FAM185A (family with sequence similarity 185 member A)

Gene

• Entrez ID: 222234
• Gene name: Family with sequence similarity 185 member A
• Gene symbol: FAM185A
• Synonyms (NCBI Gene): -
• Chromosome: 7
• Chromosome location: 7q22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT613616	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT613615	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT613614	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT613613	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613612	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT613616	hsa-miR-7109-3p	HITS-CLIP	23824327
MIRT613615	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT613614	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT613613	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT613612	hsa-miR-510-3p	HITS-CLIP	23824327
MIRT982454	hsa-miR-1293	CLIP-seq
MIRT982455	hsa-miR-183	CLIP-seq
MIRT982456	hsa-miR-192	CLIP-seq
MIRT982457	hsa-miR-215	CLIP-seq
MIRT982458	hsa-miR-2861	CLIP-seq
MIRT982459	hsa-miR-323-3p	CLIP-seq
MIRT982460	hsa-miR-4470	CLIP-seq
MIRT982461	hsa-miR-4483	CLIP-seq
MIRT982462	hsa-miR-4528	CLIP-seq
MIRT982463	hsa-miR-541	CLIP-seq
MIRT982464	hsa-miR-654-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	HTP	34800366

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8N0U4
• Protein name: Protein FAM185A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13349	DUF4097	207 → 345	Putative adhesin	Family

• Sequence:

  MLAPCSGWELGCFRLCLRQVRLWAGAGRWACWACQARPYSSGGSERWPGSETEVPPPGPG
  RRTLKEWTLQVSPFGRLRARLPCHLAVRPLDPLTYPDGDRVLVAVCGVEGGVRGLDGLQV
  KYDEDLEEMAIVSDTIHPQASVEVNAPLKFGLDIKSSGSGCVKVQSIEGDNCKIETEHGT
  SILQSVKGQKLHVQTKGGKVICLGTVYGNIDIHASDKSAVTIDKLQGSSVTVSTEDGLLK
  AKYLYTESSFLSSAAGDITLGSVHGNITLQSKMGNITVDSSSGCLKASTNQGAIDVYVSQ
  LGKVELKSHKGSIIVKVPSSLQAHLQLSGKEVDVNSEVHVQEMAEVRKDDVVTVTGLMNQ
  ASKREKWIKADAPKGTVSFRRQSWFQSLKLQD

• Sequence length: 392

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIGESTIVE SYSTEM DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DIVERTICULAR DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEMORRHOID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Diverticular Diseases	Diverticular Diseases	GWASCAT_DG	30177863		★☆☆☆☆ Found in Text Mining only