Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	221443
Gene name	O-acyl-ADP-ribose deacylase 1
Gene symbol	OARD1
Synonyms (NCBI Gene)	C6orf130TARG1dJ34B21.3
Chromosome	6
Chromosome location	6p21.1
Summary	The protein encoded by this gene is a deacylase that can convert O-acetyl-ADP-ribose to ADP-ribose and acetate, O-propionyl-ADP-ribose to ADP-ribose and propionate, and O-butyryl-ADP-ribose to ADP-ribose and butyrate. The ADP-ribose product is able to inh

Show/Hide all (60)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024088	hsa-miR-1-3p	Microarray	18668037
MIRT030559	hsa-miR-24-3p	Microarray	19748357
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT516112	hsa-miR-1182	PAR-CLIP	20371350
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	20371350
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT516112	hsa-miR-1182	PAR-CLIP	20371350
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	20371350
MIRT516110	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT516109	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT516107	hsa-miR-3674	PAR-CLIP	20371350
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	21572407
MIRT516112	hsa-miR-1182	PAR-CLIP	21572407
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	21572407
MIRT516110	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT516109	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT516107	hsa-miR-3674	PAR-CLIP	21572407
MIRT528408	hsa-miR-129-5p	PAR-CLIP	21572407
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	22012620
MIRT516112	hsa-miR-1182	PAR-CLIP	22012620
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	22012620
MIRT516110	hsa-miR-6832-5p	PAR-CLIP	22012620
MIRT516109	hsa-miR-4732-5p	PAR-CLIP	22012620
MIRT516107	hsa-miR-3674	PAR-CLIP	22012620
MIRT528408	hsa-miR-129-5p	PAR-CLIP	22012620
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT516112	hsa-miR-1182	PAR-CLIP	23446348
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT516110	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516109	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT516107	hsa-miR-3674	PAR-CLIP	23446348
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT516112	hsa-miR-1182	PAR-CLIP	20371350
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	20371350
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	20371350
MIRT516112	hsa-miR-1182	PAR-CLIP	20371350
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	20371350
MIRT516110	hsa-miR-6832-5p	PAR-CLIP	20371350
MIRT516109	hsa-miR-4732-5p	PAR-CLIP	20371350
MIRT516107	hsa-miR-3674	PAR-CLIP	20371350
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	21572407
MIRT516112	hsa-miR-1182	PAR-CLIP	21572407
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	21572407
MIRT516110	hsa-miR-6832-5p	PAR-CLIP	21572407
MIRT516109	hsa-miR-4732-5p	PAR-CLIP	21572407
MIRT516107	hsa-miR-3674	PAR-CLIP	21572407
MIRT528408	hsa-miR-129-5p	PAR-CLIP	21572407
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	22012620
MIRT516112	hsa-miR-1182	PAR-CLIP	22012620
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	22012620
MIRT516110	hsa-miR-6832-5p	PAR-CLIP	22012620
MIRT516109	hsa-miR-4732-5p	PAR-CLIP	22012620
MIRT516107	hsa-miR-3674	PAR-CLIP	22012620
MIRT528408	hsa-miR-129-5p	PAR-CLIP	22012620
MIRT516113	hsa-miR-4524b-3p	PAR-CLIP	23446348
MIRT516112	hsa-miR-1182	PAR-CLIP	23446348
MIRT516111	hsa-miR-4524a-3p	PAR-CLIP	23446348
MIRT516110	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516109	hsa-miR-4732-5p	PAR-CLIP	23446348
MIRT516107	hsa-miR-3674	PAR-CLIP	23446348

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001883	Function	Purine nucleoside binding	IDA	21849506
GO:0005515	Function	Protein binding	IPI	23481255, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA	29712969
GO:0005654	Component	Nucleoplasm	IEA
GO:0005694	Component	Chromosome	IEA
GO:0005730	Component	Nucleolus	IDA	29712969
GO:0005730	Component	Nucleolus	IEA
GO:0006974	Process	DNA damage response	IBA
GO:0006974	Process	DNA damage response	IMP	23481255
GO:0016787	Function	Hydrolase activity	IEA
GO:0042278	Process	Purine nucleoside metabolic process	IBA
GO:0042278	Process	Purine nucleoside metabolic process	IDA	21849506
GO:0047407	Function	ADP-ribosyl-[dinitrogen reductase] hydrolase activity	IBA
GO:0051725	Process	Protein de-ADP-ribosylation	IDA	23474714
GO:0061463	Function	O-acetyl-ADP-ribose deacetylase activity	IDA	21849506
GO:0061463	Function	O-acetyl-ADP-ribose deacetylase activity	IEA
GO:0090734	Component	Site of DNA damage	IDA	23481255
GO:0140291	Process	Peptidyl-glutamate ADP-deribosylation	IDA	23474714, 23481255
GO:0140293	Function	ADP-ribosylglutamate hydrolase activity	IDA	23474714, 23481255

MIM	HGNC	e!Ensembl
614393	21257	ENSG00000124596

Q9Y530

Protein name

ADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-)

Protein function

ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose (PubMed:21849506, PubMed:23474714, PubMed:23481255). Specifically acts as a glutamate

PDB

2EEE , 2L8R , 2LGR , 4J5Q , 4J5R , 4J5S

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01661	Macro	31 → 136	Macro domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:23481255}.

Sequence

MASSLNEDPEGSRITYVKGDLFACPKTDSLAHCISEDCRMGAGIAVLFKKKFGGVQELLN
QQKKSGEVAVLKRDGRYIYYLITKKRASHKPTYENLQKSLEAMKSHCLKNGVTDLSMPRI
GCGLDRLQWENVSAMIEEVFEATDIKITVYTL

Sequence length

152

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTRIC CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METASTATIC COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	38511601	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	29986096	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	23481255	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	23481255		★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	GWASCAT_DG	26129866		★★★★★ ★☆☆☆☆ Found in Text Mining only

OARD1 (O-acyl-ADP-ribose deacylase 1)