ATXN7L1 (ataxin 7 like 1)

Gene

• Entrez ID: 222255
• Gene name: Ataxin 7 like 1
• Gene symbol: ATXN7L1
• Synonyms (NCBI Gene): ATXN7L4
• Chromosome: 7
• Chromosome location: 7q22.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031296	hsa-miR-19b-3p	Sequencing	20371350
MIRT640167	hsa-miR-4282	HITS-CLIP	23824327
MIRT219886	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT219884	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT219885	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT539030	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT539029	hsa-miR-300	PAR-CLIP	21572407
MIRT539028	hsa-miR-3910	PAR-CLIP	21572407
MIRT539027	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT539026	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT539025	hsa-miR-605-3p	PAR-CLIP	21572407
MIRT539024	hsa-miR-5689	PAR-CLIP	21572407
MIRT539040	hsa-miR-141-3p	PAR-CLIP	22012620
MIRT539039	hsa-miR-200a-3p	PAR-CLIP	22012620
MIRT539038	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT539037	hsa-miR-3662	PAR-CLIP	22012620
MIRT539036	hsa-miR-3646	PAR-CLIP	22012620
MIRT539035	hsa-miR-1183	PAR-CLIP	22012620
MIRT539034	hsa-miR-5680	PAR-CLIP	22012620
MIRT539033	hsa-miR-4325	PAR-CLIP	22012620
MIRT539032	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT539031	hsa-miR-552-5p	PAR-CLIP	22012620
MIRT539030	hsa-miR-381-3p	PAR-CLIP	22012620
MIRT539029	hsa-miR-300	PAR-CLIP	22012620
MIRT539028	hsa-miR-3910	PAR-CLIP	22012620
MIRT539027	hsa-miR-6882-5p	PAR-CLIP	22012620
MIRT539026	hsa-miR-101-5p	PAR-CLIP	22012620
MIRT539025	hsa-miR-605-3p	PAR-CLIP	22012620
MIRT539024	hsa-miR-5689	PAR-CLIP	22012620
MIRT441137	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT441137	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT640167	hsa-miR-4282	HITS-CLIP	23824327
MIRT219886	hsa-miR-3606-3p	HITS-CLIP	23824327
MIRT219884	hsa-miR-513a-3p	HITS-CLIP	23824327
MIRT219885	hsa-miR-513c-3p	HITS-CLIP	23824327
MIRT539030	hsa-miR-381-3p	PAR-CLIP	21572407
MIRT539029	hsa-miR-300	PAR-CLIP	21572407
MIRT539028	hsa-miR-3910	PAR-CLIP	21572407
MIRT539027	hsa-miR-6882-5p	PAR-CLIP	21572407
MIRT539026	hsa-miR-101-5p	PAR-CLIP	21572407
MIRT539025	hsa-miR-605-3p	PAR-CLIP	21572407
MIRT539024	hsa-miR-5689	PAR-CLIP	21572407
MIRT539040	hsa-miR-141-3p	PAR-CLIP	22012620
MIRT539039	hsa-miR-200a-3p	PAR-CLIP	22012620
MIRT539038	hsa-miR-548c-3p	PAR-CLIP	22012620
MIRT539037	hsa-miR-3662	PAR-CLIP	22012620
MIRT539036	hsa-miR-3646	PAR-CLIP	22012620
MIRT539035	hsa-miR-1183	PAR-CLIP	22012620
MIRT539034	hsa-miR-5680	PAR-CLIP	22012620
MIRT539033	hsa-miR-4325	PAR-CLIP	22012620
MIRT539032	hsa-miR-302c-5p	PAR-CLIP	22012620
MIRT539031	hsa-miR-552-5p	PAR-CLIP	22012620
MIRT539030	hsa-miR-381-3p	PAR-CLIP	22012620
MIRT539029	hsa-miR-300	PAR-CLIP	22012620
MIRT539028	hsa-miR-3910	PAR-CLIP	22012620
MIRT539027	hsa-miR-6882-5p	PAR-CLIP	22012620
MIRT539026	hsa-miR-101-5p	PAR-CLIP	22012620
MIRT539025	hsa-miR-605-3p	PAR-CLIP	22012620
MIRT539024	hsa-miR-5689	PAR-CLIP	22012620
MIRT811517	hsa-miR-101	CLIP-seq
MIRT811518	hsa-miR-103a	CLIP-seq
MIRT811519	hsa-miR-106a	CLIP-seq
MIRT811520	hsa-miR-106b	CLIP-seq
MIRT811521	hsa-miR-107	CLIP-seq
MIRT811522	hsa-miR-1224-3p	CLIP-seq
MIRT811523	hsa-miR-1236	CLIP-seq
MIRT811524	hsa-miR-1260	CLIP-seq
MIRT811525	hsa-miR-1260b	CLIP-seq
MIRT811526	hsa-miR-1280	CLIP-seq
MIRT811527	hsa-miR-144	CLIP-seq
MIRT811528	hsa-miR-15a	CLIP-seq
MIRT811529	hsa-miR-15b	CLIP-seq
MIRT811530	hsa-miR-16	CLIP-seq
MIRT811531	hsa-miR-17	CLIP-seq
MIRT811532	hsa-miR-195	CLIP-seq
MIRT811533	hsa-miR-2053	CLIP-seq
MIRT811534	hsa-miR-20a	CLIP-seq
MIRT811535	hsa-miR-20b	CLIP-seq
MIRT811536	hsa-miR-2114	CLIP-seq
MIRT811537	hsa-miR-2355-5p	CLIP-seq
MIRT811538	hsa-miR-28-5p	CLIP-seq
MIRT811539	hsa-miR-3136-3p	CLIP-seq
MIRT811540	hsa-miR-3139	CLIP-seq
MIRT811541	hsa-miR-339-5p	CLIP-seq
MIRT811542	hsa-miR-3609	CLIP-seq
MIRT811543	hsa-miR-3691-3p	CLIP-seq
MIRT811544	hsa-miR-381	CLIP-seq
MIRT811545	hsa-miR-384	CLIP-seq
MIRT811546	hsa-miR-424	CLIP-seq
MIRT811547	hsa-miR-4267	CLIP-seq
MIRT811548	hsa-miR-4268	CLIP-seq
MIRT811549	hsa-miR-4283	CLIP-seq
MIRT811550	hsa-miR-4292	CLIP-seq
MIRT811551	hsa-miR-4308	CLIP-seq
MIRT811552	hsa-miR-4433	CLIP-seq
MIRT811553	hsa-miR-4459	CLIP-seq
MIRT811554	hsa-miR-4524	CLIP-seq
MIRT811555	hsa-miR-4633-3p	CLIP-seq
MIRT811556	hsa-miR-4659a-5p	CLIP-seq
MIRT811557	hsa-miR-4659b-5p	CLIP-seq
MIRT811558	hsa-miR-4711-5p	CLIP-seq
MIRT811559	hsa-miR-4738-5p	CLIP-seq
MIRT811560	hsa-miR-4768-3p	CLIP-seq
MIRT811561	hsa-miR-4796-3p	CLIP-seq
MIRT811562	hsa-miR-4797-5p	CLIP-seq
MIRT811563	hsa-miR-495	CLIP-seq
MIRT811564	hsa-miR-497	CLIP-seq
MIRT811565	hsa-miR-503	CLIP-seq
MIRT811566	hsa-miR-519d	CLIP-seq
MIRT811567	hsa-miR-545	CLIP-seq
MIRT811568	hsa-miR-548aa	CLIP-seq
MIRT811569	hsa-miR-548ah	CLIP-seq
MIRT811570	hsa-miR-637	CLIP-seq
MIRT811571	hsa-miR-646	CLIP-seq
MIRT811572	hsa-miR-663b	CLIP-seq
MIRT811573	hsa-miR-708	CLIP-seq
MIRT811574	hsa-miR-760	CLIP-seq
MIRT811575	hsa-miR-766	CLIP-seq
MIRT811576	hsa-miR-93	CLIP-seq
MIRT811519	hsa-miR-106a	CLIP-seq
MIRT811520	hsa-miR-106b	CLIP-seq
MIRT811577	hsa-miR-135a	CLIP-seq
MIRT811578	hsa-miR-135b	CLIP-seq
MIRT811579	hsa-miR-1470	CLIP-seq
MIRT811531	hsa-miR-17	CLIP-seq
MIRT811533	hsa-miR-2053	CLIP-seq
MIRT811534	hsa-miR-20a	CLIP-seq
MIRT811535	hsa-miR-20b	CLIP-seq
MIRT811580	hsa-miR-216a	CLIP-seq
MIRT811581	hsa-miR-216b	CLIP-seq
MIRT811582	hsa-miR-3153	CLIP-seq
MIRT811583	hsa-miR-3185	CLIP-seq
MIRT811584	hsa-miR-3190	CLIP-seq
MIRT811585	hsa-miR-338-5p	CLIP-seq
MIRT811542	hsa-miR-3609	CLIP-seq
MIRT811586	hsa-miR-374a	CLIP-seq
MIRT811587	hsa-miR-374b	CLIP-seq
MIRT811588	hsa-miR-376a	CLIP-seq
MIRT811589	hsa-miR-376b	CLIP-seq
MIRT811590	hsa-miR-4260	CLIP-seq
MIRT811591	hsa-miR-4469	CLIP-seq
MIRT811592	hsa-miR-4491	CLIP-seq
MIRT811593	hsa-miR-4657	CLIP-seq
MIRT811556	hsa-miR-4659a-5p	CLIP-seq
MIRT811557	hsa-miR-4659b-5p	CLIP-seq
MIRT811594	hsa-miR-4667-3p	CLIP-seq
MIRT811595	hsa-miR-4681	CLIP-seq
MIRT811596	hsa-miR-4691-3p	CLIP-seq
MIRT811597	hsa-miR-4729	CLIP-seq
MIRT811598	hsa-miR-4795-5p	CLIP-seq
MIRT811561	hsa-miR-4796-3p	CLIP-seq
MIRT811562	hsa-miR-4797-5p	CLIP-seq
MIRT811563	hsa-miR-495	CLIP-seq
MIRT811566	hsa-miR-519d	CLIP-seq
MIRT811568	hsa-miR-548aa	CLIP-seq
MIRT811569	hsa-miR-548ah	CLIP-seq
MIRT811599	hsa-miR-622	CLIP-seq
MIRT811576	hsa-miR-93	CLIP-seq
MIRT811577	hsa-miR-135a	CLIP-seq
MIRT811578	hsa-miR-135b	CLIP-seq
MIRT811577	hsa-miR-135a	CLIP-seq
MIRT811578	hsa-miR-135b	CLIP-seq
MIRT811577	hsa-miR-135a	CLIP-seq
MIRT811578	hsa-miR-135b	CLIP-seq
MIRT1940004	hsa-miR-1178	CLIP-seq
MIRT1940005	hsa-miR-1252	CLIP-seq
MIRT1940006	hsa-miR-1255a	CLIP-seq
MIRT1940007	hsa-miR-1255b	CLIP-seq
MIRT1940008	hsa-miR-1257	CLIP-seq
MIRT1940009	hsa-miR-1272	CLIP-seq
MIRT1940010	hsa-miR-3123	CLIP-seq
MIRT1940011	hsa-miR-335	CLIP-seq
MIRT1940012	hsa-miR-4426	CLIP-seq
MIRT1940013	hsa-miR-4647	CLIP-seq
MIRT1940014	hsa-miR-4662b	CLIP-seq
MIRT1940015	hsa-miR-4790-3p	CLIP-seq
MIRT1940016	hsa-miR-574-5p	CLIP-seq
MIRT1940017	hsa-miR-648	CLIP-seq
MIRT1940018	hsa-miR-671-5p	CLIP-seq
MIRT1940019	hsa-miR-759	CLIP-seq
MIRT1940004	hsa-miR-1178	CLIP-seq
MIRT1940008	hsa-miR-1257	CLIP-seq
MIRT1940009	hsa-miR-1272	CLIP-seq
MIRT2179078	hsa-miR-221	CLIP-seq
MIRT2179079	hsa-miR-222	CLIP-seq
MIRT2179080	hsa-miR-3074-5p	CLIP-seq
MIRT1940010	hsa-miR-3123	CLIP-seq
MIRT2179081	hsa-miR-3140-3p	CLIP-seq
MIRT1940011	hsa-miR-335	CLIP-seq
MIRT2179082	hsa-miR-3647-3p	CLIP-seq
MIRT2179083	hsa-miR-370	CLIP-seq
MIRT1940015	hsa-miR-4790-3p	CLIP-seq
MIRT2179084	hsa-miR-548v	CLIP-seq
MIRT1940016	hsa-miR-574-5p	CLIP-seq
MIRT1940017	hsa-miR-648	CLIP-seq
MIRT1940018	hsa-miR-671-5p	CLIP-seq
MIRT1940019	hsa-miR-759	CLIP-seq
MIRT1940004	hsa-miR-1178	CLIP-seq
MIRT1940008	hsa-miR-1257	CLIP-seq
MIRT1940015	hsa-miR-4790-3p	CLIP-seq
MIRT1940016	hsa-miR-574-5p	CLIP-seq
MIRT1940017	hsa-miR-648	CLIP-seq
MIRT1940019	hsa-miR-759	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32814053

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9ULK2
• Protein name: Ataxin-7-like protein 1 (Ataxin-7-like protein 4)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08313	SCA7	277 → 345	SCA7, zinc-binding domain	Domain

• Sequence:

  MTSERSRIPCLSAAAAEGTGKKQQEGRAMATLDRKVPSPEAFLGKPWSSWIDAAKLHCSD
  NVDLEEAGKEGGKSREVMRLNKEDMHLFGHYPAHDDFYLVVCSACNQVVKPQVFQSHCER
  RHGSMCRPSPSPVSPASNPRTSLVQVKTKACLSGHHSASSTSKPFKTPKDNLLTSSSKQH
  TVFPAKGSRDKPCVPVPVVSLEKIPNLVKADGANVKMNSTTTTAVSASSTSSSAVSTPPL
  IKPVLMSKSVPPSPEKILNGKGILPTTIDKKHQNGTKNSNKPYRRLSEREFDPNKHCGVL
  DPETKKPCTRSLTCKTHSLSHRRAVPGRKKQFDLLLAEHKAKSREKEVKDKEHLLTSTRE
  ILPSQSGPAQDSLLGSSGSSGPEPKVASPAKSRPPNSVLPRPSSANSISSSTSSNHSGHT
  PEPPLPPVGGDLASRLSSDEGEMDGADESEKLDCQFSTHHPRPLAFCSFGSRLMGRGYYV
  FDRRWDRFRFALNSMVEKHLNSQMWKKIPPAADSPLPSPAAHITTPVPASVLQPFSNPSA
  VYLPSAPISSRLTSSYIMTSAMLSNAAFVTSPDPSALMSHTTAFPHVAATLSIMDSTFKA
  PSAVSPIPAVIPSPSHKPSKTKTSKSSKVKDLSTRSDESPSNKKRKPQSSTSSSSSSSSS
  SLQTSLSSPLSGPHKKNCVLNASSALNSYQAAPPYNSLSVHNSNNGVSPLSAKLEPSGRT
  SLPGGPADIVRQVGAVGGSSDSCPLSVPSLALHAGDLSLASHNAVSSLPLSFDKSEGKKR
  KNSSSSSKACKITKMPGMNSVHKKNPPSLLAPVPDPVNSTSSRQVGKNSSLALSQSSPSS
  ISSPGHSRQNTNRTGRIRTLP

• Sequence length: 861

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CERVICAL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENTAL CARIES	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHEDEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer`s Disease	Alzheimer disease	GWASDB_DG	22881374		★☆☆☆☆ Found in Text Mining only
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	22881374		★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	GWASCAT_DG	29631575		★☆☆☆☆ Found in Text Mining only