TMEM217 (transmembrane protein 217)

Gene

• Entrez ID: 221468
• Gene name: Transmembrane protein 217
• Gene symbol: TMEM217
• Synonyms (NCBI Gene): C6orf128, dJ355M6.2
• Chromosome: 6
• Chromosome location: 6p21.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017435	hsa-miR-335-5p	Microarray	18185580
MIRT1435496	hsa-miR-10a	CLIP-seq
MIRT1435497	hsa-miR-10b	CLIP-seq
MIRT1435498	hsa-miR-1275	CLIP-seq
MIRT1435499	hsa-miR-129-5p	CLIP-seq
MIRT1435500	hsa-miR-3200-5p	CLIP-seq
MIRT1435501	hsa-miR-3545-3p	CLIP-seq
MIRT1435502	hsa-miR-3663-5p	CLIP-seq
MIRT1435503	hsa-miR-3937	CLIP-seq
MIRT1435504	hsa-miR-4251	CLIP-seq
MIRT1435505	hsa-miR-4260	CLIP-seq
MIRT1435506	hsa-miR-4292	CLIP-seq
MIRT1435507	hsa-miR-4329	CLIP-seq
MIRT1435508	hsa-miR-4525	CLIP-seq
MIRT1435509	hsa-miR-4635	CLIP-seq
MIRT1435510	hsa-miR-4646-5p	CLIP-seq
MIRT1435511	hsa-miR-4665-5p	CLIP-seq
MIRT1435512	hsa-miR-4680-5p	CLIP-seq
MIRT1435513	hsa-miR-4723-5p	CLIP-seq
MIRT1435514	hsa-miR-4797-5p	CLIP-seq
MIRT1435515	hsa-miR-625	CLIP-seq
MIRT1435516	hsa-miR-224	CLIP-seq
MIRT1435517	hsa-miR-3607-3p	CLIP-seq
MIRT1435518	hsa-miR-3686	CLIP-seq
MIRT1435519	hsa-miR-377	CLIP-seq
MIRT2130498	hsa-miR-3934	CLIP-seq
MIRT2130499	hsa-miR-5095	CLIP-seq
MIRT2130500	hsa-miR-548p	CLIP-seq
MIRT2130501	hsa-miR-552	CLIP-seq
MIRT1435498	hsa-miR-1275	CLIP-seq
MIRT1435499	hsa-miR-129-5p	CLIP-seq
MIRT2351836	hsa-miR-1915	CLIP-seq
MIRT2351837	hsa-miR-3616-5p	CLIP-seq
MIRT2351838	hsa-miR-3647-5p	CLIP-seq
MIRT2351839	hsa-miR-3650	CLIP-seq
MIRT2351840	hsa-miR-3925-3p	CLIP-seq
MIRT2130498	hsa-miR-3934	CLIP-seq
MIRT1435505	hsa-miR-4260	CLIP-seq
MIRT1435508	hsa-miR-4525	CLIP-seq
MIRT2351841	hsa-miR-4632	CLIP-seq
MIRT1435511	hsa-miR-4665-5p	CLIP-seq
MIRT1435513	hsa-miR-4723-5p	CLIP-seq
MIRT2351842	hsa-miR-4726-3p	CLIP-seq
MIRT2351843	hsa-miR-4735-5p	CLIP-seq
MIRT2351844	hsa-miR-4772-3p	CLIP-seq
MIRT2351845	hsa-miR-4775	CLIP-seq
MIRT2351846	hsa-miR-4794	CLIP-seq
MIRT2351847	hsa-miR-4795-5p	CLIP-seq
MIRT1435514	hsa-miR-4797-5p	CLIP-seq
MIRT2130499	hsa-miR-5095	CLIP-seq
MIRT2351848	hsa-miR-515-5p	CLIP-seq
MIRT2351849	hsa-miR-519a	CLIP-seq
MIRT2351850	hsa-miR-519b-3p	CLIP-seq
MIRT2351851	hsa-miR-519c-3p	CLIP-seq
MIRT2351852	hsa-miR-550b	CLIP-seq
MIRT2130501	hsa-miR-552	CLIP-seq
MIRT2351853	hsa-miR-573	CLIP-seq
MIRT2351854	hsa-miR-590-3p	CLIP-seq
MIRT1435515	hsa-miR-625	CLIP-seq
MIRT2351855	hsa-miR-766	CLIP-seq
MIRT2351856	hsa-miR-924	CLIP-seq
MIRT2351836	hsa-miR-1915	CLIP-seq
MIRT2351842	hsa-miR-4726-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q8N7C4
• Protein name: Transmembrane protein 217
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15049	DUF4534	11 → 171	Protein of unknown function (DUF4534)	Family

• Sequence:

  MKQQQWCGMTAKMGTVLSGVFTIMAVDMYLIFEQKHLGNGSCTEITPKYRGASNIINNFI
  ICWSFKIVLFLSFITILISCFLLYSVYAQIFRGLVIYIVWIFFYETANVVIQILTNNDFD
  IKEVRIMRWFGLVSRTVMHCFWMFFVINYAHITYKNRSQGNIISYKRRISTAEILHSRNK
  RLSISSGFSGSHLESQYFERQSFHTSIFTCLSPVPSSAPSTCRYTIDVC

• Sequence length: 229

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, BASAL CELL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PULMONARY ARTERIAL HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	23037145		★☆☆☆☆ Found in Text Mining only
PIGMENTARY DISORDER, RETICULATE, WITH SYSTEMIC MANIFESTATIONS	Pigmentary Disorder, Reticulate, With Systemic Manifestations	BEFREE	28431867		★☆☆☆☆ Found in Text Mining only