsa-miR-2115	CLIP-seq
MIRT1960750	hsa-miR-216a	CLIP-seq
MIRT1960751	hsa-miR-31	CLIP-seq
MIRT880044	hsa-miR-3152-5p	CLIP-seq
MIRT880046	hsa-miR-3187-3p	CLIP-seq
MIRT880051	hsa-miR-3663-5p	CLIP-seq
MIRT880052	hsa-miR-371-5p	CLIP-seq
MIRT880053	hsa-miR-371b-5p	CLIP-seq
MIRT1960752	hsa-miR-375	CLIP-seq
MIRT880054	hsa-miR-3934	CLIP-seq
MIRT1960753	hsa-miR-3976	CLIP-seq
MIRT880060	hsa-miR-4324	CLIP-seq
MIRT880062	hsa-miR-4435	CLIP-seq
MIRT1960754	hsa-miR-4438	CLIP-seq
MIRT880072	hsa-miR-4701-5p	CLIP-seq
MIRT880073	hsa-miR-4716-5p	CLIP-seq
MIRT880074	hsa-miR-4727-5p	CLIP-seq
MIRT1960755	hsa-miR-4731-5p	CLIP-seq
MIRT1960756	hsa-miR-4733-5p	CLIP-seq
MIRT880076	hsa-miR-4753-3p	CLIP-seq
MIRT880077	hsa-miR-4755-3p	CLIP-seq
MIRT1960757	hsa-miR-4775	CLIP-seq
MIRT880080	hsa-miR-4781-3p	CLIP-seq
MIRT880081	hsa-miR-498	CLIP-seq
MIRT880083	hsa-miR-5095	CLIP-seq
MIRT880084	hsa-miR-5096	CLIP-seq
MIRT1960758	hsa-miR-512-3p	CLIP-seq
MIRT880090	hsa-miR-544b	CLIP-seq
MIRT880091	hsa-miR-548s	CLIP-seq
MIRT880093	hsa-miR-552	CLIP-seq
MIRT880096	hsa-miR-588	CLIP-seq
MIRT1960759	hsa-miR-590-3p	CLIP-seq
MIRT880097	hsa-miR-640	CLIP-seq
MIRT1960760	hsa-miR-759	CLIP-seq
MIRT880098	hsa-miR-764	CLIP-seq
MIRT880028	hsa-miR-1178	CLIP-seq
MIRT880029	hsa-miR-1200	CLIP-seq
MIRT2197413	hsa-miR-122	CLIP-seq
MIRT2197414	hsa-miR-1255a	CLIP-seq
MIRT2197415	hsa-miR-1255b	CLIP-seq
MIRT880033	hsa-miR-125a-3p	CLIP-seq
MIRT880036	hsa-miR-1343	CLIP-seq
MIRT1960750	hsa-miR-216a	CLIP-seq
MIRT2197416	hsa-miR-3135b	CLIP-seq
MIRT880044	hsa-miR-3152-5p	CLIP-seq
MIRT2197417	hsa-miR-3157-3p	CLIP-seq
MIRT2197418	hsa-miR-3652	CLIP-seq
MIRT880051	hsa-miR-3663-5p	CLIP-seq
MIRT2197419	hsa-miR-3691-5p	CLIP-seq
MIRT880052	hsa-miR-371-5p	CLIP-seq
MIRT880053	hsa-miR-371b-5p	CLIP-seq
MIRT2197420	hsa-miR-3919	CLIP-seq
MIRT880054	hsa-miR-3934	CLIP-seq
MIRT2197421	hsa-miR-412	CLIP-seq
MIRT2197422	hsa-miR-4305	CLIP-seq
MIRT880059	hsa-miR-4317	CLIP-seq
MIRT880060	hsa-miR-4324	CLIP-seq
MIRT2197423	hsa-miR-4430	CLIP-seq
MIRT2197424	hsa-miR-4436a	CLIP-seq
MIRT1960754	hsa-miR-4438	CLIP-seq
MIRT880064	hsa-miR-450b-5p	CLIP-seq
MIRT2197425	hsa-miR-4700-3p	CLIP-seq
MIRT880074	hsa-miR-4727-5p	CLIP-seq
MIRT1960755	hsa-miR-4731-5p	CLIP-seq
MIRT880076	hsa-miR-4753-3p	CLIP-seq
MIRT880077	hsa-miR-4755-3p	CLIP-seq
MIRT2197426	hsa-miR-4756-3p	CLIP-seq
MIRT880078	hsa-miR-4763-5p	CLIP-seq
MIRT2197427	hsa-miR-4797-5p	CLIP-seq
MIRT880081	hsa-miR-498	CLIP-seq
MIRT880083	hsa-miR-5095	CLIP-seq
MIRT1960758	hsa-miR-512-3p	CLIP-seq
MIRT880086	hsa-miR-518a-5p	CLIP-seq
MIRT880089	hsa-miR-527	CLIP-seq
MIRT880090	hsa-miR-544b	CLIP-seq
MIRT880092	hsa-miR-550a	CLIP-seq
MIRT880093	hsa-miR-552	CLIP-seq
MIRT2197428	hsa-miR-579	CLIP-seq
MIRT2197429	hsa-miR-587	CLIP-seq
MIRT880097	hsa-miR-640	CLIP-seq
MIRT1960760	hsa-miR-759	CLIP-seq
MIRT880098	hsa-miR-764	CLIP-seq
MIRT2197430	hsa-miR-873	CLIP-seq
MIRT2197431	hsa-miR-874	CLIP-seq
MIRT880101	hsa-miR-891b	CLIP-seq
MIRT2197432	hsa-miR-938	CLIP-seq
MIRT2197428	hsa-miR-579	CLIP-seq
MIRT2197429	hsa-miR-587	CLIP-seq
MIRT880033	hsa-miR-125a-3p	CLIP-seq
MIRT880036	hsa-miR-1343	CLIP-seq
MIRT1960750	hsa-miR-216a	CLIP-seq
MIRT880054	hsa-miR-3934	CLIP-seq
MIRT880074	hsa-miR-4727-5p	CLIP-seq
MIRT880081	hsa-miR-498	CLIP-seq
MIRT1960758	hsa-miR-512-3p	CLIP-seq
MIRT880097	hsa-miR-640	CLIP-seq
MIRT1960760	hsa-miR-759	CLIP-seq
MIRT880098	hsa-miR-764	CLIP-seq
MIRT880101	hsa-miR-891b	CLIP-seq
MIRT880033	hsa-miR-125a-3p	CLIP-seq
MIRT1960750	hsa-miR-216a	CLIP-seq
MIRT880054	hsa-miR-3934	CLIP-seq
MIRT1960754	hsa-miR-4438	CLIP-seq
MIRT1960755	hsa-miR-4731-5p	CLIP-seq
MIRT880083	hsa-miR-5095	CLIP-seq
MIRT1960758	hsa-miR-512-3p	CLIP-seq
MIRT880097	hsa-miR-640	CLIP-seq
MIRT1960760	hsa-miR-759	CLIP-seq
MIRT880098	hsa-miR-764	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IBA
GO:0001618	Function	Virus receptor activity	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005886	Component	Plasma membrane	IDA	24241537
GO:0005886	Component	Plasma membrane	IEA
GO:0005912	Component	Adherens junction	IBA
GO:0007043	Process	Cell-cell junction assembly	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0008013	Function	Beta-catenin binding	IBA
GO:0016020	Component	Membrane	IEA
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA
GO:0016342	Component	Catenin complex	IBA
GO:0016477	Process	Cell migration	IBA
GO:0034332	Process	Adherens junction organization	IBA
GO:0044331	Process	Cell-cell adhesion mediated by cadherin	IBA
GO:0045296	Function	Cadherin binding	IBA
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0098609	Process	Cell-cell adhesion	IEA

MIM	HGNC	e!Ensembl
615610	26308	ENSG00000128536

Q6ZTQ4

Protein name

Cadherin-related family member 3 (Cadherin-like protein 28)

Protein function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.; (Microbial infe

PDB

6PPO , 6PSF , 7KNV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00028	Cadherin	141 → 227	Cadherin domain	Domain
PF00028	Cadherin	241 → 336	Cadherin domain	Domain
PF00028	Cadherin	466 → 557	Cadherin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in bronchial epithelium from adults and in fetal lung tissue. {ECO:0000269|PubMed:24241537}.

Sequence

MQEAIILLALLGAMSGGEALHLILLPATGNVAENSPPGTSVHKFSVKLSASLSPVIPGFP
QIVNSNPLTEAFRVNWLSGTYFEVVTTGMEQLDFETGPNIFDLQIYVKDEVGVTDLQVLT
VQVTDVNEPPQFQGNLAEGLHLYIVERANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS
FRMSANGTLFSTTELDFEAGHRSFHLIVEVRDSGGLKASTELQVNIVNLNDEVPRFTSPT
RVYTVLEELSPGTIVANITAEDPDDEGFPSHLLYSITTVSKYFMINQLTGTIQVAQRIDR
DAGELRQNPTISLEVLVKDRPYGGQENRIQITFIVEDVNDNPATCQKFTFSIMVPERTAK
GTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFLQDPAGSGKIVLIGDLDYENPSN
LAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDRPSYVFDVSERRPARTRV
GQVRATDKDLPQSSLLYSISTGGASLQYPNVFWINPKTGELQLVTKVDCETTPIYILRIQ
ATNNEDTSSVTVTVNILEENDEKPICTPNSYFLALPVDLKVGTNIQNFKLTCTDLDSSPR
SFRYSIGPGNVNNHFTFSPNAGSNVTRLLLTSRFDYAGGFDKIWDYKLLVYVTDDNLMSD
RKKAEALVETGTVTLSIKVIPHPTTIITTTPRPRVTYQVLRKNVYSPSAWYVPFVITLGS
ILLLGLLVYLVVLLAKAIHRHCPCKTGKNKEPLTKKGETKTAERDVVVETIQMNTIFDGE
AIDPVTGETYEFNSKTGARKWKDPLTQMPKWKESSHQGAAPRRVTAGEGMGSLRSANWEE
DELSGKAWAEDAGLGSRNEGGKLGNPKNRNPAFMNRAYPKPHPGK

Sequence length

885

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (18)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FIBRILLATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHILDHOOD ONSET ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Papillary renal cell carcinoma type 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Susceptibility to nonsyndromic otitis media	Uncertain significance; Conflicting classifications of pathogenicity; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma	Asthma	CTD_human_DG	24241537		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	BEFREE	25848009, 28318885, 29121479, 29350142, 30930175		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	Pubtator	25848009, 26119467, 28318885, 29121479, 30532249, 30916989, 30930175, 31841129, 33213402, 35050846, 36967681	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Asthma	Asthma	GWASCAT_DG	27182965		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Childhood asthma	Asthma	BEFREE	24241537, 25848009, 29121479, 30916989, 30930175, 31610042, 31841129		★★★★★ ★☆☆☆☆ Found in Text Mining only
Childhood asthma	Asthma	GWASCAT_DG	24241537		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	GWASCAT_DG	30450575		★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiratory Tract Diseases	Respiratory system infectious disease	Pubtator	29121479	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Respiratory Tract Infections	Respiratory system infectious disease	Pubtator	29121479, 36967681	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CDHR3 (cadherin related family member 3)