Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	221400
Gene name	Tudor domain containing 6
Gene symbol	TDRD6
Synonyms (NCBI Gene)	CT41.2NY-CO-45SPATA36TDR2bA446F17.4
Chromosome	6
Chromosome location	6p12.3
Summary	This gene encodes a tudor domain-containing protein and component of the chromatoid body, a type of ribonucleoprotein granule present in male germ cells. Studies in rodents have demonstrated a role for the encoded protein in spermiogenesis and the nonsens

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miRTarBase ID	miRNA	Experiments	Reference
MIRT642748	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT642746	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT642747	hsa-miR-3183	HITS-CLIP	23824327
MIRT642745	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT642744	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT642743	hsa-miR-138-1-3p	HITS-CLIP	23824327
MIRT642742	hsa-miR-4469	HITS-CLIP	23824327
MIRT642741	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT642740	hsa-miR-4287	HITS-CLIP	23824327
MIRT642739	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT642738	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT642737	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT642736	hsa-miR-155-5p	HITS-CLIP	23824327
MIRT642735	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT642748	hsa-miR-6800-3p	HITS-CLIP	23824327
MIRT642746	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT642747	hsa-miR-3183	HITS-CLIP	23824327
MIRT642745	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT642744	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT642743	hsa-miR-138-1-3p	HITS-CLIP	23824327
MIRT642742	hsa-miR-4469	HITS-CLIP	23824327
MIRT642741	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT642740	hsa-miR-4287	HITS-CLIP	23824327
MIRT642739	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT642738	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT642737	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT642736	hsa-miR-155-5p	HITS-CLIP	23824327
MIRT642735	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT1417134	hsa-miR-196a	CLIP-seq
MIRT1417135	hsa-miR-196b	CLIP-seq
MIRT1417136	hsa-miR-329	CLIP-seq
MIRT1417137	hsa-miR-331-5p	CLIP-seq
MIRT1417138	hsa-miR-362-3p	CLIP-seq
MIRT1417139	hsa-miR-374a	CLIP-seq
MIRT1417140	hsa-miR-374b	CLIP-seq
MIRT1417141	hsa-miR-3927	CLIP-seq
MIRT1417142	hsa-miR-3973	CLIP-seq
MIRT1417143	hsa-miR-4477b	CLIP-seq
MIRT1417144	hsa-miR-4506	CLIP-seq
MIRT1417145	hsa-miR-4714-3p	CLIP-seq
MIRT1417146	hsa-miR-520g	CLIP-seq
MIRT1417147	hsa-miR-520h	CLIP-seq
MIRT1417148	hsa-miR-629	CLIP-seq
MIRT1417149	hsa-miR-1252	CLIP-seq
MIRT1417150	hsa-miR-23a	CLIP-seq
MIRT1417151	hsa-miR-23b	CLIP-seq
MIRT1417152	hsa-miR-23c	CLIP-seq
MIRT1417153	hsa-miR-3128	CLIP-seq
MIRT1417154	hsa-miR-3611	CLIP-seq
MIRT1417155	hsa-miR-4528	CLIP-seq
MIRT1417156	hsa-miR-4720-5p	CLIP-seq
MIRT1417157	hsa-miR-4799-3p	CLIP-seq
MIRT1417158	hsa-miR-656	CLIP-seq
MIRT2125132	hsa-miR-1179	CLIP-seq
MIRT2125133	hsa-miR-3658	CLIP-seq
MIRT2125134	hsa-miR-4775	CLIP-seq
MIRT2125135	hsa-miR-590-3p	CLIP-seq
MIRT2347525	hsa-miR-4307	CLIP-seq
MIRT2347526	hsa-miR-4423-3p	CLIP-seq
MIRT2347527	hsa-miR-4666-5p	CLIP-seq
MIRT2395629	hsa-miR-1279	CLIP-seq
MIRT2395630	hsa-miR-145	CLIP-seq
MIRT2125134	hsa-miR-4775	CLIP-seq
MIRT2395631	hsa-miR-4778-3p	CLIP-seq
MIRT2125135	hsa-miR-590-3p	CLIP-seq

Show/Hide all (10)

GO ID	Ontology	Definition	Evidence
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0007283	Process	Spermatogenesis	IBA
GO:0007283	Process	Spermatogenesis	IEA
GO:0007283	Process	Spermatogenesis	ISS
GO:0030154	Process	Cell differentiation	IEA
GO:0030719	Process	P granule organization	IBA
GO:0033391	Component	Chromatoid body	ISS
GO:0034587	Process	PiRNA processing	IBA
GO:0043186	Component	P granule	IBA

MIM	HGNC	e!Ensembl
611200	21339	ENSG00000180113

O60522

Protein name

Tudor domain-containing protein 6 (Antigen NY-CO-45) (Cancer/testis antigen 41.2) (CT41.2)

Protein function

Tudor domain-containing protein involved in germ cell development, more specifically the formation of chromatoid body (during spermiogenesis), Balbiani body (during oogenesis), germ plasm (upon fertilization), and for proper miRNA expression and

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00567	TUDOR	26 → 133	Tudor domain	Domain
PF00567	TUDOR	246 → 380	Tudor domain	Domain
PF00567	TUDOR	483 → 604	Tudor domain	Domain
PF00567	TUDOR	768 → 886	Tudor domain	Domain
PF00567	TUDOR	982 → 1102	Tudor domain	Domain
PF00567	TUDOR	1301 → 1422	Tudor domain	Domain
PF00567	TUDOR	1515 → 1638	Tudor domain	Domain

Sequence

MCSTPGMPAPGASLALRVSFVDVHPDVIPVQLWGLVGERRGEYLRLSREIQEAAATRGQW
ALGSASASPGELCLVQVGLLWHRCRVVSRQAQESRVFLLDEGRTITAGAGSLAPGRREFF
NLPSEVLGCVLAGLVPAGCGAGSGEPPQHWPADAVDFLSNLQGKEVHGCVLDVLLLHRLV
LLEVPDVFQQMRELGLARRVPDSLFRSLLERYLTAATASVGSGVPVLSRVPLKQKQPGLD
YFYPQLQLGVTEAVVITQVCHPHRIHCQLRSVSQEIHRLSESMAQVYRGSTGTGDENSTS
ATWEEREESPDKPGSPCASCGLDGHWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLR
YLLPEYFRMPVVTYPCALYGLWDGGRGWSRSQVGDLKTLILGKAVNAKIEFYCSFEHVYY
VSLYGEDGINLNRVFGVQSCCLADRVLQSQATEEEEPETSQSQSPAEEVDEEISLPALRS
IRLKMNAFYDAQVEFVKNPSEFWIRLRKHNVTFSKLMRRMCGFYSSASKLDGVVLKPEPD
DLCCVKWKENGYYRAIVTKLDDKSVDVFLVDRGNSENVDWYDVRMLLPQFRQLPILAVKC
TLADIWPLGKTWSQEAVSFFKKTVLHKELVIHILDKQDHQYVIEILDESRTGEENISKVI
AQAGYAKYQEFETKENILVNAHSPGHVSNHFTTESNKIPFAKTGEGEQKAKRENKTTSVS
KALSDTTVVTNGSTELVVQEKVKRASVYFPLMQNCLEIKPGSSSKGELEVGSTVEVRVSY
VENPGYFWCQLTRNIQGLKTLMSDIQYYCKNTAAPHQRNTLACLAKRTVNRQWSRALISG
IQSVEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKAQAFRCSLYNLIQPVGQNPFVWDV
KAIQAFNEFIDNAWQKNLELKCTIFALASINEELFNIVDLLTPFQSACHFLVEKRLARPV
KLQKPLESSVQLHSYFYSTHDMKIGSEELVYITHIDDPWTFYCQLARNANILEQLSCSIT
QLSKVLLNLKTSPLNPGTLCLAKYTDGNWYRGIVIEKEPKKVFFVDFGNIYVVTSDDLLP
IPSDAYDVLLLPMQAVRCSLSDIPDHIPEEVVVWFQETILDKSLKALVVAKDPDGTLIIE
LYGDNIQISASINKKLGLLSYKDRIRKKESEVLCSTTETLEEKNENMKLPCTEYLSKSVG
YKLPNKEILEESYKPQINSSYKELKLLQSLTKTNLVTQYQDSVGNKNSQVFPLTTEKKEE
ISAETPLKTARVEATLSERKIGDSCDKDLPLKFCEFPQKTIMPGFKTTVYVSHINDLSDF
YVQLIEDEAEISHLSERLNSVKTRPEYYVGPPLQRGDMICAVFPEDNLWYRAVIKEQQPN
DLLSVQFIDYGNVSVVHTNKIGRLDLVNAILPGLCIHCSLQGFEVPDNKNSKKMMHYFSQ
RTSEAAIRCEFVKFQDRWEVILADEHGIIADDMISRYALSEKSQVELSTQVIKSASSKSV
NKSDIDTSVFLNWYNPEKKMIRAYATVIDGPEYFWCQFADTEKLQCLEVEVQTAGEQVAD
RRNCIPCPYIGDPCIVRYREDGHYYRALITNICEDYLVSVRLVDFGNIEDCVDPKALWAI
PSELLSVPMQAFPCCLSGFNISEGLCSQEGNDYFYEIITEDVLEITILEIRRDVCDIPLA
IVDLKSKGKSINEKMEKYSKTGIKSALPYENIDSEIKQTLGSYNLDVGLKKLSNKAVQNK
IYMEQQTDELAEITEKDVNIIGTKPSNFRDPKTDNICEGFENPCKDKIDTEELEGELECH
LVDKAEFDDKYLITGFNTLLPHANETKEILELNSLEVPLSPDDESKEFLELESIELQNSL
VVDEEKGELSPVPPNVPLSQECVTKGAMELFTLQLPLSCEAEKQPELELPTAQLPLDDKM
DPLSLGVSQKAQESMCTEDMRKSSCVESFDDQRRMSLHLHGADCDPKTQNEMNICEEEFV
EYKNRDAISALMPLFSEEESSDGSKHNNGLPDHISAQLQNTYTLKAFTVGSKCVVWSSLR
NTWSKCEILETAEEGTRVLNLSNGMEEIVNPENVWNGIPKLDKSPPEKRGLEVMEI

Sequence length

2096

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Gastric cancer	Uncertain significance; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Long QT syndrome	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALE INFERTILITY WITH AZOOSPERMIA OR OLIGOZOOSPERMIA DUE TO SINGLE GENE MUTATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet, GenCC Disgenet, GenCC	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TDRD6-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Colon Carcinoma	Colon Carcinoma	BEFREE	12124339		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32828126	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Coronary Aneurysm	Coronary aneurysm	Pubtator	19948975	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infertility	Infertility	Pubtator	36241908	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	12124339		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oligospermia	Oligospermia	BEFREE	29551503		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	31682594	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	33711033	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

TDRD6 (tudor domain containing 6)