Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	221294
Gene name	5'-nucleotidase domain containing 1
Gene symbol	NT5DC1
Synonyms (NCBI Gene)	C6orf200LP2642NT5C2L1
Chromosome	6
Chromosome location	6q22.1
Summary	While the exact function of the protein encoded by this gene is not known, it belongs to the 5`(3`)-deoxyribonucleotidase family. [provided by RefSeq, May 2010]

170

Show/Hide all (170)

miRTarBase ID	miRNA	Experiments	Reference
MIRT003876	hsa-miR-15a-5p	Microarray	18362358
MIRT004370	hsa-miR-16-5p	Microarray	18362358
MIRT047616	hsa-miR-10a-5p	CLASH	23622248
MIRT710876	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT710875	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT710874	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710872	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT710876	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT710875	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT710874	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710873	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT710872	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT663892	hsa-miR-595	HITS-CLIP	21572407
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT517726	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT663895	hsa-miR-548n	HITS-CLIP	23824327
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	23824327
MIRT517729	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT663892	hsa-miR-595	HITS-CLIP	23824327
MIRT517728	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT517726	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT517730	hsa-miR-548at-5p	PAR-CLIP	23446348
MIRT517729	hsa-miR-561-3p	PAR-CLIP	23446348
MIRT517728	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT517727	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT517726	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT517728	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT517728	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT517728	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT517728	hsa-miR-223-5p	HITS-CLIP	27418678
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	27418678
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	27418678
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	27418678
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	27418678
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	27418678
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	27418678
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	27418678
MIRT663895	hsa-miR-548n	HITS-CLIP	27418678
MIRT663895	hsa-miR-548n	HITS-CLIP	27418678
MIRT663895	hsa-miR-548n	HITS-CLIP	27418678
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	27418678
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	27418678
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	27418678
MIRT517729	hsa-miR-561-3p	HITS-CLIP	27418678
MIRT517729	hsa-miR-561-3p	HITS-CLIP	27418678
MIRT517729	hsa-miR-561-3p	HITS-CLIP	27418678
MIRT517729	hsa-miR-561-3p	HITS-CLIP	27418678
MIRT517726	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT517726	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT517726	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT517726	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT663892	hsa-miR-595	HITS-CLIP	27418678
MIRT663892	hsa-miR-595	HITS-CLIP	27418678
MIRT663892	hsa-miR-595	HITS-CLIP	27418678
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT710876	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT710875	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT710874	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710872	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT710876	hsa-miR-483-3p	HITS-CLIP	19536157
MIRT710875	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT710874	hsa-miR-3667-3p	HITS-CLIP	19536157
MIRT710873	hsa-miR-2355-5p	HITS-CLIP	19536157
MIRT710872	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT663892	hsa-miR-595	HITS-CLIP	21572407
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	21572407
MIRT517726	hsa-miR-574-5p	HITS-CLIP	21572407
MIRT663895	hsa-miR-548n	HITS-CLIP	23824327
MIRT663894	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT663893	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT517730	hsa-miR-548at-5p	HITS-CLIP	23824327
MIRT517729	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT663892	hsa-miR-595	HITS-CLIP	23824327
MIRT517728	hsa-miR-223-5p	HITS-CLIP	23824327
MIRT517727	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT517726	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT517730	hsa-miR-548at-5p	PAR-CLIP	23446348
MIRT517729	hsa-miR-561-3p	PAR-CLIP	23446348
MIRT517728	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT517727	hsa-miR-6867-5p	PAR-CLIP	23446348
MIRT517726	hsa-miR-574-5p	PAR-CLIP	23446348
MIRT1195750	hsa-miR-101	CLIP-seq
MIRT1195751	hsa-miR-1185	CLIP-seq
MIRT1195752	hsa-miR-125a-3p	CLIP-seq
MIRT740173	hsa-miR-1264	CLIP-seq
MIRT1195753	hsa-miR-129-5p	CLIP-seq
MIRT1195754	hsa-miR-1323	CLIP-seq
MIRT1195755	hsa-miR-144	CLIP-seq
MIRT1195756	hsa-miR-146a	CLIP-seq
MIRT1195757	hsa-miR-146b-5p	CLIP-seq
MIRT1195758	hsa-miR-190	CLIP-seq
MIRT1195759	hsa-miR-190b	CLIP-seq
MIRT1195760	hsa-miR-3201	CLIP-seq
MIRT1195761	hsa-miR-326	CLIP-seq
MIRT1195762	hsa-miR-330-5p	CLIP-seq
MIRT1195763	hsa-miR-34b	CLIP-seq
MIRT1195764	hsa-miR-3654	CLIP-seq
MIRT1195765	hsa-miR-3679-5p	CLIP-seq
MIRT1195766	hsa-miR-3691-3p	CLIP-seq
MIRT1195767	hsa-miR-378	CLIP-seq
MIRT1195768	hsa-miR-378b	CLIP-seq
MIRT1195769	hsa-miR-378c	CLIP-seq
MIRT1195770	hsa-miR-378d	CLIP-seq
MIRT1195771	hsa-miR-378e	CLIP-seq
MIRT1195772	hsa-miR-378f	CLIP-seq
MIRT1195773	hsa-miR-378h	CLIP-seq
MIRT1195774	hsa-miR-378i	CLIP-seq
MIRT1195775	hsa-miR-3914	CLIP-seq
MIRT1195776	hsa-miR-422a	CLIP-seq
MIRT740174	hsa-miR-4326	CLIP-seq
MIRT1195777	hsa-miR-4452	CLIP-seq
MIRT1195778	hsa-miR-4480	CLIP-seq
MIRT1195779	hsa-miR-4676-5p	CLIP-seq
MIRT1195780	hsa-miR-4719	CLIP-seq
MIRT1195781	hsa-miR-4791	CLIP-seq
MIRT1195782	hsa-miR-516b	CLIP-seq
MIRT1195783	hsa-miR-548o	CLIP-seq
MIRT1195784	hsa-miR-548u	CLIP-seq
MIRT1195785	hsa-miR-575	CLIP-seq
MIRT1195786	hsa-miR-576-5p	CLIP-seq
MIRT1195787	hsa-miR-579	CLIP-seq
MIRT1195788	hsa-miR-580	CLIP-seq
MIRT1195789	hsa-miR-582-5p	CLIP-seq
MIRT1195790	hsa-miR-589	CLIP-seq
MIRT1195791	hsa-miR-593	CLIP-seq
MIRT1195792	hsa-miR-606	CLIP-seq
MIRT1195793	hsa-miR-765	CLIP-seq
MIRT1195794	hsa-miR-873	CLIP-seq
MIRT2056810	hsa-miR-155	CLIP-seq
MIRT2056811	hsa-miR-4720-3p	CLIP-seq
MIRT2056812	hsa-miR-4804-3p	CLIP-seq
MIRT2056813	hsa-miR-561	CLIP-seq
MIRT2285286	hsa-miR-200b	CLIP-seq
MIRT2285287	hsa-miR-200c	CLIP-seq
MIRT2285288	hsa-miR-429	CLIP-seq
MIRT2285289	hsa-miR-4659a-3p	CLIP-seq
MIRT2285290	hsa-miR-4659b-3p	CLIP-seq
MIRT2285291	hsa-miR-513a-3p	CLIP-seq
MIRT1195786	hsa-miR-576-5p	CLIP-seq
MIRT1195792	hsa-miR-606	CLIP-seq
MIRT1195775	hsa-miR-3914	CLIP-seq
MIRT1195779	hsa-miR-4676-5p	CLIP-seq
MIRT1195785	hsa-miR-575	CLIP-seq
MIRT1195794	hsa-miR-873	CLIP-seq
MIRT1195751	hsa-miR-1185	CLIP-seq
MIRT1195758	hsa-miR-190	CLIP-seq
MIRT1195759	hsa-miR-190b	CLIP-seq
MIRT2686639	hsa-miR-2053	CLIP-seq
MIRT1195760	hsa-miR-3201	CLIP-seq
MIRT1195761	hsa-miR-326	CLIP-seq
MIRT1195762	hsa-miR-330-5p	CLIP-seq
MIRT1195765	hsa-miR-3679-5p	CLIP-seq
MIRT1195766	hsa-miR-3691-3p	CLIP-seq
MIRT2686640	hsa-miR-369-3p	CLIP-seq
MIRT2686641	hsa-miR-374a	CLIP-seq
MIRT2686642	hsa-miR-374b	CLIP-seq
MIRT2686643	hsa-miR-4428	CLIP-seq
MIRT1195778	hsa-miR-4480	CLIP-seq
MIRT1195781	hsa-miR-4791	CLIP-seq
MIRT1195782	hsa-miR-516b	CLIP-seq
MIRT1195791	hsa-miR-593	CLIP-seq
MIRT1195793	hsa-miR-765	CLIP-seq
MIRT2686644	hsa-miR-769-5p	CLIP-seq
MIRT2686645	hsa-miR-889	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0008253	Function	5'-nucleotidase activity	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
621076	21556	ENSG00000178425

Q5TFE4

Protein name

5'-nucleotidase domain-containing protein 1 (EC 3.1.3.-)

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05761	5_nucleotid	1 → 377		Family

Sequence

MAQHFSLAACDVVGFDLDHTLCRYNLPESAPLIYNSFAQFLVKEKGYDKELLNVTPEDWD
FCCKGLALDLEDGNFLKLANNGTVLRASHGTKMMTPEVLAEAYGKKEWKHFLSDTGMACR
SGKYYFYDNYFDLPGALLCARVVDYLTKLNNGQKTFDFWKDIVAAIQHNYKMSAFKENCG
IYFPEIKRDPGRYLHSCPESVKKWLRQLKNAGKILLLITSSHSDYCRLLCEYILGNDFTD
LFDIVITNALKPGFFSHLPSQRPFRTLENDEEQEALPSLDKPGWYSQGNAVHLYELLKKM
TGKPEPKVVYFGDSMHSDIFPARHYSNWETVLILEELRGDEGTRSQRPEESEPLEKKGKY
EGPKAKPLNTSSKKWGSFFIDSVLGLENTEDSLVYTWSCKRISTYSTIAIPSIEAIAELP
LDYKFTRFSSSNSKTAGYYPNPPLVLSSDETLISK

Sequence length

455

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (13)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CARPAL TUNNEL SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENTAL CARIES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLAUCOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MACULAR DEGENERATION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METAPHYSEAL CHONDRODYSPLASIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METAPHYSEAL CHONDRODYSPLASIA SCHMID TYPE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUTROPENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (10)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Age related macular degeneration	Age-related macular degeneration	GWASCAT_DG	23455636		★★★★★ ★☆☆☆☆ Found in Text Mining only
Age related macular degeneration	Age-related macular degeneration	GWASDB_DG	23455636		★★★★★ ★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Attention deficit hyperactivity disorder	Pubtator	27754487	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36820551	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	22736055		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	23982958	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	CTD_human_DG	22535842		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Metaphyseal chondrodysplasia Schmid type	Metaphyseal chondrodysplasia	CLINVAR_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Myopia	Myopia	GWASCAT_DG	27182965		★★★★★ ★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★★★★★ ★☆☆☆☆ Found in Text Mining only

NT5DC1 (5'-nucleotidase domain containing 1)