Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	221472
Gene name	FYVE, RhoGEF and PH domain containing 2
Gene symbol	FGD2
Synonyms (NCBI Gene)	ZFYVE4
Chromosome	6
Chromosome location	6p21.2
Summary	The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocyt

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017089	hsa-miR-335-5p	Microarray	18185580
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT995193	hsa-miR-142-3p	CLIP-seq
MIRT995194	hsa-miR-2113	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT995199	hsa-miR-3174	CLIP-seq
MIRT995200	hsa-miR-3197	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT995209	hsa-miR-3940-3p	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995211	hsa-miR-4432	CLIP-seq
MIRT995212	hsa-miR-4453	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT995216	hsa-miR-4538	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT995218	hsa-miR-4716-5p	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995220	hsa-miR-4797-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT995223	hsa-miR-499-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT995225	hsa-miR-921	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995090	hsa-miR-24	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995200	hsa-miR-3197	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT1995097	hsa-miR-3929	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT1995099	hsa-miR-4284	CLIP-seq
MIRT1995100	hsa-miR-4419b	CLIP-seq
MIRT1995101	hsa-miR-4478	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT1995103	hsa-miR-4649-3p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT1995105	hsa-miR-890	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT2229194	hsa-miR-4786-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT2229195	hsa-miR-769-5p	CLIP-seq
MIRT1995089	hsa-miR-1304	CLIP-seq
MIRT1995091	hsa-miR-2467-5p	CLIP-seq
MIRT995195	hsa-miR-29a	CLIP-seq
MIRT995196	hsa-miR-29b	CLIP-seq
MIRT995197	hsa-miR-29c	CLIP-seq
MIRT1995092	hsa-miR-3188	CLIP-seq
MIRT1995093	hsa-miR-3192	CLIP-seq
MIRT995201	hsa-miR-34a	CLIP-seq
MIRT995202	hsa-miR-34c-5p	CLIP-seq
MIRT995204	hsa-miR-3614-5p	CLIP-seq
MIRT1995094	hsa-miR-3672	CLIP-seq
MIRT1995098	hsa-miR-3975	CLIP-seq
MIRT995210	hsa-miR-4260	CLIP-seq
MIRT995213	hsa-miR-449a	CLIP-seq
MIRT995214	hsa-miR-449b	CLIP-seq
MIRT1995102	hsa-miR-4505	CLIP-seq
MIRT995219	hsa-miR-4766-5p	CLIP-seq
MIRT995221	hsa-miR-485-5p	CLIP-seq
MIRT995222	hsa-miR-486-3p	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT2449656	hsa-miR-3667-5p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT2449656	hsa-miR-3667-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT2532804	hsa-miR-4300	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT2532805	hsa-miR-920	CLIP-seq
MIRT995192	hsa-miR-1283	CLIP-seq
MIRT995198	hsa-miR-3120-5p	CLIP-seq
MIRT2449655	hsa-miR-3122	CLIP-seq
MIRT995203	hsa-miR-3613-3p	CLIP-seq
MIRT995205	hsa-miR-3664-5p	CLIP-seq
MIRT995206	hsa-miR-3675-3p	CLIP-seq
MIRT1995095	hsa-miR-3689a-3p	CLIP-seq
MIRT1995096	hsa-miR-3689c	CLIP-seq
MIRT2449657	hsa-miR-3689d	CLIP-seq
MIRT995207	hsa-miR-371-5p	CLIP-seq
MIRT995208	hsa-miR-371b-5p	CLIP-seq
MIRT2449658	hsa-miR-3913-5p	CLIP-seq
MIRT2532804	hsa-miR-4300	CLIP-seq
MIRT995211	hsa-miR-4432	CLIP-seq
MIRT995215	hsa-miR-4522	CLIP-seq
MIRT995217	hsa-miR-4684-5p	CLIP-seq
MIRT1995104	hsa-miR-4728-5p	CLIP-seq
MIRT995220	hsa-miR-4797-5p	CLIP-seq
MIRT995223	hsa-miR-499-5p	CLIP-seq
MIRT995224	hsa-miR-605	CLIP-seq
MIRT2532805	hsa-miR-920	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001726	Component	Ruffle	IEA
GO:0001726	Component	Ruffle	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IBA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	ISS
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	TAS
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005794	Component	Golgi apparatus	ISS
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0007010	Process	Cytoskeleton organization	IBA
GO:0007010	Process	Cytoskeleton organization	ISS
GO:0008270	Function	Zinc ion binding	IEA
GO:0008360	Process	Regulation of cell shape	ISS
GO:0016020	Component	Membrane	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030036	Process	Actin cytoskeleton organization	ISS
GO:0031267	Function	Small GTPase binding	ISS
GO:0031901	Component	Early endosome membrane	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043087	Process	Regulation of GTPase activity	ISS
GO:0046847	Process	Filopodium assembly	IBA
GO:0046847	Process	Filopodium assembly	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	IEA
GO:0051056	Process	Regulation of small GTPase mediated signal transduction	TAS
GO:1901981	Function	Phosphatidylinositol phosphate binding	IEA

MIM	HGNC	e!Ensembl
605091	3664	ENSG00000146192

Q7Z6J4

Protein name

FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4)

Protein function

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, pho

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00621	RhoGEF	106 → 288	RhoGEF domain	Domain
PF00169	PH	320 → 418	PH domain	Domain
PF01363	FYVE	453 → 518	FYVE zinc finger	Domain
PF00169	PH	528 → 641	PH domain	Domain

Sequence

MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEA
VGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVAR
LHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANP
RIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQH
HMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDL
WEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGA
QFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQI
EKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHH
CRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSA
TPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVT
VGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD

Sequence length

655

Interactions

View interactions

	Reactome
			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLONIC NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CYSTS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (7)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Corpus Luteum Cyst	Corpus Luteum Cyst	CTD_human_DG	21239663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hirschsprung Disease	Hirschsprung Disease	BEFREE	28399120		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	GWASCAT_DG	30595370		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	21324547		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	30397228	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Cysts	Ovarian Cysts	CTD_human_DG	21239663		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

FGD2 (FYVE, RhoGEF and PH domain containing 2)